IF 2.9

Anemia Pub Date : 2016-02-29 DOI: 10.1155/2016/9310905

V. Pathak, K. Ghosh

引用次数: 37

Prevalence of Anemia and Its Associated Factors among Pregnant Women Attending Antenatal Care in Health Institutions of Arba Minch Town, Gamo Gofa Zone, Ethiopia: A Cross-Sectional Study 埃塞俄比亚Gamo Gofa区Arba Minch镇卫生机构产前保健孕妇贫血患病率及其相关因素:一项横断面研究

IF 2.9

Anemia Pub Date : 2016-02-22 DOI: 10.1155/2016/1073192

A. Bekele, M. Tilahun, Aleme Mekuria

{"title":"Prevalence of Anemia and Its Associated Factors among Pregnant Women Attending Antenatal Care in Health Institutions of Arba Minch Town, Gamo Gofa Zone, Ethiopia: A Cross-Sectional Study","authors":"A. Bekele, M. Tilahun, Aleme Mekuria","doi":"10.1155/2016/1073192","DOIUrl":"https://doi.org/10.1155/2016/1073192","url":null,"abstract":"Background. Anemia during pregnancy is a major cause of morbidity and mortality of pregnant women in developing countries and has both maternal and fetal consequences. Despite its known serious effect on health, there is very little research based evidence on this vital public health problem in Gamo Gofa zone in general and in Arba Minch town of Southern Ethiopia in particular. Therefore, this study aims to assess the prevalence and factors associated with anemia among pregnant women attending antenatal care in health institutions of Arba Minch town, Gamo Gofa zone, Southern Ethiopia. Method. Institution-based, cross-sectional study was conducted from February 16 to April 8, 2015, among 332 pregnant women who attended antenatal care at government health institutions of Arba Minch town. Interviewer-administered questionnaire supplemented by laboratory tests was used to obtain the data. Bivariate and multivariate logistic regressions were used to identify predictors of anemia. Result. The prevalence of anemia among antenatal care attendant pregnant women of Arba Minch town was 32.8%. Low average monthly income of the family (AOR = 4.0; 95% CI: 5.62–11.01), having birth interval less than two years (AOR = 3.1; 95% CI: 6.01, 10.23), iron supplementation (AOR = 2.31; 95% CI: 7.21, 9.31), and family size >2 (AOR = 2.8; 95% CI: 1.17, 6.81) were found to be independent predictors of anemia in pregnancy. Conclusion. Anemia is found to be a moderate public health problem in the study area. Low average monthly income, birth interval less than two years, iron supplementation, and large family size were found to be risk factors for anemia in pregnancy. Awareness creation towards birth spacing, nutritional counselling on consumption of iron-rich foods, and iron supplementation are recommended to prevent anemia among pregnant women with special emphasis on those having low income and large family size.","PeriodicalId":46055,"journal":{"name":"Anemia","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2016-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/1073192","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64203245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 94

Antianemic Treatment of Cancer Patients in German Routine Practice: Data from a Prospective Cohort Study—The Tumor Anemia Registry 德国常规实践中癌症患者的抗贫血治疗:来自肿瘤贫血登记的前瞻性队列研究的数据

IF 2.9

Anemia Pub Date : 2016-02-04 DOI: 10.1155/2016/8057650

T. Steinmetz, J. Schröder, M. Plath, H. Link, M. Vogt, M. Frank, N. Marschner

{"title":"Antianemic Treatment of Cancer Patients in German Routine Practice: Data from a Prospective Cohort Study—The Tumor Anemia Registry","authors":"T. Steinmetz, J. Schröder, M. Plath, H. Link, M. Vogt, M. Frank, N. Marschner","doi":"10.1155/2016/8057650","DOIUrl":"https://doi.org/10.1155/2016/8057650","url":null,"abstract":"The aim of this prospective cohort study was to assess current antianemic treatment of cancer patients in German routine practice, including diagnostics, treatments, and quality of life (QoL). 88 study sites recruited 1018 patients at the start of antianemic treatment with hemoglobin (Hb) levels <11 g/dL (females) or <12 g/dL (males). Patients were followed up for 12 weeks. 63% of the patients had inoperable solid tumors, 22% operable solid tumors, and 15% hematological malignancies. Over 85% received chemotherapy. Median age was 67 years; 48% were male. Red blood cell transfusions (RBCTx) were given to 59% of all patients and to 55% of the patients with Hb ≥8 g/dL on day 1 of the observation period (day 1 treatment). Erythropoiesis-stimulating agents (ESAs) were the second most frequently applied day 1 treatment (20%), followed by intravenous (IV) iron (15%) and ESA + IV iron (6%). Only about a third of patients were tested for blood serum iron parameters at the start of treatment. Overall, more than half of the patients had long-term responses to antianemic therapy. Our data suggest that in routine practice diagnostics for treatable causes of anemia are underused. A high proportion of cancer patients receive RBCTx. It should be discussed whether thorough diagnostics and earlier intervention could decrease the need for RBCTx. This trial is registered with NCT01795690.","PeriodicalId":46055,"journal":{"name":"Anemia","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2016-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/8057650","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64547205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Sickle-Cell Disease Healthcare Cost in Africa: Experience of the Congo 非洲镰状细胞病的医疗费用:刚果的经验

