Multiple Sclerosis International最新文献_第10页

Factors Associated with Neurologists' Provision of MS Patient Care. 神经科医生提供多发性硬化症患者护理的相关因素。

IF 2.5

Multiple Sclerosis International Pub Date : 2014-01-01 Epub Date: 2014-04-24 DOI: 10.1155/2014/624790

Michael T Halpern, Stephanie M Teixeira-Poit, Heather Kane, Corey Frost, Michael Keating, Murrey Olmsted

{"title":"Factors Associated with Neurologists' Provision of MS Patient Care.","authors":"Michael T Halpern, Stephanie M Teixeira-Poit, Heather Kane, Corey Frost, Michael Keating, Murrey Olmsted","doi":"10.1155/2014/624790","DOIUrl":"https://doi.org/10.1155/2014/624790","url":null,"abstract":"Neurologists are central to providing quality care for individuals with MS. However, neurologist shortages may restrict access to care for MS patients. To examine factors influencing neurologists' provision of MS care, we surveyed 1,700 US neurologists to assess demographic/practice characteristics, training, and attitudes toward MS care. The study population consisted of 573 respondents: 87 (15.2%) MS subspecialists and 486 (84.8%) \"other neurologists,\" including subspecialists in other neurology areas (i.e., non-MS) and general neurologists. MS subspecialists indicating they \"enjoy interacting with MS patients\" had a significantly greater rate of MS patients seen per week. In separate analyses of the \"other neurologists\" group, the rate of MS patients seen was lower among neurologists in university-based groups or those practicing in major cities; female neurologists; and neurologists who indicated lack of sufficient knowledge regarding MS patient care. Rates of MS patients seen were significantly greater for other neurologists who agreed that MS care involved \"ability to improve patient outcomes and quality of life\"; \"dynamic area with evolving treatment options\"; and \"enjoy interacting with MS patients.\" Understanding factors influencing MS patient care by neurologists and developing policies for appropriate access to care is critical for optimal outcomes among this population. ","PeriodicalId":46096,"journal":{"name":"Multiple Sclerosis International","volume":"2014 ","pages":"624790"},"PeriodicalIF":2.5,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/624790","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32440786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

The prevalence of familial multiple sclerosis in saskatoon, Saskatchewan. 萨斯喀彻温省萨斯卡通市的家族性多发性硬化症患病率。

IF 2.5

Multiple Sclerosis International Pub Date : 2014-01-01 Epub Date: 2014-02-03 DOI: 10.1155/2014/545080

Walter J Hader, Irene M Yee

{"title":"The prevalence of familial multiple sclerosis in saskatoon, Saskatchewan.","authors":"Walter J Hader, Irene M Yee","doi":"10.1155/2014/545080","DOIUrl":"10.1155/2014/545080","url":null,"abstract":"Background. A population-based prevalent cohort of 150 clinical definite multiple sclerosis (MS) cases (102 women; 48 men) ascertained on January 1, 1977, Saskatoon, Saskatchewan, was found to have a familial rate of MS as 17.3%. Objectives. To determine the occurrence of familial MS cases and the frequency of MS among the biological relatives of the study cohort. Methods. The search for new familial cases MS affected relatives continued for 35 years until 2012. The natural history of the disease of sporadic cases is compared with that of the familial cases. SPSS V19 and Kaplan-Meier survival analysis were used for data analysis. Results. Of the 150 unrelated MS patients, 49 cases (32.7%) (36 women and 13 men) were reported of having at least one family member with MS. There were a total of 86 affected relatives, 26 (30.2%) first-degree relatives, 15 (17.4%) second-degree relatives, 20 (23.3%) third-degree relatives, and 25 (29.1%) distant relatives. The average age of MS onset for men with sporadic MS was 33.9 (SD = 10) years and 27.6 (SD = 8.4) years for familial cases and 29.3 (SD = 8.3) years and 26.8 (SD = 8.5) years for women. Conclusion. This 35-year longitudinal natural history study reveals a high frequency of cases with family members developing MS and supports a genetic influence in the etiology of MS. ","PeriodicalId":46096,"journal":{"name":"Multiple Sclerosis International","volume":"2014 ","pages":"545080"},"PeriodicalIF":2.5,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3941120/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32213391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between Smoking and Health Outcomes in Postmenopausal Women Living with Multiple Sclerosis. 绝经后多发性硬化症妇女吸烟与健康结果的关系

