Anemia最新文献_第9页

Ferric Carboxymaltose as Treatment in Women with Iron-Deficiency Anemia. 羧麦芽糖铁治疗妇女缺铁性贫血。

IF 2.9

Anemia Pub Date : 2017-01-01 Epub Date: 2017-04-13 DOI: 10.1155/2017/9642027

Melvin H Seid, Angelia D Butcher, Ashwin Chatwani

{"title":"Ferric Carboxymaltose as Treatment in Women with Iron-Deficiency Anemia.","authors":"Melvin H Seid, Angelia D Butcher, Ashwin Chatwani","doi":"10.1155/2017/9642027","DOIUrl":"https://doi.org/10.1155/2017/9642027","url":null,"abstract":"Objective. To evaluate safety and efficacy of intravenous ferric carboxymaltose (FCM) versus standard medical care (SMC) for iron-deficiency anemia (IDA) in postpartum women and women with heavy menstrual bleeding. Study Design. This open-label, multicenter study randomized women with IDA (hemoglobin ≤ 11.0 g/dL) to single doses of FCM (15 mg/kg [maximum 1000 mg]) or SMC (this treatment was determined by the investigator and there may have been no treatment). Safety data (primary outcome) were collected for 30 days. Results. Of 2045 subjects enrolled (FCM: n = 1023; SMC: n = 1022), 996 received FCM and 1022 received SMC. At least 1 serious adverse event (AE) was reported by 0.6% and 2.2% of subjects in the FCM and SMC groups, respectively; none were considered treatment related. The difference in serious AEs was primarily due to higher rates of uterine leiomyoma, uterine hemorrhage, and menorrhagia in SMC subjects with heavy menstrual bleeding. Common AEs were generally predictable, with higher rates of infusion site reactions in FCM subjects and gastrointestinal AEs in SMC subjects. Mean hemoglobin increases were greater in the FCM group than the SMC group. Conclusion. FCM was well tolerated and effectively increased mean hemoglobin levels in postpartum women or women with heavy menstrual bleeding and IDA. This trial is registered with ClinicalTrials.gov, NCT00548860.","PeriodicalId":46055,"journal":{"name":"Anemia","volume":"2017 ","pages":"9642027"},"PeriodicalIF":2.9,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/9642027","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34981065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Efficacy and Tolerability of Intravenous Ferric Carboxymaltose in Patients with Iron Deficiency at a Hospital Outpatient Clinic: A Retrospective Cohort Study of Real-World Clinical Practice. 医院门诊静脉注射羧麦芽糖铁治疗缺铁患者的疗效和耐受性:一项现实世界临床实践的回顾性队列研究。

IF 2.9

Anemia Pub Date : 2017-01-01 Epub Date: 2017-07-03 DOI: 10.1155/2017/3106890

António Robalo Nunes, Ana Palricas Costa, Sara Lemos Rocha, Ana Garcia de Oliveira

{"title":"Efficacy and Tolerability of Intravenous Ferric Carboxymaltose in Patients with Iron Deficiency at a Hospital Outpatient Clinic: A Retrospective Cohort Study of Real-World Clinical Practice.","authors":"António Robalo Nunes, Ana Palricas Costa, Sara Lemos Rocha, Ana Garcia de Oliveira","doi":"10.1155/2017/3106890","DOIUrl":"https://doi.org/10.1155/2017/3106890","url":null,"abstract":"Ferric carboxymaltose (FCM) is an intravenous iron formulation to correct iron deficiency. Although its use has been extensively studied in clinical trials, real-world evidence regarding FCM treatment is scarce. Our aim was to evaluate the efficacy and tolerability of FCM treatment in patients with iron deficiency, with or without anemia, at a hospital outpatient clinic. Data was collected retrospectively from medical records. During this 2-year study, 459 patients were included. Mean age was 58.6 ± 17.5 years and most patients received cumulative FCM doses of 501-1000 mg (63.2%). Six weeks after administration of FCM, efficacy endpoints hemoglobin increase ≥2 g/dL, hemoglobin increase ≥3 g/dL, and transferrin saturation > 20% were attained by 41%, 20%, and 63% of patients, respectively. Patients who received higher FCM doses showed significant reduced odds of not achieving hemoglobin increase ≥2 g/dL (501-1000 mg, adjusted odds ratio [OR]: 0.34, 95% confidence interval [CI] 0.18-0.62; 1001-3000 mg, OR: 0.19, 95% CI 0.07-0.49), compared to 500 mg doses. Treatment-emergent adverse events were documented in <4% of patients. In conclusion, FCM treatment was effective and well-tolerated by outpatients with iron deficiency at a hospital clinic, and its dosage should be adjusted to improve iron deficiency management in clinical practice.","PeriodicalId":46055,"journal":{"name":"Anemia","volume":"2017 ","pages":"3106890"},"PeriodicalIF":2.9,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/3106890","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35275374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Low Hemoglobin among Pregnant Women in Midwives Practice of Primary Health Care, Jatinangor, Indonesia: Iron Deficiency Anemia or β-Thalassemia Trait? 印度尼西亚贾提南戈尔初级卫生保健助产士的低血红蛋白孕妇:缺铁性贫血或β-地中海贫血特征?

