FARMACIA HOSPITALARIA最新文献

{"title":"Phytosterol content in lipid components used in patients receiving parenteral nutrition.","authors":"David Berlana, Belén Montañes, Consuelo Pellicer, Amelia María Chica Marchal, Gabriel Mercadal-Orfila, Sara Espla, Paloma Castellano, Laia Pérez-Cordón, Carmen Ripa, Natividad Lago, Amparo Vázquez, Jan Thomas De Pourcq, Josep Lluch, Ana C Murcia López, Mariola Sirvent","doi":"10.1016/j.farma.2026.06.007","DOIUrl":"https://doi.org/10.1016/j.farma.2026.06.007","url":null,"abstract":"<p><strong>Objective: </strong>To quantify the phytosterol content of lipid emulsions (LE) used for parenteral nutrition (PN) and of lipid-based medications administered to PN patients, and to compare the phytosterol load across different formulations.</p><p><strong>Methods: </strong>Observational, cross-sectional, multicenter study. Over a 6-month period (September 2021-February 2022), 13 hospitals collected samples from different batches of multi-chamber PN bags, LE vials, and lipid-containing medications used in patients receiving PN. Phytosterols were analyzed by gas chromatography with flame ionization detection. A descriptive and comparative analysis was carried out between products and emulsion groups (pure soybean oil, and mixtures containing medium-chain triglycerides, olive oil, or fish oil).</p><p><strong>Results: </strong>Phytosterol content was determined in 76 samples: 62 multi-chamber bags, 12 LE vials, and 2 propofol vials. Multi-chamber bags containing omega-3-enriched emulsions had a significantly lower phytosterol load than those without omega-3 (808.8; standard deviation [SD] 109.8 vs 1,210.4; SD 262.6 μg/g lipid; p < 0.01). Bags with 100% soybean oil lipids showed the highest phytosterol content (1,879.3; SD 111.2 vs 944.9; SD 195.6 μg/g lipid; p < 0.01). An additional phytosterol contribution was observed from lipid-based drugs such as propofol (109.4; SD 6.2 μg/mL).</p><p><strong>Conclusions: </strong>Phytosterol content in PN varies substantially according to the lipid emulsion used. Formulations that include fish oil and reduce the proportion of soybean oil deliver a lower phytosterol load, which may be advantageous in patients at risk of PN-associated liver dysfunction. These findings provide an objective basis for product selection and for future studies exploring the relationship between phytosterol exposure and PN-related hepatotoxicity.</p>","PeriodicalId":45860,"journal":{"name":"FARMACIA HOSPITALARIA","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148882001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clasificación normalizada de intervenciones farmacéuticas en unidades de cuidados intensivos","authors":"Esther Domingo Chiva,&nbsp;Fernando Becerril Moreno,&nbsp;Miguel Ángel Amor García,&nbsp;Laura Doménech Moral,&nbsp;Tatiana Betancor García,&nbsp;Carla Bastida Fernández,&nbsp;Marta Albanell Fernández,&nbsp;Irene Aquerreta González,&nbsp;Sara Cobo Sacristán,&nbsp;Amaia Egüés Lugea,&nbsp;Aurora Fernández Polo,&nbsp;Sara Ortiz Pérez,&nbsp;María Martín Cerezuela","doi":"10.1016/j.farma.2026.01.008","DOIUrl":"10.1016/j.farma.2026.01.008","url":null,"abstract":"<div><div>A standardized classification system was developed to harmonize the documentation of pharmaceutical interventions throughout the pharmacotherapeutic process in intensive care units caring for critically ill adult patients. The Intensive Care and Critical Patient Pharmacists Group (FarMIC) created an initial proposal, which was evaluated in a first phase through one week of intervention recording. After analyzing 168 interventions, modifications were made to improve applicability. In a subsequent phase, volunteer hospital pharmacists used the adapted classification for another week, documenting an additional 562 interventions. The analysis of discrepancies and suggestions allowed the consensus of a final classification comprising 35 types of interventions related to issues in indication, effectiveness, safety, and other aspects such as pharmacist consultations, therapeutic drug monitoring, and nutritional support. This classification provides a homogeneous framework that facilitates the standardization of pharmaceutical interventions in critically ill patients and promotes data comparability across centers.</div></div>","PeriodicalId":45860,"journal":{"name":"FARMACIA HOSPITALARIA","volume":"50 5","pages":"Pages 325-330"},"PeriodicalIF":1.