AnemiaPub Date : 2020-02-07eCollection Date: 2020-01-01DOI: 10.1155/2020/3041738
Maha F Yacoub, Hala Fouad Ferwiz, Fadwa Said
{"title":"Effect of Interleukin and Hepcidin in Anemia of Chronic Diseases.","authors":"Maha F Yacoub, Hala Fouad Ferwiz, Fadwa Said","doi":"10.1155/2020/3041738","DOIUrl":"https://doi.org/10.1155/2020/3041738","url":null,"abstract":"<p><strong>Background: </strong>Anemia of chronic disease (ACD) also termed as the anemia of inflammation has been found to be associated with inflammations, chronic infections, and cancers, particularly in old age. Recent studies revealed that interleukin-6 (IL-6), a proinflammatory cytokine, and hepcidin, an antimicrobial hepatic peptide, play a key role in ACD pathogenesis. <i>Patients and Methods.</i> The study included 40 subjects with chronic diseases and 40 normal subjects of the same age group. Red cell indices, levels of IL-6 and hepcidin, and iron profile were measured in all participants using Bayer ADVIA 120, VITROS 5600, Integrated System/2008, and ELISA assay, respectively.</p><p><strong>Results: </strong>The level of hemoglobin was considerably less in patients of chronic diseases referred to as \"cases\" than the normal subjects or \"controls\" (8.7 ± 1.5 vs. 13.2 ± 0.9). Red blood corpuscle (RBC) count, hematocrit (HCT) level, serum iron, mean corpuscular hemoglobin concentration (MCHC), and serum total iron-binding capacity (TIBC) were found to be significantly lower in the cases as compared to controls (<i>p</i> < 0.001). Serum IL-6 and hepcidin levels were substantially higher in the cases than in the controls (<i>p</i> < 0.001). Serum IL-6 and hepcidin levels were substantially higher in the cases than in the controls (<i>p</i> < 0.001). Serum IL-6 and hepcidin levels were substantially higher in the cases than in the controls (.</p><p><strong>Conclusion: </strong>This study detected a significant increase in serum IL-6 and hepcidin levels in patients with ACD than the controls. These findings offer an insight into the role played by both cytokine and peptide in the pathogenesis of ACD and thus provide a rationale for future use of novel drugs inhibiting their effects on iron metabolism.</p>","PeriodicalId":46055,"journal":{"name":"Anemia","volume":"2020 ","pages":"3041738"},"PeriodicalIF":2.9,"publicationDate":"2020-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/3041738","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37675004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AnemiaPub Date : 2020-01-21eCollection Date: 2020-01-01DOI: 10.1155/2020/1628357
Nazneen Habib, Saif-Ur-Rehman Saif Abbasi, Wajid Aziz
{"title":"An Analysis of Societal Determinant of Anemia among Adolescent Girls in Azad Jammu and Kashmir, Pakistan.","authors":"Nazneen Habib, Saif-Ur-Rehman Saif Abbasi, Wajid Aziz","doi":"10.1155/2020/1628357","DOIUrl":"https://doi.org/10.1155/2020/1628357","url":null,"abstract":"<p><p>Societal determinants of health are of recognized importance for understanding the causal association of society and health of an individual. Iron deficiency anemia (IDA) is a challenging public health problem across the globe instigating from a broader sociocultural background. It is more prevalent among pregnant women, children under the age of five years, and adolescent girls. Adolescent girls are vulnerable to develop IDA because of additional nutritional demand of the body needed for growth spurt, blood loss due to onset of menarche, malnourishment, and poor dietary iron intake. In this study, we explore the societal determinants of anemia among adolescent girls in Azad Jammu and Kashmir (AJK), Pakistan. A cross-sectional study was conducted in the Muzaffarabad division of AJK on randomly selected 626 adolescent girls. The data were collected using a pretested self-administered interview schedule comprising mainly closed-ended questions with a few open-ended questions. Descriptive statistics was computed for describing the data, and bivariate regression and logistic regression were used to determine the association of anemia with its societal determinants. Multiple linear regression is used to determine the relationship of different determinants (independent variables) with the hemoglobin level (dependent variable) of the respondents. The prevalence of anemia among adolescent girls is 47.9%, of which 47.7% have mild anemia, 51.7% have moderate anemia, and 5.7% have severe anemia, which reveals that anemia is a severe public health problem among adolescent girls in the study area. The findings aver that anemia occurrence was significantly associated with the respondent's and her parental education, economic well-being, prevalence of communicable diseases, menstrual disorder, exercise habits, meals regularity, and type of sewerage system.