IF 2.9

Anemia Pub Date : 2016-01-01 Epub Date: 2016-04-04 DOI: 10.1155/2016/1729147

Shuchismita Behera, Gandham Bulliyya

{"title":"Magnitude of Anemia and Hematological Predictors among Children under 12 Years in Odisha, India.","authors":"Shuchismita Behera, Gandham Bulliyya","doi":"10.1155/2016/1729147","DOIUrl":"10.1155/2016/1729147","url":null,"abstract":"Background. Anemia is a wide spread public health problem in India which affects children. The present study evaluates the prevalence of anemia and status of various hematological parameters among children of Khurda district, Odisha. Method. A total of 313 children aged 0-12 years were enrolled for the study which included preschool (0-5 years) and school aged (6-12 years) groups. Hematological indicators were measured by standard procedures, which include red blood cell (RBC) indicators, white blood cell (WBC) indicators, and plasma ferritin. Results. Mean hemoglobin (Hb) of the study population was 10.43 ± 3.33 g/dL and prevalence of anemia was 62%. In this population, boys had a lower mean Hb value than that of the girls. All grades of anemia were higher among school age children than preschool children. Mean plasma ferritin was found to be higher in school age boys than their counterpart girls. The mean level of WBC count was found to be higher among preschool age boys than among the school age boys (p = 0.025). Conclusion. The prevalence of anemia was higher with concomitant acute infection among study population, which is a matter of concern. Since the hematological parameters are interrelated with each other as well as with the age and gender, relevant intervention strategy and constant monitoring are needed while providing public health nutrition programs to eradicate anemia. ","PeriodicalId":46055,"journal":{"name":"Anemia","volume":"2016 ","pages":"1729147"},"PeriodicalIF":2.9,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834407/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34441331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Absolute Reticulocyte Count and Reticulocyte Hemoglobin Content as Predictors of Early Response to Exclusive Oral Iron in Children with Iron Deficiency Anemia. 绝对网织红细胞计数和网织红细胞血红蛋白含量作为缺铁性贫血儿童口服铁治疗早期反应的预测指标。

IF 2.9

Anemia Pub Date : 2016-01-01 Epub Date: 2016-03-22 DOI: 10.1155/2016/7345835

Emilia Parodi, Maria Teresa Giraudo, Fulvio Ricceri, Maria Luigia Aurucci, Raffaela Mazzone, Ugo Ramenghi

{"title":"Absolute Reticulocyte Count and Reticulocyte Hemoglobin Content as Predictors of Early Response to Exclusive Oral Iron in Children with Iron Deficiency Anemia.","authors":"Emilia Parodi, Maria Teresa Giraudo, Fulvio Ricceri, Maria Luigia Aurucci, Raffaela Mazzone, Ugo Ramenghi","doi":"10.1155/2016/7345835","DOIUrl":"https://doi.org/10.1155/2016/7345835","url":null,"abstract":"We report data regarding kinetic of response to oral iron in 34 iron deficiency anemia children. Twenty-four/34 patients (70.5%) reached reference value of hemoglobin (Hb) concentration for age and sex at day + 30 from the beginning of treatment (complete early responders (CERs)), and 4/34 (12%) reached an Hb concentration at least 50% higher than the original (partial early responders (PERs)). CHr at T1 (within 7 days from the beginning of treatment) was significantly different in the different groups (22.95 in CERs versus 18.41 in other patients; p = 0.001; 22.42 in early responders versus 18.07 in NERs; p = 0.001). Relative increase of CHr from T0 to T1 resulted significantly higher in CERs than in other patients (0.21 versus 0.11, p = 0.042) and in early responders than in NERs (0.22 versus 0.004, p = 0.006). Multivariate logistic models revealed a higher probability of being a complete early responder due to relative increase of ARC from T0 to T1 [OR (95% CI) = 44.95 (1.54–1311.98)] and to CHr at T1 [OR (95% CI) =3.18 (1.24–8.17)]. Our preliminary data confirm CHr as early and accurate predictor of hematological response to oral iron.","PeriodicalId":46055,"journal":{"name":"Anemia","volume":"2016 ","pages":"7345835"},"PeriodicalIF":2.9,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/7345835","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34473346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 22

Evaluation of Serum Leptin Levels and Growth in Patients with β-Thalassaemia Major. β-地中海贫血患者血清瘦素水平和生长的评价。