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147366952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Translated article] Standardized classification of pharmaceutical interventions in intensive care units","authors":"Esther Domingo Chiva,&nbsp;Fernando Becerril Moreno,&nbsp;Miguel Ángel Amor García,&nbsp;Laura Doménech Moral,&nbsp;Tatiana Betancor García,&nbsp;Carla Bastida Fernández,&nbsp;Marta Albanell Fernández,&nbsp;Irene Aquerreta González,&nbsp;Sara Cobo Sacristán,&nbsp;Amaia Egüés Lugea,&nbsp;Aurora Fernández Polo,&nbsp;Sara Ortiz Pérez,&nbsp;María Martín Cerezuela","doi":"10.1016/j.farma.2026.03.011","DOIUrl":"10.1016/j.farma.2026.03.011","url":null,"abstract":"<div><div>A standardized classification system was developed to harmonize the documentation of pharmaceutical interventions throughout the pharmacotherapeutic process in intensive care units caring for critically ill adult patients. The Intensive Care and Critical Patient Pharmacists Group (FarMIC) created an initial proposal, which was evaluated in a first phase through one week of intervention recording. After analyzing 168 interventions, modifications were made to improve applicability. In a subsequent phase, volunteer hospital pharmacists used the adapted classification for another week, documenting an additional 562 interventions. The analysis of discrepancies and suggestions allowed the consensus of a final classification comprising 35 types of interventions related to issues in indication, effectiveness, safety, and other aspects such as pharmacist consultations, therapeutic drug monitoring, and nutritional support. This classification provides a homogeneous framework that facilitates the standardization of pharmaceutical interventions in critically ill patients and promotes data comparability across centers.</div></div>","PeriodicalId":45860,"journal":{"name":"FARMACIA HOSPITALARIA","volume":"50 5","pages":"Pages T325-T330"},"PeriodicalIF":1.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147844189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prioridades, motivaciones, preocupaciones y expectativas generacionales de los farmacéuticos hospitalarios en España","authors":"Covadonga Pérez Menéndez Conde,&nbsp;Beatriz Martínez Castro,&nbsp;María Pérez Abánades,&nbsp;Edurne Fernández de Gamarra-Martínez,&nbsp;Eva Negro-Vega","doi":"10.1016/j.farma.2026.01.007","DOIUrl":"10.1016/j.farma.2026.01.007","url":null,"abstract":"<div><h3>Objective</h3><div>To analyze generational differences in priorities, motivations, concerns, and professional expectations among pharmacists working in Hospital Pharmacy Services in Spain, in order to generate actionable evidence to guide strategies for managing intergenerational relationships and work engagement, as well as professional development and team well-being.</div></div><div><h3>Method</h3><div>Cross-sectional descriptive study based on an online survey of members of the Spanish Society of Hospital Pharmacists (SEFH) who were practicing as pharmacists or undergoing specialty training in Hospital Pharmacy Services in Spain. The questionnaire, reviewed by an expert panel, was administered from 16 to 29 January 2024 and comprised 18 items grouped into three sections: demographic data, socio-occupational context, and professional domain. Descriptive and between-generation comparative analyses were conducted using ANOVA, Kruskal–Wallis, Fisher's exact test, and χ² (<em>p</em> &lt; 0.05).</div></div><div><h3>Results</h3><div>A total of 620 professionals participated (16% of SEFH members). Recommendation of the hospital as a workplace was high and similar across generations; however, ratings of the Hospital Pharmacy Service and perceptions of the current status of Hospital Pharmacy differed, with higher scores among older cohorts. Work climate and work–life balance were the most valued job factors, with generational preferences differing for items such as teaching, professional recognition, and autonomy. Stress was the most frequently reported concern across all cohorts, with intergenerational differences in other work-related factors. Generational variation was also observed in key work concerns, professional motivations, perceptions of the current state of Hospital Pharmacy, and strategic priorities. Differences by generation were also observed in professional motivations and expectations, including institutional engagement and perceived future challenges in Hospital Pharmacy.