Prabhudas Nelaturi, Sangeetha P Kademani, Krishna Sumanth Nallagangula, Sambandam Ravikumar
{"title":"Role of MicroRNAs in Alcohol-Related Liver Disease","authors":"Prabhudas Nelaturi, Sangeetha P Kademani, Krishna Sumanth Nallagangula, Sambandam Ravikumar","doi":"10.1080/07347324.2023.2256756","DOIUrl":"https://doi.org/10.1080/07347324.2023.2256756","url":null,"abstract":"Alcohol-related liver disease (ARLD) is the most prevalent type of chronic liver disease and one of the most serious health problems worldwide. Individuals consuming more than 40 g of alcohol per day can develop alcoholic fatty liver (AFL). Progression of AFL to alcoholic steatohepatitis leading to ARLD. The risk factors such as oxidative stress, inflammatory response, and genetic and epigenetic factors might explain considerable variation in ARLD pathogenesis. Diagnosis of patients with ARLD involved assessing alcohol use disorder and signs of advanced liver disease. Increasing number of patients with advanced stages of ARLD is observed due to failure in early detection and treatment. Alcohol abstinence, nutritional therapy and corticosteroids are the best treatment for all stages of ARLD. Therapies targeting IL-22/STAT3, TNF receptor superfamily, antioxidant signal, LPS, inflammasomes, hormones and microRNAs are used in treatment of ARLD as translational research. MicroRNAs are non-coding RNAs mainly involved in underlying mechanisms of development and pathogenesis of ARLD. The current review summarizes the role of aberrant regulation of microRNAs involved during oxidative stress, epigenetic modulations and inflammatory response in ARLD and also focused on the underlying mechanism of microRNAs in different stages of liver diseases such as liver fibrosis, liver cirrhosis and hepatocellular carcinoma.","PeriodicalId":45949,"journal":{"name":"Alcoholism Treatment Quarterly","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136108074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Alcohol-Induced Psychosis-Like Symptoms Leading to Abstinence from Alcohol","authors":"Shahnawaz Ahmad","doi":"10.1080/07347324.2023.2256686","DOIUrl":"https://doi.org/10.1080/07347324.2023.2256686","url":null,"abstract":"ABSTRACT This report discusses an 18-year-old adolescent who, after experiencing unusual psychosis-like symptoms following alcohol consumption, decided to abstain from alcohol. Although alcohol-induced psychosis is not rare, this case stands out as the adolescent’s symptoms sharply contrasted with typical expectations of alcohol’s effects, and the adolescent encountered traumatic hallucinations and fear after consuming alcohol, leading to days of discomfort and difficulty concealing his experiences from his parents; faced with the risk of his parents discovering his alcohol use, he decided to quit entirely and maintain abstinence from alcohol.","PeriodicalId":45949,"journal":{"name":"Alcoholism Treatment Quarterly","volume":"1 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2023-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42757691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Current and Emerging Research for Alcohol and Substance Treatment","authors":"Zachery Sneed, Regina B. Baronia","doi":"10.1080/07347324.2023.2253513","DOIUrl":"https://doi.org/10.1080/07347324.2023.2253513","url":null,"abstract":"We conclude the 41 volume of our journal with a good selection of interesting and useful studies, reports and works. The final issue for this volume highlights studies on providers and special populations in treatment and recovery. Belus and colleagues present their findings from a clinical trial with a focus on how sexual or gender minority (SGM) status may influence treatment outcomes. These researchers examined an abstinence-focused mixed inpatient-outpatient substance use treatment program within a predominantly unemployed population of African Americans who were living with HIV. The research presents findings on substance use/reuse rates. The identified rates among individuals with a sexual or gender minority (SGM) status differed in that there was an increased risk of reuse among SGM individuals. Bobak presents a brief report, via program evaluation methodology, on an educational workshop completed in a recovery home. In particular, this workshop was focused on encouraging the use of medication-assisted treatments (MATs) and NARCAN to prevent and reduce opioid overdoses. Information is presented on participant abilities to identify an opioid overdose and take steps to reverse it. This report provides an example of a community-based organization implementing a novel program, subjecting it to research and focusing on quality enhancement. Ricciutti reports on an interesting study exploring the effect of stigma among mental health and chemical dependency counselors toward