Melinda R Mitchell, Janet Chaseling, Lee Jones, Toni White, Andrew Bernie, Larisa M Haupt, Lyn R Griffiths, Kirsty M Wright
{"title":"Improving the strategy to identify historical military remains: a literature review and Y-STR meta-analysis.","authors":"Melinda R Mitchell, Janet Chaseling, Lee Jones, Toni White, Andrew Bernie, Larisa M Haupt, Lyn R Griffiths, Kirsty M Wright","doi":"10.1093/fsr/owad050","DOIUrl":"10.1093/fsr/owad050","url":null,"abstract":"<p><p>The identification of historical military remains by Unrecovered War Casualties-Army (UWC-A) currently relies on Y-chromosome Short Tandem Repeat (Y-STR) testing when maternal relatives are not available, or when a mitochondrial DNA match does not provide sufficient certainty of identification. However, common Y-STR profiles (using Yfiler™) between sets of remains or families often prevent identification. To resolve these cases, an investigation of additional Y-DNA markers is needed for their potential inclusion into the DNA identification strategy. The number of genetic transmissions between missing soldiers and their living relatives needs to be considered to avoid false exclusions between paternal relatives. Analysis of 236 World War I/II (WWI/II) era pairs of relatives identified up to seven genetic transmissions between WWII soldiers and their living relatives, and nine for WWI. Previous Y-STR meta-analyses were published approximately 10 years ago when rapidly mutating markers were relatively new. This paper reports a contemporary literature review and meta-analysis of 35 studies (which includes 23 studies not previously used in meta-analysis) and 23 commonly used Y-STR's mutation rates to inform the inclusion of additional loci to UWC-A's DNA identification strategy. Meta-analysis found mutation data for a given Y-STR locus could be pooled between studies and that the mutation rates were significantly different between some loci (at <i>P</i> < 0.05). Based on this meta-analysis, we have identified two additional markers from PowerPlex® Y23 for potential inclusion in UWC-A's identification strategy. Further avenues for potential experimental exploration are discussed.</p><p><strong>Key points: </strong>From 236 UWC-A pairs of relatives, we observed up to nine genetic transmissions between WWI soldiers and their living relatives, and seven for WWII.MedCalc® software for meta-analysis utilizing the Freeman-Tukey transformation was run, which analysed 35 published studies and 23 commonly used loci. Previous Y-STR mutation rate meta-analyses are now 10 years old; this paper includes 23 studies that were not included in previous meta-analyses.Through meta-analysis, we identify two markers from PowerPlex® Y23 for potential inclusion in UWC-A's historical remains identification strategy (alongside Yfiler™). We discuss potential next steps for experimental exploration of additional Y-DNA markers.</p>","PeriodicalId":45852,"journal":{"name":"Forensic Sciences Research","volume":"9 1","pages":"owad050"},"PeriodicalIF":1.3,"publicationDate":"2023-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10982847/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140337055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xuebing Chen, Hui Xu, Wei Cui, Ming Zhao, Bofeng Zhu
{"title":"Comprehensive explorations of population characteristics and genetic background of the Chinese Mongolian group from Northwest China via a self-developed multiplex InDel panel","authors":"Xuebing Chen, Hui Xu, Wei Cui, Ming Zhao, Bofeng Zhu","doi":"10.1093/fsr/owad047","DOIUrl":"https://doi.org/10.1093/fsr/owad047","url":null,"abstract":"\u0000 This study aimed to investigate the genetic polymorphisms and population characteristics of the Mongolian group from northwest China (NCM) through the self-developed panel of 43 autosomal insertion/deletion (A-InDel) polymorphism genetic markers. Herein, 288 unrelated healthy individuals from the NCM group were employed to obtain the genetic data of 43 A-InDels through PCR amplification and InDel genotyping. In addition, multiplex forensic genetic analyses were performed between the NCM group and 27 reference populations. There were no deviations from Hardy–Weinberg equilibrium (HWE) in the NCM group. The observed heterozygosity (Ho) value ranged from 0.3128 to 0.5592, and the combined power of discrimination (CPD) and the cumulative probability of exclusion (CPE) values were 0.9999999999999999999877 and 0.999814, respectively, in the NCM group. Forensic parameters indicate that this panel is polymorphic and informative in the NCM group and can be used as an effective complementary tool for forensic personal identification. Furthermore, the results of pairwise genetic distance, principal component analysis, multidimensional scaling analysis, phylogenetic tree construction, and admixture analysis between the NCM group and 27 reference populations reveal that there is a close genetic