</div></div><div><h3>Conclusions</h3><div>This study shows intergenerational differences in priorities, concerns, motivations, and expectations among hospital pharmacists. Although work climate and work–life balance remain among the most selected priorities and stress is the main concern across all cohorts, generation-specific patterns across the evaluated dimensions suggest the need for management and professional development approaches tailored to multigenerational teams.</div></div>","PeriodicalId":45860,"journal":{"name":"FARMACIA HOSPITALARIA","volume":"50 5","pages":"Pages 331-339"},"PeriodicalIF":1.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147460474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Translated article] Generational priorities, motivations, concerns, and expectations of hospital pharmacists in Spain","authors":"Covadonga Pérez Menéndez Conde,&nbsp;Beatriz Martínez Castro,&nbsp;María Pérez Abánades,&nbsp;Edurne Fernández de Gamarra-Martínez,&nbsp;Eva Negro-Vega","doi":"10.1016/j.farma.2026.03.013","DOIUrl":"10.1016/j.farma.2026.03.013","url":null,"abstract":"<div><h3>Objective</h3><div>To analyze generational differences in priorities, motivations, concerns, and professional expectations among pharmacists working in Hospital Pharmacy Services in Spain, in order to generate actionable evidence to guide strategies for managing intergenerational relationships and work engagement, as well as professional development and team well-being.</div></div><div><h3>Method</h3><div>Cross-sectional descriptive study based on an online survey of members of the Spanish Society of Hospital Pharmacists who were practicing as pharmacists or undergoing specialty training in Hospital Pharmacy Services in Spain. The questionnaire, reviewed by an expert panel, was administered from 16 to 29 January 2024 and comprised 18 items grouped into three sections: demographic data, socio-occupational context, and professional domain. Descriptive and between-generation comparative analyses were conducted using ANOVA, Kruskal–Wallis, Fisher's exact test, and χ² (<em>p</em> &lt; 0.05).</div></div><div><h3>Results</h3><div>A total of 620 professionals participated (16% members). Recommendation of the hospital as a workplace was high and similar across generations; however, ratings of the Hospital Pharmacy Service and perceptions of the current status of Hospital Pharmacy differed, with higher scores among older cohorts. Work climate and work–life balance were the most valued job factors, with generational preferences differing for items such as teaching, professional recognition, and autonomy. Stress was the most frequently reported concern across all cohorts, with intergenerational differences in other work-related factors. Generational variation was also observed in key work concerns, professional motivations, perceptions of the current state of Hospital Pharmacy, and strategic priorities. Differences by generation were also observed in professional motivations and expectations, including institutional engagement and perceived future challenges in Hospital Pharmacy.</div></div><div><h3>Conclusions</h3><div>This study shows intergenerational differences in priorities, concerns, motivations, and expectations among hospital pharmacists. Although work climate and work–life balance remain among the most selected priorities and stress is the main concern across all cohorts, generation-specific patterns across the evaluated dimensions suggest the need for management and professional development approaches tailored to multigenerational teams.</div></div>","PeriodicalId":45860,"journal":{"name":"FARMACIA HOSPITALARIA","volume":"50 5","pages":"Pages T331-T339"},"PeriodicalIF":1.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147864524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors for emergency department revisit among elderly patients with gastrointestinal bleeding secondary to oral anticoagulant therapy","authors":"Andrea Garrido Quintero,&nbsp;Silvia Cercas Lobo,&nbsp;Jesus Ruiz Ramos,&nbsp;Adrián Plaza Díaz,&nbsp;Ane González Díez,&nbsp;Antonio Cañón Santos,&nbsp;Ana Villarejo Jiménez,&nbsp;María Carmenza Pérez Méndez,&nbsp;Mireia Puig Campmany","doi":"10.1016/j.farma.2025.12.009","DOIUrl":"10.1016/j.farma.2025.12.009","url":null,"abstract":"<div><h3>Background</h3><div>Gastrointestinal bleeding is a frequent cause of emergency department visits among anticoagulated patients. Antidepressants may potentiate bleeding risk by impairing platelet aggregation. The impact of concomitant antidepressant use on emergency room re-visits for gastrointestinal bleeding in anticoagulated elderly patients remains unclear.