美国两个不同地理区域Behҫet病患者临床特征的比较

IF 1 Q4 RHEUMATOLOGY

Egyptian Rheumatologist Pub Date : 2025-07-02 DOI:10.1016/j.ejr.2025.06.002

Hamdy Ahmed , Sebastian E. Sattui , Dongmei Sun , Ammar Alkassm , Angelo Gaffo

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引用次数: 0

摘要

目前关于美国Behҫet疾病（BD）特征的区域差异的数据很少。这项研究的目的是探索美国两个不同地区的这些差异：东北部和东南部。患者和方法本研究在三个医疗中心进行。回顾了2012年至2019年期间患有BD的ICD-9/10 （136.1/M25.2）代码的患者的医疗记录。纳入的病例符合国际BD标准（ICBD）和国际研究小组（ISG）标准。收集了人口统计学、临床和实验室特征的数据。特征按地理区域、性别和种族/民族进行比较。结果153例患者符合ICBD标准；东北77号和东南76号。大多数患者为女性（73%）和白人（73%），诊断时的中位年龄为31岁。美国东南部的白人非西班牙裔患者比例更高（85.3%对61%），东北部的西班牙裔患者比例更高（11%对0%）。女性生殖器溃疡（92.5% vs 69%, p = 0.01）和关节痛（34.2% vs 14.3%, p = 0.03）的发生率较高。使用ISG标准发现相似的种族/民族趋势，但临床特征没有差异。男性在HLA-B51阳性患者（50%）比阴性患者（22.6%）更常见（p = 0.048），与生殖器溃疡较少（55.6%对87%，p = 0.013）和胃肠道病变较多（50%对16.1%,p = 0.01）相关。结论在美国，两个不同地理区域的BD患者在人口学和临床特征上差异不大。

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Comparison of clinical characteristics of patients with Behҫet’s disease in two different geographical areas in the United States

Aim of the work

The current data regarding regional differences in the characteristics of Behҫet disease (BD) within the United States are scarce. The aim of the study is to explore these differences in two distinct regions of the United States: Northeast and Southeast.

Patients and Methods

This chart review study was conducted at three medical centers. Medical records from patients with ICD-9/10 (136.1/M25.2) codes for BD between 2012 and 2019 were reviewed. Cases included fulfilled the international criteria for BD (ICBD) and International Study Group (ISG) criteria. Data on demographics, clinical and laboratory features was collected. Characteristics were compared by geographic region, sex, and race/ethnicity.

Results

A total of 153 patients met ICBD criteria; 77 Northeast and 76 Southeast. The majority of the patients were female (73 %), and white race (73 %), with and median age at diagnosis of 31 years. There was a greater proportion of White non-Hispanic patients in southeast US (85.3 % vs 61 %) and more Hispanic in Northeast (11 % vs 0 %). Females had a higher incidence of genital ulcers (92.5 % vs 69 %, p = 0.01) and arthralgia (34.2 % vs 14.3 %, p = 0.03). Similar trends of race/ethnicity were found using ISG criteria, but no differences in clinical characteristics. Males were more frequent in patients with positive HLA-B51 (50 %) vs negative (22.6 %) (p = 0.048), associated with fewer genital ulcers (55.6 % vs 87 %, p = 0.013), and more gastrointestinal involvement (50 % vs 16.1 %, p = 0.01).