International Journal of Veterinary Science and Medicine最新文献

{"title":"Dual effects of ipecac alkaloids with potent antiviral activity against foot-and-mouth disease virus as replicase inhibitors and direct virucides.","authors":"Achiraya Pantanam, Natjira Mana, Ploypailin Semkum, Varanya Lueangaramkul, Nantawan Phecharat, Porntippa Lekcharoensuk, Sirin Theerawatanasirikul","doi":"10.1080/23144599.2024.2408189","DOIUrl":"10.1080/23144599.2024.2408189","url":null,"abstract":"<p><p>Foot-and-Mouth Disease (FMD) is a contagious, blistering disease caused by the Foot-and-Mouth Disease virus (FMDV), which affects livestock globally. Currently, no commercial antiviral agent is available for effective disease control. This study investigated the antiviral potential of natural-derived alkaloids against FMDV in BHK-21 cells. Twelve alkaloids were assessed for their antiviral activities at various stages of FMDV infection, including pre-viral entry, post-viral entry, and prophylactic assays, as well as attachment and penetration assays by evaluating cytopathic effect reduction and directed-virucidal effects. The results showed that ipecac alkaloids, cephaeline (CPL) and emetine (EMT), exhibited dual effects with robust antiviral efficacy by reducing cytopathic effect and inhibiting FMDV replication in a dose-dependent manner. Evaluation through immunoperoxidase monolayer assay and RT-PCR indicated effectiveness at post-viral entry stage, with sub-micromolar EC₅₀ values for CPL and EMT at 0.05 and 0.24 µM, respectively, and high selective indices. Prophylactic effects prevented infection with EC₅₀ values of 0.23 and 0.64 µM, respectively. Directed-virucidal effects demonstrated significant reduction of extracellular FMDV, with CPL exhibiting a dose-dependent effect. Furthermore, the replicase (3Dpol) inhibition activity was identified using the FMDV minigenome assay, which revealed strong inhibition with IC₅₀ values of 0.15 µM for CPL and 4.20 µM for EMT, consistent with the decreased negative-stranded RNA production. Molecular docking confirmed the interaction of CPL and EMT with residues in the active site of FMDV 3Dpol. In conclusion, CPL and EMT exhibited promising efficacy through their dual effects and provide an alternative approach for controlling FMD in livestock.</p>","PeriodicalId":45744,"journal":{"name":"International Journal of Veterinary Science and Medicine","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11445910/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142366881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of <i>Fasciola gigantica</i> in freshwater snail <i>Radix</i> (<i>Lymnaea</i>) spp. In the highly parasite-prevalent area of Nakhon Ratchasima Province, Thailand.","authors":"Pongsakorn Martviset, Pathanin Chantree, Amornrat Geadkaew-Krenc, Pantip Piyatadsananon, Ruttiroj Jirojwong, Chompunoot Wangboon, Mantana Jamklang, Sirilak Chumkiew, Rawipreeya Poomkhokrak, Nanthawat Kosa, Salisa Chaimon, Bumpenporn Sanannam, Rudi Grams, Wansika Phadungsil","doi":"10.1080/23144599.2024.2396700","DOIUrl":"https://doi.org/10.1080/23144599.2024.2396700","url":null,"abstract":"<p><p>This study investigates the distribution of the <i>Lymnaea</i> (<i>Radix</i>) spp. in Pak Chong district, Nakhon Ratchasima province, northeast Thailand, where a vast cattle farming area is located and has a high prevalence of <i>Fasciola</i> spp. in the cattle. By random selection, 1,414 snails were collected from the natural and man-made ponds. The snails were recorded for morphology and processed for DNA isolation. The snail species were investigated by conventional PCR using a 16S rDNA-specific primer. The result demonstrated that all collected snails were <i>R</i>. (<i>L</i>.) <i>rubiginosa</i>. Moreover, the infection of <i>Fasciola</i> gigantica in the snails was investigated by PCR using a cytochrome c oxidase I (COX1)-specific primer. The results illustrated that the overall prevalence was 22.5% (318/1414), with the highest prevalence in the Nong Sa Rai subdistrict at 73.6% (81/110), which is the highest prevalence of <i>Fasciola gigantica</i> in the snail host that has ever been reported. The lowest prevalence existed in the Pong Ta Long subdistrict at 3.7% (4/109). Our results corresponded to the previous report on the <i>Fasciola</i> spp. infection in the cattle from this area, and the geographical analysis revealed that the most suspected factor would be the earth dam located in these subdistricts, where many animals live freely during the day. Our findings could be helpful for further parasite control and could trigger the study of the biology and associated factors in the future.