IF 2.2

Multiple Sclerosis International Pub Date : 2014-01-01 Epub Date: 2014-04-22 DOI: 10.1155/2014/686045

Rachel Jawahar, Unsong Oh, Charles Eaton, Nicole Wright, Hilary Tindle, Kate L Lapane

{"title":"Association between Smoking and Health Outcomes in Postmenopausal Women Living with Multiple Sclerosis.","authors":"Rachel Jawahar, Unsong Oh, Charles Eaton, Nicole Wright, Hilary Tindle, Kate L Lapane","doi":"10.1155/2014/686045","DOIUrl":"10.1155/2014/686045","url":null,"abstract":"Background. In multiple sclerosis (MS), symptom management and improved health-related quality of life (HrQOL) may be modified by smoking. Objective. To evaluate the extent to which smoking is associated with worsened health outcomes and HrQOL for postmenopausal women with MS. Methods. We identified 251 Women's Health Initiative Observational Study participants with a self-reported MS diagnosis. Using a linear model, we estimated changes from baseline to 3 years for activities of daily living, total metabolic equivalent tasks (MET) hours per week, mental and physical component scales (MCS, PCS) of the SF-36, and menopausal symptoms adjusting for years since menopause and other confounders. Results. Nine percent were current and 50% past smokers. Age at smoking initiation was associated with significant changes in MCS during menopause. PCS scores were unchanged. While women who had ever smoked experienced an increase in physical activity during menopause, the physical activity levels of women who never smoked declined. Residual confounding may explain this finding. Smoking was not associated with change in menopausal symptoms during the 3-year follow-up. Conclusion. Smoking was not associated with health outcomes among post-menopausal women with MS. ","PeriodicalId":46096,"journal":{"name":"Multiple Sclerosis International","volume":"2014 ","pages":"686045"},"PeriodicalIF":2.2,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016891/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32367219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Outcome measures in relapsing-remitting multiple sclerosis: capturing disability and disease progression in clinical trials. 复发缓解型多发性硬化症的结果测量：在临床试验中捕捉残疾和疾病进展情况。

IF 2.5

Multiple Sclerosis International Pub Date : 2014-01-01 Epub Date: 2014-05-04 DOI: 10.1155/2014/262350

Amy M Lavery, Leonard H Verhey, Amy T Waldman

引用次数: 0

Impact of a 5-day expedition to machu picchu on persons with multiple sclerosis. 马丘比丘5天探险对多发性硬化症患者的影响。

IF 2.5

Multiple Sclerosis International Pub Date : 2014-01-01 Epub Date: 2014-05-21 DOI: 10.1155/2014/761210

Marie Beatrice D'hooghe, Peter Feys, Sam Deltour, Isabelle Van de Putte, Jan De Meue, Daphne Kos, Bert O Eijnde, Paul Van Asch