IF 2.9

Anemia Pub Date : 2016-02-02 DOI: 10.1155/2016/2046535

L. Ngolet, M. Moyen Engoba, I. Kocko, A. Elira Dokékias, J. Mombouli, G. Moyen

{"title":"Sickle-Cell Disease Healthcare Cost in Africa: Experience of the Congo","authors":"L. Ngolet, M. Moyen Engoba, I. Kocko, A. Elira Dokékias, J. Mombouli, G. Moyen","doi":"10.1155/2016/2046535","DOIUrl":"https://doi.org/10.1155/2016/2046535","url":null,"abstract":"Background. Lack of medical coverage in Africa leads to inappropriate care that has an impact on the mortality rate. In this study, we aimed to evaluate the cost of severe acute sickle-cell related complications in Brazzaville. Methods. A retrospective study was conducted in 2014 in the Paediatric Intensive Care Unit. It concerned 94 homozygote sickle-cell children that developed severe acute sickle-cell disease related complications (average age 69 months). For each patient, we calculated the cost of care complication. Results. The household income was estimated as low (<XAF 90,000/<USD 158.40) in 27.7%. The overall median cost for hospitalization for sickle-cell related acute complications was XAF 65,460/USD 115.21. Costs were fluctuating depending on the generating factors of the severe acute complications (p = 0.041). They were higher in case of complications generated by bacterial infections (ranging from XAF 66,765/USD 117.50 to XAF 135,271.50/USD 238.07) and lower in case of complications associated with malaria (ranging from XAF 28,305/49.82 to XAF 64,891.63/USD 114.21). The mortality rate was 17% and was associated with the cost of the case management (p = 0.006). Conclusion. The case management cost of severe acute complications of sickle-cell disease in children is high in Congo.","PeriodicalId":46055,"journal":{"name":"Anemia","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2016-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/2046535","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64258115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Magnitude of Anemia and Hematological Predictors among Children under 12 Years in Odisha, India. 印度奥迪沙 12 岁以下儿童贫血症的严重程度和血液学预测因素。

IF 2.9

Anemia Pub Date : 2016-01-01 Epub Date: 2016-04-04 DOI: 10.1155/2016/1729147

Shuchismita Behera, Gandham Bulliyya

{"title":"Magnitude of Anemia and Hematological Predictors among Children under 12 Years in Odisha, India.","authors":"Shuchismita Behera, Gandham Bulliyya","doi":"10.1155/2016/1729147","DOIUrl":"10.1155/2016/1729147","url":null,"abstract":"Background. Anemia is a wide spread public health problem in India which affects children. The present study evaluates the prevalence of anemia and status of various hematological parameters among children of Khurda district, Odisha. Method. A total of 313 children aged 0-12 years were enrolled for the study which included preschool (0-5 years) and school aged (6-12 years) groups. Hematological indicators were measured by standard procedures, which include red blood cell (RBC) indicators, white blood cell (WBC) indicators, and plasma ferritin. Results. Mean hemoglobin (Hb) of the study population was 10.43 ± 3.33 g/dL and prevalence of anemia was 62%. In this population, boys had a lower mean Hb value than that of the girls. All grades of anemia were higher among school age children than preschool children. Mean plasma ferritin was found to be higher in school age boys than their counterpart girls. The mean level of WBC count was found to be higher among preschool age boys than among the school age boys (p = 0.025). Conclusion. The prevalence of anemia was higher with concomitant acute infection among study population, which is a matter of concern. Since the hematological parameters are interrelated with each other as well as with the age and gender, relevant intervention strategy and constant monitoring are needed while providing public health nutrition programs to eradicate anemia. ","PeriodicalId":46055,"journal":{"name":"Anemia","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834407/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34441331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Serum Leptin Levels and Growth in Patients with β-Thalassaemia Major. β-地中海贫血患者血清瘦素水平和生长的评价。

