Multiple Sclerosis International最新文献_第10页

Outcome measures in relapsing-remitting multiple sclerosis: capturing disability and disease progression in clinical trials. 复发缓解型多发性硬化症的结果测量：在临床试验中捕捉残疾和疾病进展情况。

IF 2.5

Multiple Sclerosis International Pub Date : 2014-01-01 Epub Date: 2014-05-04 DOI: 10.1155/2014/262350

Amy M Lavery, Leonard H Verhey, Amy T Waldman

引用次数: 0

Impact of a 5-day expedition to machu picchu on persons with multiple sclerosis. 马丘比丘5天探险对多发性硬化症患者的影响。

IF 2.5

Multiple Sclerosis International Pub Date : 2014-01-01 Epub Date: 2014-05-21 DOI: 10.1155/2014/761210

Marie Beatrice D'hooghe, Peter Feys, Sam Deltour, Isabelle Van de Putte, Jan De Meue, Daphne Kos, Bert O Eijnde, Paul Van Asch

{"title":"Impact of a 5-day expedition to machu picchu on persons with multiple sclerosis.","authors":"Marie Beatrice D'hooghe, Peter Feys, Sam Deltour, Isabelle Van de Putte, Jan De Meue, Daphne Kos, Bert O Eijnde, Paul Van Asch","doi":"10.1155/2014/761210","DOIUrl":"https://doi.org/10.1155/2014/761210","url":null,"abstract":"Persons with multiple sclerosis (MS) are less physically active than nondiseased persons and often report low self-efficacy levels. In the context of an awareness project to promote physical activity and participation in MS, we addressed the impact of training for and participation in a unique expedition. Medical events, relapses, and self-reported neurological worsening were followed from 6 months before and up to 4 months afterwards. Validated patient-reported outcome measures were used to assess fatigue, self-efficacy in exercising, walking abilities, and illness perception. Nine participants completed the training, expedition, and observational study. Minor events, relapses, and/or neurological worsening were reported in six participants. The three participants with mild disability and no cardiovascular risk factors or comorbidities were free of medical and neurological events. We found a significant reduction of motor fatigue at last when compared with the first assessment. The reduction tended to be more evident in participants with mild disability (Expanded Disability Status Scale (EDSS) <4 at baseline). Cognitive fatigue, self-efficacy, and self-reported walking abilities did not change significantly. Illness perceptions tended to be reduced over time in the domains of consequences, identity, and concerns. Overall, no major adverse events occurred. ","PeriodicalId":46096,"journal":{"name":"Multiple Sclerosis International","volume":"2014 ","pages":"761210"},"PeriodicalIF":2.5,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/761210","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32456960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Spatial analysis of global prevalence of multiple sclerosis suggests need for an updated prevalence scale. 全球多发性硬化症患病率的空间分析表明需要更新患病率量表。

IF 2.5

Multiple Sclerosis International Pub Date : 2014-01-01 Epub Date: 2014-02-16 DOI: 10.1155/2014/124578

Brett J Wade

{"title":"Spatial analysis of global prevalence of multiple sclerosis suggests need for an updated prevalence scale.","authors":"Brett J Wade","doi":"10.1155/2014/124578","DOIUrl":"https://doi.org/10.1155/2014/124578","url":null,"abstract":"Multiple sclerosis (MS) is a demyelinating disease of the central nervous system with an unknown aetiology. MS has a geographic pattern of prevalence with high prevalence rates between 45 degrees and 65 degrees north. In much of the northern hemisphere, there exists a prevalence gradient, with increasing prevalence from south to north. While genetics may partially explain the latitudinal gradient, it is not strong enough to exclude exogenous variables. Kurtzke initially came up with a three-zone scale for low, medium, and high prevalence zones. He defined high as 30 or more per 100,000, medium as 5-29 per 100,000, and low as less than 5 per 100,000. In this study, 131 geographic datasets (geocases) were spatially analyzed to determine whether the existing global prevalence scale needed to be updated. The mean prevalence rate was 67.83/100,000 with rates ranging from 350/100,000 to 0/100,000. The results of this study suggest that the commonly referenced scale for global MS prevalence needs to be updated with added zones to reflect significantly higher prevalence rates in some areas of the world. We suggest a five-zone scale: very high (170-350), high (70-170), medium (38-70), low (13-38), and very low (0-13). ","PeriodicalId":46096,"journal":{"name":"Multiple Sclerosis International","volume":"2014 ","pages":"124578"},"PeriodicalIF":2.5,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/124578","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32230109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 59