</p>","PeriodicalId":46055,"journal":{"name":"Anemia","volume":"2020 ","pages":"1628357"},"PeriodicalIF":2.9,"publicationDate":"2020-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/1628357","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37633634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AnemiaPub Date : 2019-11-13eCollection Date: 2019-01-01DOI: 10.1155/2019/1598920
Danielle J Roberts, Temesgen Zewotir
{"title":"District Effect Appraisal in East Sub-Saharan Africa: Combating Childhood Anaemia.","authors":"Danielle J Roberts, Temesgen Zewotir","doi":"10.1155/2019/1598920","DOIUrl":"https://doi.org/10.1155/2019/1598920","url":null,"abstract":"<p><strong>Background: </strong>Anaemia in children is a significant health problem that receives little attention. This study aimed at determining the factors significantly associated with anaemia in children aged 6 to 59 months in Kenya, Malawi, Tanzania, and Uganda while accounting for the spatial heterogeneity within and between the districts of the four countries. In addition, the performance of the districts with regard to their impact on anaemia was assessed and ranked.</p><p><strong>Methods: </strong>A generalised additive mixed model with a spatial effect based on the geographical coordinates of the clusters was used. A district-level random effect was included to further account for the heterogeneity as well as to rank the performance of the districts based on the best linear unbiased prediction (BLUP).</p><p><strong>Results: </strong>The results depicted significant spatial heterogeneity between and within the districts of the countries. After accounting for such spatial heterogeneity, child-level characteristics (gender, malaria test result, and mother's highest education level), household-level characteristics (household size, household's wealth index Z-score, the type of toilet facility available, and the type of place of residence), and the country of residence were found to be significantly associated with the child's anaemia status. There was a significant interaction between the type of place of residence and the country of residence. Based on the BLUP for the district-level random effect, the top 3 best- and worst-performing districts within each country were identified.</p><p><strong>Conclusion: </strong>The ranking of the performance of the districts allows for the worst-performing districts to be targeted for further research in order to improve their anaemia control strategies, as well as for the best-performing districts to be identified to further determine why they are performing better and then to use these districts as role models in efforts to overcome childhood anaemia.</p>","PeriodicalId":46055,"journal":{"name":"Anemia","volume":"2019 ","pages":"1598920"},"PeriodicalIF":2.9,"publicationDate":"2019-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2019/1598920","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37498816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AnemiaPub Date : 2019-11-12DOI: 10.1155/2019/4640635
Saleema Wani, Mariyam Noushad, Shabana Ashiq
