AnemiaPub Date : 2018-04-23eCollection Date: 2018-01-01DOI: 10.1155/2018/4157876
Abdullah Ahmed Al-Alimi, Salem Bashanfer, Mohammed Abdo Morish
{"title":"Prevalence of Iron Deficiency Anemia among University Students in Hodeida Province, Yemen.","authors":"Abdullah Ahmed Al-Alimi, Salem Bashanfer, Mohammed Abdo Morish","doi":"10.1155/2018/4157876","DOIUrl":"https://doi.org/10.1155/2018/4157876","url":null,"abstract":"<p><strong>Background: </strong>Iron deficiency anemia (IDA) is one of the most common types of nutritional anemia in the worldwide and considered a major public health problem in developing countries especially in Yemen. Therefore, this cross-sectional study was conducted to determine the prevalence and risk factors of IDA among apparently healthy Yemeni students at Hodeida University.</p><p><strong>Method: </strong>Five hundred blood samples (326 males and 174 females) were collected randomly from medical students at Hodeida University. Participants were subjected to different tests including complete blood counts (CBC), serum ferritin (SF), serum iron (SI), and total iron binding capacity (TIBC). Moreover, a questionnaire was designed to collect demographics, food and drink habits, and socioeconomic status.</p><p><strong>Result: </strong>The overall prevalence of IDA was 30.4% (<i>n</i> = 152), of whom 54.00% were females (<i>n</i> = 82) and 46.0% were males (<i>n</i> = 70). Students aged 20-22 years were found more anemic with prevalence 59.2% than students aged 17-19 years (25.0%) and 23-25 years (15.8%). Statistical analysis showed regularly having breakfast had significant (<i>p</i> < 0.001) role in preventing development of IDA compared with irregularly having breakfast. Infrequent consumption of vegetables/fruits; meat, fish, chicken; tea drinking; low household income; smoking and khat <i>(Catha edulis)</i> chewing showed a significant role (<i>p</i> < 0.001) in provoking of IDA, whereas consumption of coffee and cola showed insignificant influence (<i>p</i> = 0.585; <i>p</i> = 0.513) on IDA.</p><p><strong>Conclusion: </strong>This study revealed that the majority of university students, especially females, have IDA that might become worse by malnutrition, lifestyle habits, and lack of awareness. Our results suggest that IDA can be prevented by providing proper knowledge on the healthful diet, improved lifestyle, and harmful effect of IDA to the students.</p>","PeriodicalId":46055,"journal":{"name":"Anemia","volume":"2018 ","pages":"4157876"},"PeriodicalIF":2.9,"publicationDate":"2018-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2018/4157876","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36178619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AnemiaPub Date : 2018-04-10eCollection Date: 2018-01-01DOI: 10.1155/2018/8906258
Mirza Sultan Ahmad, Hadia Farooq, Sumaira Noor Maham, Zonaira Qayyum, Abdul Waheed, Waqar Nasir
{"title":"Frequency of Anemia and Iron Deficiency among Children Starting First Year of School Life and Their Association with Weight and Height.","authors":"Mirza Sultan Ahmad, Hadia Farooq, Sumaira Noor Maham, Zonaira Qayyum, Abdul Waheed, Waqar Nasir","doi":"10.1155/2018/8906258","DOIUrl":"https://doi.org/10.1155/2018/8906258","url":null,"abstract":"<p><p>The objectives of the study were to ascertain frequency of anemia and iron deficiency among children starting first year of school life and test association with height and weight. One in four children starting first year of school life in five schools of Rabwah, Pakistan, was included. Full blood counts and ferritin levels of the children included in the study were checked. Status of their height and weight was determined according to <i>Z</i>-score charts. Chi-square test was used to test association. Two hundred and ninety-five children with median age of 67 months were included in the study. Out of 295, 240 (81.4%) had normal Hb and 55 (18.6%) had anemia. Ferritin levels were found to be below normal level in 242 (82%) children. There was no significant difference between hemoglobin and ferritin levels of children belonging to different categories of height and weight. Spearman test showed that there was very weak correlation between ferritin and hemoglobin levels (<i>r</i><sub><i>s</i></sub> = .163). Our conclusions were that iron deficiency without anemia is very frequent among children starting first year of school. Regression models show that ferritin levels cannot be predicted by independent variables like status of height and weight on <i>Z</i>-score charts, age, gender, and anemia.</p>","PeriodicalId":46055,"journal":{"name":"Anemia","volume":"2018 ","pages":"8906258"},"PeriodicalIF":2.9,"publicationDate":"2018-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2018/8906258","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36177992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AnemiaPub Date : 2018-01-15eCollection Date: 2018-01-01DOI: 10.1155/2018/3950687
