Multiple Sclerosis International最新文献_第7页

Management of Multiple Sclerosis in the Breastfeeding Mother. 母乳喂养母亲的多发性硬化管理。

IF 2.5

Multiple Sclerosis International Pub Date : 2016-01-01 Epub Date: 2016-02-04 DOI: 10.1155/2016/6527458

Saneea Almas, Jesse Vance, Teresa Baker, Thomas Hale

{"title":"Management of Multiple Sclerosis in the Breastfeeding Mother.","authors":"Saneea Almas, Jesse Vance, Teresa Baker, Thomas Hale","doi":"10.1155/2016/6527458","DOIUrl":"10.1155/2016/6527458","url":null,"abstract":"Multiple Sclerosis (MS) is an autoimmune neurological disease characterized by inflammation of the brain and spinal cord. Relapsing-Remitting MS is characterized by acute attacks followed by remission. Treatment is aimed at halting these attacks; therapy may last for months to years. Because MS disproportionately affects females and commonly begins during the childbearing years, clinicians treat pregnant or nursing MS patients. The intent of this review is to perform an in-depth analysis into the safety of drugs used in breastfeeding women with MS. This paper is composed of several drugs used in the treatment of MS and current research regarding their safety in breastfeeding including immunomodulators, immunosuppressants, monoclonal antibodies, corticosteroids, and drugs used for symptomatic treatment. Typically, some medications are large polar molecules which often do not pass into the milk in clinically relevant amounts. For this reason, interferon beta is likely safe for the infant when given to a breastfeeding mother. However, other drugs with particularly dangerous side effects may not be recommended. While treatment options are available and some data from clinical studies does exist, there continues to be a need for investigation and ongoing review of the medications used in breastfeeding mothers. ","PeriodicalId":46096,"journal":{"name":"Multiple Sclerosis International","volume":"2016 1","pages":"6527458"},"PeriodicalIF":2.5,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4757692/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64482961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EVASEP: A Noninterventional Study Describing the Perception of Neurologists, Patients, and Caregivers on Caregivers' Role in the Support of Patients Suffering from Multiple Sclerosis Treated with Subcutaneous Interferon Beta 1a. EVASEP:一项描述神经科医生、患者和护理人员对护理人员在支持接受皮下干扰素β 1a治疗的多发性硬化症患者中的作用的非介入性研究。

IF 2.5

Multiple Sclerosis International Pub Date : 2016-01-01 Epub Date: 2016-08-01 DOI: 10.1155/2016/4986073

Cécile Donzé, Bruno Lenne, Anne-Sophie Jean Deleglise, Christian Kempf, Yasmine Bellili, Patrick Hautecoeur

{"title":"EVASEP: A Noninterventional Study Describing the Perception of Neurologists, Patients, and Caregivers on Caregivers' Role in the Support of Patients Suffering from Multiple Sclerosis Treated with Subcutaneous Interferon Beta 1a.","authors":"Cécile Donzé, Bruno Lenne, Anne-Sophie Jean Deleglise, Christian Kempf, Yasmine Bellili, Patrick Hautecoeur","doi":"10.1155/2016/4986073","DOIUrl":"https://doi.org/10.1155/2016/4986073","url":null,"abstract":"Background. The perception of the role of caregivers for people with multiple sclerosis (MS) is important but poorly studied, particularly in patients with low levels of disability. Objectives. To describe the perceptions of the role of caregivers from the perspective of the caregiver, the patient, and neurologists. Methods. This observational study was conducted in France on patients with relapsing remitting MS treated with subcutaneous (SC) interferon-β-1a (IFN-β-1a) for more than 24 months. Results. Caregiver, patients, and neurologists all considered providing moral support and fighting against the disease as the most important role of the care provider. Moral support was considered significantly more important by caregivers than the patients and neurologists (p = 0.002) and caregivers considered their role in helping patients to fight disease more important than did the neurologists (p = 0.006). Knowledge of disease and available treatments were less important among support providers than patients (p = 0.007 and p = 0.001). Conclusion. There are many unmet needs in the perception of the role of caregivers for people with MS which need to be addressed to deliver the most effective care package for patients and to support the needs of the support provider. ","PeriodicalId":46096,"journal":{"name":"Multiple Sclerosis International","volume":"2016 ","pages":"4986073"},"PeriodicalIF":2.5,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/4986073","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34337820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

