Journal of Clinical and Experimental Hematopathology最新文献_第9页

Benefit of prednisolone alone in nodal peripheral T-cell lymphoma with T follicular helper phenotype. 强的松龙单独治疗伴有T滤泡辅助表型的淋巴结周围T细胞淋巴瘤的益处。

IF 1.5

Journal of Clinical and Experimental Hematopathology Pub Date : 2023-01-01 DOI: 10.3960/jslrt.22038

Wataru Kitamura, Hiroki Kobayashi, Tomohiro Urata, Yumiko Sato, Yusuke Naoi, Tadashi Yoshino, Yoshinobu Maeda, Shoichi Kuyama

{"title":"Benefit of prednisolone alone in nodal peripheral T-cell lymphoma with T follicular helper phenotype.","authors":"Wataru Kitamura, Hiroki Kobayashi, Tomohiro Urata, Yumiko Sato, Yusuke Naoi, Tadashi Yoshino, Yoshinobu Maeda, Shoichi Kuyama","doi":"10.3960/jslrt.22038","DOIUrl":"https://doi.org/10.3960/jslrt.22038","url":null,"abstract":"A 71-year-old Japanese man presented with severe thrombocytopenia. A whole-body CT at presentation showed small cervical, axillary, and para-aortic lymphadenopathy, leading to suspicion of immune thrombocytopenia due to lymphoma. Biopsy was difficult to perform because of severe thrombocytopenia. Thus, he received prednisolone (PSL) therapy and his platelet count gradually recovered. Two and a half years after PSL therapy initiation, his cervical lymphadenopathy slightly progressed without other clinical symptoms. Hence, a biopsy from the left cervical lymph node was performed, and he was diagnosed with nodal peripheral T-cell lymphoma (PTCL) with T follicular helper (TFH) phenotype. Due to various complications, we continued treatment with prednisolone alone after the diagnosis of lymphoma; however, there was no further increase in lymph node enlargement and no other lymphoma-related symptoms for one and a half years after diagnosis. Although immunosuppressive therapy has been reported to produce a response in some patients with angioimmunoblastic T-cell lymphoma, our experience suggests that a similar subset may exist in patients with nodal PTCL with TFH phenotype, which has the same cellular origin. Immunosuppressive therapies may constitute an alternative treatment option even in the era of novel molecular-targeted therapies, especially for elderly patients who are ineligible for chemotherapy.","PeriodicalId":45936,"journal":{"name":"Journal of Clinical and Experimental Hematopathology","volume":"63 1","pages":"37-42"},"PeriodicalIF":1.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/21/ac/jslrt-63-37.PMC10158724.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9414227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Highlights: Follicular lymphoma. 亮点：滤泡性淋巴瘤

IF 1.5

Journal of Clinical and Experimental Hematopathology Pub Date : 2023-01-01 DOI: 10.3960/jslrt.23051

Katsuyoshi Takata

引用次数: 0

Use of R-mini-CHP in combination with polatuzumab vedotin (pola-R-mini-CHP) as the primary treatment in ≥80-year-old cases with diffuse large B-cell lymphoma. 将 R-mini-CHP 联合 polatuzumab vedotin（pola-R-mini-CHP）作为弥漫大 B 细胞淋巴瘤≥80 岁病例的主要治疗方法。

IF 1.5

Journal of Clinical and Experimental Hematopathology Pub Date : 2023-01-01 DOI: 10.3960/jslrt.23043

Yasunobu Sekiguchi, Hiroki Tsutsumi, Ayumi Gomyo, Masahisa Kudo, Yoshie Iizaki, Nobuo Maseki, Machiko Kawamura, Kazuhiko Kobayashi, Yu Nishimura, Hiroaki Kanda, Hideaki Nitta, Masaaki Noguchi, Hirofumi Kobayashi

引用次数: 0

Two cases of primary diffuse large B-cell lymphoma of the CNS associated with t(8;14)(q24;q32) or t(3;14)(q27;q32) identified by G-banding and fluorescence in situ hybridization applied to metaphase spreads. 2例CNS原发性弥漫性大b细胞淋巴瘤与t(8;14)(q24;q32)或t(3;14)(q27;q32)相关，g带和荧光原位杂交应用于中期扩散。

IF 1.5

Journal of Clinical and Experimental Hematopathology Pub Date : 2022-12-28 DOI: 10.3960/jslrt.22019

