Egyptian Rheumatologist最新文献

{"title":"Clinical signficance of human leucocytic antigen (HLA-B27) in patients with early and late-onset axial spondyloarthritis","authors":"Ebru Yilmaz ,&nbsp;Özlem Toluk","doi":"10.1016/j.ejr.2024.10.001","DOIUrl":"10.1016/j.ejr.2024.10.001","url":null,"abstract":"<div><h3>Aim of the work</h3><div>To compare the clinical, laboratory and radiological features of patients with positive human leucocytic antigen (HLA)-B27 in patients with early-onset (EOSpA) and late-onset (LOSpA) axial spondyloarthritis.</div></div><div><h3>Patients and methods</h3><div>The study included 195 axial-SpA patients with positive HLA-B27 divided into those ≤45 years (EOSpA) and those &gt;45 years (LOSpA). Characteristics of the patients, medications received as well as Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Functional Index (BASFI), Maastricht Ankylosing Spondylitis Enthesitis Score (MASES), Bath Ankylosing Spondylitis Radiological Index (BASRI), Ankylosing Spondylitis Disease Activity Score (ASDAS) scores were recorded.</div></div><div><h3>Results</h3><div>The mean age of the patients was 43.6 ± 13.3 years and 121 (62.1 %) were females. Shoulder pain, peripheral arthritis, and adhesive capsulitis were significantly more common in LOSpA (20 %,13.7 % and 5.3 %; p = 0.001, p = 0.017, and p = 0.026) whereas dorsal and low back pain were significantly more prominent in EOSpA (20 % and 61 %; p = 0.011 and p = 0.001). There was a significant difference between the two groups in terms of gender, body mass index (BMI), smoking, anti-tumor necrosis factor (TNF)-α use, C-reactive protein (CRP), BASFI, BASDAI, ASDAS, MASES and BASRI scores (p &lt; 0.001, p &lt; 0.001, p = 0.016, p &lt; 0.001, p &lt; 0.001, p = 0.009, p &lt; 0.001, p = 0.018, p &lt; 0.001, p &lt; 0.001, respectively). On regression analysis, male gender and high CRP were associated with EOSpA (p = 0.011, and p = 0.001), while early-stage sacroiliitis, non-steroidal anti-inflammatory drug (NSAID) use, high BASFI and BASRI were related to LOSpA (p = 0.004, p = 0.003, p &lt; 0.0001 and p &lt; 0.0001).</div></div><div><h3>Conclusion</h3><div>LOSpA was associated with female gender, peripheral involvement, lower levels of inflammatory markers, higher functional status and disease activity, higher enthesitis and radiological scores, and less use of anti-TNF-α.</div></div>","PeriodicalId":46152,"journal":{"name":"Egyptian Rheumatologist","volume":"47 1","pages":"Pages 12-15"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142529187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The journey of pain management for fibromyalgia patients: A ten year experience from Tunisia","authors":"Selma Bouden ,&nbsp;Hadwa Beji ,&nbsp;Leila Rouached ,&nbsp;Aicha Ben Tekaya ,&nbsp;Ines Mahmoud ,&nbsp;Rawdha Tekaya ,&nbsp;Olfa Saidane ,&nbsp;Leila Abdelmoula","doi":"10.1016/j.ejr.2024.08.003","DOIUrl":"10.1016/j.ejr.2024.08.003","url":null,"abstract":"<div><h3>Introduction</h3><p>Fibromyalgia often deteriorates the quality of life of patients on physical, emotional, socio-familial, and professional levels.</p></div><div><h3>Aim of the work</h3><p>To describe the characteristics of fibromyalgia patients and to assess the impact of fibromyalgia on their quality of life.</p></div><div><h3>Patients and methods</h3><p>A questionnaire was provided to the fibromyalgia patients at the pain management center of Tunis, during the last ten years and the sociodemographic data, journey characteristics and satisfaction regarding the quality of their care were recorded and the impact of fibromyalgia on the quality of life was assessed using the Fibromyalgia Impact Questionnaire (FIQ).</p></div><div><h3>Results</h3><p>The work included 110 patients, 93 females and 13 males (F:M 7.2:1) and a mean age of 52 ± 12 years. 65 % reported an initial pain visual analog scale (VAS) ≥ 7. The mean consultation and diagnostic delays were 75 ± 30 and 44 ± 28 months, respectively. 