Egyptian Rheumatologist最新文献

{"title":"Coronavirus disease 2019 (COVID-19) infection in patients with rheumatic diseases: Clinical characteristics and relation to anti-rheumatic therapy","authors":"Fatma M. Aboud ,&nbsp;Shaimaa S. Yousef ,&nbsp;Mona M. El Bably ,&nbsp;Rasha N. Thabet","doi":"10.1016/j.ejr.2023.08.003","DOIUrl":"https://doi.org/10.1016/j.ejr.2023.08.003","url":null,"abstract":"<div><h3>Background</h3><p>Rheumatic disease (RD) patients are risky to severe coronavirus disease-2019 (COVID-19) infection, however, antirheumatic drugs may treat the infection and improve the outcome.</p></div><div><h3>Aim of the work</h3><p>To describe the clinical manifestations of COVID-19 infection in patients with rheumatic diseases and to investigate the relationship with antirheumatic therapy.</p></div><div><h3>Patients and methods</h3><p>The study included 215 RD patients. Patients' clinical characteristics and medications received were recorded as well as history of COVID-19 infection.</p></div><div><h3>Results</h3><p>The RD patients had systemic lupus erythematosus (SLE) (40.5%), rheumatoid arthritis (35.8%), psoriatic arthritis (PsA) (7.4%), ankylosing spondylitis (AS) (5.1%), gout (4.2%), systemic sclerosis (SSc) (3.3%), dermatomyositis (1.9%), Behςets disease (1.4%) and adult-onset Stills disease (0.5%). COVID-19 infection was reported in 124 (57.7%) RD patients. Body-ache was the commonest manifestation (n = 116;93.5%) followed by headache (n = 97;78%), fever (n = 90;72.5%). Infected patients were significantly older, with higher frequency of diabetes and hypertension without significant difference regarding type of RD or treatment except for lower frequency of biologics (n = 7;5.7%) compared to noninfected (n = 22;24.2%)(p &lt; 0.001) patients. 95(76.6%) received home treatment, 27(21.7%) were hospitalized and 2(1.6%) needed intensive care. Hospitalized patients were significantly older (p &lt; 0.001), had longer disease duration (p = 0.017), higher frequency of diabetes/hypertension (p &lt; 0.001) and lower frequency of azathioprine intake (p &lt; 0.034). Recovery period significantly correlated with disease duration (r = 0.197,p = 0.028) and age (r = 0.392,p &lt; 0.001).</p></div><div><h3>Conclusion</h3><p>Body-aches, headache and fever were the commonest symptoms of COVID-19 infection in RD patients. Most infections were mild. Severe infection was related to older age, longer disease duration, diabetes and hypertension. The RDs and therapy were not associated with COVID-19 infection outcome.</p></div>","PeriodicalId":46152,"journal":{"name":"Egyptian Rheumatologist","volume":"45 4","pages":"Pages 314-318"},"PeriodicalIF":0.9,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49790358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical features, radiological characteristics, and outcome of coronavirus disease-2019 (COVID-19) infection among hospitalized patients with autoimmune and rheumatic diseases: A multicenter study","authors":"Samar Tharwat ,&nbsp;Gehad A. Saleh ,&nbsp;Haidy Ali Mohammed ,&nbsp;Mohammed Kamal Nassar ,&nbsp;Marwa Saleh ,&nbsp;Esraa Jamal ,&nbsp;Shaimaa El-Ashwah","doi":"10.1016/j.ejr.2023.09.004","DOIUrl":"https://doi.org/10.1016/j.ejr.2023.09.004","url":null,"abstract":"<div><h3>Background</h3><p>A general comprehension of coronavirus disease-2019 (COVID-19) characteristics in patients with autoimmune and/or rheumatic diseases (ARDs) is required</p></div><div><h3>Aim of the work</h3><p>To identify COVID-19 infection characteristics in hospitalized patients with ARDs and identify factors contributing to mortality in this population.</p></div><div><h3>Patients and methods</h3><p>This study enrolled symptomatic ARD patients with COVID-19 infection and a control group of COVID-19 infected subjects matched in age and gender. Clinical and laboratory data were obtained, and chest computerized tomography images were analyzed for severity using COVID-19 Reporting and Data System (CO-RADS) and CT total severity score (CT-TSS).