Élida Mara Braga Rocha, Luiz Carlos de Abreu, Amanda Forster Lopes, Claudio Leone, Patrícia Dore Vieira, Italla Maria Pinheiro Bezerra, Sophia Cornbluth Szarfarc
{"title":"Relation of Food Insecurity and Hemoglobin Level in Preschool Aged Children.","authors":"Élida Mara Braga Rocha, Luiz Carlos de Abreu, Amanda Forster Lopes, Claudio Leone, Patrícia Dore Vieira, Italla Maria Pinheiro Bezerra, Sophia Cornbluth Szarfarc","doi":"10.1155/2018/3950687","DOIUrl":"https://doi.org/10.1155/2018/3950687","url":null,"abstract":"<p><strong>Background: </strong>The iron deficiency anemia is a worldwide public problem, especially in developing countries, related to increased body needs and inadequate supply of iron from the diet.</p><p><strong>Objective: </strong>To analyze the association of food insecurity with hemoglobin concentration and the prevalence of anemia in preschool aged children in the city of Taubaté, São Paulo, Brazil.</p><p><strong>Methods: </strong>A cross-sectional study was conducted with 306 children of preschool age. The nutritional status was assessed according to hemoglobin level and anthropometric indicators. Socioeconomic data and Brazilian Household Food Insecurity Measurement Scale (EBIA) results were obtained from interview with parents.</p><p><strong>Results: </strong>The prevalence of anemia was around 19% of preschool aged children and 41.2% families presented food insecurity. The anthropometric indicators were not associated with food insecurity and even though the bivariate analysis demonstrated that mild food insecurity affects the hemoglobin level, after adjusting the multivariate model this association lost significance (<i>p</i> > 0.05).</p><p><strong>Conclusion: </strong>The prevalence of anemia of 19.2% and the household food insecurity was found among 42.2% of the population.</p>","PeriodicalId":46055,"journal":{"name":"Anemia","volume":"2018 ","pages":"3950687"},"PeriodicalIF":2.9,"publicationDate":"2018-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2018/3950687","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35938787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AnemiaPub Date : 2017-01-01Epub Date: 2017-04-13DOI: 10.1155/2017/9642027
Melvin H Seid, Angelia D Butcher, Ashwin Chatwani
{"title":"Ferric Carboxymaltose as Treatment in Women with Iron-Deficiency Anemia.","authors":"Melvin H Seid, Angelia D Butcher, Ashwin Chatwani","doi":"10.1155/2017/9642027","DOIUrl":"https://doi.org/10.1155/2017/9642027","url":null,"abstract":"<p><p><i>Objective</i>. To evaluate safety and efficacy of intravenous ferric carboxymaltose (FCM) versus standard medical care (SMC) for iron-deficiency anemia (IDA) in postpartum women and women with heavy menstrual bleeding. <i>Study Design</i>. This open-label, multicenter study randomized women with IDA (hemoglobin ≤ 11.0 g/dL) to single doses of FCM (15 mg/kg [maximum 1000 mg]) or SMC (this treatment was determined by the investigator and there may have been no treatment). Safety data (primary outcome) were collected for 30 days. <i>Results</i>. Of 2045 subjects enrolled (FCM: <i>n</i> = 1023; SMC: <i>n</i> = 1022), 996 received FCM and 1022 received SMC. At least 1 serious adverse event (AE) was reported by 0.6% and 2.2% of subjects in the FCM and SMC groups, respectively; none were considered treatment related. The difference in serious AEs was primarily due to higher rates of uterine leiomyoma, uterine hemorrhage, and menorrhagia in SMC subjects with heavy menstrual bleeding. Common AEs were generally predictable, with higher rates of infusion site reactions in FCM subjects and gastrointestinal AEs in SMC subjects. Mean hemoglobin increases were greater in the FCM group than the SMC group. <i>Conclusion</i>. FCM was well tolerated and effectively increased mean hemoglobin levels in postpartum women or women with heavy menstrual bleeding and IDA. This trial is registered with ClinicalTrials.gov, NCT00548860.</p>","PeriodicalId":46055,"journal":{"name":"Anemia","volume":"2017 ","pages":"9642027"},"PeriodicalIF":2.9,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/9642027","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34981065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AnemiaPub Date : 2017-01-01Epub Date: 2017-07-03DOI: 10.1155/2017/3106890