IF 2.9

Anemia Pub Date : 2017-01-01 Epub Date: 2017-05-29 DOI: 10.1155/2017/6935648

Ari Indra Susanti, Edhyana Sahiratmadja, Gatot Winarno, Adhi Kristianto Sugianli, Herman Susanto, Ramdan Panigoro

{"title":"Low Hemoglobin among Pregnant Women in Midwives Practice of Primary Health Care, Jatinangor, Indonesia: Iron Deficiency Anemia or β-Thalassemia Trait?","authors":"Ari Indra Susanti, Edhyana Sahiratmadja, Gatot Winarno, Adhi Kristianto Sugianli, Herman Susanto, Ramdan Panigoro","doi":"10.1155/2017/6935648","DOIUrl":"https://doi.org/10.1155/2017/6935648","url":null,"abstract":"Low hemoglobin (Hb) or anemia is common among pregnant women in developing countries which may cause adverse pregnancy outcomes and maternal deaths. Our study aimed to assess Hb level measured by midwives in primary health care facility at rural area of Jatinangor, Indonesia, and to explore whether the anemia was due to iron deficiency (IDA) or β-thalassemia trait (β-TT). Pregnant women (n = 105) had finger prick test for Hb level during a regular antenatal care examination from October to November 2016. Hb level by finger prick test was compared with venous blood, measured by complete blood count (CBC). Indices including MCV and MCH and indices of Shine & Lal, Mentzer, Srivastava, Engels & Frase, Ehsani, and Sirdah were analyzed to differentiate anemia due to IDA and anemia due to suspect β-TT. HbA2 was measured to confirm β-TT. Anemic pregnant women were found in 86.7% by finger prick test compared to 21.9% (n = 23) by CBC. The prevalence of β-TT in our study was 5.7%. Hb measurement among pregnant women in low resource area is highly important; however, finger prick test in this study showed a high frequency of anemia which may lead to iron oversupplementation. A standard CBC is encouraged; MCV and MCH would help midwives to identify β-TT.","PeriodicalId":46055,"journal":{"name":"Anemia","volume":"2017 ","pages":"6935648"},"PeriodicalIF":2.9,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/6935648","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35105992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 21

Factors Associated with Growth Retardation in Children Suffering from Sickle Cell Anemia: First Report from Central Africa. 镰状细胞性贫血儿童生长迟缓的相关因素:来自中非的第一份报告。

IF 2.9

Anemia Pub Date : 2017-01-01 Epub Date: 2017-01-30 DOI: 10.1155/2017/7916348

Aimé Lukusa Kazadi, René Makuala Ngiyulu, Jean Lambert Gini-Ehungu, Jean Marie Mbuyi-Muamba, Michel Ntetani Aloni