</p></div><div><h3>Results</h3><p>The study included 50 ARD patients and 29 controls with COVID-19 infection. The ARD patients mean age was 49.8 ± 16.3 years and demonstrated a significant association with fever (p = 0.004), fatigue (p = 0.007), cough (p &lt; 0.001), higher levels of serum bilirubin (p = 0.003), serum creatinine (p = 0.051) and D-dimer (p = 0.001). ARD patients were more frequently admitted to the intensive care unit (40% vs 10.3%, p = 0.005) and tended to have a higher mortality rate (32% vs 13.8%, p = 0.11). Ground glass opacity was the predominant pattern in ARD patients (74% vs 37.9%), while consolidation was predominant in the control (55.2% vs 20%). The respiratory rate (p = 0.002), oxygen saturation (p = 0.005), ICU admission (&lt;0.001) and pulmonary consolidation (p &lt; 0.001), CO-RADS (p = 0.03) and CT-TSS (p &lt; 0.001) were significant predictors of mortality. CO-RADS predicts at cut off 4.5 (sensitivity 56.3%, specificity 70.6%) and CT-TSS at cut off 7.5 (sensitivity 75%, specificity 82.4%).</p></div><div><h3>Conclusions</h3><p>In-hospital mortality is high in COVID-19 patients with ARDs and many predictors are determined.</p></div>","PeriodicalId":46152,"journal":{"name":"Egyptian Rheumatologist","volume":"45 4","pages":"Pages 338-343"},"PeriodicalIF":0.9,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49790360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and electrophysiological characteristics of peripheral neuropathy in Cuban systemic lupus erythematosus patients","authors":"Elena Noris-García ,&nbsp;Yanaisy Alvarez ,&nbsp;Bárbara A. Hernández ,&nbsp;Carlos O. Mitjáns ,&nbsp;María A. Robinson-Agramonte ,&nbsp;Diego O. Souza ,&nbsp;Carlos A. Gonçalves","doi":"10.1016/j.ejr.2023.06.002","DOIUrl":"https://doi.org/10.1016/j.ejr.2023.06.002","url":null,"abstract":"<div><h3>Background</h3><p>Peripheral neuropathy (PN) is one of the most heterogeneous and poorly understood or characterized manifestations in systemic lupus erythematosus (SLE). The aim of this study was to describe the clinical and electrophysiological features, and neuropathic disease associations, in Cuban SLE patients.</p></div><div><h3>Patients and methods</h3><p>One hundred and two consecutive SLE patients admitted to the Psychoneuroimmunology service at the National Institute of Nephrology were included in the study. Patients with other disorders known to cause neuropathy were excluded. Demographic, clinical and laboratory data were obtained using a pre-defined questionnaire. Nerve conduction studies were carried out in both upper and lower limbs. Neuropathy was defined as the presence of clinical symptoms and/or signs and bilateral abnormal nerve conduction study parameters.</p></div><div><h3>Results</h3><p>The 102 patients were 99 females and 3 males with mean age of 46 ± 12 years and disease duration 8 ± 9 years. PN was found in 55/102 (53.9%) patients; 48 (87.3%) had clinical peripheral neuropathy manifestations and 7 (12.7%) were asymptomatic. Nerve conduction studies suggested asymmetric axonal-demyelination neuropathy pattern. Mixed sensory-motor neuropathy was the most common involvement in 23(41.8%) cases. The most frequent pattern was polyneuropathy. Compared to those without neuropathy, SLE-related polyneuropathy patients were significantly older, but had no other significant associations with demographic, disease duration or serological/immunological data.</p></div><div><h3>Conclusion</h3><p>Peripheral nervous system manifestations are common in SLE; may be related to an increased susceptibility of peripheral nerves to effects of aging. Nerve conduction studies are recommended, therefore, for inclusion in the follow-up of SLE patients especially in the older population.</p></div>","PeriodicalId":46152,"journal":{"name":"Egyptian Rheumatologist","volume":"45 4","pages":"Pages 273-277"},"PeriodicalIF":0.9,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49790385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contraceptive use in women of childbearing ability with rheumatoid arthritis: A university hospital-based survey","authors":"Ibtisam M.A. Jali","doi":"10.1016/j.ejr.2023.09.005","DOIUrl":"https://doi.org/10.1016/j.ejr.2023.09.005","url":null,"abstract":"<div><h3>Aim of the work</h3><p>The study aimed to determine the pattern of contraceptive use in rheumatoid arthritis (RA) patients in Saudi Arabia.