{"title":"Impact of a 5-day expedition to machu picchu on persons with multiple sclerosis.","authors":"Marie Beatrice D'hooghe, Peter Feys, Sam Deltour, Isabelle Van de Putte, Jan De Meue, Daphne Kos, Bert O Eijnde, Paul Van Asch","doi":"10.1155/2014/761210","DOIUrl":"https://doi.org/10.1155/2014/761210","url":null,"abstract":"Persons with multiple sclerosis (MS) are less physically active than nondiseased persons and often report low self-efficacy levels. In the context of an awareness project to promote physical activity and participation in MS, we addressed the impact of training for and participation in a unique expedition. Medical events, relapses, and self-reported neurological worsening were followed from 6 months before and up to 4 months afterwards. Validated patient-reported outcome measures were used to assess fatigue, self-efficacy in exercising, walking abilities, and illness perception. Nine participants completed the training, expedition, and observational study. Minor events, relapses, and/or neurological worsening were reported in six participants. The three participants with mild disability and no cardiovascular risk factors or comorbidities were free of medical and neurological events. We found a significant reduction of motor fatigue at last when compared with the first assessment. The reduction tended to be more evident in participants with mild disability (Expanded Disability Status Scale (EDSS) <4 at baseline). Cognitive fatigue, self-efficacy, and self-reported walking abilities did not change significantly. Illness perceptions tended to be reduced over time in the domains of consequences, identity, and concerns. Overall, no major adverse events occurred. ","PeriodicalId":46096,"journal":{"name":"Multiple Sclerosis International","volume":"2014 ","pages":"761210"},"PeriodicalIF":2.5,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/761210","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32456960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Spatial analysis of global prevalence of multiple sclerosis suggests need for an updated prevalence scale. 全球多发性硬化症患病率的空间分析表明需要更新患病率量表。

IF 2.5

Multiple Sclerosis International Pub Date : 2014-01-01 Epub Date: 2014-02-16 DOI: 10.1155/2014/124578

Brett J Wade

{"title":"Spatial analysis of global prevalence of multiple sclerosis suggests need for an updated prevalence scale.","authors":"Brett J Wade","doi":"10.1155/2014/124578","DOIUrl":"https://doi.org/10.1155/2014/124578","url":null,"abstract":"Multiple sclerosis (MS) is a demyelinating disease of the central nervous system with an unknown aetiology. MS has a geographic pattern of prevalence with high prevalence rates between 45 degrees and 65 degrees north. In much of the northern hemisphere, there exists a prevalence gradient, with increasing prevalence from south to north. While genetics may partially explain the latitudinal gradient, it is not strong enough to exclude exogenous variables. Kurtzke initially came up with a three-zone scale for low, medium, and high prevalence zones. He defined high as 30 or more per 100,000, medium as 5-29 per 100,000, and low as less than 5 per 100,000. In this study, 131 geographic datasets (geocases) were spatially analyzed to determine whether the existing global prevalence scale needed to be updated. The mean prevalence rate was 67.83/100,000 with rates ranging from 350/100,000 to 0/100,000. The results of this study suggest that the commonly referenced scale for global MS prevalence needs to be updated with added zones to reflect significantly higher prevalence rates in some areas of the world. We suggest a five-zone scale: very high (170-350), high (70-170), medium (38-70), low (13-38), and very low (0-13). ","PeriodicalId":46096,"journal":{"name":"Multiple Sclerosis International","volume":"2014 ","pages":"124578"},"PeriodicalIF":2.5,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/124578","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32230109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 59

Correlations between MRI and Information Processing Speed in MS: A Meta-Analysis. MRI与MS信息处理速度的相关性:一项meta分析。

IF 2.5

Multiple Sclerosis International Pub Date : 2014-01-01 Epub Date: 2014-03-25 DOI: 10.1155/2014/975803