relationship between the NCM group and East Asian populations, especially the Chinese Hui group (CHH) group from the northwest China, consistent with the geographical location. These findings contribute to the ongoing genetic exploration and insights into the genetic architecture of the NCM group.","PeriodicalId":45852,"journal":{"name":"Forensic Sciences Research","volume":"48 3","pages":""},"PeriodicalIF":1.3,"publicationDate":"2023-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138948959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Corpses identification in mass disasters and other violence: the ethical challenges of a humanitarian approach","authors":"Vina Vaswani, Luciana Caenazzo, Derek R. Congram","doi":"10.1093/fsr/owad048","DOIUrl":"https://doi.org/10.1093/fsr/owad048","url":null,"abstract":"\u0000 In October 2022, the Centre for Ethics of Yenepoya University hosted a national workshop entitled: ‘Respect for human dignity of the unidentified dead from mass disasters and other violence: strategies for the ethical management of biological samples and personal data’. The aim was to explore and share experience and ethical considerations regarding the management and identification of human remains in the event of disasters, with the purpose to arrive at a general consensus about what constitutes the ethical foundation of the management of unidentified human remains in forensic practice and, in particular, contextualizing this in India.\u0000 The main ethical consideration that emerged was racing the missing and identifying the dead are crucial to maintaining or restoring basic human rights and responsible relief activities.\u0000 Identification is not only an organizational and scientific achievement but, regardless of circumstances, it is also necessarily and always an activity with significant political, epistemic and philosophical relevance and consequence.\u0000 In India, it could be important to consider new legal provisions for the management of human samples so that this would provide a starting point for the treatment of human remains managed for forensic purposes with uniformity in the Country. Another important step in which governments should take part regards the involvement and education of the general public to develop their interest in this important goal.\u0000 In the field of forensic anthropology, artificial intelligence can support, through the use of algorithms, the decision-making process that leads to the identification of the victim or its remains. Furthermore, they can be used to extract new knowledge from huge databases and shorten identification through computer automation of data binding activities.\u0000 Applying AI tools in forensic sciences to collect new information from massive datasets to enhance knowledge, and reduce human subjectivity and errors, provides a greater scientific basis that could improve the strength of the evidence and support the admissibility of expert evidence.\u0000 In light of the general lack of national/international guidance about ethical oversight for identification and care of human remains, the fact that regulations are frequently not adequate to govern ethical aspects, we hope that an internationally recognized body should develop such guidance in collaboration with relevant organizations.","PeriodicalId":45852,"journal":{"name":"Forensic Sciences Research","volume":"82 23","pages":""},"PeriodicalIF":1.3,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138957889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Improving accuracy of age estimates for insect evidence—calibration of physiological age at emergence (k) using insect size but without ‘k versus size’ model","authors":"Jędrzej Wydra, Łukasz Smaga, S. Matuszewski","doi":"10.1093/fsr/owad049","DOIUrl":"https://doi.org/10.1093/fsr/owad049","url":null,"abstract":"\u0000 Postmortem interval (PMI) may be estimated based on the age of insect evidence collected on a death scene. Reference data that are used in such estimation frequently comprise thermal summation constant (ie, k), which is equal to the insect age upon completion of immature development expressed in accumulated degree-days or degree-hours (ADD or ADH). Essentially, k is a central point of an insect group and it may poorly represent insect evidence that is near the limits of variation for the group. Accordingly, it was postulated to calibrate k for particular insect evidence and insect size and sex were found to be useful for this purpose in some of the species. However, the calibration is only possible by using the model that correlates k with insect size. Since very few such models were published, this lack of data limits the calibration of k in forensic casework. In this article we develop a formula that is useful for the calibration of k without the use of ‘k versus size’ model (and related datasets). The formula uses k from the general thermal summation