</p></div><div><h3>Patients and methods</h3><p>This study was conducted among women with RA and childbearing ability who were seen at rheumatology clinics in King Abdul-Aziz University Hospital (KAUH) through a survey on the medications received and contraceptive method used.</p></div><div><h3>Results</h3><p>Their mean age was 27.5 ± 4.6 years and had disease duration of 3.6 ± 0.9 years. Rheumatoid factor and anti-cyclic citrullinated peptide are positive. 29.2% of the patients were illiterate and only 8.2% attended high school. Of the 158 women, 36 (86.1%) were Saudis. Methotrexate was received alone (19.6%) or in various combinations in the rest of the patients (80.4%). 109 (69%), used combined oral pills, 38 (24%) used intra-uterine device (IUD) while 7 (11%) used non-medical methods of contraception such as using condoms, withdrawal and abstinence. Using combined oral pills were used significantly more among Saudis (72.1% vs 50%) as well as IUDs (27.2% vs 4.5%)(p &lt; 0.0001), and those who attended middle school significantly used more combined oral pills (80.4%) while those with high school used more IUDs (38.5%) (p = 0.01).</p></div><div><h3>Conclusion</h3><p>The commonest contraceptive method was oral contraceptives in female RA patients. However, a considerable percentage used IUD. There is a need for effective contraceptive counseling as part of routine chronic disease care and that will improve childbearing women’s contraceptive knowledge and contraceptive choice. This could be the key to decrease unintended pregnancies among these women.</p></div>","PeriodicalId":46152,"journal":{"name":"Egyptian Rheumatologist","volume":"45 4","pages":"Pages 329-332"},"PeriodicalIF":0.9,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49790391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rheumatological manifestations in patients with malignancies: Relation to immune modulation therapy","authors":"Nouran M. Elshahat ,&nbsp;Howaida E. Mansour ,&nbsp;Amina BadrEldin ,&nbsp;Maryam A. Abdel Rahman ,&nbsp;Lobna R. Ezz El Arab ,&nbsp;Nermeen N. Aziz","doi":"10.1016/j.ejr.2023.09.001","DOIUrl":"https://doi.org/10.1016/j.ejr.2023.09.001","url":null,"abstract":"<div><p>Background: The relation between malignancies and rheumatic diseases (RDs) is complex with commonly shared symptoms. Rheumatological manifestations of malignancies may present as paraneoplastic syndromes and could follow chemotherapy. Aim of the work: to investigate rheumatic manifestations of patients with hematologic or solid malignancies and the relation to immune-modulation therapy. Patients and methods: The study included 25 patients with hematological and another 25 with solid malignancies. Patients were subjected to medical history, recording medications received, musculoskeletal examination and laboratory assessment. Results: The mean age and F:M of patients with hematological (43.7 ± 16.04 y and F:M 1.5:1) was significantly lower than those with solid (53.6 ± 14.3 y and F:M 7.3:1) malignancies (p = 0.025 and p = 0.024). Rheumatological manifestations as the first presentation was significantly higher in patients with haematological (60%) compared to solid (20%) malignancies (p = 0.004). Articular involvement was the commonest rheumatological manifestation (72%) followed by mucocutaneous (18%), oral/genital ulcers (10%), thromboembolic events (10%), Raynauds (8%), dry eyes (8%), myositis (6%) and myalgia (4%). The total leucocytic count and serum uric acid were significantly lower in patients with solid tumors (p = 0.045 and p = 0.026 respectively) and autoimmune markers were similar. Dry eye (16.7%), oral/genital ulcers (20.8%) and Raynaud‘s (16.7%) was present only in patients receiving anti-cancer treatment (n = 24). Paradoxically, arthritis was more frequent in those not receiving chemotherapy (n = 17) while myalgia (25%) was evident in those receiving checkpoint inhibitors (n = 8). Conclusion: Rheumatological manifestations occur with solid and hematological malignancies before or throughout the disease course and the most frequent was articular. Myalgia was associated with checkpoint inhibitors.