Multiple Sclerosis International最新文献_第7页

Free Light Chains and Intrathecal B Cells Activity in Multiple Sclerosis: A Prospective Study and Meta-Analysis. 多发性硬化症中的游离光链和鞘内 B 细胞活性：前瞻性研究与 Meta 分析。

IF 2.2

Multiple Sclerosis International Pub Date : 2016-01-01 Epub Date: 2016-12-28 DOI: 10.1155/2016/2303857

Gabriella Passerini, Gloria Dalla Costa, Francesca Sangalli, Lucia Moiola, Bruno Colombo, Massimo Locatelli, Giancarlo Comi, Roberto Furlan, Vittorio Martinelli

{"title":"Free Light Chains and Intrathecal B Cells Activity in Multiple Sclerosis: A Prospective Study and Meta-Analysis.","authors":"Gabriella Passerini, Gloria Dalla Costa, Francesca Sangalli, Lucia Moiola, Bruno Colombo, Massimo Locatelli, Giancarlo Comi, Roberto Furlan, Vittorio Martinelli","doi":"10.1155/2016/2303857","DOIUrl":"10.1155/2016/2303857","url":null,"abstract":"Background. The presence of CSF oligoclonal bands (OBs) is an independent prognostic factor for multiple sclerosis (MS), but the difficulties in the standardization of the test and the interlaboratory variation in reporting have contributed to its limited use in the diagnosis of the disease. Standard nephelometric assays to measure free light chains (FLC) levels have been recently developed and the test may improve the detection of intrathecal B cells activity. Methods. The presence of OBs, kappa and lambda FLC levels, and standard indices of intrathecal inflammation were assessed in 100 consecutive patients, including patients with MS, clinically isolated syndromes (CIS), other inflammatory diseases of the CNS, and other noninflammatory diseases. Results. Both KFLC and LFLC correlated strongly with the presence of OCBs and with all common tests for intrathecal inflammation (p < 0.001 for all comparisons). KFLC and LFLC were significantly different in patients with MS and CIS compared to the other groups (p < 0.001 and p < 0.001, resp.) and had a better diagnostic accuracy than all the other tests (area under the curve 82.3 % for KFLC index and 79.3 % for LFLC index). Conclusion. Nephelometric assays for KFLC in CSF reliably detect intrathecal immunoglobulin synthesis and discriminate MS patients.","PeriodicalId":46096,"journal":{"name":"Multiple Sclerosis International","volume":"2016 1","pages":"2303857"},"PeriodicalIF":2.2,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5225376/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64266869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lack of Association between Pulse Steroid Therapy and Bone Mineral Density in Patients with Multiple Sclerosis. 脉冲类固醇疗法与多发性硬化症患者的骨质密度之间缺乏关联。

IF 2.5

Multiple Sclerosis International Pub Date : 2016-01-01 Epub Date: 2016-02-04 DOI: 10.1155/2016/5794910

Serap Zengin Karahan, Cavit Boz, Sevgi Kilic, Nuray Can Usta, Mehmet Ozmenoglu, Vildan Altunayoglu Cakmak, Sibel Gazioglu

{"title":"Lack of Association between Pulse Steroid Therapy and Bone Mineral Density in Patients with Multiple Sclerosis.","authors":"Serap Zengin Karahan, Cavit Boz, Sevgi Kilic, Nuray Can Usta, Mehmet Ozmenoglu, Vildan Altunayoglu Cakmak, Sibel Gazioglu","doi":"10.1155/2016/5794910","DOIUrl":"10.1155/2016/5794910","url":null,"abstract":"Multiple sclerosis (MS) has been associated with reduced bone mineral density (BMD). The purpose of this study was to determine the possible factors affecting BMD in patients with MS. We included consecutive 155 patients with MS and 90 age- and sex-matched control subjects. Patients with MS exhibited significantly lower T-scores and Z-scores in the femoral neck and trochanter compared to the controls. Ninety-four (61%) patients had reduced bone mass in either the lumbar spine or the femoral neck; of these, 64 (41.3%) had osteopenia and 30 (19.4%) had osteoporosis. The main factors affecting BMD were disability, duration of MS, and smoking. There was a negative relationship between femoral BMD and EDSS and disease duration. No association with lumbar BMD was determined. There were no correlations between BMD at any anatomic region and cumulative corticosteroid dose. BMD is significantly lower in patients with MS than in healthy controls. Reduced BMD in MS is mainly associated with disability and duration of the disease. Short courses of high dose steroid therapy did not result in an obvious negative impact on BMD in the lumbar spine and femoral neck in patients with MS. ","PeriodicalId":46096,"journal":{"name":"Multiple Sclerosis International","volume":"2016 1","pages":"5794910"},"PeriodicalIF":2.5,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4757708/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64440293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Management of Multiple Sclerosis in the Breastfeeding Mother. 母乳喂养母亲的多发性硬化管理。