{"title":"REGAIN STUDY: Retrospective Study to Assess the Effectiveness, Tolerability, and Safety of Ferric Carboxymaltose in the Management of Iron Deficiency Anemia in Pregnant Women","authors":"Saleema Wani, Mariyam Noushad, Shabana Ashiq","doi":"10.1155/2019/4640635","DOIUrl":"https://doi.org/10.1155/2019/4640635","url":null,"abstract":"Iron deficiency anemia (IDA) during pregnancy arises because of preexisting inadequate stores or complex physiological changes and can lead to serious maternal and fetal complications. Oral iron, either as iron sulfate or fumarate, with or without folic acid, is the most commonly used treatment for IDA in pregnancy. Intravenous (IV) iron has a role in the treatment of IDA in pregnancy, particularly in women who present late, display severe anemia (Hb ≤ 9 g/dL), or risk factors, and are intolerant/noncompliant of oral iron. Previously, administration of IV iron was minimal, owing to potentially serious anaphylactic reactions. Recently, new IV iron products have been developed, offering better compliance, tolerability, efficacy, and a good safety profile. Our study aimed to assess the effectiveness, safety, and tolerability of IV ferric carboxymaltose (FCM) in the treatment of IDA in pregnant women in the UAE. Data from 1001 pregnant women who received at least one administration of FCM (500, 1000, or 1500 mg) during their second or third trimester of pregnancy (2 years backward from study initiation) were collected retrospectively from electronic medical records at Corniche Hospital, Abu Dhabi, UAE. Results showed that 41.4% of the women were able to achieve an increase of ≥2 g/dL in blood hemoglobin overall. A change of ≥2 g/dL was achieved by 27.5% of women administered a dose of 500 mg, 39.2% of women administered a dose of 1000 mg, and 63.9% of women administered a dose of 1500 mg of IV FCM. This indicates a directly proportional relationship between increasing IV FCM dose and the increase of ≥2 g/dL in blood hemoglobin. A total of 7 (0.7%) women reported mild, nonserious adverse events during the study. Within the limits of this retrospective study, IV FCM therapy was safe and effective in increasing the mean hemoglobin of pregnant women with IDA.","PeriodicalId":46055,"journal":{"name":"Anemia","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2019-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2019/4640635","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48961377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AnemiaPub Date : 2019-10-22eCollection Date: 2019-01-01DOI: 10.1155/2019/1413906
Merry M V Seu, Johanes C Mose, Ramdan Panigoro, Edhyana Sahiratmadja
{"title":"Anemia Prevalence after Iron Supplementation among Pregnant Women in Midwifes Practice of Primary Health Care Facilities in Eastern Indonesia.","authors":"Merry M V Seu, Johanes C Mose, Ramdan Panigoro, Edhyana Sahiratmadja","doi":"10.1155/2019/1413906","DOIUrl":"10.1155/2019/1413906","url":null,"abstract":"<p><strong>Background: </strong>Iron deficiency anemia (IDA) in pregnant women is common, and iron supplementation is given during pregnancy to reduce birth complication. This study aimed to explore the prevalence of anemia and type of anemia after iron supplementation among pregnant women in the eastern part of Indonesia.</p><p><strong>Methods: </strong>A cross-sectional study design was conducted between January and March 2019 in three Primary Health Care (PHC) facilities at Kupang, West Timor. After consent, pregnant women who had taken their iron supplementation for at least 3 months were asked for iron pills intake by using a self-designed questionnaire and by counting the pills leftover. Complete blood count examination was performed, and the type of anemia was assessed using Shine and Lal index (SLI; MCV <i>∗</i> MCV <i>∗</i> MCH/100) to determine whether anemia was due to iron deficiency or <i>β</i>-thalassemia trait (<i>β</i>-TT). In a subset of iron tablets distributed in the PHCs, Fe-concentration was measured.</p><p><strong>Results: </strong>Of 102 pregnant women included, only 25.5% had taken the pills with a pill count of >80%. Interestingly, Fe-concentration in the pills from three different PHC facilities varied between 75% and 100%. After iron supplementation, however, anemia was detected in 34.3%, and based on SLI, 14.7% was suspected because of iron deficiency and 19.6% was suspective of <i>β</i>-TT. Of note, nonanemic pregnant women (17.6%) had also low SLI, suggesting <i>β</i>-TT or other hemoglobinopathies.</p><p><strong>Conclusion: </strong>Assessment of Shine and Lal index as the first step to screen the type of anemia in pregnant women from a limited area is of potential value, especially because Indonesia is located in the thalassemia belt area. An integrative approach and counseling among pregnant women with <i>β</i>-TT and their partners will increase thalassemia awareness and optimal birth management.</p>","PeriodicalId":46055,"journal":{"name":"Anemia","volume":"2019 1","pages":"1413906"},"PeriodicalIF":2.2,"publicationDate":"2019-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6854238/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42623417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AnemiaPub Date : 2019-06-25DOI: 10.1155/2019/2139717