</div></div><div><h3>Objective</h3><div>This study aimed to assess the risk factors for Emergency Department (ED) re-visit within 90 days after an initial bleeding episode in elderly patients on oral anticoagulant (OAC) therapy.</div></div><div><h3>Methods</h3><div>A retrospective observational study was conducted at a hospital in Catalonia, including patients over 65 years treated with OACs who presented to the ED for gastrointestinal bleeding between 2018 and 2024. Data were obtained from electronic health records, including comorbidities, chronic medications, and discharge treatments. The primary outcome was ED revisit for bleeding within 90 days. Multivariate logistic regression was used to identify independent predictors.</div></div><div><h3>Results</h3><div>Of 143 patients included [mean age 82.4 years; 51.7% women], 26.7% were on antidepressants, 8.3% on antiplatelet agents, and 77.6% on proton pump inhibitors. Over a mean follow-up of 90 days, 23,1% patients re-visited the emergency room with bleeding. Univariate analysis identified chronic kidney disease, antidepressant therapy, and antiplatelet use as significant factors. In multivariate models, independent predictors were chronic kidney disease (OR 2.50; 95% CI 1.07–5.85; p = 0.034), antidepressant use (OR 2.56; 95% CI 1.07–6.14; p = 0.034), and concomitant antiplatelet therapy (OR 4.55; 95% CI 1.27–16.28; p = 0.020).</div></div><div><h3>Conclusions</h3><div>In elderly patients anticoagulated, the addition of antidepressants significantly increases the risk of ED re-visit for gastrointestinal bleeding within 90 days. Chronic kidney disease and concomitant antiplatelet therapy also emerge as key risk factors.</div></div>","PeriodicalId":45860,"journal":{"name":"FARMACIA HOSPITALARIA","volume":"50 5","pages":"Pages 303-307"},"PeriodicalIF":1.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146203344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Artículo traducido] Riesgo de reconsulta a urgencias en pacientes ancianos con hemorragia gastrointestinal secundaria a anticoagulantes orales","authors":"Andrea Garrido Quintero,&nbsp;Silvia Cercas Lobo,&nbsp;Jesus Ruiz Ramos,&nbsp;Adrián Plaza Díaz,&nbsp;Ane González Díez,&nbsp;Antonio Cañón Santos,&nbsp;Ana Villarejo Jiménez,&nbsp;María Carmenza Pérez Méndez,&nbsp;Mireia Puig Campmany","doi":"10.1016/j.farma.2026.03.002","DOIUrl":"10.1016/j.farma.2026.03.002","url":null,"abstract":"<div><h3>Background</h3><div>Gastrointestinal bleeding is a frequent cause of emergency department visits among anticoagulated patients. Antidepressants may potentiate bleeding risk by impairing platelet aggregation. The impact of concomitant antidepressant use on emergency room re-visits for gastrointestinal bleeding in anticoagulated elderly patients remains unclear.</div></div><div><h3>Objective</h3><div>This study aimed to assess the risk factors for Emergency Department (ED) re-visit within 90 days after an initial bleeding episode in elderly patients on oral anticoagulant (OAC) therapy.</div></div><div><h3>Methods</h3><div>A retrospective observational study was conducted at a hospital in Catalonia, including patients over 65 years treated with OACs who presented to the ED for gastrointestinal bleeding between 2018 and 2024. Data were obtained from electronic health records, including comorbidities, chronic medications, and discharge treatments. The primary outcome was ED revisit for bleeding within 90 days. Multivariate logistic regression was used to identify independent predictors.</div></div><div><h3>Results</h3><div>Of 143 patients included [mean age 82.4 years; 51.7% women], 26.7% were on antidepressants, 8.3% on antiplatelet agents, and 77.6% on proton pump inhibitors. Over a mean follow-up of 90 days, 23.1% patients re-visited the emergency room with bleeding. Univariate analysis identified chronic kidney disease, antidepressant therapy, and antiplatelet use as significant factors. In multivariate models, independent predictors were chronic kidney disease (OR 2.50; 95% CI 1.07–5.85; p = 0.034), antidepressant use (OR 2.56; 95% CI 1.07–6.14; <em>p</em> = 0.034), and concomitant antiplatelet therapy (OR 4.55; 95% CI 1.27–16.28; <em>p</em> = 0.020).