model for a species (with its standard error), size range for the species (retrieved from entomology literature) and size measurements for particular insect evidence. The calibration of k with the formula was validated using the Creophilus maxillosus (Coleoptera: Staphylinidae) and Necrodes littoralis (Coleoptera: Silphidae) datasets. It was particularly useful while analyzing unusually small and large insects, in case of which the formula reduced the inaccuracy of k from the general model on average by about 25 ADD in C. maxillosus and about 40 ADD in N. littoralis. We discuss the limitations and prospects of the calibration protocol that employs the formula.","PeriodicalId":45852,"journal":{"name":"Forensic Sciences Research","volume":" 602","pages":""},"PeriodicalIF":1.3,"publicationDate":"2023-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138960511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Muhamad Adib bin Ahmad, Loong Chuen Lee, Nur Ain Najihah Binti Mohd Rosdi, Nadirah Binti Abd Hamid, A. Ishak, Hukil Sino
{"title":"Comparing baseline correction algorithms in discriminating brownish soils from five proximity locations based on UPLC and PLS-DA methods","authors":"Muhamad Adib bin Ahmad, Loong Chuen Lee, Nur Ain Najihah Binti Mohd Rosdi, Nadirah Binti Abd Hamid, A. Ishak, Hukil Sino","doi":"10.1093/fsr/owad045","DOIUrl":"https://doi.org/10.1093/fsr/owad045","url":null,"abstract":"\u0000 \u0000 \u0000 Soil is commonly collected from an outdoor crime scene, and thus it is helpful in linking a suspect and a victim to a crime scene. The chemical profiles of soils can be acquired via chemical instruments such as Ultra-Performance Liquid Chromatography (UPLC). However, the UPLC chromatogram often interferes with an unstable baseline. In this paper, we compared the performance of five baseline correction (BC) algorithms, i.e., asymmetric least squares, fill peak (FP), iterative restricted least squares, median window (MW), and modified polynomial fitting, in discriminating 30 chromatograms of brownish soils by five locations of origin, i.e., PP, HK, KU, BL and KB. The performances of the preprocessed sub-datasets were first visually inspected through the mean chromatograms and then further explored via scores plots of principal component analysis. Eventually, the predictive performances of the PLS-DA models estimated from 1000 pairs of training and testing samples (i.e., prepared via iterative random resampling split at 75:25) were studied to identify the best BC method. Mean raw chromatograms of the ten soil samples were different from each other, with evident fluctuated baselines. AsLS and MW corrected chromatograms demonstrated the most significant improvement compared to the raw counterpart. Meanwhile, the scores plot of PCA revealed that most of the sub-datasets produced three separate clusters. Then, the sub-datasets were modelled via the partial least squares-discriminant analysis (PLS-DA) technique. MW emerged as the excellent BC method based on the mean prediction accuracy estimated using 1000 pairs of training and testing samples. In conclusion, MW outperformed the other BC methods in correcting the UPLC data of soil.\u0000 \u0000 \u0000 \u0000","PeriodicalId":45852,"journal":{"name":"Forensic Sciences Research","volume":" 30","pages":""},"PeriodicalIF":1.3,"publicationDate":"2023-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138962029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
E. C. Ribeiro, D. D. de Mendonça, P. G. de Barros Silva, L. Kurita, A. D. de Aguiar, F. M. Tuji, Frederico Sampaio Neves, F. Carvalho, Fábio Wildson Gurgel Costa
{"title":"Potential role of the Sella Turcica x-ray imaging aspects for sex estimation in the field of Forensic anthropology: a systematic review and metanalysis","authors":"E. C. Ribeiro, D. D. de Mendonça, P. G. de Barros Silva, L. Kurita, A. D. de Aguiar, F. M. Tuji, Frederico Sampaio Neves, F. Carvalho, Fábio Wildson Gurgel Costa","doi":"10.1093/fsr/owad046","DOIUrl":"https://doi.org/10.1093/fsr/owad046","url":null,"abstract":"\u0000 \u0000 \u0000 Several studies have evaluated the parameters of normality of the Sella Turcica (ST), which is important face to different craniofacial syndromes that may affect this structure. Therefore, this research summarized the scientific evidence on the role of ST in the sex estimation of non-syndromic individuals. The research protocol was registered (PROSPERO # CRD42021256469), followed by an electronic search in six databases (PubMed, LILACS, Web of Science, Scopus, EMBASE, LIVIVO) and gray literature (Google scholar, OpenGrey). Meta-analysis of linear (width, length, height, and diameter) and volumetric measurements, in addition to an assessment of risk of bias (RoB) and certainty of evidence, were performed. After the screening of 986 articles, 13 were evaluated by meta-analysis (1307 males and 1231 females). In subgroup analysis, females had lower values for width (lateral radiograph; −0.67 mm; P = 0.040), length (computed tomography; −0.23 mm; P = 0.020), and diameter (computed tomography; −0.27 mm; P < 0.001) compared to males. There was no statistically significant difference regarding height (P = 0.95), area (P = 0.72), and volume (P = 0.21). Most studies exhibited moderate RoB, and the certainty of evidence of the outcomes was very low. In this review, significant differences were observed between the sexes for the length and diameter of the ST; however, the heterogeneity of the studies must be considered.