IF 2.9

Anemia Pub Date : 2016-01-01 Epub Date: 2016-03-21 DOI: 10.1155/2016/8454286

Lamia Mustafa Al-Naama, Meaad Kadum Hassan, Muhannad Maki Abdul Karim

{"title":"Evaluation of Serum Leptin Levels and Growth in Patients with β-Thalassaemia Major.","authors":"Lamia Mustafa Al-Naama, Meaad Kadum Hassan, Muhannad Maki Abdul Karim","doi":"10.1155/2016/8454286","DOIUrl":"https://doi.org/10.1155/2016/8454286","url":null,"abstract":"Background. Iron deposition in the body can damage the endocrine glands of patients with β-thalassaemia major (β-TM). Leptin plays a key role in the regulation of appetite, body fat mass, and endocrine function. Objectives. This study aimed to evaluate the relationship between serum leptin and growth and pubertal development in patients with β-TM, as well as whether serum leptin can predict growth retardation and delayed puberty in these patients. Methods. Fifty β-TM patients (aged 8-20 years) and 75 age-matched healthy controls were recruited. Anthropometric data and sexual maturity ratings were assessed. Serum leptin was measured by ELISA. Results. Serum leptin levels were significantly lower in patients with β-TM than in healthy individuals (P < 0.001). Leptin levels were also significantly reduced in female patients with short stature (P < 0.002) and in patients who displayed delayed puberty (P = 0.032) compared to those with normal stature who had reached puberty. The sensitivity of leptin for predicting short stature and delayed puberty among patients was 84.6% and 92.3%, respectively. Conclusion. Low serum leptin is sensitive to predict short stature and significant in β-TM females only. This link could thus be used as a guide for further therapeutic or hormonal modulation. ","PeriodicalId":46055,"journal":{"name":"Anemia","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/8454286","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34411803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Absolute Reticulocyte Count and Reticulocyte Hemoglobin Content as Predictors of Early Response to Exclusive Oral Iron in Children with Iron Deficiency Anemia. 绝对网织红细胞计数和网织红细胞血红蛋白含量作为缺铁性贫血儿童口服铁治疗早期反应的预测指标。

IF 2.9

Anemia Pub Date : 2016-01-01 Epub Date: 2016-03-22 DOI: 10.1155/2016/7345835

Emilia Parodi, Maria Teresa Giraudo, Fulvio Ricceri, Maria Luigia Aurucci, Raffaela Mazzone, Ugo Ramenghi

{"title":"Absolute Reticulocyte Count and Reticulocyte Hemoglobin Content as Predictors of Early Response to Exclusive Oral Iron in Children with Iron Deficiency Anemia.","authors":"Emilia Parodi, Maria Teresa Giraudo, Fulvio Ricceri, Maria Luigia Aurucci, Raffaela Mazzone, Ugo Ramenghi","doi":"10.1155/2016/7345835","DOIUrl":"https://doi.org/10.1155/2016/7345835","url":null,"abstract":"We report data regarding kinetic of response to oral iron in 34 iron deficiency anemia children. Twenty-four/34 patients (70.5%) reached reference value of hemoglobin (Hb) concentration for age and sex at day + 30 from the beginning of treatment (complete early responders (CERs)), and 4/34 (12%) reached an Hb concentration at least 50% higher than the original (partial early responders (PERs)). CHr at T1 (within 7 days from the beginning of treatment) was significantly different in the different groups (22.95 in CERs versus 18.41 in other patients; p = 0.001; 22.42 in early responders versus 18.07 in NERs; p = 0.001). Relative increase of CHr from T0 to T1 resulted significantly higher in CERs than in other patients (0.21 versus 0.11, p = 0.042) and in early responders than in NERs (0.22 versus 0.004, p = 0.006). Multivariate logistic models revealed a higher probability of being a complete early responder due to relative increase of ARC from T0 to T1 [OR (95% CI) = 44.95 (1.54–1311.98)] and to CHr at T1 [OR (95% CI) =3.18 (1.24–8.17)]. Our preliminary data confirm CHr as early and accurate predictor of hematological response to oral iron.","PeriodicalId":46055,"journal":{"name":"Anemia","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/7345835","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34473346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 22

Using Soluble Transferrin Receptor and Taking Inflammation into Account When Defining Serum Ferritin Cutoffs Improved the Diagnosis of Iron Deficiency in a Group of Canadian Preschool Inuit Children from Nunavik. 在确定血清铁蛋白切断时，使用可溶性转铁蛋白受体并考虑炎症改善了一组来自努那维克的加拿大学龄前因纽特儿童缺铁的诊断。

IF 2.9

Anemia Pub Date : 2016-01-01 Epub Date: 2016-06-13 DOI: 10.1155/2016/6430214

Huguette Turgeon O'Brien, Rosanne Blanchet, Doris Gagné, Julie Lauzière, Carole Vézina