</p>","PeriodicalId":45744,"journal":{"name":"International Journal of Veterinary Science and Medicine","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11389629/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142298193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microstructural architecture of the bony scutes, spine, and rays of the bony fins in the common pleco <i>(Hypostomus plecostomus)</i>.","authors":"Hanan H Abd-Elhafeez, Diaa Massoud, Mohammed S Mahmoud, Nada Abdellah, Abdallah S Salah, Nor-Elhoda Mohamed, Mennatallah Ali Abdelrhman Sayed, Mohamed Shaalan, Catrin S Rutland, Alaa Sayed Abu-ELhamed, Soha A Soliman, Fatma El-Zahraa A Mustafa","doi":"10.1080/23144599.2024.2374201","DOIUrl":"10.1080/23144599.2024.2374201","url":null,"abstract":"<p><p>Studying scute and fin morphology are advantageous approaches for phylogenetic identification and provide information on biological linkages and evolutionary history that are essential for deciphering the fossil record. Despite this, no prior research has precisely characterized the histological structures of scutes in the common pleco. Therefore, this research investigated the microstructure and organization of bone tissue within the dermal skeleton, including the scutes and fins, in the common pleco, using light microscopy, stereomicroscopy, and scanning electron microscopy. The dermal scutes were organized in a pentagonal shape with denticular coverage and were obliquely aligned with the caudal portion pointing dorsally. The dermal scutes consisted of three distinct portions: the central, preterminal, and terminal portions. Each portion comprised three layers: a superficial bony plate, a basal bony plate, and a mid-plate. Both the superficial and basal bony plates were composed of lamellar bone and lamellar zonal bone, whilst the mid-plate consisted of secondary osteons and woven bone. In the terminal portion, the superficial and basal bony plates became thinner. The pectoral fin consists of spines and rays composed of lepidotrichium (two symmetrical hemi-rays). The spine contained centrifugal and centripetal lamellar and trabecular bones. A centripetal fibrous bone was implanted between the lamellar bones. Besides being oriented in a V shape, the hemi-rays were also composed of thin centrifugal and centripetal lamellar bones and trabecular bones. A fibrous bone was identified between the centrifugal and centripetal bones. The trabecular bone and lamellar bone were made up of bone spicules.</p>","PeriodicalId":45744,"journal":{"name":"International Journal of Veterinary Science and Medicine","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11376312/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142141359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seroprevalence and molecular detection of <i>Brucella</i> infection in livestock in the United Arab Emirates.","authors":"Gobena Ameni, Aboma Zewude, Berecha Bayissa, Ibrahim Abdalla Alfaki, Abdallah A Albizreh, Naeema Alhosani, Khaja Mohteshamuddin, Berhanu Adenew Degefa, Mohamed Elfatih Hamad, Meera Saeed Alkalbani, Mohamed Moustafa Abdelhalim, Assem Sobhi Abdelazim, Rafeek Aroul Koliyan, Kaltham Kayaf, Mervat Mari Al Nuaimat, Robert Barigye, Arve Lee Willingham, Markos Tibbo, Bedaso Mammo Edo, Teshale Sori, Yassir Mohammed Eltahir","doi":"10.1080/23144599.2024.2384015","DOIUrl":"10.1080/23144599.2024.2384015","url":null,"abstract":"<p><p>Small ruminants and camels are important livestock species in the United Arab Emirates (UAE), although <i>Brucella</i> infection can limit their productivity. This study aimed to investigate the seroprevalence of <i>Brucella</i> infection and its associated risk factors in small ruminants and camels in the Emirate of Abu Dhabi. Additionally, seropositive animals were tested for the DNA of <i>Brucella</i>. Multispecies competitive enzyme-linked immunosorbent assay (c-ELISA) and multispecies indirect (i-ELISA) were used to test 3,086 animals from 2022 to 2023. <i>Brucella</i> cell surface 31 kDa protein (bcsp31) gene-based real-time polymerase chain reaction (q-PCR) was used to detect <i>Brucella</i> DNA. Multivariate logistic regression was used to assess the association between seroprevalence and potential risk factors. The overall seroprevalences of <i>Brucella</i> infection were 1.7% (95% confidence interval [CI], 1.2%-2.2%) and 5.8% (95% CI, 5.0%-6.7%) based on serial and parallel testing, respectively. The DNA of <i>Brucella</i> was detected in 13 of the 51 seropositive animals. The overall seroprevalence of <i>Brucella</i> infection was associated with the region, type of animal holding, species, and age of the animals. In conclusion, this study documented <i>Brucella</i> infection in small ruminants and camels in the Emirate of Abu Dhabi, warranting necessary intervention strategies to eliminate <i>Brucella</i> infections in livestock populations.