\u0000 \u0000 \u0000 \u0000","PeriodicalId":45852,"journal":{"name":"Forensic Sciences Research","volume":"53 1","pages":""},"PeriodicalIF":1.3,"publicationDate":"2023-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138965154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aman Chowdhry, Priyanka Kapoor, Deepak Bhargava, D. Bagga, Abhishek Mehta
{"title":"Comparison of Demirjian’s comprehensive chart with the London Atlas of tooth development in children and adolescents: a pilot study","authors":"Aman Chowdhry, Priyanka Kapoor, Deepak Bhargava, D. Bagga, Abhishek Mehta","doi":"10.1093/fsr/owad044","DOIUrl":"https://doi.org/10.1093/fsr/owad044","url":null,"abstract":"\u0000 Dental age estimation has its application in various subdisciplines of medicine and dentistry. New methods of dental age estimation are emerging and it’s important that we compare different methods to determine which one is more closely related to the chronological age. Demirjian’s method is one of the most widely used technique and has been tested in various ethnic populations globally. In 2016, Another, approach to dental age estimation is the London atlas of human tooth development and eruption. No study has compared both Demirjian’s comprehensive chart and London atlas method in the Indian population. Hence, in the current study we estimated dental age using both Demirjian’s comprehensive chart and London atlas method for association with the known chronologic age in children and adolescent orthodontic. The study also attempted to determine if sexual dimorphism existed in dental age estimated by the two methods. Dental age estimation was performed for both the methods on 100 orthopantomogram records (50 males and 50 females, aged 6-16 years) of orthodontic patients. The data were compared and analysed using paired t-tests. There was an overestimation of dental age by Demirjian’s comprehensive chart on an average of +1.3 in males and +0.5 in females, whereas using London Atlas, it was +1.4 years in males and +0.5 years in females. The mean of underestimation was -0.6 years in males and -0.8 years in females using Demirjian’s comprehensive chart, whereas it was -0.8 years in males and -0.5 years in females. A statistically significant difference (P<0.0001) was found when mean chronological age (11.6±2.6) of the participants was compared with dental age estimated using either Demirjian’s comprehensive chart (12.3±2.8) or London Atlas (11.8±2.9). The trends in this pilot study point towards more accuracy of London atlas over Demirjian’s method when done using comprehensive chart for estimating dental age. Studies with larger sample and on diverse ethnic population should be done to validate this finding.","PeriodicalId":45852,"journal":{"name":"Forensic Sciences Research","volume":"3 5","pages":""},"PeriodicalIF":1.3,"publicationDate":"2023-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138585762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gordon G Giesbrecht, Mitesh Patel, Rafid Javid, Scott Murray, Vrushil Patel, Noah Wiens, Darren Xie, Ian Jeffrey, Philip Ferguson
{"title":"Ground penetrating radar used to detect drowning victims under ice.","authors":"Gordon G Giesbrecht, Mitesh Patel, Rafid Javid, Scott Murray, Vrushil Patel, Noah Wiens, Darren Xie, Ian Jeffrey, Philip Ferguson","doi":"10.1093/fsr/owad040","DOIUrl":"https://doi.org/10.1093/fsr/owad040","url":null,"abstract":"<p><p>Every year, people drown after falling through ice on rivers and lakes. In some cases, the body of the victim floats up to the underside of the ice, making detection and recovery difficult using traditional search methods with divers. A robust and contact-less sensing system is required to locate drowning victims that does not put rescue teams at risk of falling through the ice themselves. In this paper, we demonstrate the feasibility of a ground penetrating radar (GPR) for detecting deceased drowning victims that have floated up to the underside of the ice. We placed three euthanized pigs simulating drowning victims under ice ranging in thickness from 5 to 26 cm. We dragged a GPR at 500 MHz and 1 GHz across the ice to detect the simulated victims using an autocorrelation-based detection technique. Results showed that both frequencies were able to detect the rough shape of the simulated victims at ice thicknesses up to 42 cm, with the 1-GHz data showing slightly more resolution than the 500-MHz data. These results show promise and suggest future development of an autonomous drone-based GPR detection system.