IF 2.9

Anemia Pub Date : 2016-01-01 Epub Date: 2016-03-21 DOI: 10.1155/2016/8454286

Lamia Mustafa Al-Naama, Meaad Kadum Hassan, Muhannad Maki Abdul Karim

{"title":"Evaluation of Serum Leptin Levels and Growth in Patients with β-Thalassaemia Major.","authors":"Lamia Mustafa Al-Naama, Meaad Kadum Hassan, Muhannad Maki Abdul Karim","doi":"10.1155/2016/8454286","DOIUrl":"https://doi.org/10.1155/2016/8454286","url":null,"abstract":"Background. Iron deposition in the body can damage the endocrine glands of patients with β-thalassaemia major (β-TM). Leptin plays a key role in the regulation of appetite, body fat mass, and endocrine function. Objectives. This study aimed to evaluate the relationship between serum leptin and growth and pubertal development in patients with β-TM, as well as whether serum leptin can predict growth retardation and delayed puberty in these patients. Methods. Fifty β-TM patients (aged 8-20 years) and 75 age-matched healthy controls were recruited. Anthropometric data and sexual maturity ratings were assessed. Serum leptin was measured by ELISA. Results. Serum leptin levels were significantly lower in patients with β-TM than in healthy individuals (P < 0.001). Leptin levels were also significantly reduced in female patients with short stature (P < 0.002) and in patients who displayed delayed puberty (P = 0.032) compared to those with normal stature who had reached puberty. The sensitivity of leptin for predicting short stature and delayed puberty among patients was 84.6% and 92.3%, respectively. Conclusion. Low serum leptin is sensitive to predict short stature and significant in β-TM females only. This link could thus be used as a guide for further therapeutic or hormonal modulation. ","PeriodicalId":46055,"journal":{"name":"Anemia","volume":"2016 ","pages":"8454286"},"PeriodicalIF":2.9,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/8454286","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34411803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Using Soluble Transferrin Receptor and Taking Inflammation into Account When Defining Serum Ferritin Cutoffs Improved the Diagnosis of Iron Deficiency in a Group of Canadian Preschool Inuit Children from Nunavik. 在确定血清铁蛋白切断时，使用可溶性转铁蛋白受体并考虑炎症改善了一组来自努那维克的加拿大学龄前因纽特儿童缺铁的诊断。

IF 2.9

Anemia Pub Date : 2016-01-01 Epub Date: 2016-06-13 DOI: 10.1155/2016/6430214

Huguette Turgeon O'Brien, Rosanne Blanchet, Doris Gagné, Julie Lauzière, Carole Vézina

{"title":"Using Soluble Transferrin Receptor and Taking Inflammation into Account When Defining Serum Ferritin Cutoffs Improved the Diagnosis of Iron Deficiency in a Group of Canadian Preschool Inuit Children from Nunavik.","authors":"Huguette Turgeon O'Brien, Rosanne Blanchet, Doris Gagné, Julie Lauzière, Carole Vézina","doi":"10.1155/2016/6430214","DOIUrl":"https://doi.org/10.1155/2016/6430214","url":null,"abstract":"The prevalence of iron depletion, iron deficient erythropoiesis (IDE), and iron deficiency anemia (IDA) was assessed in preschool Inuit children using soluble transferrin receptor (sTfR) and traditional indicators of iron status while disregarding or taking inflammation into account when defining SF cutoffs. Iron depletion was defined as follows: (1) SF < 15 μg/L regardless of the C-reactive protein (CRP) level and (2) SF < 15 or <50 μg/L with CRP ≤ 5 or >5 mg/L, respectively. IDE corresponded to iron depletion combined with total iron binding capacity > 72 μmol/L and/or transferrin saturation < 16%. Iron depletion and IDE affected almost half of the children when accounting for inflammation, compared to one-third when the SF cutoff was defined regardless of CRP level (P < 0.0001). The prevalence of IDE adjusted for inflammation (45.1%) was very similar to the prevalence observed when sTfR was used as a sole marker of IDE (47.4%). The prevalence of anemia was 15%. The prevalence of IDA (IDE + hemoglobin < 110 g/L) was higher when accounting for than when disregarding inflammation (8.0% versus 6.2%, P = 0.083). Using sTfR and different SF cutoffs for children with versus without inflammation improved the diagnosis of iron depletion and IDE. Our results confirm that Inuit children are at particularly high risk for iron deficiency. ","PeriodicalId":46055,"journal":{"name":"Anemia","volume":"2016 ","pages":"6430214"},"PeriodicalIF":2.9,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/6430214","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34641113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Transfusion Thresholds, Quality of Life, and Current Approaches in Myelodysplastic Syndromes. 骨髓增生异常综合征的输血阈值、生活质量和当前治疗方法。

IF 2.9

Anemia Pub Date : 2016-01-01 Epub Date: 2016-04-19 DOI: 10.1155/2016/8494738

Ioannis Koutsavlis

引用次数: 25

The Cost-Effectiveness of Continuous Erythropoiesis Receptor Activator Once Monthly versus Epoetin Thrice Weekly for Anaemia Management in Chronic Haemodialysis Patients 慢性血液透析患者每月1次连续使用红细胞生成受体激活剂与每周3次生成素治疗贫血的成本-效果比较