António Robalo Nunes, Ana Palricas Costa, Sara Lemos Rocha, Ana Garcia de Oliveira
{"title":"Efficacy and Tolerability of Intravenous Ferric Carboxymaltose in Patients with Iron Deficiency at a Hospital Outpatient Clinic: A Retrospective Cohort Study of Real-World Clinical Practice.","authors":"António Robalo Nunes, Ana Palricas Costa, Sara Lemos Rocha, Ana Garcia de Oliveira","doi":"10.1155/2017/3106890","DOIUrl":"https://doi.org/10.1155/2017/3106890","url":null,"abstract":"<p><p>Ferric carboxymaltose (FCM) is an intravenous iron formulation to correct iron deficiency. Although its use has been extensively studied in clinical trials, real-world evidence regarding FCM treatment is scarce. Our aim was to evaluate the efficacy and tolerability of FCM treatment in patients with iron deficiency, with or without anemia, at a hospital outpatient clinic. Data was collected retrospectively from medical records. During this 2-year study, 459 patients were included. Mean age was 58.6 ± 17.5 years and most patients received cumulative FCM doses of 501-1000 mg (63.2%). Six weeks after administration of FCM, efficacy endpoints hemoglobin increase ≥2 g/dL, hemoglobin increase ≥3 g/dL, and transferrin saturation > 20% were attained by 41%, 20%, and 63% of patients, respectively. Patients who received higher FCM doses showed significant reduced odds of not achieving hemoglobin increase ≥2 g/dL (501-1000 mg, adjusted odds ratio [OR]: 0.34, 95% confidence interval [CI] 0.18-0.62; 1001-3000 mg, OR: 0.19, 95% CI 0.07-0.49), compared to 500 mg doses. Treatment-emergent adverse events were documented in <4% of patients. In conclusion, FCM treatment was effective and well-tolerated by outpatients with iron deficiency at a hospital clinic, and its dosage should be adjusted to improve iron deficiency management in clinical practice.</p>","PeriodicalId":46055,"journal":{"name":"Anemia","volume":"2017 ","pages":"3106890"},"PeriodicalIF":2.9,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/3106890","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35275374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AnemiaPub Date : 2017-01-01Epub Date: 2017-05-29DOI: 10.1155/2017/6935648
Ari Indra Susanti, Edhyana Sahiratmadja, Gatot Winarno, Adhi Kristianto Sugianli, Herman Susanto, Ramdan Panigoro
{"title":"Low Hemoglobin among Pregnant Women in Midwives Practice of Primary Health Care, Jatinangor, Indonesia: Iron Deficiency Anemia or <i>β</i>-Thalassemia Trait?","authors":"Ari Indra Susanti, Edhyana Sahiratmadja, Gatot Winarno, Adhi Kristianto Sugianli, Herman Susanto, Ramdan Panigoro","doi":"10.1155/2017/6935648","DOIUrl":"https://doi.org/10.1155/2017/6935648","url":null,"abstract":"Low hemoglobin (Hb) or anemia is common among pregnant women in developing countries which may cause adverse pregnancy outcomes and maternal deaths. Our study aimed to assess Hb level measured by midwives in primary health care facility at rural area of Jatinangor, Indonesia, and to explore whether the anemia was due to iron deficiency (IDA) or β-thalassemia trait (β-TT). Pregnant women (n = 105) had finger prick test for Hb level during a regular antenatal care examination from October to November 2016. Hb level by finger prick test was compared with venous blood, measured by complete blood count (CBC). Indices including MCV and MCH and indices of Shine & Lal, Mentzer, Srivastava, Engels & Frase, Ehsani, and Sirdah were analyzed to differentiate anemia due to IDA and anemia due to suspect β-TT. HbA2 was measured to confirm β-TT. Anemic pregnant women were found in 86.7% by finger prick test compared to 21.9% (n = 23) by CBC. The prevalence of β-TT in our study was 5.7%. Hb measurement among pregnant women in low resource area is highly important; however, finger prick test in this study showed a high frequency of anemia which may lead to iron oversupplementation. A standard CBC is encouraged; MCV and MCH would help midwives to identify β-TT.","PeriodicalId":46055,"journal":{"name":"Anemia","volume":"2017 ","pages":"6935648"},"PeriodicalIF":2.9,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/6935648","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35105992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AnemiaPub Date : 2017-01-01Epub Date: 2017-01-30DOI: 10.1155/2017/7916348