94 % of patients were initially misdiagnosed, despite consulting more than two different physicians. The mean FIQ total was 77.5 ± 13.Age, female gender, and manual professions were related to a more impaired physical impact of fibromyalgia (p = 0.02; p = 0.01; p = 0.03, respectively). Patients whose fibromyalgia trigger was persistent stress (n = 50) reported more impaired FIQ (p = 0.001). Patients with shorter consultation and diagnostic delays reported more improvement (p = 0.001 and p = 0.01, respectively). Patients treated with tricyclic antidepressants and vitamins felt significantly improved (p = 0.02 and p = 0.002). Non-pharmacological treatments included physical therapy, yoga, acupuncture, and thermal baths.</p></div><div><h3>Conclusions</h3><p>The quality of life in fibromyalgia patients is frequently impaired, and the journey is complex and ambivalent.</p></div>","PeriodicalId":46152,"journal":{"name":"Egyptian Rheumatologist","volume":"46 4","pages":"Pages 194-197"},"PeriodicalIF":1.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142048953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knee ultrasonography in end stage kidney disease patients","authors":"Amany M. Diab ,&nbsp;Manal Eldeeb ,&nbsp;Samar S. Yousuf ,&nbsp;Amr M. Shaker","doi":"10.1016/j.ejr.2024.07.003","DOIUrl":"10.1016/j.ejr.2024.07.003","url":null,"abstract":"<div><h3>Aim of the work</h3><p>To detect ultrasonographic findings in the knees of end stage kidney disease (ESKD) patients on regular hemodialysis.</p></div><div><h3>Patients and methods</h3><p>Thirty adult ESKD patients on regular hemodialysis for more than one year were studied. Patients with gout, knee joint replacement or injection with steroids were excluded. Knee ultrasonography was done to evaluate the femoral cartilage as regards its thickness, sharpness or urate crystal deposition.</p></div><div><h3>Results</h3><p>This study included 13 male (43.3 %) and 17 females (56.7 %) with mean age 45 ± 12 years, body mass index (BMI) 26.4 ± 5.4 Kg/m2, duration of hemodialysis 1.5–27 years and serum uric acid 3.6 (1–10). Femoral cartilage double contour sign was present in 11 (36.7 %) patients, suprapatellar effusion in 20 (66.7 %), suprapatellar aggregates in 10 (33.3 %), medial patellar effusion in 8 (26.7 %), lateral patellar effusion in 12 (40 %) and lateral patellar aggregate was in 6 (20 %). Serum uric acid (SUA) level tended to correlate with body mass index (BMI), total cholesterol, LDL, fasting blood sugar (FBS), and platelet counts without significance and negatively correlated to age, hemoglobin (Hb) level, total leucocytic count (TLC), size of suprapatellar effusion and duration of hemodialysis.</p></div><div><h3>Conclusion</h3><p>Effusion, urate crystal deposition, double contour and aggregate were frequently observed in knee ultrasound in ESRD patients on hemodialysis. Both double contour and aggregates were the most common combined ultrasound finding. The ultrasonographic findings were not related to the duration of hemodialysis or uric acid level.</p></div>","PeriodicalId":46152,"journal":{"name":"Egyptian Rheumatologist","volume":"46 4","pages":"Pages 185-189"},"PeriodicalIF":1.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141950547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Esophageal stenosis as an initial presentation of Behçet’s disease: A case report and literature review","authors":"Samaher Almousa ,&nbsp;Aya Alhalaki ,&nbsp;Ali Ahmad ,&nbsp;Adnan Abdulhaleem ,&nbsp;Ramy Khazem","doi":"10.1016/j.ejr.2024.06.001","DOIUrl":"https://doi.org/10.1016/j.ejr.2024.06.001","url":null,"abstract":"<div><h3>Introduction</h3><p>Behçet’s disease (BD) is a multiorgan inflammatory vascular disease of unknown etiology, affecting vessels of any size and type. While, gastrointestinal involvement in BD is uncommon, esophageal Behçet’s disease (EBD) is rarely reported, especially in the Mediterranean region.</p></div><div><h3>Aim of the work</h3><p>To report a case with esophageal stenosis as an initial presentation of BD and compare to reported cases worldwide.