</div></div><div><h3>Conclusions</h3><div>In elderly patients anticoagulated, the addition of antidepressants significantly increases the risk of ED re-visit for gastrointestinal bleeding within 90 days. Chronic kidney disease and concomitant antiplatelet therapy also emerge as key risk factors.</div></div>","PeriodicalId":45860,"journal":{"name":"FARMACIA HOSPITALARIA","volume":"50 5","pages":"Pages T303-T307"},"PeriodicalIF":1.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147575624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality indicators of the pharmaceutical preparation process in the hospital pharmacy service.","authors":"Elena Blanco-Saiz, Marta Hernández-Segurado, Macarena Bonilla-Porras, María Isabel Panadero-Esteban, Eva Castillo-Bazán, Jorge Barros-Sáez, Gema Toledano-Mayoral, Ignacio Mahillo-Fernández, Francisco Javier Bécares-Martínez","doi":"10.1016/j.farma.2026.06.005","DOIUrl":"https://doi.org/10.1016/j.farma.2026.06.005","url":null,"abstract":"<p><strong>Objective: </strong>To describe the quality indicators applied to the pharmaceutical preparation process in the Hospital Pharmacy Service of a tertiary hospital between 2018 and 2024, to assess their evolution, and to record the reported incidents and improvement measures implemented.</p><p><strong>Method: </strong>Observational, retrospective, longitudinal study. Seven quality indicators related to centralized pharmaceutical preparations were monitored: incidents in the repackaging of oral solids, preparation of cytostatic mixtures, handling of investigational drugs, preparation of parenteral nutrition, and preparation of sterile magistral formulations, as well as preparation time for cytostatic mixtures and rejection rate after quality control of parenteral nutrition and cytostatic mixtures. Reference values, quality targets, and alert thresholds were defined mainly on the basis of the Hospital Pharmacy Service's prior experience. Data were collected quarterly from internal records, and a temporal trend analysis was performed.</p><p><strong>Results: </strong>The indicators showed interannual variability. Incidents were recorded in the repackaging of oral solids (labeling, traceability, and dosing errors) and in the preparation of cytostatic mixtures and investigational drugs (technical errors related to volume, diluent, or product presentation). Preparation time for cytostatic mixtures remained within the reference range. Incidence rates were very low for parenteral nutrition and sterile magistral formulations. Improvement measures included space reorganization, automation, structured technical training, standardized procedures, and reinforcement of control and traceability. In the temporal analysis, preparation time for cytostatic mixtures showed a downward trend, whereas incidents involving investigational drugs showed an upward trend, with no significant lineal trend in the remaining indicators.</p><p><strong>Conclusions: </strong>Systematic monitoring through quality indicators enabled the identification of areas of improvement in the pharmaceutical preparation process and supported decision-making within a patient safety framework. These findings support the value of continuous surveillance and a culture of quality in the hospital pharmacy service.</p>","PeriodicalId":45860,"journal":{"name":"FARMACIA HOSPITALARIA","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148841425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implementation of safe practices for the use of high-risk medications in Spanish hospitals.","authors":"María José Otero, Nuria Prieto-Santos, Rita Martín Muñoz, Rebeca Padilla Peinado, José Manuel Caro-Teller, Rocío Montiel Villalonga, Mónica Climente Martí, Monike de Miguel Cascón, Laura Doménech Moral, Judit García Aparicio, Ana Herranz Alonso, Montserrat Pérez Encinas","doi":"10.1016/j.farma.2026.06.013","DOIUrl":"https://doi.org/10.1016/j.farma.2026.06.013","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the implementation of safe practices for the use of high-risk medications in Spanish hospitals and to identify priority areas for improvement.