Aimé Lukusa Kazadi, René Makuala Ngiyulu, Jean Lambert Gini-Ehungu, Jean Marie Mbuyi-Muamba, Michel Ntetani Aloni
{"title":"Factors Associated with Growth Retardation in Children Suffering from Sickle Cell Anemia: First Report from Central Africa.","authors":"Aimé Lukusa Kazadi, René Makuala Ngiyulu, Jean Lambert Gini-Ehungu, Jean Marie Mbuyi-Muamba, Michel Ntetani Aloni","doi":"10.1155/2017/7916348","DOIUrl":"https://doi.org/10.1155/2017/7916348","url":null,"abstract":"<p><p><i>Background</i>. The aim of this study was to investigate and determine the risk factors associated with poor growth among SCA children. <i>Methods.</i> A cross-sectional study was conducted in Kinshasa, the capital's country. The nutritional status was assessed using the Z scores of the anthropometric indices. <i>Results.</i> We gathered data on the 256 patients, 138 females (53.9%), who entered the study. The mean age at presentation was 8.4 ± 4.9 years of age. Underweight, stunting, and wasting were found, respectively, in 47.7%, 10.5%, and 50.3% of SCA children. A history of hand-foot syndrome, more than 3 blood transfusions, being less than 12 months of age when receiving the first transfusion, more than two severe sickle crises per year, a medical history of severe infections, and the presence of hepatomegaly were associated with poor growth. When comparing sickle cell patients under 12 years of age (<i>n</i> = 159) to a group of 296 age-matched children with normal Hb-AA, a significantly higher proportion of subjects with stunting and underweight were found among SCA. <i>Conclusion.</i> Nutritional status encountered in Congolese sickle cell children has been described for the first time in this study. A high prevalence of poor growth in SCA children was found in our study.</p>","PeriodicalId":46055,"journal":{"name":"Anemia","volume":"2017 ","pages":"7916348"},"PeriodicalIF":2.9,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/7916348","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34775927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AnemiaPub Date : 2016-12-12DOI: 10.1155/2016/9817358
Aklilu Alemayehu, Lealem Gedefaw, T. Yemane, Yaregal Asres
{"title":"Prevalence, Severity, and Determinant Factors of Anemia among Pregnant Women in South Sudanese Refugees, Pugnido, Western Ethiopia","authors":"Aklilu Alemayehu, Lealem Gedefaw, T. Yemane, Yaregal Asres","doi":"10.1155/2016/9817358","DOIUrl":"https://doi.org/10.1155/2016/9817358","url":null,"abstract":"Background. Anemia is one of the major health problems among refugee pregnant women in the world. Anemia among pregnant women is multifactorial and results in detrimental consequences on the mothers and infants. The aim of this study was to determine the prevalence, severity, and determinants of anemia among pregnant women in South Sudanese refugees, Pugnido western, Ethiopia. Methods. A facility-based cross-sectional study was conducted in Pugnido Administration Refugee and Returnee Affairs Health Center from April 15 to June 30, 2015. Demographic and related data were collected using questionnaire based interview. Complete blood count was done using CELL-DYN 1800 (Abbott USA). Blood smear and fecal specimen were examined for hemoparasite and intestinal parasite, respectively. Bivariate and multivariate logistic regression analyses were done using SPSS-Version 20.0. Results. The overall prevalence of anemia was 36.1%, from whom 2.3% had severe anemia. Being in third trimester, eating meat at most once a week, drinking tea immediately after meal at least once a day, having mid-upper arm circumference below 21 centimeters, and intestinal parasitic infection were identified as independent factors of anemia. Conclusion. More than one-third of pregnant women had anemia in this study. Intervention based strategies on identified determinant factors will be very important to combat anemia among the group.","PeriodicalId":46055,"journal":{"name":"Anemia","volume":"2016 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2016-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/9817358","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64641823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AnemiaPub Date : 2016-11-08DOI: 10.1155/2016/5725634