Hitoshi Ohno, Fumiyo Maekawa, Misumi Nakagawa, Yoshinari Chagi, Miho Nakagawa, Chiyuki Kishimori, Katsuhiro Fukutsuka, Masahiko Hayashida, Kayo Takeoka, Wataru Maruyama, Naoya Ukyo, Shinji Sumiyoshi

{"title":"Two cases of primary diffuse large B-cell lymphoma of the CNS associated with t(8;14)(q24;q32) or t(3;14)(q27;q32) identified by G-banding and fluorescence in situ hybridization applied to metaphase spreads.","authors":"Hitoshi Ohno, Fumiyo Maekawa, Misumi Nakagawa, Yoshinari Chagi, Miho Nakagawa, Chiyuki Kishimori, Katsuhiro Fukutsuka, Masahiko Hayashida, Kayo Takeoka, Wataru Maruyama, Naoya Ukyo, Shinji Sumiyoshi","doi":"10.3960/jslrt.22019","DOIUrl":"https://doi.org/10.3960/jslrt.22019","url":null,"abstract":"We describe two patients with primary diffuse large B-cell lymphoma of the central nervous system (PCNS-DLBCL). The first patient (case 1) was a woman in her late 70s who presented with a tumor in the left frontal lobe, whereas the second patient (case 2) was a man in his early 70s who presented with a left frontal lobe tumor associated with intratumoral hemorrhage. The histopathology of the tumor specimen disclosed the proliferation of large cells with centroblastic (case 1) or immunoblastic/plasmablastic (case 2) cytomorphology and an accumulation of the tumor cells within the perivascular space. The cells in both cases were positive for CD20, CD79a, BCL6, IRF4/MUM1, MYC, and BCL2 and negative for CD5 and CD10. G-banding revealed t(8;14)(q24;q32) in case 1, and the tetraploid-range karyotype including two or three copies of der(3)t(3;14)(q27;q32) and der(14)t(3;14)(q27;q32) in case 2. Fluorescence in situ hybridization applied to metaphase spreads confirmed colocalization of MYC and IGH (case 1) and BCL6 and IGH (case 2) hybridization signals on the relevant derivative chromosomes. Case 1 carried the MYD88L265P mutation. This case report provides clear evidence for the occurrence of t(8;14)(q24;q32) and t(3;14)(q27;q32) in PCNS-DLBCL using metaphase-based cytogenetic analysis.","PeriodicalId":45936,"journal":{"name":"Journal of Clinical and Experimental Hematopathology","volume":"62 4","pages":"242-248"},"PeriodicalIF":1.5,"publicationDate":"2022-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/9c/0b/jslrt-62-242.PMC9898718.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10690103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Severe autoimmune pancytopenia after autologous hematopoietic stem cell transplantation for Hodgkin lymphoma. 自体造血干细胞移植治疗霍奇金淋巴瘤后严重自身免疫性全血细胞减少症。

IF 1.5

Journal of Clinical and Experimental Hematopathology Pub Date : 2022-12-28 DOI: 10.3960/jslrt.22006

Yuta Fukui, Akira Honda, Hirofumi Takano, Takafumi Obo, Hideaki Mizuno, Yosuke Masamoto, Mineo Kurokawa

{"title":"Severe autoimmune pancytopenia after autologous hematopoietic stem cell transplantation for Hodgkin lymphoma.","authors":"Yuta Fukui, Akira Honda, Hirofumi Takano, Takafumi Obo, Hideaki Mizuno, Yosuke Masamoto, Mineo Kurokawa","doi":"10.3960/jslrt.22006","DOIUrl":"https://doi.org/10.3960/jslrt.22006","url":null,"abstract":"Autoimmune pancytopenia is rarely seen with Hodgkin lymphoma, and only one pediatric case of pancytopenia after autologous hematopoietic stem cell transplantation (HSCT) has been reported. We herein report a case of autoimmune pancytopenia that developed after autologous HSCT for nodular lymphocyte predominant Hodgkin lymphoma (NLPHL). A 56-year-old Japanese woman underwent autologous HSCT for NLPHL. She developed autoimmune pancytopenia seven months after autologous HSCT. In this case, PSL was effective, and the blood cell counts normalized completely. However, the patient suffered from a fatal infection, probably because of immunosuppression caused by prolonged administration of PSL, as well as a history of several chemotherapies and autologous HSCT. To our knowledge, this is the first adult case of autoimmune pancytopenia after autologous HSCT for Hodgkin lymphoma. To further validate the optimal treatment strategy for autoimmune cytopenia after autologous HSCT, more cases are necessary.","PeriodicalId":45936,"journal":{"name":"Journal of Clinical and Experimental Hematopathology","volume":"62 4","pages":"217-221"},"PeriodicalIF":1.5,"publicationDate":"2022-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b8/9d/jslrt-62-217.PMC9898711.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10700335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Acute undifferentiated leukemia limited to neck lymph nodes and a large mediastinal mass. 急性未分化白血病局限于颈部淋巴结和大纵隔肿块。