Correlations between MRI and Information Processing Speed in MS: A Meta-Analysis. MRI与MS信息处理速度的相关性:一项meta分析。

IF 2.5

Multiple Sclerosis International Pub Date : 2014-01-01 Epub Date: 2014-03-25 DOI: 10.1155/2014/975803

S M Rao, A L Martin, R Huelin, E Wissinger, Z Khankhel, E Kim, K Fahrbach

{"title":"Correlations between MRI and Information Processing Speed in MS: A Meta-Analysis.","authors":"S M Rao, A L Martin, R Huelin, E Wissinger, Z Khankhel, E Kim, K Fahrbach","doi":"10.1155/2014/975803","DOIUrl":"https://doi.org/10.1155/2014/975803","url":null,"abstract":"Objectives. To examine relationships between conventional MRI measures and the paced auditory serial addition test (PASAT) and symbol digit modalities test (SDMT). Methods. A systematic literature review was conducted. Included studies had ≥30 multiple sclerosis (MS) patients, administered the SDMT or PASAT, and measured T2LV or brain atrophy. Meta-analysis of MRI/information processing speed (IPS) correlations, analysis of MRI/IPS significance tests to account for reporting bias, and binomial testing to detect trends when comparing correlation strengths of SDMT versus PASAT and T2LV versus atrophy were conducted. Results. The 39 studies identified frequently reported only significant correlations, suggesting reporting bias. Direct meta-analysis was only feasible for correlations between SDMT and T2LV (r = -0.45, P < 0.001) and atrophy in patients with mixed-MS subtypes (r = -0.54, P < 0.001). Familywise Holm-Bonferroni testing found that selective reporting was not the source of at least half of significant results reported. Binomial tests (P = 0.006) favored SDMT over PASAT in strength of MRI correlations. Conclusions. A moderate-to-strong correlation exists between impaired IPS and MRI in mixed MS populations. Correlations with MRI were stronger for SDMT than for PASAT. Neither heterogeneity among populations nor reporting bias appeared to be responsible for these findings. ","PeriodicalId":46096,"journal":{"name":"Multiple Sclerosis International","volume":"2014 ","pages":"975803"},"PeriodicalIF":2.5,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/975803","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32314083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 74

Periventricular lesions help differentiate neuromyelitis optica spectrum disorders from multiple sclerosis. 脑室周围病变有助于区分视神经脊髓炎与多发性硬化症。

IF 2.5

Multiple Sclerosis International Pub Date : 2014-01-01 Epub Date: 2014-02-09 DOI: 10.1155/2014/986923

Eytan Raz, John P Loh, Luca Saba, Mirza Omari, Joseph Herbert, Yvonne Lui, Ilya Kister