</p>","PeriodicalId":45744,"journal":{"name":"International Journal of Veterinary Science and Medicine","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11346334/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142074242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Generation of induced pluripotent stem cells from the Asian bats.","authors":"Younsu Lee, Okjae Koo, Islam M Saadeldin","doi":"10.1080/23144599.2024.2384835","DOIUrl":"10.1080/23144599.2024.2384835","url":null,"abstract":"<p><p>Preservation of native Korean bats is crucial for maintaining ecological balance, as they play a vital role in insect control, pollination, and seed dispersal within their ecosystems. The present study details the establishment of bat induced pluripotent stem cells (BatiPSCs) from two Asian and Korean bats (<i>Hypsugo alaschanicus</i> and <i>Pipistrellus abramus</i>) using the Sendai Reprogramming Kit. Colonies of BatiPSCs, exhibiting distinctive features, were manually selected and expanded following successful transfection. Characterization of BatiPSCs revealed the expression of pluripotency markers, such as Octamer-binding transcription factor 4 (Oct4), SRY (sex-determining region Y)-box 2 and Nanog, with notably increased Oct4 levels and reduced Myc proto-oncogene expression compared with those noted in other induced pluripotent stem cell sources. BatiPSCs displayed positive staining for alkaline phosphatase and demonstrated the ability to form embryoid bodies, while also inducing teratomas in non-immune nude mice. Additionally, green fluorescent protein (GFP)-expressing BatiPSCs were generated and used for chimeric mouse production, with slight GFP signals detected in the neck region of the resulting mouse foetuses. These findings demonstrate the successful generation and characterization of BatiPSCs, emphasizing their potential applications in chimeric animal models, and the protection of endangered bat species.</p>","PeriodicalId":45744,"journal":{"name":"International Journal of Veterinary Science and Medicine","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11321101/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141976918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Freeze-drying protocols and methods of maintaining the in-vitro biological activity of horse platelet lysate.","authors":"Chiara Bernardini, Noemi Romagnoli, Isabelle Casalini, Maria Elena Turba, Alessandro Spadari, Monica Forni, Fabio Gentilini","doi":"10.1080/23144599.2024.2380586","DOIUrl":"10.1080/23144599.2024.2380586","url":null,"abstract":"<p><p>Platelet lysate, derived from platelets, are valuable biological products rich in bioactive molecules. Their use promotes tissue healing and modulates inflammation. However, maintaining the stability and bioactivity of platelet lysate is challenging since they degrade rapidly at room temperature. This study focused on the possibility to confer enhanced stability to freeze-dried equine platelet lysate as an alternative to platelet-rich plasma (PRP). Platelet lysate (PL) was derived from PRP and freeze-dried either as such or using various adjuvants. Primary cell cultures of porcine Vascular Wall-Mesenchymal Stem Cells were treated with different PL formulations, and cell viability was assessed using an MTT assay. Overall, the addition of PL significantly improved cell viability as compared to controls without growth factor supplementation or with foetal bovine serum. Notably, the freeze-drying process maintained the effectiveness of the PL for at least a week. Furthermore, the study revealed that varying the horse as the source of PL could yield varying effects on cell viability. Detailed freeze-drying protocols were established, including freezing, primary drying and secondary drying phases, and the type of adjuvant. This study demonstrated the potential of freeze-dried equine PL as a viable alternative to PRP and highlighted the importance of precise freeze-drying protocols and adjuvants for standardization. Equine PL showed promise for medical treatment in horses, offering advantages such as extended shelf life, ease of handling, and reduced transportation costs, with the potential for broadened therapeutic usage.