IF 2.9

Anemia Pub Date : 2015-12-30 DOI: 10.1155/2015/189404

O. Maoujoud, S. Ahid, H. Dkhissi, Z. Oualim, Y. Cherrah

{"title":"The Cost-Effectiveness of Continuous Erythropoiesis Receptor Activator Once Monthly versus Epoetin Thrice Weekly for Anaemia Management in Chronic Haemodialysis Patients","authors":"O. Maoujoud, S. Ahid, H. Dkhissi, Z. Oualim, Y. Cherrah","doi":"10.1155/2015/189404","DOIUrl":"https://doi.org/10.1155/2015/189404","url":null,"abstract":"Introduction. The aim of this study was to compare the cost-effectiveness of continuous erythropoietin receptor activator (CERA) once monthly to epoetin beta (EpoB) thrice weekly to maintain haemoglobin (Hb) within the range 10.5–12 g/dL. Methods. Prospective cohort study and cost-effectiveness analysis. Chronic haemodialysis patients (CHP), being treated with EpoB, were selected for two periods of follow-up: period 1, maintaining prior treatment with EpoB, and period 2, conversion to CERA once monthly. Hb concentrations and costs were measured monthly. Health care payer perspective for one year was adopted. Results. 75 CHP completed the study, with a mean age of 52.9 ± 14.3 years. Baseline Hb was 11.14 ± 1.18 g/dL in EpoB phase and 11.46 ± 0.79 g/dL in CERA phase; we observed a significant increase in the proportion of patients successfully treated (Hb within the recommended range), 65.3% versus 70.7%, p: 0.008, and in the average effectiveness by 4% (0.55 versus 0.59). Average cost-effectiveness ratios were 6013.86 and 5173.64$, with an ICER CERA to EpoB at −6457.5$. Conclusion. Our health economic evaluation of ESA use in haemodialysis patients suggests that the use of CERA is cost-effective compared with EpoB.","PeriodicalId":46055,"journal":{"name":"Anemia","volume":"2015 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2015-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/189404","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64832554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Hyperglycaemic Environment: Contribution to the Anaemia Associated with Diabetes Mellitus in Rats Experimentally Induced with Alloxan 高血糖环境:对四氧嘧啶诱导的大鼠与糖尿病相关的贫血的贡献

IF 2.9

Anemia Pub Date : 2015-11-30 DOI: 10.1155/2015/848921

Oseni Bashiru Shola, Fakoya Olatunde Olugbenga

{"title":"Hyperglycaemic Environment: Contribution to the Anaemia Associated with Diabetes Mellitus in Rats Experimentally Induced with Alloxan","authors":"Oseni Bashiru Shola, Fakoya Olatunde Olugbenga","doi":"10.1155/2015/848921","DOIUrl":"https://doi.org/10.1155/2015/848921","url":null,"abstract":"Background. Diabetes mellitus characterized by hyperglycaemia presents with various complications amongst which anaemia is common particularly in those with overt nephropathy or renal impairment. The present study has examined the contribution of the hyperglycaemic environment in diabetic rats to the anaemia associated with diabetes mellitus. Method. Sixty male albino rats weighing 175–250 g were selected for this study and divided equally into control and test groups. Hyperglycaemia was induced with 170 kgbwt−1 alloxan intraperitoneally in the test group while control group received sterile normal saline. Blood samples obtained from the control and test rats were assayed for packed cell volume (PCV), haemoglobin (Hb), red blood cell count (RBC), reticulocyte count, glucose, plasma haemoglobin, potassium, and bilirubin. Result. Significant reduction (P < 0.01) in PCV (24.40 ± 3.87 versus 40.45 ± 3.93) and haemoglobin (7.81 ± 1.45 versus 13.39 ± 0.40) with significant increase (P < 0.01) in reticulocyte count (12.4 ± 1.87 versus 3.69 ± 0.47), plasma haemoglobin (67.50 ± 10.85 versus 34.20 ± 3.83), and potassium (7.04 ± 0.75 versus 4.52 ± 0.63) was obtained in the test while plasma bilirubin showed nonsignificant increase (0.41 ± 0.04 versus 0.24 ± 0.06). Conclusion. The increased plasma haemoglobin and potassium levels indicate an intravascular haemolytic event while the nonsignificant increased bilirubin showed extravascular haemolysis. These play contributory roles in the anaemia associated with diabetes mellitus.","PeriodicalId":46055,"journal":{"name":"Anemia","volume":"60 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2015-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/848921","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65182619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Prevalence and Risk Factors for Complications in Patients with Nontransfusion Dependent Alpha- and Beta-Thalassemia 非输血依赖性α -和β -地中海贫血患者并发症的患病率和危险因素