{"title":"Periventricular lesions help differentiate neuromyelitis optica spectrum disorders from multiple sclerosis.","authors":"Eytan Raz, John P Loh, Luca Saba, Mirza Omari, Joseph Herbert, Yvonne Lui, Ilya Kister","doi":"10.1155/2014/986923","DOIUrl":"https://doi.org/10.1155/2014/986923","url":null,"abstract":"Objective. To compare periventricular lesions in multiple sclerosis (MS) and neuromyelitis optica spectrum disorders (NMOsd). Materials and Methods. Sagittal and axial fluid attenuated inversion recovery (FLAIR) sequences of 20 NMOsd and 40 group frequency-matched MS patients were evaluated by two neuroradiologists. On axial FLAIR, periventricular area was characterized as free of lesions/smooth-bordered (\"type A\") or jagged-bordered (\"type B\") pattern. On sagittal FLAIR, the images were evaluated for presence of \"Dawson's fingers.\" Results. Type A pattern was observed in 80% of NMOsd patients by Reader 1 and 85% by Reader 2 but only in 5% MS patients by either Reader. Type B was seen in 15% NMOsd patients by Reader 1 and 20% by Reader 2 and in 95% MS patients by either Reader. Dawson's fingers were observed in no NMOsd patients by Reader 1 and 5% by Reader 2. In MS, Dawson's fingers were seen in 92.5% patients by Reader 1 and 77.5% by Reader 2. The differences in periventricular patterns and Dawson's finger detection between NMOsd and MS were highly significant (P < 0.001). Conclusions. Dawson's fingers and \"jagged-bordered\" periventricular hyperintensities are typical of MS and almost never seen in NMOsd, which suggests a practical method for differentiating the two diseases. ","PeriodicalId":46096,"journal":{"name":"Multiple Sclerosis International","volume":"2014 ","pages":"986923"},"PeriodicalIF":2.5,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/986923","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32205551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

The contribution of immune and glial cell types in experimental autoimmune encephalomyelitis and multiple sclerosis. 免疫和胶质细胞类型在实验性自身免疫性脑脊髓炎和多发性硬化症中的作用。

IF 2.5

Multiple Sclerosis International Pub Date : 2014-01-01 Epub Date: 2014-10-12 DOI: 10.1155/2014/285245

Samuel S Duffy, Justin G Lees, Gila Moalem-Taylor

{"title":"The contribution of immune and glial cell types in experimental autoimmune encephalomyelitis and multiple sclerosis.","authors":"Samuel S Duffy, Justin G Lees, Gila Moalem-Taylor","doi":"10.1155/2014/285245","DOIUrl":"https://doi.org/10.1155/2014/285245","url":null,"abstract":"Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system characterised by widespread areas of focal demyelination. Its aetiology and pathogenesis remain unclear despite substantial insights gained through studies of animal models, most notably experimental autoimmune encephalomyelitis (EAE). MS is widely believed to be immune-mediated and pathologically attributable to myelin-specific autoreactive CD4+ T cells. In recent years, MS research has expanded beyond its focus on CD4+ T cells to recognise the contributions of multiple immune and glial cell types to the development, progression, and amelioration of the disease. This review summarises evidence of T and B lymphocyte, natural killer cell, macrophage/microglial, astrocytic, and oligodendroglial involvement in both EAE and MS and the intercommunication and influence of each cell subset in the inflammatory process. Despite important advances in the understanding of the involvement of these cell types in MS, many questions still remain regarding the various subsets within each cell population and their exact contribution to different stages of the disease. ","PeriodicalId":46096,"journal":{"name":"Multiple Sclerosis International","volume":"2014 ","pages":"285245"},"PeriodicalIF":2.5,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/285245","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32795598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 97

Comparisons of Costs between Black Caribbean and White British Patients with Advanced Multiple Sclerosis in the UK. 英国加勒比黑人和英国白人晚期多发性硬化症患者的费用比较。

IF 2.5

Multiple Sclerosis International Pub Date : 2014-01-01 Epub Date: 2014-02-05 DOI: 10.1155/2014/613701

Wayne Smith, Paul McCrone, Cassie Goddard, Wei Gao, Rachel Burman, Diana Jackson, Irene Higginson, Eli Silber, Jonathan Koffman