S M Rao, A L Martin, R Huelin, E Wissinger, Z Khankhel, E Kim, K Fahrbach

{"title":"Correlations between MRI and Information Processing Speed in MS: A Meta-Analysis.","authors":"S M Rao, A L Martin, R Huelin, E Wissinger, Z Khankhel, E Kim, K Fahrbach","doi":"10.1155/2014/975803","DOIUrl":"https://doi.org/10.1155/2014/975803","url":null,"abstract":"Objectives. To examine relationships between conventional MRI measures and the paced auditory serial addition test (PASAT) and symbol digit modalities test (SDMT). Methods. A systematic literature review was conducted. Included studies had ≥30 multiple sclerosis (MS) patients, administered the SDMT or PASAT, and measured T2LV or brain atrophy. Meta-analysis of MRI/information processing speed (IPS) correlations, analysis of MRI/IPS significance tests to account for reporting bias, and binomial testing to detect trends when comparing correlation strengths of SDMT versus PASAT and T2LV versus atrophy were conducted. Results. The 39 studies identified frequently reported only significant correlations, suggesting reporting bias. Direct meta-analysis was only feasible for correlations between SDMT and T2LV (r = -0.45, P < 0.001) and atrophy in patients with mixed-MS subtypes (r = -0.54, P < 0.001). Familywise Holm-Bonferroni testing found that selective reporting was not the source of at least half of significant results reported. Binomial tests (P = 0.006) favored SDMT over PASAT in strength of MRI correlations. Conclusions. A moderate-to-strong correlation exists between impaired IPS and MRI in mixed MS populations. Correlations with MRI were stronger for SDMT than for PASAT. Neither heterogeneity among populations nor reporting bias appeared to be responsible for these findings. ","PeriodicalId":46096,"journal":{"name":"Multiple Sclerosis International","volume":"2014 ","pages":"975803"},"PeriodicalIF":2.5,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/975803","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32314083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 74

Periventricular lesions help differentiate neuromyelitis optica spectrum disorders from multiple sclerosis. 脑室周围病变有助于区分视神经脊髓炎与多发性硬化症。

IF 2.5

Multiple Sclerosis International Pub Date : 2014-01-01 Epub Date: 2014-02-09 DOI: 10.1155/2014/986923

Eytan Raz, John P Loh, Luca Saba, Mirza Omari, Joseph Herbert, Yvonne Lui, Ilya Kister

{"title":"Periventricular lesions help differentiate neuromyelitis optica spectrum disorders from multiple sclerosis.","authors":"Eytan Raz, John P Loh, Luca Saba, Mirza Omari, Joseph Herbert, Yvonne Lui, Ilya Kister","doi":"10.1155/2014/986923","DOIUrl":"https://doi.org/10.1155/2014/986923","url":null,"abstract":"Objective. To compare periventricular lesions in multiple sclerosis (MS) and neuromyelitis optica spectrum disorders (NMOsd). Materials and Methods. Sagittal and axial fluid attenuated inversion recovery (FLAIR) sequences of 20 NMOsd and 40 group frequency-matched MS patients were evaluated by two neuroradiologists. On axial FLAIR, periventricular area was characterized as free of lesions/smooth-bordered (\"type A\") or jagged-bordered (\"type B\") pattern. On sagittal FLAIR, the images were evaluated for presence of \"Dawson's fingers.\" Results. Type A pattern was observed in 80% of NMOsd patients by Reader 1 and 85% by Reader 2 but only in 5% MS patients by either Reader. Type B was seen in 15% NMOsd patients by Reader 1 and 20% by Reader 2 and in 95% MS patients by either Reader. Dawson's fingers were observed in no NMOsd patients by Reader 1 and 5% by Reader 2. In MS, Dawson's fingers were seen in 92.5% patients by Reader 1 and 77.5% by Reader 2. The differences in periventricular patterns and Dawson's finger detection between NMOsd and MS were highly significant (P < 0.001). Conclusions. Dawson's fingers and \"jagged-bordered\" periventricular hyperintensities are typical of MS and almost never seen in NMOsd, which suggests a practical method for differentiating the two diseases. ","PeriodicalId":46096,"journal":{"name":"Multiple Sclerosis International","volume":"2014 ","pages":"986923"},"PeriodicalIF":2.5,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/986923","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32205551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

The contribution of immune and glial cell types in experimental autoimmune encephalomyelitis and multiple sclerosis. 免疫和胶质细胞类型在实验性自身免疫性脑脊髓炎和多发性硬化症中的作用。