IF 2.5

Multiple Sclerosis International Pub Date : 2016-01-01 Epub Date: 2016-02-04 DOI: 10.1155/2016/6527458

Saneea Almas, Jesse Vance, Teresa Baker, Thomas Hale

{"title":"Management of Multiple Sclerosis in the Breastfeeding Mother.","authors":"Saneea Almas, Jesse Vance, Teresa Baker, Thomas Hale","doi":"10.1155/2016/6527458","DOIUrl":"10.1155/2016/6527458","url":null,"abstract":"Multiple Sclerosis (MS) is an autoimmune neurological disease characterized by inflammation of the brain and spinal cord. Relapsing-Remitting MS is characterized by acute attacks followed by remission. Treatment is aimed at halting these attacks; therapy may last for months to years. Because MS disproportionately affects females and commonly begins during the childbearing years, clinicians treat pregnant or nursing MS patients. The intent of this review is to perform an in-depth analysis into the safety of drugs used in breastfeeding women with MS. This paper is composed of several drugs used in the treatment of MS and current research regarding their safety in breastfeeding including immunomodulators, immunosuppressants, monoclonal antibodies, corticosteroids, and drugs used for symptomatic treatment. Typically, some medications are large polar molecules which often do not pass into the milk in clinically relevant amounts. For this reason, interferon beta is likely safe for the infant when given to a breastfeeding mother. However, other drugs with particularly dangerous side effects may not be recommended. While treatment options are available and some data from clinical studies does exist, there continues to be a need for investigation and ongoing review of the medications used in breastfeeding mothers. ","PeriodicalId":46096,"journal":{"name":"Multiple Sclerosis International","volume":"2016 1","pages":"6527458"},"PeriodicalIF":2.5,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4757692/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64482961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EVASEP: A Noninterventional Study Describing the Perception of Neurologists, Patients, and Caregivers on Caregivers' Role in the Support of Patients Suffering from Multiple Sclerosis Treated with Subcutaneous Interferon Beta 1a. EVASEP:一项描述神经科医生、患者和护理人员对护理人员在支持接受皮下干扰素β 1a治疗的多发性硬化症患者中的作用的非介入性研究。

IF 2.5

Multiple Sclerosis International Pub Date : 2016-01-01 Epub Date: 2016-08-01 DOI: 10.1155/2016/4986073

Cécile Donzé, Bruno Lenne, Anne-Sophie Jean Deleglise, Christian Kempf, Yasmine Bellili, Patrick Hautecoeur

{"title":"EVASEP: A Noninterventional Study Describing the Perception of Neurologists, Patients, and Caregivers on Caregivers' Role in the Support of Patients Suffering from Multiple Sclerosis Treated with Subcutaneous Interferon Beta 1a.","authors":"Cécile Donzé, Bruno Lenne, Anne-Sophie Jean Deleglise, Christian Kempf, Yasmine Bellili, Patrick Hautecoeur","doi":"10.1155/2016/4986073","DOIUrl":"https://doi.org/10.1155/2016/4986073","url":null,"abstract":"Background. The perception of the role of caregivers for people with multiple sclerosis (MS) is important but poorly studied, particularly in patients with low levels of disability. Objectives. To describe the perceptions of the role of caregivers from the perspective of the caregiver, the patient, and neurologists. Methods. This observational study was conducted in France on patients with relapsing remitting MS treated with subcutaneous (SC) interferon-β-1a (IFN-β-1a) for more than 24 months. Results. Caregiver, patients, and neurologists all considered providing moral support and fighting against the disease as the most important role of the care provider. Moral support was considered significantly more important by caregivers than the patients and neurologists (p = 0.002) and caregivers considered their role in helping patients to fight disease more important than did the neurologists (p = 0.006). Knowledge of disease and available treatments were less important among support providers than patients (p = 0.007 and p = 0.001). Conclusion. There are many unmet needs in the perception of the role of caregivers for people with MS which need to be addressed to deliver the most effective care package for patients and to support the needs of the support provider. ","PeriodicalId":46096,"journal":{"name":"Multiple Sclerosis International","volume":"2016 ","pages":"4986073"},"PeriodicalIF":2.5,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/4986073","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34337820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