P. Parbey, E. Tarkang, E. Manu, Hubert Amu, M. Ayanore, F. Y. Aku, S. A. Ziema, S. Bosoka, M. Adjuik, M. Kweku
{"title":"Risk Factors of Anaemia among Children under Five Years in the Hohoe Municipality, Ghana: A Case Control Study","authors":"P. Parbey, E. Tarkang, E. Manu, Hubert Amu, M. Ayanore, F. Y. Aku, S. A. Ziema, S. Bosoka, M. Adjuik, M. Kweku","doi":"10.1155/2019/2139717","DOIUrl":"https://doi.org/10.1155/2019/2139717","url":null,"abstract":"Background Anaemia is one of the major causes of death among children under five years in Ghana. We examined the risk factors of anaemia among children under five years in the Hohoe Municipality, Ghana. Methods This facility-based matched case control study recruited 210 children (70 cases and 140 controls) aged 6 to 59 months. Stratified and simple random sampling techniques were used to select mothers attending Child Welfare Clinic (CWC) for the screening of their children. Data were collected using a semistructured questionnaire. Finger prick blood was collected to estimate the haemoglobin (Hb) level and thick film was prepared to determine malaria parasitaemia. Axillary temperature was measured using an +electronic thermometer and anthropometric measurements were done using a weighing scale and inelastic tape measure. Continuous variables were presented as means and standard deviations and categorical variables as frequencies and proportions. Conditional logistic regression was used to determine the strength of association between the dependent and the independent variables. Statistical significance was considered at p value of <0.05. Results The prevalence of anaemia was high (53.8%), while children whose mothers received iron supplementation during pregnancy were 7.64 times more likely to be anaemic compared with those who did not [AOR=7.64 (95% CI:1.41-41.20.93); p=0.018]. Children with poor dietary diversity were 9.15 times more likely to have anaemia [AOR=9.15 (95% CI: 3.13-26.82); p< 0.001]; and children whose mothers were farmers and traders were 83% [AOR = 0.17 (95% CI: 0.05-0.60); p=0.006] and 79% [AOR=0.21 (95% CI: 0.06-0.74); p=0.014], respectively, less likely to have anaemia. Conclusion The biologic, intermediate, and underlying factors that were significantly associated with anaemia comprised maternal iron supplementation, poor dietary diversity, farmers, and traders. Given that iron supplementation during pregnancy did not protect children against anaemia, we recommend the child's nutritional dietary diversity is encouraged.","PeriodicalId":46055,"journal":{"name":"Anemia","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2019-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2019/2139717","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42896870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AnemiaPub Date : 2019-04-01eCollection Date: 2019-01-01DOI: 10.1155/2019/3457347
Eman Tariq Ali, Azza Sajed Jabbar, Ali Nazar Mohammed
{"title":"A Comparative Study of Interleukin 6, Inflammatory Markers, Ferritin, and Hematological Profile in Rheumatoid Arthritis Patients with Anemia of Chronic Disease and Iron Deficiency Anemia.","authors":"Eman Tariq Ali, Azza Sajed Jabbar, Ali Nazar Mohammed","doi":"10.1155/2019/3457347","DOIUrl":"https://doi.org/10.1155/2019/3457347","url":null,"abstract":"<p><strong>Background: </strong>Interleukin-6 (IL-6) proinflammatory cytokine is associated with the pathogenesis of rheumatoid arthritis and development of anemia in it. This is a comparative study of inflammatory and hematological parameters in RA patients with anemia of chronic disease (ACD) and iron deficiency anemia (IDA). It aimed to demonstrate the changes in serum level of IL-6, ferritin level, and hematological parameters in different groups of patients with RA and to find out the potential correlation between serum level of IL-6 and ferritin level and the relationship between serum level of IL-6 and iron status.