IF 2.5

Multiple Sclerosis International Pub Date : 2014-01-01 Epub Date: 2014-10-12 DOI: 10.1155/2014/285245

Samuel S Duffy, Justin G Lees, Gila Moalem-Taylor

{"title":"The contribution of immune and glial cell types in experimental autoimmune encephalomyelitis and multiple sclerosis.","authors":"Samuel S Duffy, Justin G Lees, Gila Moalem-Taylor","doi":"10.1155/2014/285245","DOIUrl":"https://doi.org/10.1155/2014/285245","url":null,"abstract":"Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system characterised by widespread areas of focal demyelination. Its aetiology and pathogenesis remain unclear despite substantial insights gained through studies of animal models, most notably experimental autoimmune encephalomyelitis (EAE). MS is widely believed to be immune-mediated and pathologically attributable to myelin-specific autoreactive CD4+ T cells. In recent years, MS research has expanded beyond its focus on CD4+ T cells to recognise the contributions of multiple immune and glial cell types to the development, progression, and amelioration of the disease. This review summarises evidence of T and B lymphocyte, natural killer cell, macrophage/microglial, astrocytic, and oligodendroglial involvement in both EAE and MS and the intercommunication and influence of each cell subset in the inflammatory process. Despite important advances in the understanding of the involvement of these cell types in MS, many questions still remain regarding the various subsets within each cell population and their exact contribution to different stages of the disease. ","PeriodicalId":46096,"journal":{"name":"Multiple Sclerosis International","volume":"2014 ","pages":"285245"},"PeriodicalIF":2.5,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/285245","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32795598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 97

Comparisons of Costs between Black Caribbean and White British Patients with Advanced Multiple Sclerosis in the UK. 英国加勒比黑人和英国白人晚期多发性硬化症患者的费用比较。

IF 2.5

Multiple Sclerosis International Pub Date : 2014-01-01 Epub Date: 2014-02-05 DOI: 10.1155/2014/613701

Wayne Smith, Paul McCrone, Cassie Goddard, Wei Gao, Rachel Burman, Diana Jackson, Irene Higginson, Eli Silber, Jonathan Koffman

{"title":"Comparisons of Costs between Black Caribbean and White British Patients with Advanced Multiple Sclerosis in the UK.","authors":"Wayne Smith, Paul McCrone, Cassie Goddard, Wei Gao, Rachel Burman, Diana Jackson, Irene Higginson, Eli Silber, Jonathan Koffman","doi":"10.1155/2014/613701","DOIUrl":"https://doi.org/10.1155/2014/613701","url":null,"abstract":"Background. Multiple sclerosis (MS) is now more common among black and minority ethnic groups in the UK but little is known about the costs of care amongst different ethnic groups. Objective. This study examined and compared service use and costs for people severely affected with MS from Black Caribbean (BC) and White British (WB) backgrounds in the UK and identified predictors of cost for both groups. Method. Population-based cross-sectional study of 43 BC and 43 WB patients with MS (EDSS ≥ 6) and their informal caregivers recruited from an MS service in southeast London. Interviews collected data on health and social service use and informal care support. Costs were calculated using UK unit cost data. Using regression analyses we compared costs between the ethnic groups and identified possible predictors of cost. Results. The mean (SD) costs for the WB and BC groups were £ 25,778 ( £ 39,387) and £ 23,186 ( £ 30,433), respectively. Results identified no significant difference in total cost between the two ethnic groups. The EDSS score alone was a significant predictor of cost. Conclusion. Similar costs between ethnic groups indicate that with regard to this MS service and geographical area, access to care was not affected by ethnicity. ","PeriodicalId":46096,"journal":{"name":"Multiple Sclerosis International","volume":"2014 ","pages":"613701"},"PeriodicalIF":2.5,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/613701","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32192052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7