</p></div><div><h3>Case presentation</h3><p>A 30-year-old Syrian male presented with dysphagia, odynophagia with weight loss 20 kg. He had a history of recurrent oral ulcers and was otherwise healthy. On examination he appeared pale, dehydrated with normal systemic examination. Blood tests revealed anemia (hemoglobin 10.5 mg/dl), elevated erythrocyte sedimentation rate (ESR) (90 mm/1^sthr) and C-reactive protein (CRP)(98 mg/dl)levels. Upper gastrointestinal endoscopy showed mild ulceration with edema and mucosal thickness at the upper sphincter of the esophagus, leading to stenosis. Biopsy showed nonspecific inflammation, without granulomas or signs of malignancy. Percutaneous endoscopic gastrostomy (PEG) tube was placed and during hospitalization he developed genital ulcers and hemoptysis, with chest computed tomography revealing pulmonary vasculitis. The patient was diagnosed with BD, and treated with methylprednisolone and cyclophosphamide, leading to significant improvement. After two months he could swallow normally, and the PEG tube was removed with no recurrence after one year follow-up. He was maintained on azathioprine 100 g/day and prednisolone 7.5 mg/day.</p></div><div><h3>Conclusion</h3><p>BD is a diagnostic challenge due to its diverse manifestations and geographic variations. EBD is rare and can cause disability. Early diagnosis of EBD and appropriate treatment are crucial for improving outcomes.</p></div>","PeriodicalId":46152,"journal":{"name":"Egyptian Rheumatologist","volume":"46 4","pages":"Pages 157-160"},"PeriodicalIF":1.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141483614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between dry eye disease subtypes and rheumatoid arthritis","authors":"Hugo Pena-Verdeal ,&nbsp;Jacobo Garcia-Queiruga ,&nbsp;Belén Sabucedo-Villamarin ,&nbsp;Carlos Garcia-Resua ,&nbsp;Maria J. Giraldez ,&nbsp;Eva Yebra-Pimentel","doi":"10.1016/j.ejr.2024.06.002","DOIUrl":"https://doi.org/10.1016/j.ejr.2024.06.002","url":null,"abstract":"<div><h3>Aim of the work</h3><p>To evaluate the association of dry eye disease (DED) subtypes (aqueous deficient dry eye, ADDE and evaporative dry eye, EDE) and the presence of rheumatoid arthritis (RA) in patients.</p></div><div><h3>Patients and methods</h3><p>260 volunteer DED participants were recruited for an observational cross-sectional study based on the Tear Film Ocular Society Dry Eye Workshop II criteria, which included tear film osmolarity, fluorescence break-up time, and ocular surface damage assessment. Participants were recruited using QR linked to designated mobile forms to obtain symptomatology status, demographics, and RA diagnosis by their medical doctor. Tear meniscus and lipid layer were also evaluated to differentiate between ADDE, EDE, or mixed dry eye in addition to the DED diagnostic criteria. Participants with mixed dry eye were excluded from the analysis to avoid bias.</p></div><div><h3>Results</h3><p>After initial recruitment, 149 eligible participants with an ADDE or EDE diagnosis were included in the final analysis, where 12,1% have an RA diagnosis. The ADDE group had a higher likelihood of having RA (OR = 4.69, 95 %CI = 1.46–15.01) than the EDE group. Additionally, the number of participants with RA in the ADDE group was statistically higher than those in the EDE group (all p = 0.006). Furthermore, a correlation was obtained between RA and a diagnosis of ADDE (p = 0.005).</p></div><div><h3>Conclusion</h3><p>There was a significant association between ADDE and the presence of RA in patients and the association was more likely compared to those with EDE. This finding underscores the need for specific diagnostic and management strategies for RA patients presenting with DED.</p></div>","PeriodicalId":46152,"journal":{"name":"Egyptian Rheumatologist","volume":"46 4","pages":"Pages 161-165"},"PeriodicalIF":1.