</p><p><strong>Key points: </strong>Floating bodies are successfully detected under both ice and snow using a commercial ground penetrating radar system with ice depths reaching up to 26 cm in a controlled environment.The differences between using radar systems operating at/around 500 MHz and 1 GHz were not pronounced from the point of view of detection.Future studies should investigate the capabilities for detecting bodies in more realistic settings.</p>","PeriodicalId":45852,"journal":{"name":"Forensic Sciences Research","volume":"8 4","pages":"280-287"},"PeriodicalIF":1.3,"publicationDate":"2023-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10894067/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139973944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Corte-Real, P. Almiro, Mafalda Silva, T. Nunes, João Abreu, Carla Carreira, Duarte Nuno Vieira
{"title":"Oral health professional intervention and child physical abuse—European legal approach","authors":"A. Corte-Real, P. Almiro, Mafalda Silva, T. Nunes, João Abreu, Carla Carreira, Duarte Nuno Vieira","doi":"10.1093/fsr/owad042","DOIUrl":"https://doi.org/10.1093/fsr/owad042","url":null,"abstract":"\u0000 Physical violence against children and adolescents is an issue of Global Public Health. This study aims to identify traumatic injuries and the medical–legal temporary framework of the victim’s profile in the European legal approach. Participants and Setting: The clinical reports of a Portuguese European Clinical Academic Center database were analyzed. An observational and prospective cohort study was performed. A descriptive analysis of the variables was conducted, considering gender, bimodal age groups, place of residence, offender data, place of occurrence, etiology, localization, type of injuries, personal injury assessment by Quantum doloris, and injury time. The statistical analysis was performed by Spearman’s rho and Kendall’s tau-b correlation tests, Pearson’s chi-square test of independence (χ2), and Mann–Whitney and Kruskal–Wallis nonparametric tests (P < 0.05). The relationship between age groups and the place of occurrence was statistically significant (P = 0.001). Orofacial and nonorofacial injuries were related (P = 0.035). The General Data Protection Regulation is not a barrier to the treatment and sharing of justified data but a framework for safeguarding individuals’ fundamental rights, including the Right to Health. Meticulous reporting of the clinical situation involves the victim, the occurrence, and the potential offender.","PeriodicalId":45852,"journal":{"name":"Forensic Sciences Research","volume":"28 3","pages":""},"PeriodicalIF":1.3,"publicationDate":"2023-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138598045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A bibliometric analysis of research trends for missing persons globally and in East Asia from 2000 to 2021","authors":"Zixuan Zeng, Ishmael Dikeledi, Yehui Lv","doi":"10.1093/fsr/owad041","DOIUrl":"https://doi.org/10.1093/fsr/owad041","url":null,"abstract":"\u0000 A bibliometric analysis was performed to explore the current research status and development trends for missing persons globally and in East Asia and to identify research hotspots and frontiers relating to this topic. A search was conducted to identify relevant literature on missing persons using the Web of Science Core Collection database for the period 2000–2021. Subsequently, a knowledge map was constructed using CiteSpace software to perform a visual analysis of the distribution of authors and institutions, journals, national/regional distribution; citation frequency; high-frequency keywords; and emerging research hotspots. The results showed firstly that discussions on missing persons and related topics in East Asia are held at the regional scale. There is a paucity of research on this topic, which has been conducted on a limited scale, lacks depth and possibly innovation and entails limited discussion in this region. Secondly, there is a lack of social science research on missing persons and related topics worldwide. Thirdly, relevant research in East Asia should continue to preserve its own characteristics, effectively addressing current issues and enabling more people to participate in social science-oriented discussions focusing on the topic of missing persons. This approach provides a promising direction for pursuing the sustainable development of the topic of missing persons.","PeriodicalId":45852,"journal":{"name":"Forensic Sciences Research","volume":"21 6","pages":""},"PeriodicalIF":1.3,"publicationDate":"2023-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138596678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}