{"title":"Factors Associated with Growth Retardation in Children Suffering from Sickle Cell Anemia: First Report from Central Africa.","authors":"Aimé Lukusa Kazadi, René Makuala Ngiyulu, Jean Lambert Gini-Ehungu, Jean Marie Mbuyi-Muamba, Michel Ntetani Aloni","doi":"10.1155/2017/7916348","DOIUrl":"https://doi.org/10.1155/2017/7916348","url":null,"abstract":"Background. The aim of this study was to investigate and determine the risk factors associated with poor growth among SCA children. Methods. A cross-sectional study was conducted in Kinshasa, the capital's country. The nutritional status was assessed using the Z scores of the anthropometric indices. Results. We gathered data on the 256 patients, 138 females (53.9%), who entered the study. The mean age at presentation was 8.4 ± 4.9 years of age. Underweight, stunting, and wasting were found, respectively, in 47.7%, 10.5%, and 50.3% of SCA children. A history of hand-foot syndrome, more than 3 blood transfusions, being less than 12 months of age when receiving the first transfusion, more than two severe sickle crises per year, a medical history of severe infections, and the presence of hepatomegaly were associated with poor growth. When comparing sickle cell patients under 12 years of age (n = 159) to a group of 296 age-matched children with normal Hb-AA, a significantly higher proportion of subjects with stunting and underweight were found among SCA. Conclusion. Nutritional status encountered in Congolese sickle cell children has been described for the first time in this study. A high prevalence of poor growth in SCA children was found in our study.","PeriodicalId":46055,"journal":{"name":"Anemia","volume":"2017 ","pages":"7916348"},"PeriodicalIF":2.9,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/7916348","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34775927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 25

Prevalence, Severity, and Determinant Factors of Anemia among Pregnant Women in South Sudanese Refugees, Pugnido, Western Ethiopia 埃塞俄比亚西部普格尼多南苏丹难民孕妇贫血的患病率、严重程度和决定因素

IF 2.9

Anemia Pub Date : 2016-12-12 DOI: 10.1155/2016/9817358

Aklilu Alemayehu, Lealem Gedefaw, T. Yemane, Yaregal Asres

{"title":"Prevalence, Severity, and Determinant Factors of Anemia among Pregnant Women in South Sudanese Refugees, Pugnido, Western Ethiopia","authors":"Aklilu Alemayehu, Lealem Gedefaw, T. Yemane, Yaregal Asres","doi":"10.1155/2016/9817358","DOIUrl":"https://doi.org/10.1155/2016/9817358","url":null,"abstract":"Background. Anemia is one of the major health problems among refugee pregnant women in the world. Anemia among pregnant women is multifactorial and results in detrimental consequences on the mothers and infants. The aim of this study was to determine the prevalence, severity, and determinants of anemia among pregnant women in South Sudanese refugees, Pugnido western, Ethiopia. Methods. A facility-based cross-sectional study was conducted in Pugnido Administration Refugee and Returnee Affairs Health Center from April 15 to June 30, 2015. Demographic and related data were collected using questionnaire based interview. Complete blood count was done using CELL-DYN 1800 (Abbott USA). Blood smear and fecal specimen were examined for hemoparasite and intestinal parasite, respectively. Bivariate and multivariate logistic regression analyses were done using SPSS-Version 20.0. Results. The overall prevalence of anemia was 36.1%, from whom 2.3% had severe anemia. Being in third trimester, eating meat at most once a week, drinking tea immediately after meal at least once a day, having mid-upper arm circumference below 21 centimeters, and intestinal parasitic infection were identified as independent factors of anemia. Conclusion. More than one-third of pregnant women had anemia in this study. Intervention based strategies on identified determinant factors will be very important to combat anemia among the group.","PeriodicalId":46055,"journal":{"name":"Anemia","volume":"2016 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2016-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/9817358","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64641823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 33

Malaria, Moderate to Severe Anaemia, and Malarial Anaemia in Children at Presentation to Hospital in the Mount Cameroon Area: A Cross-Sectional Study 喀麦隆山地区送医儿童的疟疾、中度至重度贫血和疟疾贫血:一项横断面研究