</p>","PeriodicalId":45744,"journal":{"name":"International Journal of Veterinary Science and Medicine","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11308971/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141907964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and risk factors of coxiellosis in meat goat herds: an epidemiological investigation in Northeastern Thailand.","authors":"Sarinya Rerkyusuke, Sawarin Lerk-U-Suke, Peerapol Sukon, Patchara Phuektes","doi":"10.1080/23144599.2024.2379713","DOIUrl":"10.1080/23144599.2024.2379713","url":null,"abstract":"<p><p>Q fever/coxiellosis poses a significant threat to both human and animal health, with goats serving as important reservoirs for disease transmission. This study aimed to evaluate the prevalence of coxiellosis and identify associated risk factors within meat goat herds in northeastern Thailand. A total of 39 meat goat herds were examined, with 84.61% of these herds experiencing reproductive disorders suggestive of <i>Coxiella burnetii</i> infection. Serum samples (<i>n</i> = 513) and vaginal swabs (<i>n</i> = 334) were collected from 522 goats for serological and molecular analyses, respectively. Results unveiled an overall herd prevalence of 74.35% (29/39), with a within-herd prevalence of 15.49% (95% CI: 10.86-20.12). Univariate analysis indicated that knowledge about the transmission of coxiellosis in herd owners serves as a protective factor against <i>C. burnetii</i> infection at the herd level (OR: 0.10; 95% CI: 0.01-0.92; <i>p</i> = 0.04). Multivariable analysis identified two significant risk factors associated with <i>C. burnetii</i> infection at the herd level, including herd establishment exceeding 5 years (OR: 7.14; 95% CI: 1.05-48.4; <i>p</i> = 0.04), as well as reproductive failures including abortion, infertility, and weak offspring (OR: 17.65; 95% CI: 1.76-177.45; <i>p</i> = 0.01). Individual-level risk factors included female gender (OR: 8.42; 95% CI: 1.14-62.42; <i>p</i> = 0.03), crossbreeding (OR: 2.52; 95% CI: 1.32-4.82; <i>p</i> = 0.005), and clinical signs of anaemia (OR: 1.63; 95% CI: 1.01-2.64; <i>p</i> = 0.04). These findings underscore the widespread prevalence of Q fever in meat goat herds within the study area and emphasize the necessity of implementing targeted control strategies.</p>","PeriodicalId":45744,"journal":{"name":"International Journal of Veterinary Science and Medicine","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11285351/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141793745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-typhoidal <i>Salmonella</i> in Nigeria: do outcomes of 'multisectoral' surveillance, treatment and control justify the intervention costs?","authors":"Abdullahi O Sanni, Abdurrahman H Jibril, Olubunmi G Fasanmi, Oluwawemimo O Adebowale, Alexander R Jambalang, Aminu Shittu, Annelize Jonker, Latifah O Abdulkarim, Folorunso O Fasina","doi":"10.1080/23144599.2024.2365567","DOIUrl":"10.1080/23144599.2024.2365567","url":null,"abstract":"<p><p>Non-typhoidal salmonellosis (NTS) is significant and an economic burden in Nigeria. To determine whether investment in NTS control is economically justifiable, Outbreak Costing Tool (OCT) was used to estimate the robust funding of public and animal health systems for epidemio-surveillance and control of multisectoral NTS outbreaks in Nigeria. Health, production, and economic data were collected and used to populate the tool for evaluation. The multisectoral NTS burden for the year 2020 in Nigeria was US$ 930,887,379.00. Approximately 4,835 technical officers, and 3,700 non-technical staff (<i>n</i> = 8,535) were needed with an investment of >2.2 million work hours. The investment cost for NTS control was US$ 53,854,660.87. The non-labour-related cost was 89.21% of the total intervention costs. The overall intervention's investment was 374.15% of the estimated national and subnational systems' annual budget for diarrhoeal diseases, and the outbreak response period attracted the highest costs (53%) of the total intervention. In conclusion, intervention against NTS was beneficial (benefit - cost ratio: 17.29), hence justifying the need for multisectoral surveillance-response against NTS in Nigeria. Complex sectoral silos must give way to coordinated collaborations to optimize benefits; and over-centralization of health interventions' associated delays must be removed through decentralized sub-national-focused framework that empowers rapid investigation, response, control, data collection, and analyses. It should assist anticipatory planning, and outbreak investigation and reduce critical response time. Anticipatory planning tools, when applied pre-emptively, can benefit budgeting, identify gaps, and assist in the delivery of cost-saving and effective measures against infectious disease.