IF 1.5

Journal of Clinical and Experimental Hematopathology Pub Date : 2022-12-28 DOI: 10.3960/jslrt.22012

Kenta Hayashino, Masayuki Matsuda, Keigo Fujishita, Jun Iwata, Miki Mizobuchi, Munenori Uemura, Kenji Yorita, Akiko Maeshima, Toshi Imai

{"title":"Acute undifferentiated leukemia limited to neck lymph nodes and a large mediastinal mass.","authors":"Kenta Hayashino, Masayuki Matsuda, Keigo Fujishita, Jun Iwata, Miki Mizobuchi, Munenori Uemura, Kenji Yorita, Akiko Maeshima, Toshi Imai","doi":"10.3960/jslrt.22012","DOIUrl":"https://doi.org/10.3960/jslrt.22012","url":null,"abstract":"In the 2016 update of the World Health Organization (WHO) classification of myeloid neoplasms, acute undifferentiated leukemia (AUL) was defined by a lack of lineage-specific markers. AUL has very poor prognosis and no established therapies due to its rarity. We report a case of a 31-year-old man with AUL who showed complete molecular response to an acute lymphoblastic leukemia (ALL)-based regimen and received allogeneic hematopoietic stem cell transplantation. The patient's blast cells were CD7-positive and localized to lymph nodes in the neck and to a large mediastinal mass; there was also rearrangement of the T-cell receptor delta locus. Although the tumor showed characteristics of T-cell lymphoblastic lymphoma, it was categorized as AUL based on WHO classification. This case suggests that a high-intensity conditioning regimen could be effective for rare cases of AUL that present only in the extramedullary mass, and chemotherapy for AUL should be selected based on the characteristics of the blasts.","PeriodicalId":45936,"journal":{"name":"Journal of Clinical and Experimental Hematopathology","volume":"62 4","pages":"222-225"},"PeriodicalIF":1.5,"publicationDate":"2022-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f6/e3/jslrt-62-222.PMC9898720.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10700334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diffuse large B-cell lymphoma in the course of systemic sarcoidosis: A case report and review of 30 Japanese patients with sarcoidosis-lymphoma syndrome. 弥漫性大b细胞淋巴瘤伴全身性结节病:30例日本结节病-淋巴瘤综合征病例报告及复习。

IF 1.5

Journal of Clinical and Experimental Hematopathology Pub Date : 2022-12-28 DOI: 10.3960/jslrt.22015

Toshihiko Matsuo, Takehiro Tanaka, Rika Omote, Toshiaki Okada, Kenji Notohara, Kazuya Okada