{"title":"Comparisons of Costs between Black Caribbean and White British Patients with Advanced Multiple Sclerosis in the UK.","authors":"Wayne Smith, Paul McCrone, Cassie Goddard, Wei Gao, Rachel Burman, Diana Jackson, Irene Higginson, Eli Silber, Jonathan Koffman","doi":"10.1155/2014/613701","DOIUrl":"https://doi.org/10.1155/2014/613701","url":null,"abstract":"Background. Multiple sclerosis (MS) is now more common among black and minority ethnic groups in the UK but little is known about the costs of care amongst different ethnic groups. Objective. This study examined and compared service use and costs for people severely affected with MS from Black Caribbean (BC) and White British (WB) backgrounds in the UK and identified predictors of cost for both groups. Method. Population-based cross-sectional study of 43 BC and 43 WB patients with MS (EDSS ≥ 6) and their informal caregivers recruited from an MS service in southeast London. Interviews collected data on health and social service use and informal care support. Costs were calculated using UK unit cost data. Using regression analyses we compared costs between the ethnic groups and identified possible predictors of cost. Results. The mean (SD) costs for the WB and BC groups were £ 25,778 ( £ 39,387) and £ 23,186 ( £ 30,433), respectively. Results identified no significant difference in total cost between the two ethnic groups. The EDSS score alone was a significant predictor of cost. Conclusion. Similar costs between ethnic groups indicate that with regard to this MS service and geographical area, access to care was not affected by ethnicity. ","PeriodicalId":46096,"journal":{"name":"Multiple Sclerosis International","volume":"2014 ","pages":"613701"},"PeriodicalIF":2.5,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/613701","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32192052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Treatment with Anti-EGF Ab Ameliorates Experimental Autoimmune Encephalomyelitis via Induction of Neurogenesis and Oligodendrogenesis. 抗egf抗体通过诱导神经发生和少突胶质发生改善实验性自身免疫性脑脊髓炎

IF 2.5

Multiple Sclerosis International Pub Date : 2014-01-01 Epub Date: 2014-12-30 DOI: 10.1155/2014/926134

Yifat Amir-Levy, Karin Mausner-Fainberg, Arnon Karni

{"title":"Treatment with Anti-EGF Ab Ameliorates Experimental Autoimmune Encephalomyelitis via Induction of Neurogenesis and Oligodendrogenesis.","authors":"Yifat Amir-Levy, Karin Mausner-Fainberg, Arnon Karni","doi":"10.1155/2014/926134","DOIUrl":"https://doi.org/10.1155/2014/926134","url":null,"abstract":"Background. The neural stem cells (NSCs) migrate to the damaged sites in multiple sclerosis (MS) and in experimental autoimmune encephalomyelitis (EAE). However, the differentiation into neurons or oligodendrocytes is blocked. Epidermal growth factor (EGF) stimulates NSC proliferation and mobilization to demyelinated lesions but also induces astrogenesis and glial scar. Objective. To examine the clinical and histopathological effects of EGF neutralization on EAE. Methods. EAE-induced SJL mice were intravenously treated with either anti-EGF neutralizing antibody (Ab) or isotype control or PBS. On day 9 after immunization, 3 mice of each group were daily treated for 9 days with BrdU and then sacrificed for immunohistochemical analysis. Results. Treatment with anti-EGF Ab significantly ameliorated EAE symptoms during the second relapse. Anti-EGF Ab induced a shift from BrdU(+)GFAP(+) NSCs to BrdU(+)DCX(+) neuroblasts in the subventricular zone (SVZ), increased BrdU(+)NeuN(+) neurons in the granular cell layer of the dentate gyrus, and increased BrdU(+)O4(+) oligodendrocytes in the SVZ. There was no change in the inflammatory infiltrates in response to anti-EGF Ab. Conclusions. Therapy with anti-EGF Ab ameliorates EAE via induction of neurogenesis and oligodendrogenesis. No immunosuppressive effect was found. Further investigation is needed to support these notions of beneficial effect of anti-EGF Ab in MS. ","PeriodicalId":46096,"journal":{"name":"Multiple Sclerosis International","volume":"2014 ","pages":"926134"},"PeriodicalIF":2.5,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/926134","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32993816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Sound Lateralization Test Distinguishes Unimpaired MS Patients from Healthy Controls. 声音侧化试验可区分未受损的多发性硬化症患者和健康对照。

IF 2.5

Multiple Sclerosis International Pub Date : 2014-01-01 Epub Date: 2014-07-15 DOI: 10.1155/2014/462043

Joshua H Bacon, Ilya Kister, Tamar E Bacon, Eliana Pasternak, Yael Strauchler, Joseph Herbert