individuals treated for SUD, and found a range of participants in both professions holding stigma toward this client population. This showed a need to understand the predictors of stigma and how it may impact the quality of treatment provided. Next, Thorkildsen and peers report on an online survey that used scenarios to assess recovery perceptions and positive-risk taking approaches among mental health support workers. This group of workers treat clients with co-occurring disorders of mental illness and substance use. The authors found an overemphasis on topics and techniques common to the field including aversive and paternalistic strategies. The researchers asserted that recovery-oriented practices need a more thorough and authentic implementation within mental health settings. Namgyal Bhutia reported on the prevalence of substance use disorder in an Indian city. The authors noted a considerable number of deaths associated with substance use and a high percentage of respondents identified the impact of substances on their own communities. Concepts around stigma, acknowledgment, and increasing awareness within the community are presented. Hatch and colleagues offered a perspective on the use of Alcohol Severity Index (ASI) among incarcerated populations and noted several shortcomings in the assessment, including validity, time of assessment, and window of detection. The authors also advocate for improving assessment within the prison population with a focus on enhancing treat","PeriodicalId":45949,"journal":{"name":"Alcoholism Treatment Quarterly","volume":"41 1","pages":"371 - 372"},"PeriodicalIF":0.9,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48819602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Dialectical Behavior Therapy Skills Affecting Drinking in Daily Life","authors":"M. McCool","doi":"10.1080/07347324.2023.2251910","DOIUrl":"https://doi.org/10.1080/07347324.2023.2251910","url":null,"abstract":"ABSTRACT More research is needed on the effects of Dialectical Behavior Therapy (DBT) skills on alcohol use. Even less is known about how the use of DBT skills affects drinking in the daily lives of individuals receiving treatment. The present study aims to examine the effects of DBT skills on daily quantity of drinks consumed using DBT diary cards. Forty-eight participants were recruited from a partial hospitalization program. DBT skill domains and daily quantity of drinks consumed were measured using the program’s DBT diary card. Multilevel modeling procedures were used to examine the effects of each DBT skills domain and total DBT skills used on the same and next-day quantity of drinks consumed when controlling for age and length of stay. Previous-day mindfulness skills were the only predictor to achieve significance when applying a p-value correction. Prior to a p-value correction same-day emotion regulation and distress tolerance skills were associated with decreases in drinking. Individual DBT skills may be associated with decreases in drinking behaviors and more research is needed to examine them as mechanisms of behavior change.","PeriodicalId":45949,"journal":{"name":"Alcoholism Treatment Quarterly","volume":"41 1","pages":"504 - 517"},"PeriodicalIF":0.9,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41877187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Perspective on Using the Addiction Severity Index in Prison Populations","authors":"Shelby M. Hatch, Z. Nichols, Eugene W. Wang","doi":"10.1080/07347324.2023.2248924","DOIUrl":"https://doi.org/10.1080/07347324.2023.2248924","url":null,"abstract":"ABSTRACT Despite significant social efforts to reduce substance-related imprisonment, the United States prison population continues to have high percentages of individuals who suffer from substance use disorders. This already marginalized group continues to make up substantial portions of the incarcerated population. This perspective paper overviews the Alcohol Severity Index (ASI) and its use within incarcerated populations. It highlights several shortcomings of the assessment, including validity, time of the assessment, the window of detection, and individual inmate consequences due to high assessment scores. In addition, it advocates for change within the assessment process of substance use disorders within the prison population that would navigate toward better outcomes for both inmates and the prison system.","PeriodicalId":45949,"journal":{"name":"Alcoholism Treatment Quarterly","volume":"41 1","pages":"442 - 455"},"PeriodicalIF":0.9,"publicationDate":"2023-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46433469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Multidimensional Nature of Substance Use Disorder: Explorations in Gangtok","authors":"Yeshey Namgyal