IF 2.9

Anemia Pub Date : 2016-01-01 Epub Date: 2016-06-13 DOI: 10.1155/2016/6430214

Huguette Turgeon O'Brien, Rosanne Blanchet, Doris Gagné, Julie Lauzière, Carole Vézina

{"title":"Using Soluble Transferrin Receptor and Taking Inflammation into Account When Defining Serum Ferritin Cutoffs Improved the Diagnosis of Iron Deficiency in a Group of Canadian Preschool Inuit Children from Nunavik.","authors":"Huguette Turgeon O'Brien, Rosanne Blanchet, Doris Gagné, Julie Lauzière, Carole Vézina","doi":"10.1155/2016/6430214","DOIUrl":"https://doi.org/10.1155/2016/6430214","url":null,"abstract":"The prevalence of iron depletion, iron deficient erythropoiesis (IDE), and iron deficiency anemia (IDA) was assessed in preschool Inuit children using soluble transferrin receptor (sTfR) and traditional indicators of iron status while disregarding or taking inflammation into account when defining SF cutoffs. Iron depletion was defined as follows: (1) SF < 15 μg/L regardless of the C-reactive protein (CRP) level and (2) SF < 15 or <50 μg/L with CRP ≤ 5 or >5 mg/L, respectively. IDE corresponded to iron depletion combined with total iron binding capacity > 72 μmol/L and/or transferrin saturation < 16%. Iron depletion and IDE affected almost half of the children when accounting for inflammation, compared to one-third when the SF cutoff was defined regardless of CRP level (P < 0.0001). The prevalence of IDE adjusted for inflammation (45.1%) was very similar to the prevalence observed when sTfR was used as a sole marker of IDE (47.4%). The prevalence of anemia was 15%. The prevalence of IDA (IDE + hemoglobin < 110 g/L) was higher when accounting for than when disregarding inflammation (8.0% versus 6.2%, P = 0.083). Using sTfR and different SF cutoffs for children with versus without inflammation improved the diagnosis of iron depletion and IDE. Our results confirm that Inuit children are at particularly high risk for iron deficiency. ","PeriodicalId":46055,"journal":{"name":"Anemia","volume":"2016 ","pages":"6430214"},"PeriodicalIF":2.9,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/6430214","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34641113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Transfusion Thresholds, Quality of Life, and Current Approaches in Myelodysplastic Syndromes. 骨髓增生异常综合征的输血阈值、生活质量和当前治疗方法。

IF 2.9

Anemia Pub Date : 2016-01-01 Epub Date: 2016-04-19 DOI: 10.1155/2016/8494738

Ioannis Koutsavlis

引用次数: 25

The Cost-Effectiveness of Continuous Erythropoiesis Receptor Activator Once Monthly versus Epoetin Thrice Weekly for Anaemia Management in Chronic Haemodialysis Patients 慢性血液透析患者每月1次连续使用红细胞生成受体激活剂与每周3次生成素治疗贫血的成本-效果比较

IF 2.9

Anemia Pub Date : 2015-12-30 DOI: 10.1155/2015/189404

O. Maoujoud, S. Ahid, H. Dkhissi, Z. Oualim, Y. Cherrah

{"title":"The Cost-Effectiveness of Continuous Erythropoiesis Receptor Activator Once Monthly versus Epoetin Thrice Weekly for Anaemia Management in Chronic Haemodialysis Patients","authors":"O. Maoujoud, S. Ahid, H. Dkhissi, Z. Oualim, Y. Cherrah","doi":"10.1155/2015/189404","DOIUrl":"https://doi.org/10.1155/2015/189404","url":null,"abstract":"Introduction. The aim of this study was to compare the cost-effectiveness of continuous erythropoietin receptor activator (CERA) once monthly to epoetin beta (EpoB) thrice weekly to maintain haemoglobin (Hb) within the range 10.5–12 g/dL. Methods. Prospective cohort study and cost-effectiveness analysis. Chronic haemodialysis patients (CHP), being treated with EpoB, were selected for two periods of follow-up: period 1, maintaining prior treatment with EpoB, and period 2, conversion to CERA once monthly. Hb concentrations and costs were measured monthly. Health care payer perspective for one year was adopted. Results. 75 CHP completed the study, with a mean age of 52.9 ± 14.3 years. Baseline Hb was 11.14 ± 1.18 g/dL in EpoB phase and 11.46 ± 0.79 g/dL in CERA phase; we observed a significant increase in the proportion of patients successfully treated (Hb within the recommended range), 65.3% versus 70.7%, p: 0.008, and in the average effectiveness by 4% (0.55 versus 0.59). Average cost-effectiveness ratios were 6013.86 and 5173.64$, with an ICER CERA to EpoB at −6457.5$. Conclusion. Our health economic evaluation of ESA use in haemodialysis patients suggests that the use of CERA is cost-effective compared with EpoB.","PeriodicalId":46055,"journal":{"name":"Anemia","volume":"2015 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2015-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/189404","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64832554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Hyperglycaemic Environment: Contribution to the Anaemia Associated with Diabetes Mellitus in Rats Experimentally Induced with Alloxan 高血糖环境:对四氧嘧啶诱导的大鼠与糖尿病相关的贫血的贡献