</p></div>","PeriodicalId":46152,"journal":{"name":"Egyptian Rheumatologist","volume":"45 4","pages":"Pages 319-323"},"PeriodicalIF":0.9,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49790393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamin D level in ankylosing spondylitis male patients: A potential association with the functional status and platelet count","authors":"Esra M. Al-Naggar ,&nbsp;Shereen S. El-Sawy ,&nbsp;Doaa M Abdo ,&nbsp;Doaa H. Attia ,&nbsp;Wael S ElSawy","doi":"10.1016/j.ejr.2023.07.001","DOIUrl":"https://doi.org/10.1016/j.ejr.2023.07.001","url":null,"abstract":"<div><h3>Introductions</h3><p>Ankylosing spondylitis (AS), spondyloarthritis (SpA) prototype characteristically involves the axial skeleton and enthesis. The pathogenesis of AS is multifactorial, however it has been reported that one important factor that might contribute is vitamin D deficiency. Vitamin D and platelets share specific roles in immune response, bone health and mineral metabolism.</p></div><div><h3>Aim of the work</h3><p>To evaluate the serum vitamin D levels in AS patients and to study the relationship to clinical manifestations, disease activity, mobility and functionality.</p></div><div><h3>Patients and methods</h3><p>The study included 33 male AS patients and 33 matched control. Bath AS metrology index (BASMI), Bath AS disease activity index (BASDAI) and Bath AS functional index (BASFI) were evaluated. Serum 25-hydroxy vitamin D3 level was measured.</p></div><div><h3>Results</h3><p>The 33 patients had a mean age of 37.2 ± 10.7 years, disease duration of 12.7 ± 6.8 years. 3 were ex-smokers, 15 currently and 15 never smoke. The mean BASDAI was 4.2 ± 2.1, 19 (57.6%) had BASDAI score ≥ 4 (active). The BASMI was 5.7 ± 1.4 and BASFI was 5.3 ± 2.6. Patient’s vitamin D level (7.2 ± 5.2 ng/ml) was lower significantly than in the control (21.3 ± 10.1 ng/ml) (p &lt; 0.001). There were no differences in the level of vitamin D according to the smoking status (p = 0.9). A significant inverse relation was detected between vitamin D level and BASFI (r = -0.35, p = 0.045) and a significant correlation with the platelet level (r = 0.38, p = 0.027).</p></div><div><h3>Conclusion</h3><p>Low vitamin D level may contribute significantly to the pathogenesis of AS. It is significantly related to the impaired function in the disease and to low platelet count.</p></div>","PeriodicalId":46152,"journal":{"name":"Egyptian Rheumatologist","volume":"45 4","pages":"Pages 289-293"},"PeriodicalIF":0.9,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49790449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HLA B27-positive ankylosing spondylitis professional soccer player with a successful return to sports","authors":"Eduard Bezuglov ,&nbsp;Maria Shoshorina ,&nbsp;Mikhail Butovskiy ,&nbsp;Yuri Kuklin ,&nbsp;Kamila Kubacheva ,&nbsp;Vladimir Khaitin ,&nbsp;Ryland Morgans","doi":"10.1016/j.ejr.2023.06.001","DOIUrl":"https://doi.org/10.1016/j.ejr.2023.06.001","url":null,"abstract":"<div><h3>Background</h3><p>Ankylosing spondylitis (AS) is a disease of young adulthood and without adequate treatment it dramatically reduces physical activity.</p></div><div><h3>Aim of the work</h3><p>To present a case with AS that successfully returned to professionally playing sports after treatment.</p></div><div><h3>Case presentation</h3><p>A 19-year-old Eastern European Russian professional male soccer player with AS complained of right ankle joint pain not related to any trauma or injury and gradually intensified. The player's regular medical tests during the preceding years and were unremarkable. He would occasionally complain of discomfort in the ankle joints, sacroiliac area and symphysis but did not limit his regular training activity. He received the standard treatment of sports injuries that included: 14 days of limited physical activity, ibuprofen 200 mg twice/day, cryotherapy and joint taping. Examination revealed mobile joints, regular in shape without any swelling. Erythrocyte sedimentation rate (ESR) was 60 mm/1st hr and C-reactive protein (CRP) 50 mg/dl. AS was diagnosed as he fulfilled the classification criteria. HLA-B27 was positive, left sacroiliitis was present on magnetic resonance imaging (MRI). The Bath AS disease activity index (BASDAI) was 5.9. Treatment also included golimumab 50 mg/month. He improved, returned to regular training and continued playing sports professionally amid supportive therapy. The last BASDAI was 1.5.