{"title":"Using Soluble Transferrin Receptor and Taking Inflammation into Account When Defining Serum Ferritin Cutoffs Improved the Diagnosis of Iron Deficiency in a Group of Canadian Preschool Inuit Children from Nunavik.","authors":"Huguette Turgeon O'Brien, Rosanne Blanchet, Doris Gagné, Julie Lauzière, Carole Vézina","doi":"10.1155/2016/6430214","DOIUrl":"https://doi.org/10.1155/2016/6430214","url":null,"abstract":"The prevalence of iron depletion, iron deficient erythropoiesis (IDE), and iron deficiency anemia (IDA) was assessed in preschool Inuit children using soluble transferrin receptor (sTfR) and traditional indicators of iron status while disregarding or taking inflammation into account when defining SF cutoffs. Iron depletion was defined as follows: (1) SF < 15 μg/L regardless of the C-reactive protein (CRP) level and (2) SF < 15 or <50 μg/L with CRP ≤ 5 or >5 mg/L, respectively. IDE corresponded to iron depletion combined with total iron binding capacity > 72 μmol/L and/or transferrin saturation < 16%. Iron depletion and IDE affected almost half of the children when accounting for inflammation, compared to one-third when the SF cutoff was defined regardless of CRP level (P < 0.0001). The prevalence of IDE adjusted for inflammation (45.1%) was very similar to the prevalence observed when sTfR was used as a sole marker of IDE (47.4%). The prevalence of anemia was 15%. The prevalence of IDA (IDE + hemoglobin < 110 g/L) was higher when accounting for than when disregarding inflammation (8.0% versus 6.2%, P = 0.083). Using sTfR and different SF cutoffs for children with versus without inflammation improved the diagnosis of iron depletion and IDE. Our results confirm that Inuit children are at particularly high risk for iron deficiency. ","PeriodicalId":46055,"journal":{"name":"Anemia","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/6430214","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34641113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Transfusion Thresholds, Quality of Life, and Current Approaches in Myelodysplastic Syndromes. 骨髓增生异常综合征的输血阈值、生活质量和当前治疗方法。

IF 2.9

Anemia Pub Date : 2016-01-01 Epub Date: 2016-04-19 DOI: 10.1155/2016/8494738

Ioannis Koutsavlis

引用次数: 25

The Cost-Effectiveness of Continuous Erythropoiesis Receptor Activator Once Monthly versus Epoetin Thrice Weekly for Anaemia Management in Chronic Haemodialysis Patients 慢性血液透析患者每月1次连续使用红细胞生成受体激活剂与每周3次生成素治疗贫血的成本-效果比较

IF 2.9

Anemia Pub Date : 2015-12-30 DOI: 10.1155/2015/189404

O. Maoujoud, S. Ahid, H. Dkhissi, Z. Oualim, Y. Cherrah

{"title":"The Cost-Effectiveness of Continuous Erythropoiesis Receptor Activator Once Monthly versus Epoetin Thrice Weekly for Anaemia Management in Chronic Haemodialysis Patients","authors":"O. Maoujoud, S. Ahid, H. Dkhissi, Z. Oualim, Y. Cherrah","doi":"10.1155/2015/189404","DOIUrl":"https://doi.org/10.1155/2015/189404","url":null,"abstract":"Introduction. The aim of this study was to compare the cost-effectiveness of continuous erythropoietin receptor activator (CERA) once monthly to epoetin beta (EpoB) thrice weekly to maintain haemoglobin (Hb) within the range 10.5–12 g/dL. Methods. Prospective cohort study and cost-effectiveness analysis. Chronic haemodialysis patients (CHP), being treated with EpoB, were selected for two periods of follow-up: period 1, maintaining prior treatment with EpoB, and period 2, conversion to CERA once monthly. Hb concentrations and costs were measured monthly. Health care payer perspective for one year was adopted. Results. 75 CHP completed the study, with a mean age of 52.9 ± 14.3 years. Baseline Hb was 11.14 ± 1.18 g/dL in EpoB phase and 11.46 ± 0.79 g/dL in CERA phase; we observed a significant increase in the proportion of patients successfully treated (Hb within the recommended range), 65.3% versus 70.7%, p: 0.008, and in the average effectiveness by 4% (0.55 versus 0.59). Average cost-effectiveness ratios were 6013.86 and 5173.64$, with an ICER CERA to EpoB at −6457.5$. Conclusion. Our health economic evaluation of ESA use in haemodialysis patients suggests that the use of CERA is cost-effective compared with EpoB.","PeriodicalId":46055,"journal":{"name":"Anemia","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2015-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/189404","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64832554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

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