The Incidence of Euphoria in Multiple Sclerosis: Artefact of Measure. 多发性硬化症患者欣快感的发生率:测量的人工产物。

IF 2.5

Multiple Sclerosis International Pub Date : 2016-01-01 Epub Date: 2016-06-13 DOI: 10.1155/2016/5738425

Amy Duncan, Susan Malcolm-Smith, Ozayr Ameen, Mark Solms

{"title":"The Incidence of Euphoria in Multiple Sclerosis: Artefact of Measure.","authors":"Amy Duncan, Susan Malcolm-Smith, Ozayr Ameen, Mark Solms","doi":"10.1155/2016/5738425","DOIUrl":"https://doi.org/10.1155/2016/5738425","url":null,"abstract":"Background. A subgroup of MS patients present with \"euphoria.\" Classical authors describe this symptom as the predominant mood state of these patients, while contemporary authors regard it as rare. Objective. This study aimed to address these discrepancies and investigate the contributions made by varying operational definitions and measurement instruments. Methods. One hundred MS patients and 100 matched controls completed the classical interview of Cottrell and Wilson and the modern Neuropsychiatric Inventory in a once-off interview. Results. The MS group demonstrated high frequencies of euphoria using the classical measure but low frequencies using the contemporary measure and definition. The matched control group demonstrated significantly higher rates than the MS group using the classical measure and lower rates than the MS group using the contemporary measure. Conclusion. The discrepancies in incidence rates of euphoria noted in the literature do not reflect a change in the incidence of euphoria in MS, but rather in the definition and operationalisation of \"euphoria.\" Furthermore, these results highlight the importance of characterising what represents pathological euphoria as well as the need for better definitions and instruments of measure. ","PeriodicalId":46096,"journal":{"name":"Multiple Sclerosis International","volume":"2016 ","pages":"5738425"},"PeriodicalIF":2.5,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/5738425","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34641114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Retracted: Consensus Guidelines for CSF and Blood Biobanking for CNS Biomarker Studies. 撤回：中枢神经系统生物标记物研究的脑脊液和血液生物库共识指南》。

IF 2.5

Multiple Sclerosis International Pub Date : 2016-01-01 Epub Date: 2016-07-25 DOI: 10.1155/2016/8304273

Multiple Sclerosis International

引用次数: 0

Stride-Time Variability and Fall Risk in Persons with Multiple Sclerosis 多发性硬化症患者的跨步时间变异性和跌倒风险

IF 2.5

Multiple Sclerosis International Pub Date : 2015-12-30 DOI: 10.1155/2015/964790

Y. Moon, D. Wajda, R. Motl, J. Sosnoff

{"title":"Stride-Time Variability and Fall Risk in Persons with Multiple Sclerosis","authors":"Y. Moon, D. Wajda, R. Motl, J. Sosnoff","doi":"10.1155/2015/964790","DOIUrl":"https://doi.org/10.1155/2015/964790","url":null,"abstract":"Gait variability is associated with falls in clinical populations. However, gait variability's link to falls in persons with Multiple Sclerosis (PwMS) is not well established. This investigation examined the relationship between stride-time variability, fall risk, and physiological fall risk factors in PwMS. 17 PwMS (62.8 ± 7.4 years) and 17 age-matched controls (62.8 ± 5.9 years) performed the 6-minute walk test. Stride-time was assessed with accelerometers attached to the participants' shanks. Stride-time variability was measured by interstride coefficient of variation (CV) of stride-time. The participant's fall risk was measured by the short form physiological profile assessment (PPA). A Spearman correlation analysis was used to determine the relationship between variables. Increased fall risk was strongly associated with increased stride-time CV in both PwMS (ρ = 0.71, p < 0.01) and the controls (ρ = 0.67, p < 0.01). Fall risk was not correlated with average stride-time (p > 0.05). In PwMS, stride-time CV was related to postural sway (ρ = 0.74, p < 0.01) while in the control group, it was related to proprioception (ρ = 0.61, p < 0.01) and postural sway (ρ = 0.78, p < 0.01). Current observations suggest that gait variability is maybe more sensitive marker of fall risk than average gait parameters in PwMS. It was also noted that postural sway may be potentially targeted to modify gait variability in PwMS.","PeriodicalId":46096,"journal":{"name":"Multiple Sclerosis International","volume":"2015 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2015-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/964790","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64186175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 43