The Incidence of Euphoria in Multiple Sclerosis: Artefact of Measure. 多发性硬化症患者欣快感的发生率:测量的人工产物。

IF 2.5

Multiple Sclerosis International Pub Date : 2016-01-01 Epub Date: 2016-06-13 DOI: 10.1155/2016/5738425

Amy Duncan, Susan Malcolm-Smith, Ozayr Ameen, Mark Solms

{"title":"The Incidence of Euphoria in Multiple Sclerosis: Artefact of Measure.","authors":"Amy Duncan, Susan Malcolm-Smith, Ozayr Ameen, Mark Solms","doi":"10.1155/2016/5738425","DOIUrl":"https://doi.org/10.1155/2016/5738425","url":null,"abstract":"Background. A subgroup of MS patients present with \"euphoria.\" Classical authors describe this symptom as the predominant mood state of these patients, while contemporary authors regard it as rare. Objective. This study aimed to address these discrepancies and investigate the contributions made by varying operational definitions and measurement instruments. Methods. One hundred MS patients and 100 matched controls completed the classical interview of Cottrell and Wilson and the modern Neuropsychiatric Inventory in a once-off interview. Results. The MS group demonstrated high frequencies of euphoria using the classical measure but low frequencies using the contemporary measure and definition. The matched control group demonstrated significantly higher rates than the MS group using the classical measure and lower rates than the MS group using the contemporary measure. Conclusion. The discrepancies in incidence rates of euphoria noted in the literature do not reflect a change in the incidence of euphoria in MS, but rather in the definition and operationalisation of \"euphoria.\" Furthermore, these results highlight the importance of characterising what represents pathological euphoria as well as the need for better definitions and instruments of measure. ","PeriodicalId":46096,"journal":{"name":"Multiple Sclerosis International","volume":"2016 ","pages":"5738425"},"PeriodicalIF":2.5,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/5738425","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34641114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Retracted: Consensus Guidelines for CSF and Blood Biobanking for CNS Biomarker Studies. 撤回：中枢神经系统生物标记物研究的脑脊液和血液生物库共识指南》。

IF 2.5

Multiple Sclerosis International Pub Date : 2016-01-01 Epub Date: 2016-07-25 DOI: 10.1155/2016/8304273

Multiple Sclerosis International

引用次数: 0

Stride-Time Variability and Fall Risk in Persons with Multiple Sclerosis 多发性硬化症患者的跨步时间变异性和跌倒风险

IF 2.5

Multiple Sclerosis International Pub Date : 2015-12-30 DOI: 10.1155/2015/964790

Y. Moon, D. Wajda, R. Motl, J. Sosnoff

{"title":"Stride-Time Variability and Fall Risk in Persons with Multiple Sclerosis","authors":"Y. Moon, D. Wajda, R. Motl, J. Sosnoff","doi":"10.1155/2015/964790","DOIUrl":"https://doi.org/10.1155/2015/964790","url":null,"abstract":"Gait variability is associated with falls in clinical populations. However, gait variability's link to falls in persons with Multiple Sclerosis (PwMS) is not well established. This investigation examined the relationship between stride-time variability, fall risk, and physiological fall risk factors in PwMS. 17 PwMS (62.8 ± 7.4 years) and 17 age-matched controls (62.8 ± 5.9 years) performed the 6-minute walk test. Stride-time was assessed with accelerometers attached to the participants' shanks. Stride-time variability was measured by interstride coefficient of variation (CV) of stride-time. The participant's fall risk was measured by the short form physiological profile assessment (PPA). A Spearman correlation analysis was used to determine the relationship between variables. Increased fall risk was strongly associated with increased stride-time CV in both PwMS (ρ = 0.71, p < 0.01) and the controls (ρ = 0.67, p < 0.01). Fall risk was not correlated with average stride-time (p > 0.05). In PwMS, stride-time CV was related to postural sway (ρ = 0.74, p < 0.01) while in the control group, it was related to proprioception (ρ = 0.61, p < 0.01) and postural sway (ρ = 0.78, p < 0.01). Current observations suggest that gait variability is maybe more sensitive marker of fall risk than average gait parameters in PwMS. It was also noted that postural sway may be potentially targeted to modify gait variability in PwMS.","PeriodicalId":46096,"journal":{"name":"Multiple Sclerosis International","volume":"2015 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2015-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/964790","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64186175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 43

The Therapeutic Potential of the Ketogenic Diet in Treating Progressive Multiple Sclerosis 生酮饮食治疗进展性多发性硬化症的潜力