</p>","PeriodicalId":45744,"journal":{"name":"International Journal of Veterinary Science and Medicine","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11249158/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141621167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In field evaluation of impact on clinical signs of an inactivated autogenous vaccine against <i>Pasteurella multocida</i> in rabbits.","authors":"G Casalino, F D'Amico, G Bozzo, F R Dinardo, M Schiavitto, D Galante, A Aceti, E Ceci, D Romito, F P D'Onghia, M M Dimuccio, A Camarda, E Circella","doi":"10.1080/23144599.2024.2348900","DOIUrl":"10.1080/23144599.2024.2348900","url":null,"abstract":"<p><p>In Italy, the use of autogenous inactivated vaccines prepared with the bacterial strains isolated from affected animals is authorized by the Ministry of Health in farms where bacterial diseases occur frequently. The autogenous vaccine performed using <i>Pasteurella multocida</i> is frequently used in rabbit farms, but the feedback of its application is not available. Therefore, the aim of this study is to give information about the impact on the clinical signs of a bivalent autogenous vaccine in rabbits of a genetic centre. The vaccine was prepared using two <i>P. multocida</i> strains belonging to serogroups A and F, equipped with virulence genes and responsible for cyclical outbreak of pasteurellosis in the farm. The vaccine was administered with a first injection, followed by another one after 15 days, then another one four months after the first injection, and then continuing with a further injection every six months to all rabbits. Clinical conditions and mortality rates were monitored for two years after the first vaccination. The improvement in clinical condition and the decrease of the mortality rate were significant especially in the first year post-vaccine. In addition, the number of animals removed due to the disease decreased greatly. Based on the finding of <i>P. multocida</i> strains belonging to serogroup D and serogroup A equipped with different virulence-gene patterns from those previously found, we suggest that the vaccine was unable to prevent the introduction and spreading of new strains among the rabbits.</p>","PeriodicalId":45744,"journal":{"name":"International Journal of Veterinary Science and Medicine","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11159587/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141297002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Streptococcus iniae</i> in aquaculture: a review of pathogenesis, virulence, and antibiotic resistance.","authors":"María Zulema Juárez-Cortés, Luz Edith Casados Vázquez, Sergio Francisco Martínez Díaz, César Salvador Cardona Félix","doi":"10.1080/23144599.2024.2348408","DOIUrl":"10.1080/23144599.2024.2348408","url":null,"abstract":"<p><p>One of the main challenges in aquaculture is pathogenic bacterial control. <i>Streptococcus iniae</i> stands out for its ability to cause high mortality rates in populations of commercially important fish populations and its recent recognition as an emerging zoonotic pathogen. The rise in identifying over 80 strains some displaying antibiotic resistance coupled with the emerging occurrence of infections in marine mammal species and wild fish underscores the urgent need of understanding pathogenesis, virulence and drug resistance mechanisms of this bacterium. This understanding is crucial to ensure effective control strategies. In this context, the present review conducts a bibliometric analysis to examine research trends related to <i>S. iniae</i>, extending into the mechanisms of infection, virulence, drug resistance and control strategies, whose relevance is highlighted on vaccines and probiotics to strengthen the host immune system. Despite the advances in this field, the need for developing more efficient identification methods is evident, since they constitute the basis for accurate diagnosis and treatment.</p>","PeriodicalId":45744,"journal":{"name":"International Journal of Veterinary Science and Medicine","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11095286/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140945320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}