{"title":"Diffuse large B-cell lymphoma in the course of systemic sarcoidosis: A case report and review of 30 Japanese patients with sarcoidosis-lymphoma syndrome.","authors":"Toshihiko Matsuo, Takehiro Tanaka, Rika Omote, Toshiaki Okada, Kenji Notohara, Kazuya Okada","doi":"10.3960/jslrt.22015","DOIUrl":"https://doi.org/10.3960/jslrt.22015","url":null,"abstract":"We report a patient with sarcoidosis who developed diffuse large B-cell lymphoma. A 71-year-old woman with persistent cough was diagnosed pathologically with sarcoidosis by resection of the right upper lung lobe with a nodule after an unsuccessful attempt of transbronchial needle aspiration for mediastinal lymphadenopathy. She was referred for an eye examination and found to have spotty retinal degeneration on the lower fundi of both eyes, together with residual macular edema and vitreous opacity in the left eye. At 76 years, she underwent cataract surgery and vitrectomy to gain a visual acuity of 0.6 in the left eye. At 77 years, she developed a cough and fever, and showed leukopenia and thrombocytopenia. Computed tomography showed multiple small nodular lesions in both lungs, and bilateral hilar, mediastinal, and hepatic lymphadenopathy. Fluorodeoxyglucose positron emission tomography demonstrated high uptake in the liver, spleen, pancreatic head, and lymph nodes. Bone marrow biopsy was intact, but liver biopsy revealed anomalous large lymphoid cells in the sinusoids which were positive for CD20 and showed a high Ki-67 index, leading to the diagnosis of diffuse large B-cell lymphoma. Chemotherapy with 8 courses of THP-COP (cyclophosphamide, pirarubicin, vincristine, and prednisolone) with rituximab, followed by intrathecal injection of methotrexate, cytarabine, and dexamethasone, resulted in complete remission. She maintained complete remission for 10 years until 88 years old at present. The literature review found 30 patients, including this case, who developed lymphoma in the course of sarcoidosis. A novel pathological diagnosis is required in the setting of acute symptomatic changes and novel lesions on imaging in patients with sarcoidosis.","PeriodicalId":45936,"journal":{"name":"Journal of Clinical and Experimental Hematopathology","volume":"62 4","pages":"226-237"},"PeriodicalIF":1.5,"publicationDate":"2022-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/1e/48/jslrt-62-226.PMC9898715.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10695884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Immunohistochemistry for IRTA1 and MNDA helps differentiate gastric MALT lymphoma from chronic gastritis/reactive lymphocyte hyperplasia. 免疫组织化学检测IRTA1和MNDA有助于区分胃MALT淋巴瘤与慢性胃炎/反应性淋巴细胞增生。

IF 1.5

Journal of Clinical and Experimental Hematopathology Pub Date : 2022-12-28 DOI: 10.3960/jslrt.22021

Yoshiyuki Ayada, Takuro Igawa, Yusuke Naoi, Kyosuke Horikawa, Tetsuya Tabata, Takehiro Tanaka, Tadashi Yoshino

{"title":"Immunohistochemistry for IRTA1 and MNDA helps differentiate gastric MALT lymphoma from chronic gastritis/reactive lymphocyte hyperplasia.","authors":"Yoshiyuki Ayada, Takuro Igawa, Yusuke Naoi, Kyosuke Horikawa, Tetsuya Tabata, Takehiro Tanaka, Tadashi Yoshino","doi":"10.3960/jslrt.22021","DOIUrl":"https://doi.org/10.3960/jslrt.22021","url":null,"abstract":"It is difficult to histologically differentiate extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) from chronic gastritis (CG)/ reactive lymphoid hyperplasia (RLH). To determine whether immunohistochemistry for IRTA1 and MNDA can differentiate gastric MALT lymphoma from CG/RLH, we investigated 81 stomach biopsy specimens [Wotherspoon grade (WG) 1, 11 cases; WG 2, 9 cases; WG 3, 20 cases; WG 4, 31 cases; and WG 5, 10 cases]. According to a previously reported algorithm involving PCR for immunoglobulin heavy (IgH) chain locus rearrangement, all 81 cases were divided into three groups: CG/RLH (55 cases), MALT lymphoma (19 cases) groups, and IgH undetectable group (7 cases). We analyzed the CG/RLH and MALT lymphoma groups. The median percentage of IRTA1-positive cells was 0% (range 0%-90.6%) in the CG/RLH group and 43.5% (range 0%-97.6%) in the MALT lymphoma group (p < 0.0001). The median percentage of MNDA-positive cells was 32.4% (range 0%-97.6%) in the CG/RLH group and 55.1% (range 0%-97.6%) in the MALT lymphoma group (p = 0.0044). These results indicate that immunohistochemistry for IRTA1 and MNDA can help differentiate gastric MALT lymphoma from CG/RLH.","PeriodicalId":45936,"journal":{"name":"Journal of Clinical and Experimental Hematopathology","volume":"62 4","pages":"195-201"},"PeriodicalIF":1.5,"publicationDate":"2022-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c9/29/jslrt-62-195.PMC9898717.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10690107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Two cases of follicular lymphoma with MYC gene abnormalities that presented with bone marrow necrosis. 2例滤泡性淋巴瘤伴MYC基因异常，表现为骨髓坏死。

IF 1.5

Journal of Clinical and Experimental Hematopathology Pub Date : 2022-12-28 DOI: 10.3960/jslrt.22004

Yuri Miyazawa, Hisashi Takei, Nobuhiko Kobayashi, Naoki Akashi, Yukiko Sairenji, Manato Sugisaki, Chiaki Naito, Tetsuya Ishikawa, Hiroaki Shimizu, Takuma Ishizaki, Akihiko Yokohama, Norifumi Tsukamoto, Yuka Yoshida, Nozomi Matsumura, Yoshiyasu Takayama, Hiroshi Handa