IF 2.5

Multiple Sclerosis International Pub Date : 2015-12-29 DOI: 10.1155/2015/681289

M. Storoni, G. Plant

引用次数: 62

The Communication of Multiple Sclerosis Diagnosis: The Patients' Perspective 多发性硬化症诊断的沟通:患者的视角

IF 2.5

Multiple Sclerosis International Pub Date : 2015-12-15 DOI: 10.1155/2015/353828

M. Messina, G. Dalla Costa, M. Rodegher, L. Moiola, B. Colombo, G. Comi, V. Martinelli

{"title":"The Communication of Multiple Sclerosis Diagnosis: The Patients' Perspective","authors":"M. Messina, G. Dalla Costa, M. Rodegher, L. Moiola, B. Colombo, G. Comi, V. Martinelli","doi":"10.1155/2015/353828","DOIUrl":"https://doi.org/10.1155/2015/353828","url":null,"abstract":"Background. Multiple sclerosis (MS) is the leading cause of nontraumatic neurological disability in young adults in Europe and in the United States. The uncertainty regarding its evolution makes the diagnosis disclosure a difficult process. Objective. The aim of the study was to provide patients' global perspective towards MS diagnosis communication. Methods. 150 consecutive patients, recently diagnosed with CIS or MS, were asked to complete a 17-item questionnaire assessing factors influencing their satisfaction with the information provided. Results. Eighty-six patients fulfilled diagnostic criteria for MS and 64 for CIS. Diagnosis disclosure took place in a private setting and required in most cases (87.3%) less than 30 minutes. Most patients reported being moderately or highly satisfied with the information provided (75%). The degree of satisfaction seems significantly related to patients' younger age, a longer time dedicated to disclose the diagnosis, a CIS diagnosis, and, above all, tailored information and an adequate emotional support. Conclusion. Most patients reported a good degree of satisfaction about the communication of MS or CIS diagnosis. A fruitful relationship between patient and neurologist is essential to obtain a better acceptance of the disease, patients' compliance with chronic treatments and to improve patients' quality of life.","PeriodicalId":46096,"journal":{"name":"Multiple Sclerosis International","volume":"2015 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2015-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/353828","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64916935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Comparing Three Dual-Task Methods and the Relationship to Physical and Cognitive Impairment in People with Multiple Sclerosis and Controls 比较三种双任务方法及其与多发性硬化症患者和对照组身体和认知功能损害的关系

IF 2.5

Multiple Sclerosis International Pub Date : 2015-11-23 DOI: 10.1155/2015/650645

M. Kirkland, E. M. Wallack, Samantha N. Rancourt, M. Ploughman

{"title":"Comparing Three Dual-Task Methods and the Relationship to Physical and Cognitive Impairment in People with Multiple Sclerosis and Controls","authors":"M. Kirkland, E. M. Wallack, Samantha N. Rancourt, M. Ploughman","doi":"10.1155/2015/650645","DOIUrl":"https://doi.org/10.1155/2015/650645","url":null,"abstract":"Dual-tasking (DT) is a measure to detect impairments in people with multiple sclerosis (MS). We compared three DT methods to determine whether cognitive (Montreal Cognitive Assessment (MoCA)) or physical disability (Expanded Disease Severity Scale; EDSS) was related to DT performance. We recruited MS participants with low disability (<3 EDSS, n = 13) and high disability (≥3 EDSS, n = 9) and matched controls (n = 13). Participants walked at self-selected (SS) speed on an instrumented walkway (Protokinetics, Havertown, USA), followed by DT walks in randomized order: DT ABC (reciting every second letter of the alphabet), DT 7 (serially subtracting 7's from 100), and DT 3 (counting upwards, leaving out multiples and numbers that include 3). DT 7 resulted in the most consistent changes in performance. Both MS and control groups reduced velocity and cadence and shortened step length during DT with no significant differences between groups. Control subjects widened stride width by about 1 cm while MS subjects (collapsed as one group) did not. MS subjects with higher disability significantly increased percentage time in double support during DT compared to SS (F = 12.95, p < 0.001). The change in DS was related to cognitive and not physical disability (r = 0.54, p < 0.05).","PeriodicalId":46096,"journal":{"name":"Multiple Sclerosis International","volume":"2015 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2015-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/650645","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65081398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 35