</p></div><div><h3>Conclusions</h3><p>AS patients with initially high levels of physical activity may restore professionally playing of sports when a proper management plan is provided. Further monitoring is warranted and the creation of a database for athletes with rheumatic diseases is recommended in order to standardize treatment protocols.</p></div>","PeriodicalId":46152,"journal":{"name":"Egyptian Rheumatologist","volume":"45 4","pages":"Pages 267-272"},"PeriodicalIF":0.9,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49790450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characteristics and comorbidities in psoriatic arthritis: Experience from a single rheumatology centre in Malaysia","authors":"Wahinuddin Sulaiman ,&nbsp;Lay K. Tan ,&nbsp;Hasnah Mat ,&nbsp;Najjah Tohar ,&nbsp;Abdul Muhaimin Fathi ,&nbsp;Nia Maslia A. Kosenin ,&nbsp;Muhammad N. Naim ,&nbsp;Rafiqah F. Redzuan ,&nbsp;Nur Iffah Ab Rani ,&nbsp;Najiha A. Norhisham ,&nbsp;Ong P. Seung","doi":"10.1016/j.ejr.2023.08.002","DOIUrl":"https://doi.org/10.1016/j.ejr.2023.08.002","url":null,"abstract":"<div><h3>Aim of the work</h3><p>To evaluate the clinical features and associated comorbidities of psoriatic arthritis (PsA) patients from a single rheumatology centre in Malaysia.</p></div><div><h3>Patients and methods</h3><p>247 PsA patients in rheumatology clinic, Raja Permaisuri Bainun Hospital were included. Clinical and laboratory data were retrieved from the medical record.</p></div><div><h3>Results</h3><p>The mean age was 56 ± 13.5 years, 56.1% were female, and 38.9% were Indians. The onset of psoriasis and PsA was significantly earlier among Malays (P &lt; 0.01) whilst Indians had longer disease duration (P &lt; 0.05). The mean duration of progression from psoriasis to PsA was 8.7 years. Alcohol and nail dystrophy were common among Indians (P &lt; 0.05). Plaque psoriasis was the commonest subtype (81%) in nails (pitting, 42.5%; onycholysis, 20.7%), scalp (35.6%) and limbs (32.8%). Pustular psoriasis and onycholysis were common in males (P = 0.05 and 0.002, respectively) whilst scalp psoriasis in females (P &lt; 0.05). Peripheral arthritis was the highest (92.7%) compared to axial (8.1%); 14.6% had both. 38.9% were oligoarthritis and mostly asymmetrical (35.6%). 24% had enthesitis, 14.6% dactylitis, and 0.8% uveitis. 52.2% had hypertension, followed by dyslipidemia (44.1%), diabetes mellitus (34%), obesity (30%), ischemic heart disease (9.7%), cancer (2.4%), and tuberculosis (0.4%). No significant relationship between the pattern of arthritis and these comorbidities (P &gt; 0.05).</p></div><div><h3>Conclusion</h3><p>PsA was more prevalent in Indians. Malays have younger disease onset. Pustular psoriasis and onycholysis were common in males, while scalp psoriasis in females. Asymmetrical oligoarthritis and plaque psoriasis were the commonest pattern and psoriasis subtype respectively. Comorbidities were not associated with the pattern of arthritis in PsA patients.</p></div>","PeriodicalId":46152,"journal":{"name":"Egyptian Rheumatologist","volume":"45 4","pages":"Pages 309-313"},"PeriodicalIF":0.9,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49790390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tumor necrosis factor-α, its related immunoregulatory long non-coding RNA (THRIL) and micro-RNA 145 as potential biomarkers in lupus nephritis patients","authors":"Salsabeel M. Kahwa ,&nbsp;Olfat G. Shaker ,&nbsp;Basma M. Eissa ,&nbsp;Amany M. Wahb","doi":"10.1016/j.ejr.2023.08.004","DOIUrl":"https://doi.org/10.1016/j.ejr.2023.08.004","url":null,"abstract":"<div><h3>Aim of the work</h3><p>To explore the differential expression of tumor necrosis factor-α (TNF-α), its related immunoregulatory long non-coding RNA (THRIL), and microRNA145 (MIR145) in systemic lupus erythematosus (SLE) patients and their diagnostic utility in lupus nephritis (LN).</p></div><div><h3>Patients and methods</h3><p>The study included 60 SLE patients; 30 with LN, 30 without LN (NN), and 30 matched controls. SLE disease activity index was assessed. Serum TNF-α level was determined by enzyme linked immunosorbent assay. Serum fold change (FC) in expression of THRIL and MIR145 were assayed by real time polymerase chain reaction.