</p><p><strong>Methods: </strong>The study included 89 patients from both sexes divided into four groups (group 1: 30 iron deficiency anemia (IDA), 59 RA; group 2: 20 RA-COMBI; group 3: 23 RA-ACD; and group 4: 16 nonanemic RA). These different groups were compared with a healthy group of 50 healthy individuals. Different blood parameters (WBC, RBC, HGB, HCT, MCV, and MCH) have been evaluated. Serum concentrations of IL-6, hsCRP, anti-CCP, and ferritin were measured in all patients and healthy individual using enzyme-linked immunosorbent assay ELISA.</p><p><strong>Results: </strong>There were significant changes in most of blood parameters between the groups, and there was a significant increase in the levels of IL-6 among RA patients. This increase was highly significant among RA-ACD patients in particular, and this elevation has been directly correlated with clinical indices of disease activity such as hsCRP, ESR, anti-CCP, and ferritin. There was an inverse relationship between ferritin and all iron status parameter, such as RBC, HGB, and haematocrit.</p><p><strong>Conclusion: </strong>IL-6 and ferritin level estimation may be workable tests to differentiate the patients with IDA and ACD in RA.</p>","PeriodicalId":46055,"journal":{"name":"Anemia","volume":"2019 ","pages":"3457347"},"PeriodicalIF":2.9,"publicationDate":"2019-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2019/3457347","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37216471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AnemiaPub Date : 2019-03-21DOI: 10.1155/2019/1097547
Getachew Mengistu, Muluken Azage, Hordofa Gutema
{"title":"Iron Deficiency Anemia among In-School Adolescent Girls in Rural Area of Bahir Dar City Administration, North West Ethiopia.","authors":"Getachew Mengistu, Muluken Azage, Hordofa Gutema","doi":"10.1155/2019/1097547","DOIUrl":"10.1155/2019/1097547","url":null,"abstract":"<p><strong>Background: </strong>Anemia is a major public health problem worldwide. Adolescent girls are the most vulnerable group of population due to different reasons. The aim of this study was to assess the prevalence of anemia and associated factors among school adolescent girls in rural towns of Bahir Dar City Administration, North West Ethiopia.</p><p><strong>Methods: </strong>A cross-sectional study was conducted from March 5 to April 15, 2017, on 443 randomly selected school adolescent girls. Data were collected using pretested structured questionnaire and anthropometric measurements. Blood sample was also collected to assess the hemoglobin (Hgb) value of study participants. SPSS version 20 was used to analyze data. Descriptive statistics were used to describe data. Bivariate and multivariable logistic regression models were used to identify the associated factors with the outcome variable. Crude and adjusted odds ratios with 95% confidence interval (CI) were calculated to identify the variables significantly associated with the outcome variable.</p><p><strong>Result: </strong>The prevalence of anemia was 11.1%. Household family size <i>[AOR=3.2, 95%CI (1.29-7.89)]</i>, average household monthly income <500 ETB <i>[AOR=10; 95%CI (2.49-41.26)]</i>, 501-1000 ETB <i>[AOR=6, 95%CI (2.54-14.33)]</i>, history of intestinal parasitic infection <i>[AOR=2.7; 95% CI (1.19-6.21)]</i>, duration of menstruation flow <i>[AOR=2.4; 95%CI (1.08- 5.44)]</i>, and BMI for age <i>[AOR-3.2; 95% CI (1.43-7.05)]</i> were the predictors of anemia.</p><p><strong>Conclusion and recommendation: </strong>Anemia was a mild public health problem among school adolescent girls in the study area. Household monthly income, family size, intestinal parasite infections, duration of menstruation, and BMI for age are predictors of anemia. Thus, intervention strategies should focus on prevention and early treatment of intestinal parasite, nutritional education, screening, and iron supplementation programs to prevent anemia among school adolescent girls.</p>","PeriodicalId":46055,"journal":{"name":"Anemia","volume":"2019 ","pages":"1097547"},"PeriodicalIF":2.9,"publicationDate":"2019-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2019/1097547","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37178865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AnemiaPub Date : 2019-03-19eCollection Date: 2019-01-01DOI: 10.1155/2019/3179173