Adipsin Is Associated with Multiple Sclerosis: A Follow-Up Study of Adipokines 脂肪素与多发性硬化症相关:一项脂肪因子的随访研究

IF 2.5

Multiple Sclerosis International Pub Date : 2015-11-08 DOI: 10.1155/2015/371734

Renuka Natarajan, S. Hagman, Mari Hämälainen, T. Leppänen, P. Dastidar, E. Moilanen, I. Elovaara

{"title":"Adipsin Is Associated with Multiple Sclerosis: A Follow-Up Study of Adipokines","authors":"Renuka Natarajan, S. Hagman, Mari Hämälainen, T. Leppänen, P. Dastidar, E. Moilanen, I. Elovaara","doi":"10.1155/2015/371734","DOIUrl":"https://doi.org/10.1155/2015/371734","url":null,"abstract":"Background and Objective. The role of adipokines in regulation of immune responses has been recognized, but very little is known about their impact on multiple sclerosis (MS). In this study, we analysed whether the major adipokines are differentially expressed in plasma of patients with different MS subtypes and clinically isolated syndrome (CIS) and explored their association with major disease characteristics. Methods. The levels of adiponectin, adipsin, leptin, and resistin in the plasma of 80 patients with different subtypes of MS and CIS were followed up annually over the two years. The data obtained were correlated with disease activity, EDSS and volumes of T1-weighted lesions (T1-LV), and fluid attenuation inversion recovery lesions (FLAIR-LV) on MRI. Results. In MS group, a correlation was found between the level of adipsin and EDSS score at baseline (r = 0.506, p < 0.001). In RRMS, the levels of adipsin correlated with EDSS scores (r = 0.542, p = 0.002), T1-LV (r = 0.410, p = 0.034), and FLAIR-LV (r = 0.601, p = 0.0001) at baseline and an increase in the T1-LV over the follow-up (r = 0.582, p = 0.003). Associations with other adipokines were not detected. Conclusion. Our exploratory study provides novel insights on the impact of adipokines in MS and suggests that adipsin exerts predictive potential as a biomarker of neurodegeneration.","PeriodicalId":46096,"journal":{"name":"Multiple Sclerosis International","volume":"2015 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2015-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/371734","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64927594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 21

Epidemiology of neuromyelitis optica in the world: a systematic review and meta-analysis. 世界视神经脊髓炎的流行病学:系统回顾和荟萃分析。

IF 2.5

Multiple Sclerosis International Pub Date : 2015-01-01 Epub Date: 2015-04-20 DOI: 10.1155/2015/174720

Masoud Etemadifar, Zahra Nasr, Behrang Khalili, Maryam Taherioun, Reza Vosoughi

{"title":"Epidemiology of neuromyelitis optica in the world: a systematic review and meta-analysis.","authors":"Masoud Etemadifar, Zahra Nasr, Behrang Khalili, Maryam Taherioun, Reza Vosoughi","doi":"10.1155/2015/174720","DOIUrl":"https://doi.org/10.1155/2015/174720","url":null,"abstract":"Background. Neuromyelitis optica (Devic's disease) is a severe autoimmune inflammatory disorder of the central nervous system. Epidemiological aspects of NMO have not been systemically reviewed. In this study we systematically reviewed and assessed the quality of studies reporting the incidence and/or prevalence of NMO across the world. Methods. A comprehensive literature search using MEDLINE, EMBASE, and Web of Science for the terms \"Neuromyelitis optica,\" \"devic disease,\" \"incidence,\" \"prevalence,\" and \"epidemiology\" was conducted on January 31, 2015. Study quality was assessed using an assessment tool based on recognized guidelines and designed specifically for this study. Results. A total of 216 studies were initially identified, with only 9 meeting the inclusion criteria. High level of heterogeneity amongst studies precluded a firm conclusion. Incidence data were found in four studies and ranged from 0.053 per 100,000 per year in Cuba to 0.4 in Southern Denmark. Prevalence was reported in all studies and ranged from 0.51 per 100,000 in Cuba to 4.4 in Southern Denmark. Conclusion. This review reveals the gaps that still exist in the epidemiological knowledge of NMO in the world. Published studies have different qualities and methodology precluding a robust conclusion. Future researches focusing on epidemiological features of NMO in different nations and different ethnic groups are needed. ","PeriodicalId":46096,"journal":{"name":"Multiple Sclerosis International","volume":"2015 ","pages":"174720"},"PeriodicalIF":2.5,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/174720","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33303413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 99