I. Sumbele, Sharon Odmia Sama, H. Kimbi, G. S. Taiwé
{"title":"Malaria, Moderate to Severe Anaemia, and Malarial Anaemia in Children at Presentation to Hospital in the Mount Cameroon Area: A Cross-Sectional Study","authors":"I. Sumbele, Sharon Odmia Sama, H. Kimbi, G. S. Taiwé","doi":"10.1155/2016/5725634","DOIUrl":"https://doi.org/10.1155/2016/5725634","url":null,"abstract":"Background. Malaria remains a major killer of children in Sub-Saharan Africa, while anaemia is a public health problem with significant morbidity and mortality. Examining the factors associated with moderate to severe anaemia (MdSA) and malarial anaemia as well as the haematological characteristics is essential. Methodology. Children (1–14 years) at presentation at the Regional Hospital Annex-Buea were examined clinically and blood samples were collected for malaria parasite detection and full blood count evaluation. Results. Plasmodium falciparum, anaemia, and malarial anaemia occurred in 33.8%, 62.0%, and 23.6% of the 216 children, respectively. Anaemia prevalence was significantly higher in malaria parasite positive children and those with fever than their respective counterparts. MdSA and moderate to severe malarial anaemia (MdSMA) were detected in 38.0% and 15.3% of the participants, respectively. The prevalence of MdSA was significantly higher in children whose household head had no formal education, resided in the lowland, or was febrile, while MdSMA was significantly higher in febrile children only. Children with MdSMA had significantly lower mean white blood cell, lymphocyte, and platelet counts while the mean granulocyte count was significantly higher. Conclusion. Being febrile was the only predictor of both MdSA and MdSMA. More haematological insult occurred in children with MdSMA compared to MdSA.","PeriodicalId":46055,"journal":{"name":"Anemia","volume":"1 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2016-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/5725634","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64436816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AnemiaPub Date : 2016-02-29DOI: 10.1155/2016/9310905
V. Pathak, K. Ghosh
{"title":"Erythropoiesis in Malaria Infections and Factors Modifying the Erythropoietic Response","authors":"V. Pathak, K. Ghosh","doi":"10.1155/2016/9310905","DOIUrl":"https://doi.org/10.1155/2016/9310905","url":null,"abstract":"Anemia is the primary clinical manifestation of malarial infections and is responsible for the substantial rate of morbidity. The pathophysiology discussed till now catalogued several causes for malarial anemia among which ineffective erythropoiesis being remarkable one occurs silently in the bone marrow. A systematic literature search was performed and summarized information on erythropoietic response upon malaria infection and the factors responsible for the same. This review summarizes the clinical and experimental studies on patients, mouse models, and in vitro cell cultures reporting erythropoietic changes upon malaria infection as well as factors accountable for the same. Inadequate erythropoietic response during malaria infection may be the collective effect of various mediators generated by host immune response as well as parasite metabolites. The interplay between various modulators causing the pathophysiology needs to be explored further. Globin gene expression profiling upon malaria infection should also be looked into as abnormal production of globin chains could be a possible contributor to ineffective erythropoiesis.","PeriodicalId":46055,"journal":{"name":"Anemia","volume":"2016 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2016-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/9310905","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64608387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}