IF 2.9

Anemia Pub Date : 2015-11-30 DOI: 10.1155/2015/848921

Oseni Bashiru Shola, Fakoya Olatunde Olugbenga

{"title":"Hyperglycaemic Environment: Contribution to the Anaemia Associated with Diabetes Mellitus in Rats Experimentally Induced with Alloxan","authors":"Oseni Bashiru Shola, Fakoya Olatunde Olugbenga","doi":"10.1155/2015/848921","DOIUrl":"https://doi.org/10.1155/2015/848921","url":null,"abstract":"Background. Diabetes mellitus characterized by hyperglycaemia presents with various complications amongst which anaemia is common particularly in those with overt nephropathy or renal impairment. The present study has examined the contribution of the hyperglycaemic environment in diabetic rats to the anaemia associated with diabetes mellitus. Method. Sixty male albino rats weighing 175–250 g were selected for this study and divided equally into control and test groups. Hyperglycaemia was induced with 170 kgbwt−1 alloxan intraperitoneally in the test group while control group received sterile normal saline. Blood samples obtained from the control and test rats were assayed for packed cell volume (PCV), haemoglobin (Hb), red blood cell count (RBC), reticulocyte count, glucose, plasma haemoglobin, potassium, and bilirubin. Result. Significant reduction (P < 0.01) in PCV (24.40 ± 3.87 versus 40.45 ± 3.93) and haemoglobin (7.81 ± 1.45 versus 13.39 ± 0.40) with significant increase (P < 0.01) in reticulocyte count (12.4 ± 1.87 versus 3.69 ± 0.47), plasma haemoglobin (67.50 ± 10.85 versus 34.20 ± 3.83), and potassium (7.04 ± 0.75 versus 4.52 ± 0.63) was obtained in the test while plasma bilirubin showed nonsignificant increase (0.41 ± 0.04 versus 0.24 ± 0.06). Conclusion. The increased plasma haemoglobin and potassium levels indicate an intravascular haemolytic event while the nonsignificant increased bilirubin showed extravascular haemolysis. These play contributory roles in the anaemia associated with diabetes mellitus.","PeriodicalId":46055,"journal":{"name":"Anemia","volume":"60 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2015-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/848921","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65182619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Prevalence and Risk Factors for Complications in Patients with Nontransfusion Dependent Alpha- and Beta-Thalassemia 非输血依赖性α -和β -地中海贫血患者并发症的患病率和危险因素

IF 2.9

Anemia Pub Date : 2015-11-18 DOI: 10.1155/2015/793025

P. Winichakoon, A. Tantiworawit, T. Rattanathammethee, S. Hantrakool, C. Chai-Adisaksopha, E. Rattarittamrong, L. Norasetthada, P. Charoenkwan

{"title":"Prevalence and Risk Factors for Complications in Patients with Nontransfusion Dependent Alpha- and Beta-Thalassemia","authors":"P. Winichakoon, A. Tantiworawit, T. Rattanathammethee, S. Hantrakool, C. Chai-Adisaksopha, E. Rattarittamrong, L. Norasetthada, P. Charoenkwan","doi":"10.1155/2015/793025","DOIUrl":"https://doi.org/10.1155/2015/793025","url":null,"abstract":"Background. Nontransfusion dependent thalassemia (NTDT) is a milder form of thalassemia that does not require regular transfusion. It is associated with many complications, which differ from that found in transfusion-dependent thalassemia (TDT). Currently available information is mostly derived from beta-NTDT; consequently, more data is needed to describe complications found in the alpha-NTDT form of this disease. Methods. We retrospectively reviewed the medical records of NTDT patients from January 2012 to December 2013. Complications related to thalassemia were reviewed and compared. Results. One hundred patients included 60 females with a median age of 38 years. The majority (54 patients) had alpha-thalassemia. Overall, 83 patients had one or more complications. The three most common complications were cholelithiasis (35%), abnormal liver function (29%), and extramedullary hematopoiesis (EMH) (25%). EMH, cardiomyopathy, cholelithiasis, and pulmonary hypertension were more commonly seen in beta-thalassemia. Osteoporosis was the only complication that was more common in alpha-thalassemia. The risk factors significantly related to EMH were beta-thalassemia type and hemoglobin < 8 g/dL. The risk factors related to osteoporosis were female gender and age > 40 years. Iron overload (ferritin > 800 ng/mL) was the only risk factor for abnormal liver function. Conclusion. The prevalence of alpha-NTDT complications was lower and different from beta-thalassemia.","PeriodicalId":46055,"journal":{"name":"Anemia","volume":"2015 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2015-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/793025","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65150424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Anemia in Patients with Type 2 Diabetes Mellitus 2型糖尿病患者的贫血