{"title":"Sound Lateralization Test Distinguishes Unimpaired MS Patients from Healthy Controls.","authors":"Joshua H Bacon, Ilya Kister, Tamar E Bacon, Eliana Pasternak, Yael Strauchler, Joseph Herbert","doi":"10.1155/2014/462043","DOIUrl":"https://doi.org/10.1155/2014/462043","url":null,"abstract":"There is an urgent need to develop a practical and reliable clinical measure of disease progression in early and mild MS. We hypothesized that a test of sound lateralization, which is exquisitely sensitive to transmission delays in auditory brainstem, could be more useful for detecting processing speed deficits in mildly impaired MS subjects than standard cognitive tasks. Objective. To develop a practical test of sound lateralization for the clinic and to compare performance of MS subjects with variable disability and healthy subjects on Sound Lateralization Test (SLT) and two speed-of-processing tasks. Design. 42 healthy controls and 90 subjects with clinically definite MS, divided into no, mild, and moderate disability strata, were administered the Symbol Digit Modalities Test (SDMT), and 3-second Paced Auditory Serial Addition Test (PASAT). Results. All of the tests showed an overall difference in performance between controls and the three MS groups, but only the SLT measured a significant difference between controls and the no disability group. Conclusion. SLT is rapidly applied, technically simple, and superior to standard processing speed tests for discriminating between healthy controls and nondisabled MS subjects. SLT should be investigated as an outcome measure in early-phase trials and for monitoring early disease progression in the clinic. ","PeriodicalId":46096,"journal":{"name":"Multiple Sclerosis International","volume":"2014 ","pages":"462043"},"PeriodicalIF":2.5,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/462043","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32593723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Increasing Incidence in Relapsing-Remitting MS and High Rates among Young Women in Finland: A Thirty-Year Follow-Up. 芬兰年轻女性复发缓解型多发性硬化症发病率增加，发病率高:30年随访

IF 2.5

Multiple Sclerosis International Pub Date : 2014-01-01 Epub Date: 2014-11-09 DOI: 10.1155/2014/186950

Marja-Liisa Sumelahti, Markus H A Holmberg, Annukka Murtonen, Heini Huhtala, Irina Elovaara

{"title":"Increasing Incidence in Relapsing-Remitting MS and High Rates among Young Women in Finland: A Thirty-Year Follow-Up.","authors":"Marja-Liisa Sumelahti, Markus H A Holmberg, Annukka Murtonen, Heini Huhtala, Irina Elovaara","doi":"10.1155/2014/186950","DOIUrl":"https://doi.org/10.1155/2014/186950","url":null,"abstract":"Object. Gender and disease course specific incidences were studied in high- and medium-risk regions of MS in Finland. Methods. Age- and gender-specific incidences with 95% CIs were calculated in 10-year periods from 1981 to 2010. Poser diagnostic criteria were used and compared with the McDonald criteria from 2001 to 2010. Association between age and diagnostic delay over time was assessed by using the Kruskal-Wallis test. Results. 1419 (89%) RRMS and 198 (11%) PPMS cases were included. RRMS incidence increased with the female to male ratio (F/M) from 4,2/10(5) (F/M 1.9) to 9,7 (2.3), while that of PPMS decreased from 1,2 (1.6) to 0,7 (1.2). The use of McDonald criteria did not change the conclusion. The decreasing diagnostic delay and age at diagnosis in RRMS were associated within the 10-year periods and contrasted those in PPMS. Increasing female risk in RRMS was observed in the high-risk region. Conclusion. Increasing RRMS incidence and high female ratios shown in each age group indicate gender-specific influences acting already from childhood. A more precise definition of the risk factors and their action in MS is needed to provide a better understanding of underlying pathological processes and a rationale for the development of new preventive and treatment strategies. ","PeriodicalId":46096,"journal":{"name":"Multiple Sclerosis International","volume":"2014 ","pages":"186950"},"PeriodicalIF":2.5,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/186950","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32844358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19