The Therapeutic Potential of the Ketogenic Diet in Treating Progressive Multiple Sclerosis 生酮饮食治疗进展性多发性硬化症的潜力

IF 2.5

Multiple Sclerosis International Pub Date : 2015-12-29 DOI: 10.1155/2015/681289

M. Storoni, G. Plant

引用次数: 62

The Communication of Multiple Sclerosis Diagnosis: The Patients' Perspective 多发性硬化症诊断的沟通:患者的视角

IF 2.5

Multiple Sclerosis International Pub Date : 2015-12-15 DOI: 10.1155/2015/353828

M. Messina, G. Dalla Costa, M. Rodegher, L. Moiola, B. Colombo, G. Comi, V. Martinelli

{"title":"The Communication of Multiple Sclerosis Diagnosis: The Patients' Perspective","authors":"M. Messina, G. Dalla Costa, M. Rodegher, L. Moiola, B. Colombo, G. Comi, V. Martinelli","doi":"10.1155/2015/353828","DOIUrl":"https://doi.org/10.1155/2015/353828","url":null,"abstract":"Background. Multiple sclerosis (MS) is the leading cause of nontraumatic neurological disability in young adults in Europe and in the United States. The uncertainty regarding its evolution makes the diagnosis disclosure a difficult process. Objective. The aim of the study was to provide patients' global perspective towards MS diagnosis communication. Methods. 150 consecutive patients, recently diagnosed with CIS or MS, were asked to complete a 17-item questionnaire assessing factors influencing their satisfaction with the information provided. Results. Eighty-six patients fulfilled diagnostic criteria for MS and 64 for CIS. Diagnosis disclosure took place in a private setting and required in most cases (87.3%) less than 30 minutes. Most patients reported being moderately or highly satisfied with the information provided (75%). The degree of satisfaction seems significantly related to patients' younger age, a longer time dedicated to disclose the diagnosis, a CIS diagnosis, and, above all, tailored information and an adequate emotional support. Conclusion. Most patients reported a good degree of satisfaction about the communication of MS or CIS diagnosis. A fruitful relationship between patient and neurologist is essential to obtain a better acceptance of the disease, patients' compliance with chronic treatments and to improve patients' quality of life.","PeriodicalId":46096,"journal":{"name":"Multiple Sclerosis International","volume":"2015 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2015-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/353828","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64916935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Comparing Three Dual-Task Methods and the Relationship to Physical and Cognitive Impairment in People with Multiple Sclerosis and Controls 比较三种双任务方法及其与多发性硬化症患者和对照组身体和认知功能损害的关系

IF 2.5

Multiple Sclerosis International Pub Date : 2015-11-23 DOI: 10.1155/2015/650645

M. Kirkland, E. M. Wallack, Samantha N. Rancourt, M. Ploughman

{"title":"Comparing Three Dual-Task Methods and the Relationship to Physical and Cognitive Impairment in People with Multiple Sclerosis and Controls","authors":"M. Kirkland, E. M. Wallack, Samantha N. Rancourt, M. Ploughman","doi":"10.1155/2015/650645","DOIUrl":"https://doi.org/10.1155/2015/650645","url":null,"abstract":"Dual-tasking (DT) is a measure to detect impairments in people with multiple sclerosis (MS). We compared three DT methods to determine whether cognitive (Montreal Cognitive Assessment (MoCA)) or physical disability (Expanded Disease Severity Scale; EDSS) was related to DT performance. We recruited MS participants with low disability (<3 EDSS, n = 13) and high disability (≥3 EDSS, n = 9) and matched controls (n = 13). Participants walked at self-selected (SS) speed on an instrumented walkway (Protokinetics, Havertown, USA), followed by DT walks in randomized order: DT ABC (reciting every second letter of the alphabet), DT 7 (serially subtracting 7's from 100), and DT 3 (counting upwards, leaving out multiples and numbers that include 3). DT 7 resulted in the most consistent changes in performance. Both MS and control groups reduced velocity and cadence and shortened step length during DT with no significant differences between groups. Control subjects widened stride width by about 1 cm while MS subjects (collapsed as one group) did not. MS subjects with higher disability significantly increased percentage time in double support during DT compared to SS (F = 12.95, p < 0.001). The change in DS was related to cognitive and not physical disability (r = 0.54, p < 0.05).","PeriodicalId":46096,"journal":{"name":"Multiple Sclerosis International","volume":"2015 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2015-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/650645","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65081398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 35