IF 2.9

Anemia Pub Date : 2016-11-08 DOI: 10.1155/2016/5725634

I. Sumbele, Sharon Odmia Sama, H. Kimbi, G. S. Taiwé

{"title":"Malaria, Moderate to Severe Anaemia, and Malarial Anaemia in Children at Presentation to Hospital in the Mount Cameroon Area: A Cross-Sectional Study","authors":"I. Sumbele, Sharon Odmia Sama, H. Kimbi, G. S. Taiwé","doi":"10.1155/2016/5725634","DOIUrl":"https://doi.org/10.1155/2016/5725634","url":null,"abstract":"Background. Malaria remains a major killer of children in Sub-Saharan Africa, while anaemia is a public health problem with significant morbidity and mortality. Examining the factors associated with moderate to severe anaemia (MdSA) and malarial anaemia as well as the haematological characteristics is essential. Methodology. Children (1–14 years) at presentation at the Regional Hospital Annex-Buea were examined clinically and blood samples were collected for malaria parasite detection and full blood count evaluation. Results. Plasmodium falciparum, anaemia, and malarial anaemia occurred in 33.8%, 62.0%, and 23.6% of the 216 children, respectively. Anaemia prevalence was significantly higher in malaria parasite positive children and those with fever than their respective counterparts. MdSA and moderate to severe malarial anaemia (MdSMA) were detected in 38.0% and 15.3% of the participants, respectively. The prevalence of MdSA was significantly higher in children whose household head had no formal education, resided in the lowland, or was febrile, while MdSMA was significantly higher in febrile children only. Children with MdSMA had significantly lower mean white blood cell, lymphocyte, and platelet counts while the mean granulocyte count was significantly higher. Conclusion. Being febrile was the only predictor of both MdSA and MdSMA. More haematological insult occurred in children with MdSMA compared to MdSA.","PeriodicalId":46055,"journal":{"name":"Anemia","volume":"1 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2016-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/5725634","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64436816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 49

Erythropoiesis in Malaria Infections and Factors Modifying the Erythropoietic Response 疟疾感染中的红细胞生成和改变红细胞生成反应的因素

IF 2.9

Anemia Pub Date : 2016-02-29 DOI: 10.1155/2016/9310905

V. Pathak, K. Ghosh

引用次数: 37

Prevalence of Anemia and Its Associated Factors among Pregnant Women Attending Antenatal Care in Health Institutions of Arba Minch Town, Gamo Gofa Zone, Ethiopia: A Cross-Sectional Study 埃塞俄比亚Gamo Gofa区Arba Minch镇卫生机构产前保健孕妇贫血患病率及其相关因素:一项横断面研究

IF 2.9

Anemia Pub Date : 2016-02-22 DOI: 10.1155/2016/1073192

A. Bekele, M. Tilahun, Aleme Mekuria

{"title":"Prevalence of Anemia and Its Associated Factors among Pregnant Women Attending Antenatal Care in Health Institutions of Arba Minch Town, Gamo Gofa Zone, Ethiopia: A Cross-Sectional Study","authors":"A. Bekele, M. Tilahun, Aleme Mekuria","doi":"10.1155/2016/1073192","DOIUrl":"https://doi.org/10.1155/2016/1073192","url":null,"abstract":"Background. Anemia during pregnancy is a major cause of morbidity and mortality of pregnant women in developing countries and has both maternal and fetal consequences. Despite its known serious effect on health, there is very little research based evidence on this vital public health problem in Gamo Gofa zone in general and in Arba Minch town of Southern Ethiopia in particular. Therefore, this study aims to assess the prevalence and factors associated with anemia among pregnant women attending antenatal care in health institutions of Arba Minch town, Gamo Gofa zone, Southern Ethiopia. Method. Institution-based, cross-sectional study was conducted from February 16 to April 8, 2015, among 332 pregnant women who attended antenatal care at government health institutions of Arba Minch town. Interviewer-administered questionnaire supplemented by laboratory tests was used to obtain the data. Bivariate and multivariate logistic regressions were used to identify predictors of anemia. Result. The prevalence of anemia among antenatal care attendant pregnant women of Arba Minch town was 32.8%. Low average monthly income of the family (AOR = 4.0; 95% CI: 5.62–11.01), having birth interval less than two years (AOR = 3.1; 95% CI: 6.01, 10.23), iron supplementation (AOR = 2.31; 95% CI: 7.21, 9.31), and family size >2 (AOR = 2.8; 95% CI: 1.17, 6.81) were found to be independent predictors of anemia in pregnancy. Conclusion. Anemia is found to be a moderate public health problem in the study area. Low average monthly income, birth interval less than two years, iron supplementation, and large family size were found to be risk factors for anemia in pregnancy. Awareness creation towards birth spacing, nutritional counselling on consumption of iron-rich foods, and iron supplementation are recommended to prevent anemia among pregnant women with special emphasis on those having low income and large family size.","PeriodicalId":46055,"journal":{"name":"Anemia","volume":"2016 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2016-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/1073192","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64203245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 94