</p><p><strong>Methods: </strong>A multicenter descriptive study was conducted to assess the degree of implementation of safe practices included in the Spanish Medication Safety Self-Assessment® for High-Alert Medications. Included were Spanish hospitals that voluntarily completed the questionnaire between April and June 2025. The questionnaire comprises 186 assessment items, some with multiple components (254 in total), organized into eight sections: general practices and specific practices for neuromuscular blocking agents, intravenous potassium, insulins, methotrexate (non-oncological use), antineoplastics, anticoagulants and opioids. Mean scores and the percentages of the maximum possible score were analyzed for the overall questionnaire, each section, and each item or its components.</p><p><strong>Results: </strong>A total of 82 hospitals from 13 autonomous communities participated, most of them public (93.9%), general (97.6%) and teaching hospitals (98.8%). The overall implementation of safe practices was 52.7%, with wide variability among centers (29.7%-81.1%). General practices showed a low level of implementation (41.9%). Among therapeutic groups, the highest scores were observed for antineoplastics (80.5%), followed by neuromuscular blocking agents (64.7%), anticoagulants (61.3%) and insulins (54.8%). Values below 50% were found for opioids (49.8%), intravenous potassium (35.6%) and methotrexate (33.8%). The most widely implemented practices were related to storage (except potassium), dose expression and clinical monitoring. Those with the lowest level of implementation included several high-effectiveness technologies, such as clinical decision support alerts and barcode verification during medication preparation, dispensing and administration, as well as the integration of pharmacists into clinical units, preparation of standardized intravenous solutions in the pharmacy, and medication reconciliation at discharge. Low implementation was also observed in practices related to staff training.</p><p><strong>Conclusions: </strong>The implementation of safe practices for high-risk medications in Spanish hospitals is moderate and heterogeneous, with notable variability across therapeutic groups and processes. These findings provide a useful reference at both national and local levels to prioritize improvement initiatives and to assess the impact of future interventions aimed at reducing medication errors associated with these drugs.</p>","PeriodicalId":45860,"journal":{"name":"FARMACIA HOSPITALARIA","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148819931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Translated article] Evidence on the impact of treatment optimization on the safety of patients with liver cirrhosis.","authors":"Andrea Rodríguez Esquíroz, Javier Garjón Parra, Amaya Echeverría Gorriti, Lorea Sanz Álvarez, Marta Marín Marín, Inés Aguinaga Ontoso","doi":"10.1016/j.farma.2026.03.016","DOIUrl":"https://doi.org/10.1016/j.farma.2026.03.016","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the impact of therapy optimization on medication-related safety in patients with liver cirrhosis.</p><p><strong>Method: </strong>Systematic review of clinical trials and before-and-after studies with time series analysis in CENTRAL, MEDLINE, and INAHTA databases. The certainty of the evidence was assessed using the GRADE approach, and the risk of bias was evaluated with the ROBUST-RCT tool.</p><p><strong>Results: </strong>Six articles were identified, all corresponding to a single randomized controlled trial (116 patients) that evaluated the effectiveness of a pharmacist-led intervention (medication reconciliation and individualized health education) compared to usual care. Although no significant differences were found in all-cause mortality or the crude relative risk of hospitalization, the adjusted incidence rate analysis revealed that the intervention significantly reduced unplanned hospitalizations by 48%. Furthermore, within the intervention group, each unit increase in the rate of high-risk medication-related problems was associated with more than three-fold higher odds of mortality, independently of disease severity.</p><p><strong>Conclusions: </strong>There is a current scarcity of high-quality studies in this field. Nevertheless, the available evidence suggests that pharmaceutical follow-up is an effective strategy to reduce preventable hospitalizations in outpatients with decompensated cirrhosis. Pharmacological safety is vital for survival, justifying the integration of the pharmacist into the clinical team.</p>","PeriodicalId":45860,"journal":{"name":"FARMACIA HOSPITALARIA","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148799366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}