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141483615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microribonucleic acid-9 (miRNA-9) as a potential diagnostic marker in Behҫet’s syndrome patients","authors":"Moustafa A. Saad ,&nbsp;Hala I. El Gendy ,&nbsp;Mervat E. Behiry ,&nbsp;Olfat Shaker ,&nbsp;Ahmed H. Laymouna","doi":"10.1016/j.ejr.2024.07.004","DOIUrl":"10.1016/j.ejr.2024.07.004","url":null,"abstract":"<div><h3>Aim of the work</h3><p>Behҫet’s syndrome is a disease that causes inflammation of small, medium, and large vessels in a lot of body organs. Microribonucleic acid-9 (miRNA-9) is an important regulator of inflammation through negative feedback inhibition of the Nuclear Factor Kappa B pathway. This work objective was to assess the expression level of miRNA-9 in Behҫet’s syndrome patients and to study its relation to different activity domains.</p></div><div><h3>Patients and methods</h3><p>Sixty adult Behҫet’s syndrome patients with sixty matched controls were recruited. The activity scores of patients were calculated using Behcet’s Disease Current Activity Form (BDCAF), and the Behcet Syndrome Activity Score (BSAS). Gene expression of miRNA-9 was assessed using real-time PCR.</p></div><div><h3>Results</h3><p>The mean age of the cases was 33.8 ± 7.92 years. Male to female ratio was 6.5:1. The most frequent manifestations of activity were new eye involvement (58.3 %) followed by arthralgia (55 %) and then mouth ulcerations (41.7 %). The median activity scores were 7/20 on the BDCAF and 23/100 on the BSAS. The mean miRNA-9 showed a 53.4 fold change among cases compared to controls (p &lt; 0.001). Using the receiver operating characteristic (ROC) curve, a miRNA-9 cutoff value fold change of 1.035 would significantly discriminate patients from controls (p &lt; 0.001) with 71.7 % sensitivity and 100 % specificity. There was no statistically significant relation between miRNA-9 fold changes and the studied activity scores or the different domains of disease activity.</p></div><div><h3>Conclusions</h3><p>miRNA-9 is over-expressed in Behҫet’s syndrome and may be considered as a potential diagnostic marker and a future therapeutic target in Behcet’s syndrome.</p></div>","PeriodicalId":46152,"journal":{"name":"Egyptian Rheumatologist","volume":"46 4","pages":"Pages 190-193"},"PeriodicalIF":1.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141953716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic variations of interleukin 32(rs28372698) and interleukin 37 (rs3811047), and their serum levels in systemic lupus erythematosus patients","authors":"Wafaa Gaber ,&nbsp;Noha M. Abdel Baki ,&nbsp;Shaimaa Badran ,&nbsp;Walaa Abdelfattah ,&nbsp;Marwa K. Sallam ,&nbsp;Alkhateeb Alkemary ,&nbsp;Mai Samir ,&nbsp;Marwa H. Niazy","doi":"10.1016/j.ejr.2024.08.004","DOIUrl":"10.1016/j.ejr.2024.08.004","url":null,"abstract":"<div><h3>Background</h3><p>Systemic lupus erythematosus (SLE) is a complex autoimmune disease. The underlying pathogenesis still needs to be elucidated.</p></div><div><h3>Aim of the work</h3><p>To investigate interleukin-32 (IL-32) (rs28372698) and interleukin-37 (IL-37) (rs3811047) genetic variations, measure their serum levels in SLE patients, and evaluate their relation with disease parameters.</p></div><div><h3>Patients and methods</h3><p>This work included 46 SLE patients and 43 matched controls. The SLE disease activity index (SLEDAI) and SLE damage index (SDI) were recorded. Genetic variations were assessed by real-time polymerase chain reaction (RT-PCR), and serum levels of IL-32 and IL-37 were measured by enzyme-linked immune-sorbent assay (ELISA).</p></div><div><h3>Results</h3><p>The mean age of the patients was 29.2 ± 6.1 years, and the female: male ratio was 45:1. IL-37 genetic variation (rs3811047) GG was significantly more frequent in SLE patients (24/46,52.2 %) (p = 0.024), those with lupus nephritis (LN)(18/27,66.7 %) (p = 0.038), and active disease (15/21,68.2 %) (p = 0.002). The IL-37 G allele was significantly more represented in lupus patients (68/92,73.9 %)(p = 0.008), with IL-37 serum levels significantly increased in SLE patients (855.7 ± 465.4) compared to the control (504.1 ± 553.8) (p = 0.002). Although serum IL-32 was significantly higher in patients who received cyclophosphamide (CYC),and significantly correlated with total cholesterol, on regression analysis neither CYC nor cholesterol were significant factor for serum IL-32. The area under the curve for IL-37 serum levels to distinguish SLE patients from controls was 0.71, (CI 0.601–0.827; p = 0.001).