IF 2.9

Anemia Pub Date : 2015-11-11 DOI: 10.1155/2015/354737

J. Barbieri, P. C. Fontela, E. R. Winkelmann, C. Zimmermann, Yana Picinin Sandri, Emanelle Kerber Viera Mallet, M. Frizzo

引用次数: 76

Hospitalization Events among Children and Adolescents with Sickle Cell Disease in Basra, Iraq 伊拉克巴士拉镰状细胞病儿童和青少年住院事件

IF 2.9

Anemia Pub Date : 2015-10-26 DOI: 10.1155/2015/195469

Z. Salman, M. Hassan

{"title":"Hospitalization Events among Children and Adolescents with Sickle Cell Disease in Basra, Iraq","authors":"Z. Salman, M. Hassan","doi":"10.1155/2015/195469","DOIUrl":"https://doi.org/10.1155/2015/195469","url":null,"abstract":"Objectives. Despite improvements in the management of sickle cell disease (SCD), many patients still experience disease-related complications requiring hospitalizations. The objectives of this study were to identify causes of hospitalization among these patients and factors associated with the length of hospital stay (LOS) and readmission. Methods. Data from 160 patients (<14 years old) with SCD who were admitted to the Basra Maternity and Children's Hospital from the first of January 2012 through July 2012 were analyzed. Results. The main causes of hospitalization were acute painful crises (73.84%), infections (9.28%), acute chest syndrome (8.02%), and acute splenic sequestration crisis (6.32%). The mean LOS was 4.34 ± 2.85 days. The LOS for patients on hydroxyurea (3.41 ± 2.64 days) was shorter than that for patients who were not (4.59 ± 2.86 days), P < 0.05. The readmission rate (23.1%) was significantly higher among patients with frequent hospitalizations in the previous year (OR 9.352, 95% CI 2.011–43.49), asthma symptoms (OR 4.225, 95% CI 1.125–15.862), and opioid use (OR 6.588, 95% CI 1.104–30.336). Patients on hydroxyurea were less likely to be readmitted (OR 0.082, 95% CI 0.10–0.663). Conclusions. There is a relatively high readmission rate among patients with SCD in Basra. The use of hydroxyurea significantly decreases the LOS and readmission rate.","PeriodicalId":46055,"journal":{"name":"Anemia","volume":"2015 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2015-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/195469","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64836294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18

Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations. 缺铁性贫血患者的静脉铁剂治疗：用药注意事项。

IF 2.9

Anemia Pub Date : 2015-01-01 Epub Date: 2015-07-15 DOI: 10.1155/2015/763576

Todd A Koch, Jennifer Myers, Lawrence Tim Goodnough

{"title":"Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations.","authors":"Todd A Koch, Jennifer Myers, Lawrence Tim Goodnough","doi":"10.1155/2015/763576","DOIUrl":"10.1155/2015/763576","url":null,"abstract":"Objective. To provide clinicians with evidence-based guidance for iron therapy dosing in patients with iron deficiency anemia (IDA), we conducted a study examining the benefits of a higher cumulative dose of intravenous (IV) iron than what is typically administered. Methods. We first individually analyzed 5 clinical studies, averaging the total iron deficit across all patients utilizing a modified Ganzoni formula; we then similarly analyzed 2 larger clinical studies. For the second of the larger studies (Study 7), we also compared the efficacy and retreatment requirements of a cumulative dose of 1500 mg ferric carboxymaltose (FCM) to 1000 mg iron sucrose (IS). Results. The average iron deficit was calculated to be 1531 mg for patients in Studies 1-5 and 1392 mg for patients in Studies 6-7. The percentage of patients who were retreated with IV iron between Days 56 and 90 was significantly (p < 0.001) lower (5.6%) in the 1500 mg group, compared to the 1000 mg group (11.1%). Conclusions. Our data suggests that a total cumulative dose of 1000 mg of IV iron may be insufficient for iron repletion in a majority of patients with IDA and a dose of 1500 mg is closer to the actual iron deficit in these patients. ","PeriodicalId":46055,"journal":{"name":"Anemia","volume":"2015 ","pages":"763576"},"PeriodicalIF":2.9,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4518169/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33908955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reproductive and Obstetric Factors Are Key Predictors of Maternal Anemia during Pregnancy in Ethiopia: Evidence from Demographic and Health Survey (2011). 生殖和产科因素是埃塞俄比亚怀孕期间孕产妇贫血的关键预测因素:来自人口与健康调查的证据(2011年)。