{"title":"Two cases of follicular lymphoma with MYC gene abnormalities that presented with bone marrow necrosis.","authors":"Yuri Miyazawa, Hisashi Takei, Nobuhiko Kobayashi, Naoki Akashi, Yukiko Sairenji, Manato Sugisaki, Chiaki Naito, Tetsuya Ishikawa, Hiroaki Shimizu, Takuma Ishizaki, Akihiko Yokohama, Norifumi Tsukamoto, Yuka Yoshida, Nozomi Matsumura, Yoshiyasu Takayama, Hiroshi Handa","doi":"10.3960/jslrt.22004","DOIUrl":"https://doi.org/10.3960/jslrt.22004","url":null,"abstract":"Bone marrow necrosis (BMN) occurs most frequently in hematological malignancies and sometimes in non-hematological disorders. Lymphoid diseases causing necrosis are regarded as high-grade disease. B-lymphoblastic leukemia/lymphoma is the most common malignant cause of BMN. Here, we present two patients with follicular lymphoma (FL) and MYC gene abnormalities who developed BMN. In one case of BMN, the necrosis disappeared in response to chemotherapy, and the patient survived with complete remission. In the other case, BMN remained even after chemotherapy, and effective chemotherapy could not be administered due to suppressed hematopoiesis, which led to the lymphoma worsening and the patient's death. Indolent lymphomas, such as FL, as in these cases, have the potential to develop BMN. It is important to detect the development of BMN and administer chemotherapy early to improve patient prognosis, since severe BMN prevents patients from receiving effective treatment.","PeriodicalId":45936,"journal":{"name":"Journal of Clinical and Experimental Hematopathology","volume":"62 4","pages":"208-216"},"PeriodicalIF":1.5,"publicationDate":"2022-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/9d/39/jslrt-62-208.PMC9898713.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10700330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cholesterol metabolism and lipid droplet vacuoles; a potential target for the therapy of aggressive lymphoma. 胆固醇代谢与脂滴液泡;治疗侵袭性淋巴瘤的潜在靶点。

IF 1.5

Journal of Clinical and Experimental Hematopathology Pub Date : 2022-12-28 DOI: 10.3960/jslrt.22023

Hiromu Yano, Yukio Fujiwara, Yoshihiro Komohara

{"title":"Cholesterol metabolism and lipid droplet vacuoles; a potential target for the therapy of aggressive lymphoma.","authors":"Hiromu Yano, Yukio Fujiwara, Yoshihiro Komohara","doi":"10.3960/jslrt.22023","DOIUrl":"https://doi.org/10.3960/jslrt.22023","url":null,"abstract":"Cholesterol uptake via LDL receptor (LDLR) is increased in some malignant tumors, and incorporated LDL contribute to lipid droplet formation. Burkitt's lymphoma is known to have a large number of vacuoles in the cytoplasm, however, intracellular vacuoles are also seen in high-grade lymphomas such as adult T-cell leukemia/lymphoma, diffuse large B-cell lymphoma and primary central nervous system lymphoma. Recent studies have shown that esterified cholesterol is the main component of these vacuoles and the expression of cholesterol metabolism-related molecules such as LDLR, acetyl-CoA acetyltransferase 1 (ACAT1) which esterifies free cholesterol, and scavenger receptor class B type I (SR-BI) which effluxes free cholesterol, was significantly upregulated in lymphoma cells. Moreover, negative feedback of LDLR was not regulated even under cholesterol-rich conditions in lymphoma cells. We found that cytoplasmic free cholesterol was increased by ACAT and SR-BI inhibitors (CI-976 and BLT-1, respectively), and the accumulation of free cholesterol induced lymphoma cell apoptosis. In addition, overexpression of lipid droplet surface proteins has been correlated with poor prognosis in several malignant tumor such as ovarian cancer and clear cell renal cell carcinoma, and it is important to evaluate lipid droplet formation in malignant tumors including lymphomas.","PeriodicalId":45936,"journal":{"name":"Journal of Clinical and Experimental Hematopathology","volume":"62 4","pages":"190-194"},"PeriodicalIF":1.5,"publicationDate":"2022-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/3f/6d/jslrt-62-190.PMC9898721.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10700877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3