Bhutia","doi":"10.1080/07347324.2023.2244450","DOIUrl":"https://doi.org/10.1080/07347324.2023.2244450","url":null,"abstract":"ABSTRACT The study investigates the prevalence of substance use disorder and role of institutions in preventing it in Gangtok, a capital city of the northern Indian state of Sikkim. A survey of 816 respondents was undertaken using a short and easy-to-understand questionnaire. Results reveal that 64% of respondents identified persons with harmful drug use in their immediate families or in their neighborhoods and nearly same percentage of people conceal the actual cause of death in cases where death occurred due to drug overuse. The paper uncovers that cases of substance use disorder have increased and a considerable number of people are reported dying due to it, but families often hide the actual cause of death. The role of institutions is found to be limited in preventing it, as the process of knowledge transmission among families and patients with heavy drug use is abysmally slow. The study argues to empowering society with a potential tool, that is, knowledge transmission, and enabling them to devise meaningful tools to tackle rising cases of substance use disorder.","PeriodicalId":45949,"journal":{"name":"Alcoholism Treatment Quarterly","volume":"41 1","pages":"432 - 441"},"PeriodicalIF":0.9,"publicationDate":"2023-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44102913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ted J. Bobak, Noor Arjmand, Connor O’Brien, Mohammed F. Islam, L. Jason
{"title":"A Pilot Program Focusing on Perceptions and Acceptance of an Intervention on Medication-Assisted Treatments for Recovery Home Residents","authors":"Ted J. Bobak, Noor Arjmand, Connor O’Brien, Mohammed F. Islam, L. Jason","doi":"10.1080/07347324.2023.2248907","DOIUrl":"https://doi.org/10.1080/07347324.2023.2248907","url":null,"abstract":"ABSTRACT This brief report describes the first time a recovery home organization has both developed and evaluated an educational workshop aimed at encouraging the use of medication-assisted treatments (MATs) and NARCAN (naloxone) to prevent/reduce opioid overdoses. The one-hour program involving the use, misuse, and recovery potential of MATs and the opioid overdose reversal properties of NARCAN occurred for Oxford House residents who participated in 2019 (N = 522) and in 2021 (N = 887). Post-intervention ratings indicated that resident ratings indicated that recovery home residents acknowledged that they were able to recognize and reverse an opioid overdose, properly administer naloxone, and potentially save the life of someone who is overdosing on opioids. The findings suggest that this program might be effectively administered in recovery homes, and future studies will need to determine if the program is able to change attitudes and behaviors of residents.","PeriodicalId":45949,"journal":{"name":"Alcoholism Treatment Quarterly","volume":"41 1","pages":"386 - 393"},"PeriodicalIF":0.9,"publicationDate":"2023-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49580976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Mental Health and Chemical Dependency Counselors’ Stigma Toward Clients with Substance Use Disorders: Predictors of Stigma and Implications for Clinicians and Educators","authors":"Natalie M. Ricciutti","doi":"10.1080/07347324.2023.2246405","DOIUrl":"https://doi.org/10.1080/07347324.2023.2246405","url":null,"abstract":"ABSTRACT This study explored the degree to which counselors stigmatize individuals being treated for a SUD, and if specific characteristics predict stigma. Participants included 146 mental health counselors and chemical dependency counselors. A range of 15% to 26% of participants in both professions were found to hold stigma toward clients with SUDs, and all of the characteristics were found to have a proportion of variance ranging from .025 to .04 (or 2.5% to 4.0%). The results from this study warrant a need to explore predictors of stigma. Implications and recommendations to decrease stigma and improve the quality addiction treatment are provided.","PeriodicalId":45949,"journal":{"name":"Alcoholism Treatment Quarterly","volume":"41 1","pages":"394 - 407"},"PeriodicalIF":0.9,"publicationDate":"2023-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42381310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Group Psychotherapy with Addicted Populations: An Integration of Theory and Practice, 4th Edition","authors":"D. Schroeder, Evans H. Spears","doi":"10.1080/07347324.2023.2243233","DOIUrl":"https://doi.org/10.1080/07347324.2023.2243233","url":null,"abstract":"","PeriodicalId":45949,"journal":{"name":"Alcoholism Treatment Quarterly","volume":"41 1","pages":"518 - 519"},"PeriodicalIF":0.9,"publicationDate":"2023-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44879568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}