IF 2.9

Anemia Pub Date : 2015-01-01 Epub Date: 2015-08-31 DOI: 10.1155/2015/649815

Taddese Alemu, Melaku Umeta

{"title":"Reproductive and Obstetric Factors Are Key Predictors of Maternal Anemia during Pregnancy in Ethiopia: Evidence from Demographic and Health Survey (2011).","authors":"Taddese Alemu, Melaku Umeta","doi":"10.1155/2015/649815","DOIUrl":"https://doi.org/10.1155/2015/649815","url":null,"abstract":"Anemia is a major public health problem worldwide. In Ethiopia, a nationally representative and consistent evidence is lacking on the prevalence and determinants during pregnancy. We conducted an in-depth analysis of demographic and health survey for the year 2011 which is a representative data collected from all regions in Ethiopia. Considering maternal anemia as an outcome variable, predicting variables from sociodemographic, household, and reproductive/obstetric characteristics were identified for analyses. Logistic regression model was applied to identify predictors at P < 0.05. The prevalence of anemia among pregnant women was 23%. Maternal age, region, pregnancy trimester, number of under five children, previous history of abortion (termination of pregnancy), breastfeeding practices, and number of antenatal care visits were key independent predictors of anemia during pregnancy. In conclusion, the level of anemia during pregnancy is a moderate public health problem in Ethiopia. Yet, special preventive measures should be undertaken for pregnant women who are older in age and having too many under five children and previous history of abortion. Further evidence is expected to be generated concerning why pregnant mothers from the eastern part of the country and those with better access to radio disproportionately develop anemia more than their counterparts. ","PeriodicalId":46055,"journal":{"name":"Anemia","volume":"2015 ","pages":"649815"},"PeriodicalIF":2.9,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/649815","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34113219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 32

Efficacy and Safety of Intravenous Ferric Carboxymaltose in Geriatric Inpatients at a German Tertiary University Teaching Hospital: A Retrospective Observational Cohort Study of Clinical Practice. 德国第三大学教学医院老年住院患者静脉注射羧基麦芽糖铁的疗效和安全性:临床实践的回顾性观察队列研究。

IF 2.9

Anemia Pub Date : 2015-01-01 Epub Date: 2015-07-05 DOI: 10.1155/2015/647930

Matthias Bach, Tabea Geisel, Julia Martin, Bettina Schulze, Roland Schaefer, Garth Virgin, Juergen Stein

{"title":"Efficacy and Safety of Intravenous Ferric Carboxymaltose in Geriatric Inpatients at a German Tertiary University Teaching Hospital: A Retrospective Observational Cohort Study of Clinical Practice.","authors":"Matthias Bach, Tabea Geisel, Julia Martin, Bettina Schulze, Roland Schaefer, Garth Virgin, Juergen Stein","doi":"10.1155/2015/647930","DOIUrl":"https://doi.org/10.1155/2015/647930","url":null,"abstract":"Current iron supplementation practice in geriatric patients is erratic and lacks evidence-based recommendations. Despite potential benefits in this population, intravenous iron supplementation is often withheld due to concerns regarding pharmacy expense, perceived safety issues, and doubts regarding efficacy in elderly patients. This retrospective, observational cohort study aimed to evaluate the safety and efficacy of intravenous ferric carboxymaltose (FCM, Ferinject) in patients aged >75 years with iron deficiency anaemia (IDA). Within a twelve-month data extraction period, the charts of 405 hospitalised patients aged 65–101 years were retrospectively analysed for IDA, defined according to WHO criteria for anaemia (haemoglobin: <13.0 g/dL (m)/<12.0 g/dL (f)) in conjunction with transferrin saturation <20%. Of 128 IDA patients screened, 51 (39.8%) received intravenous iron. 38 patient charts were analysed. Mean cumulative dose of intravenous FCM was 784.4 ± 271.7 mg iron (1–3 infusions). 18 patients (47%) fulfilled treatment response criteria (≥1.0 g/dL increase in haemoglobin between baseline and hospital discharge). AEs were mild/moderate, most commonly transient increases of liver enzymes (n = 5/13.2%). AE incidence was comparable with that observed in patients <75 years. No serious AEs were observed. Ferric carboxymaltose was well tolerated and effective for correction of Hb levels and iron stores in this cohort of IDA patients aged over 75 years.","PeriodicalId":46055,"journal":{"name":"Anemia","volume":"2015 ","pages":"647930"},"PeriodicalIF":2.9,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/647930","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33889304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Anemia最新文献