Antianemic Treatment of Cancer Patients in German Routine Practice: Data from a Prospective Cohort Study—The Tumor Anemia Registry 德国常规实践中癌症患者的抗贫血治疗:来自肿瘤贫血登记的前瞻性队列研究的数据

IF 2.9

Anemia Pub Date : 2016-02-04 DOI: 10.1155/2016/8057650

T. Steinmetz, J. Schröder, M. Plath, H. Link, M. Vogt, M. Frank, N. Marschner

{"title":"Antianemic Treatment of Cancer Patients in German Routine Practice: Data from a Prospective Cohort Study—The Tumor Anemia Registry","authors":"T. Steinmetz, J. Schröder, M. Plath, H. Link, M. Vogt, M. Frank, N. Marschner","doi":"10.1155/2016/8057650","DOIUrl":"https://doi.org/10.1155/2016/8057650","url":null,"abstract":"The aim of this prospective cohort study was to assess current antianemic treatment of cancer patients in German routine practice, including diagnostics, treatments, and quality of life (QoL). 88 study sites recruited 1018 patients at the start of antianemic treatment with hemoglobin (Hb) levels <11 g/dL (females) or <12 g/dL (males). Patients were followed up for 12 weeks. 63% of the patients had inoperable solid tumors, 22% operable solid tumors, and 15% hematological malignancies. Over 85% received chemotherapy. Median age was 67 years; 48% were male. Red blood cell transfusions (RBCTx) were given to 59% of all patients and to 55% of the patients with Hb ≥8 g/dL on day 1 of the observation period (day 1 treatment). Erythropoiesis-stimulating agents (ESAs) were the second most frequently applied day 1 treatment (20%), followed by intravenous (IV) iron (15%) and ESA + IV iron (6%). Only about a third of patients were tested for blood serum iron parameters at the start of treatment. Overall, more than half of the patients had long-term responses to antianemic therapy. Our data suggest that in routine practice diagnostics for treatable causes of anemia are underused. A high proportion of cancer patients receive RBCTx. It should be discussed whether thorough diagnostics and earlier intervention could decrease the need for RBCTx. This trial is registered with NCT01795690.","PeriodicalId":46055,"journal":{"name":"Anemia","volume":"2016 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2016-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/8057650","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64547205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Sickle-Cell Disease Healthcare Cost in Africa: Experience of the Congo 非洲镰状细胞病的医疗费用:刚果的经验

IF 2.9

Anemia Pub Date : 2016-02-02 DOI: 10.1155/2016/2046535

L. Ngolet, M. Moyen Engoba, I. Kocko, A. Elira Dokékias, J. Mombouli, G. Moyen

{"title":"Sickle-Cell Disease Healthcare Cost in Africa: Experience of the Congo","authors":"L. Ngolet, M. Moyen Engoba, I. Kocko, A. Elira Dokékias, J. Mombouli, G. Moyen","doi":"10.1155/2016/2046535","DOIUrl":"https://doi.org/10.1155/2016/2046535","url":null,"abstract":"Background. Lack of medical coverage in Africa leads to inappropriate care that has an impact on the mortality rate. In this study, we aimed to evaluate the cost of severe acute sickle-cell related complications in Brazzaville. Methods. A retrospective study was conducted in 2014 in the Paediatric Intensive Care Unit. It concerned 94 homozygote sickle-cell children that developed severe acute sickle-cell disease related complications (average age 69 months). For each patient, we calculated the cost of care complication. Results. The household income was estimated as low (<XAF 90,000/<USD 158.40) in 27.7%. The overall median cost for hospitalization for sickle-cell related acute complications was XAF 65,460/USD 115.21. Costs were fluctuating depending on the generating factors of the severe acute complications (p = 0.041). They were higher in case of complications generated by bacterial infections (ranging from XAF 66,765/USD 117.50 to XAF 135,271.50/USD 238.07) and lower in case of complications associated with malaria (ranging from XAF 28,305/49.82 to XAF 64,891.63/USD 114.21). The mortality rate was 17% and was associated with the cost of the case management (p = 0.006). Conclusion. The case management cost of severe acute complications of sickle-cell disease in children is high in Congo.","PeriodicalId":46055,"journal":{"name":"Anemia","volume":"2016 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2016-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/2046535","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64258115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14