Samuel Antwi-Baffour, Jonathan Kofi Adjei, Peter Owadee Forson, Stephen Akakpo, Ransford Kyeremeh, Mahmood Abdulai Seidu
{"title":"Comorbidity of Glucose-6-Phosphate Dehydrogenase Deficiency and Sickle Cell Disease Exert Significant Effect on RBC Indices.","authors":"Samuel Antwi-Baffour, Jonathan Kofi Adjei, Peter Owadee Forson, Stephen Akakpo, Ransford Kyeremeh, Mahmood Abdulai Seidu","doi":"10.1155/2019/3179173","DOIUrl":"https://doi.org/10.1155/2019/3179173","url":null,"abstract":"<p><strong>Background: </strong>Glucose-6-phosphate dehydrogenase (G6PD) converts glucose-6-phosphate into 6-phosphogluconate in the pentose phosphate pathway and protects red blood cells (RBCs) from oxidative damage. Their deficiency therefore makes RBCs prone to haemolysis. Sickle cell disease (SCD) on the other hand is a hereditary blood disorder in which there is a single nucleotide substitution in the codon for amino acid 6 substituting glutamic acid with valine. SCD patients are prone to haemolysis due to the shape of their red blood cells and if they are deficient in G6PD, the haemolysis may escalate. Reported studies have indicated variations in the prevalence of G6PD deficiency in SCD patients and as such further work is required. The aim of this study was therefore to estimate the incidence of G-6-PD deficiency among SCD patients and to determine its impact on their RBC parameters as a measure of incidence of anaemia.</p><p><strong>Methods: </strong>A total of 120 clinically diagnosed SCD patients of genotypes HbSS and HbSC were recruited into the study. About 5ml of blood was collected via venipuncture from each patient and used to run G6PD, full blood count, and haemoglobin (Hb) electrophoresis tests. The data were analyzed using SPSS version 20 and Graphpad prism.</p><p><strong>Result: </strong>G6PD deficiency was detected in 43 (35.83%) of the participants made up of 16 (13.33%) males and 27 (22.50%) females of whom 17 (14.17%) had partial deficiency and 10 (8.33%) full deficiency. Statiscally significant differences p=0.036 and p=0.038 were established between the Hb concentration of the participants having a G6PD deficiency and those with normal G6PD activity for males and females, respectively.</p><p><strong>Conclusion: </strong>From the results obtained, it implies that G6PD deficiency may increase the severity of anaemia in SCD patients. There is therefore the need to screen all SCD patients for G6PD deficiency to ensure that their condition is not exacerbated during treatment.</p>","PeriodicalId":46055,"journal":{"name":"Anemia","volume":"2019 ","pages":"3179173"},"PeriodicalIF":2.9,"publicationDate":"2019-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2019/3179173","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37178867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AnemiaPub Date : 2019-01-01DOI: 10.1155/2019/9242607
António Robalo Nunes, Ana Palricas Costa, Sara Lemos Rocha, Ana Garcia de Oliveira
{"title":"Corrigendum to \"Efficacy and Tolerability of Intravenous Ferric Carboxymaltose in Patients with Iron Deficiency at a Hospital Outpatient Clinic: A Retrospective Cohort Study of Real-World Clinical Practice\".","authors":"António Robalo Nunes, Ana Palricas Costa, Sara Lemos Rocha, Ana Garcia de Oliveira","doi":"10.1155/2019/9242607","DOIUrl":"https://doi.org/10.1155/2019/9242607","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1155/2017/3106890.].</p>","PeriodicalId":46055,"journal":{"name":"Anemia","volume":"2019 ","pages":"9242607"},"PeriodicalIF":2.9,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2019/9242607","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36924006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}