IF 2.9

Anemia Pub Date : 2015-11-18 DOI: 10.1155/2015/793025

P. Winichakoon, A. Tantiworawit, T. Rattanathammethee, S. Hantrakool, C. Chai-Adisaksopha, E. Rattarittamrong, L. Norasetthada, P. Charoenkwan

{"title":"Prevalence and Risk Factors for Complications in Patients with Nontransfusion Dependent Alpha- and Beta-Thalassemia","authors":"P. Winichakoon, A. Tantiworawit, T. Rattanathammethee, S. Hantrakool, C. Chai-Adisaksopha, E. Rattarittamrong, L. Norasetthada, P. Charoenkwan","doi":"10.1155/2015/793025","DOIUrl":"https://doi.org/10.1155/2015/793025","url":null,"abstract":"Background. Nontransfusion dependent thalassemia (NTDT) is a milder form of thalassemia that does not require regular transfusion. It is associated with many complications, which differ from that found in transfusion-dependent thalassemia (TDT). Currently available information is mostly derived from beta-NTDT; consequently, more data is needed to describe complications found in the alpha-NTDT form of this disease. Methods. We retrospectively reviewed the medical records of NTDT patients from January 2012 to December 2013. Complications related to thalassemia were reviewed and compared. Results. One hundred patients included 60 females with a median age of 38 years. The majority (54 patients) had alpha-thalassemia. Overall, 83 patients had one or more complications. The three most common complications were cholelithiasis (35%), abnormal liver function (29%), and extramedullary hematopoiesis (EMH) (25%). EMH, cardiomyopathy, cholelithiasis, and pulmonary hypertension were more commonly seen in beta-thalassemia. Osteoporosis was the only complication that was more common in alpha-thalassemia. The risk factors significantly related to EMH were beta-thalassemia type and hemoglobin < 8 g/dL. The risk factors related to osteoporosis were female gender and age > 40 years. Iron overload (ferritin > 800 ng/mL) was the only risk factor for abnormal liver function. Conclusion. The prevalence of alpha-NTDT complications was lower and different from beta-thalassemia.","PeriodicalId":46055,"journal":{"name":"Anemia","volume":"2015 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2015-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/793025","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65150424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Anemia in Patients with Type 2 Diabetes Mellitus 2型糖尿病患者的贫血

IF 2.9

Anemia Pub Date : 2015-11-11 DOI: 10.1155/2015/354737

J. Barbieri, P. C. Fontela, E. R. Winkelmann, C. Zimmermann, Yana Picinin Sandri, Emanelle Kerber Viera Mallet, M. Frizzo

引用次数: 76

Hospitalization Events among Children and Adolescents with Sickle Cell Disease in Basra, Iraq 伊拉克巴士拉镰状细胞病儿童和青少年住院事件

IF 2.9

Anemia Pub Date : 2015-10-26 DOI: 10.1155/2015/195469

Z. Salman, M. Hassan

{"title":"Hospitalization Events among Children and Adolescents with Sickle Cell Disease in Basra, Iraq","authors":"Z. Salman, M. Hassan","doi":"10.1155/2015/195469","DOIUrl":"https://doi.org/10.1155/2015/195469","url":null,"abstract":"Objectives. Despite improvements in the management of sickle cell disease (SCD), many patients still experience disease-related complications requiring hospitalizations. The objectives of this study were to identify causes of hospitalization among these patients and factors associated with the length of hospital stay (LOS) and readmission. Methods. Data from 160 patients (<14 years old) with SCD who were admitted to the Basra Maternity and Children's Hospital from the first of January 2012 through July 2012 were analyzed. Results. The main causes of hospitalization were acute painful crises (73.84%), infections (9.28%), acute chest syndrome (8.02%), and acute splenic sequestration crisis (6.32%). The mean LOS was 4.34 ± 2.85 days. The LOS for patients on hydroxyurea (3.41 ± 2.64 days) was shorter than that for patients who were not (4.59 ± 2.86 days), P < 0.05. The readmission rate (23.1%) was significantly higher among patients with frequent hospitalizations in the previous year (OR 9.352, 95% CI 2.011–43.49), asthma symptoms (OR 4.225, 95% CI 1.125–15.862), and opioid use (OR 6.588, 95% CI 1.104–30.336). Patients on hydroxyurea were less likely to be readmitted (OR 0.082, 95% CI 0.10–0.663). Conclusions. There is a relatively high readmission rate among patients with SCD in Basra. The use of hydroxyurea significantly decreases the LOS and readmission rate.","PeriodicalId":46055,"journal":{"name":"Anemia","volume":"2015 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2015-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/195469","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64836294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18

Anemia最新文献