</p></div><div><h3>Conclusion</h3><p>The IL-37 genetic variation (rs3811047) GG was significantly elevated in SLE, LN, and active patients. G allele was significantly more represented in lupus patients. IL-37 serum levels were significantly increased in SLE patients.</p></div>","PeriodicalId":46152,"journal":{"name":"Egyptian Rheumatologist","volume":"46 4","pages":"Pages 207-212"},"PeriodicalIF":1.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142089294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hand and wrist musculoskeletal changes in systemic sclerosis patients","authors":"Caroline S. Morad ,&nbsp;Reem A. Habeeb ,&nbsp;Youssy S. Eshak Gergius ,&nbsp;Youssef S. Hendawy ,&nbsp;Sara M. Othman ,&nbsp;AlShymaa M. Farouk","doi":"10.1016/j.ejr.2024.06.004","DOIUrl":"https://doi.org/10.1016/j.ejr.2024.06.004","url":null,"abstract":"<div><h3>Aim of the work</h3><p>To study hand and wrist musculoskeletal changes among systemic sclerosis (SSc) patients.</p></div><div><h3>Patients and methods</h3><p>Thirty adult SSc patients were enrolled and subjected to detailed medical history, clinical examination, laboratory investigations, and imaging studies including X-ray and musculoskeletal ultrasound (MSUS) on both hands and wrists.</p></div><div><h3>Results</h3><p>The mean age of the studied patients was 40 ± 9.9 years, disease duration 5.4 ± 4.1 years and 28 (93.3 %) were females. Joint space narrowing (JSN) was the commonest finding in plain X-ray being detected in 9 (30 %) patients affecting mostly metacarpophalangeal joints (MCPs). Other X-ray findings included erosions (13.3 %), osteophytes (6.7 %), calcinosis (10 %), acro-osteolysis (13.3 %), and flexion contractures (3.3 %). Tenosynovitis was the most prevalent finding in MSUS detected in 43.3 % with the sclerosing pattern being the dominant type affecting mainly extensor tendons. 23.3 % of patients had active wrist synovitis, while 13.3 % of patients had wrist effusion, 13.3 % had MCP erosions, 13.3 % had MCP JSN, and 10 % had osteophytes. Patients who had no arthritis on presentation had a higher frequency of digital ulcers and tenosynovitis. Regression analysis showed that lack of hydroxychloroquine and methotrexate intake, absence of digital ulcers, presence of morning stiffness, erythrocyte sedimentation rate (ESR) &gt; 27 mm/h and C-reactive protein (CRP) &gt; 9 mg/dL, JSN by X-ray and absence of tenosynovitis by US were associated with arthritis.</p></div><div><h3>Conclusion</h3><p>Articular involvement in SSc is frequent and could be the main presenting symptom. Clinical examination, ESR and CRP testing, along with plain radiography, and musculoskeletal ultrasonography are important to detect arthritis early and treat accordingly.</p></div>","PeriodicalId":46152,"journal":{"name":"Egyptian Rheumatologist","volume":"46 4","pages":"Pages 175-179"},"PeriodicalIF":1.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141541129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A single-center experience: Enteropathic arthritis in inflammatory bowel diseases","authors":"Barış Çabuk ,&nbsp;Dilara Bulut Gökten ,&nbsp;Tevfik Solakoğlu ,&nbsp;Rafet Mete ,&nbsp;Nurten Türkel Küçükmetin ,&nbsp;Rıdvan Mercan","doi":"10.1016/j.ejr.2024.07.001","DOIUrl":"https://doi.org/10.1016/j.ejr.2024.07.001","url":null,"abstract":"<div><h3>Aim of the work</h3><p>To ascertain the frequency of enteropathic arthritis among patients diagnosed with inflammatory bowel disease (IBD) and to investigate the relation between spondyloarthritis (SpA) and patients treated for IBD.