</p></div><div><h3>Results</h3><p>The patients mean age was 32.6 ± 6.8 years and were 52 females and 8 males (F:M 6.5:1). Serum TNF-α level was significantly higher in SLE patients (108.6 ± 47.8 pg/ml) compared to control (39.6 ± 3.7 pg/ml) (p &lt; 0.001). THRIL expression was upregulated (8.3 ± 6.9<!--> <!-->vs<em>.</em> <!-->1.02 ± 0.06 FC, p &lt; 0.001) and MIR145 downregulated (0.39 ± 0.36<!--> <!-->vs<em>.</em> <!-->0.92 ± 0.94 FC, p &lt; 0.001) in SLE patients versus controls. THRIL correlated with disease activity (r = 0.27, p = 0.035) and MIR145 with C3 (r = −0.32, p = 0.04) and C4 (r = −0.36, p = 0.016) levels in SLE patients. In LN patients, TNF-α and THRIL were increased while MIR145 downregulated (p &lt; 0.001 each) and proteinuria significantly correlated with TNF-α (r = −0.4,p = 0.028), THRIL (r = 0.48, p = 0.007) and MIR145 (-0.42, p = 0.02). In NN patients, TNF-α and THRIL (p &lt; 0.001 both) were increased while MIR145 downregulated (p = 0.023). TNF-α (cutoff ≥ 122.5 pg/ml, AUC 0.67, p = 0.003), and MIR145 (cutoff ≤ 0.22 FC, AUC 0.71, p = 0.026) discriminated LN from NN. The combination of TNF-α and MIR145 discriminated better than either alone (AUC 0.75, p = 0.002).</p></div><div><h3>Conclusion</h3><p>TNF-α and MIR145 are potential biomarkers of LN in SLE.</p></div>","PeriodicalId":46152,"journal":{"name":"Egyptian Rheumatologist","volume":"45 4","pages":"Pages 299-302"},"PeriodicalIF":0.9,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49790387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum level of galectin-9 in systemic lupus erythematosus patients with lupus nephritis: Relation to clinical characteristics and disease activity","authors":"Mariam G. Abdelmonem ,&nbsp;Manal A. Mohammed ,&nbsp;Hosam Abdel Twab ,&nbsp;Eman B. Elmarghany","doi":"10.1016/j.ejr.2023.08.001","DOIUrl":"https://doi.org/10.1016/j.ejr.2023.08.001","url":null,"abstract":"<div><h3>Aim of the work</h3><p>To assess galectin-9 (Gal-9) level in the serum of systemic lupus erythematosus (SLE) patients with and without renal involvement and clarify its relation with disease activity.</p></div><div><h3>Patients and methods</h3><p>50 SLE patients; 25 with lupus nephritis (LN) and 25 without as well as 25 controls were studied. Systemic Lupus International Collaborating Clinics (SLICC) renal activity score and SLE disease activity index 2000 (SLEDAI-2 K) were determined. Serum Gal-9 was measured in all participants.</p></div><div><h3>Results</h3><p>Gal-9 level was significantly elevated in SLE patients with (16.7; 11.6–33.7 ng/ml) and without (15.9; 11.8–25 ng/ml) compared to controls (3.9; 2.8–5.4 ng/ml) (p &lt; 0.001) but was comparable between the patients groups (p = 0.83). In LN patients, serum Gal-9 and SLICC renal activity score significantly correlated (r = 0.48, p = 0.016). Serum Gal-9 significantly correlated with SLEDAI-2 K in patients with (r = 0.71, p &lt; 0.001) and without (r = 0.95, p &lt; 0.001) LN, with anti-double stranded deoxyribonucleic acid (anti-ds-DNA) titers (with r = 0.57, p &lt; 0.001 and without r = 0.79, p &lt; 0.001) and inversely with C3 (with r = -0.44, p = 0.027 and without r = -0.63, p &lt; 0.001) and C4 (with r = -0.47, p = 0.018 and without r = -0.43, p = 0.03). Gal-9 had an area under the curve (AUC) of 0.96 to distinguish SLE cases from control. However, AUC between LN group and non-nephritic SLE was 0.48. On regression, SLEDAI-2 K was the only significant factor associated with serum Gal-9 (p &lt; 0.001).</p></div><div><h3>Conclusion</h3><p>In SLE patients, significantly raised Gal-9 levels and relation with disease activity were detected indicating its clinical relevance as biomarker of disease activity and its potential value in the disease diagnosis. Its value in discriminating LN from non-nephritic SLE is limited.</p></div>","PeriodicalId":46152,"journal":{"name":"Egyptian Rheumatologist","volume":"45 4","pages":"Pages 294-298"},"PeriodicalIF":0.9,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49790388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}