</p></div><div><h3>Patients and methods</h3><p>This study examined 124 adult patients with IBD. The evaluation encompassed both axial and peripheral SpA. Information pertaining to the patients’ age, gender, age at the time of IBD and SpA diagnosis, symptoms of inflammatory low back pain (iLBP), dactylitis, peripheral arthritis, history of uveitis, pelvic X-ray, sacroiliac joint magnetic resonance imaging (MRI), ankylosing spondylitis disease actviity score (ASDAS) and Bath ankylosing spondylitis disease actvity index (BASDAI) were compiled.</p></div><div><h3>Results</h3><p>The IBD patients were 82 having ulcerative colitis (UC) and 42 Crohns disease (CD). 58 (46.8 %) were female and 66 (53.2 %) males. 36 (29 %) were diagnosed with SpA, 18 males and 18 females. The age of the patients was 49 ± 11.2 years (18–74 years). The duration of IBD was 5.96 ± 5.54 years (1–29 years). Sacroiliitis was assessed in 60 (48.3 %) patients using MRI. None of the patients had psoriasis or uveitis. Dactylitis was present in 1.6 % and enthesitis in 8 % of patients with IBD. In UC group, 18 (21.9 %) were diagnosed with SpA and in CD group, 18 (42.8 %) had SpA. No significant relationship was found between the diagnosis of UC/CD and the general SpA group.</p></div><div><h3>Conclusion</h3><p>A considerable number of individuals with IBD also experience SpA. Any delay in diagnosing enteropathic arthritis could lead to functional limitations. Therefore, timely diagnosis is crucial to facilitate optimal treatment.</p></div>","PeriodicalId":46152,"journal":{"name":"Egyptian Rheumatologist","volume":"46 4","pages":"Pages 171-174"},"PeriodicalIF":1.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141541128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"C-reactive protein/albumin ratio and its improvement with disease activity among axial spondyloarthritis and psoriatic arthritis patients: A prospective study","authors":"Noha A. Abdelsalam,&nbsp;Enas I. Abdelhady,&nbsp;Mona Rabie,&nbsp;Reham Abd Elkhalek","doi":"10.1016/j.ejr.2024.07.002","DOIUrl":"10.1016/j.ejr.2024.07.002","url":null,"abstract":"<div><p><strong>Background</strong>: The C-reactive protein /albumin ratio (CAR) has emerged as a novel biomarker in inflammatory conditions. <strong>Aim of the work:</strong> To assess the association of CAR with disease activity and its possible role as a biomarker for improvement among Axial spondyloarthritis (axSpA) and Psoriatic Arthritis (PsA) patients. <strong>Patients and methods:</strong> The study was conducted on 85 axSpA and 51 PsA patients. C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), albumin, CAR, and the AS disease activity score (ASDAS) as well as the disease activity PsA (DAPSA) score measures were calculated at baseline and after three months during the follow-up visit. <strong>Results:</strong> The CAR significantly correlated with the ASDAS in axSpA patients (r = 0.58, p &lt; 0.001) and had a tendency to correlate with the DAPSA in the PsA group. (r = 0.1, p = 0.47). There was a fair agreement between CAR and ASDAS improvements. However, CAR was not suitable for the assessment of improvement in axSpA patients compared to both ASDAS and ASDAS clinically important improvement (ASDAS-CII) (sensitivity:86 %, specificity:46.9 %, accuracy:70.7 %, and sensitivity: 14 %, specificity: 75 %, accuracy: 37.8 %, respectively) or in PsA patients compared to both DAPSA improvement and response (sensitivity: 90 %, specificity: 30 %, accuracy: 78 % and sensitivity: 30 %, specificity: 70 %, accuracy: 38 %, respectively). <strong>Conclusion:</strong> The CAR is a simple rapid inexpensive objective test for evaluating the disease activity in axSpA rather than in PsA. On follow-up, the CAR improvement was unsuitable to assess improvement among axSpA and PsA patients.</p></div>","PeriodicalId":46152,"journal":{"name":"Egyptian Rheumatologist","volume":"46 4","pages":"Pages 180-184"},"PeriodicalIF":1.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141950548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}