AIMS Public Health最新文献

{"title":"Exploration and practice of data-driven high-quality development in smart hospitals.","authors":"Lijuan Li, Chuanzi Yang, Zhiyan Zhang, Qiang Wu, Xiaojun Cao","doi":"10.3934/publichealth.2026015","DOIUrl":"10.3934/publichealth.2026015","url":null,"abstract":"<p><strong>Background: </strong>In this study, we explored a data-driven approach to smart hospital construction, addressing challenges such as data silos, fragmented processes, and delayed decision-making within healthcare systems. The proposed framework supports the high-quality development of public hospitals in China and facilitates intelligent integration among healthcare delivery, service provision, and management functions, achieving synergistic advancement of the \"trinity\" of hospital operations.</p><p><strong>Method: </strong>A phased action research method was employed, comprising three stages: (1) Infrastructure construction period (2016-2018): Achieving system interconnection and data sharing based on enterprise service bus, standardized interface transformation, and the establishment of an information security system. (2) Intelligent empowerment period (2019-2021): Implementing intelligent healthcare processes, patient services, hospital management, and closed-loop management. (3) Ecological expansion period (2022-2024): Constructing a regional pediatric alliance data collaboration network and enabling internet hospital service continuity. The core pathways include global data integration, data governance standardization, closed-loop management enhancement, intelligent decision support development, and internet hospital integration.</p><p><strong>Results: </strong>The study demonstrated four outcomes: (1) Improved data quality: Standardization, completeness, and consistency were significantly improved (<i>p</i> < 0.001). (2) Enhanced medical quality: The accuracy rate of AI-assisted diagnosis exceeded 90%, the completion rate of clinical pathways reached 96.03%, and the intensity of antibiotic use (defined daily doses) decreased from 28.27 to 17.14. (3) Optimized service efficiency: The appointment completion rate was 98.15%, the average length of stay in a hospital decreased by 42.06% (interrupted time series analysis showed that the post-intervention level was significantly reduced, <i>β</i> <sub>2</sub> = -0.701, <i>p</i> = 0.002), and the number of bed turnover increased by 128.8% (<i>β</i> <sub>2</sub> = 14.558, <i>p</i> < 0.001). (4) Significant regional collaboration: Established collaborations with 134 hospitals, with more than 2629 cases of remote consultation and transfer in the year 2024 and 88,900 times of mutual recognition of test results.</p><p><strong>Conclusion: </strong>The construction of a data-driven smart hospital, through systematic integration and intelligent empowerment, demonstrated positive outcomes in improving data quality, clinical performance, operational efficiency, and regional collaboration. This provides a replicable implementation framework for the high-quality development of public hospitals in China. Since this was a single-center exploratory study, subsequent multi-center validation is necessary. Continuous improvement of data governance and comprehensive regulatory systems is required to furthe","PeriodicalId":45684,"journal":{"name":"AIMS Public Health","volume":"13 1","pages":"273-288"},"PeriodicalIF":4.0,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13084355/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147724269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"People as frontliners in the management of disasters and public health emergencies.","authors":"Phatthranit Phattharapornjaroen, Amir Khorram-Manesh, Gülcan Taşkıran Eskici, Yuwares Sittichanbuncha, Lesley Gray","doi":"10.3934/publichealth.2026014","DOIUrl":"10.3934/publichealth.2026014","url":null,"abstract":"<p><p>Managing healthcare effectively during disasters and public health emergencies (DPHEs) is often challenging due to inadequate surge capacity across four key areas: Staff, stuff, space, and system. Expanding this capacity is vital when healthcare facilities are threatened or infrastructure fails. A promising approach involves utilizing community resources and latent individual capabilities, especially in resource-limited settings where community participation is critical. In this study, we utilized a scoping review methodology to investigate strategies for mobilizing individual capabilities within DPHE management. A systematic search was conducted across PubMed, Scopus, Web of Science, and grey literature sources. From an initial pool of 512 records, 50 documents met the inclusion criteria following a rigorous full-text review. Collaborative thematic analysis of included studies identified seven major themes: Communities as frontline actors and the evolution of the \"frontliner\" concept; effectiveness of community-based training and participatory interventions; participation, agency, and community-delivered health services in displacement and recovery contexts; institutionalization and integration of community capacity; trust, social capital, and local leadership as determinants of engagement and effectiveness; participatory tools for planning and the limits of \"participation\" in practice; and community engagement in public health emergencies and epidemic response. Leveraging local capacities and resources in community centric DPHE management can augment formal response systems as long as they are effective, sustained, and meaningful. However, significant gaps remain regarding implementation, sustainability, power dynamics, and equity. Future research needs to move beyond descriptive accounts and focus on strategies to overcome barriers to participation, ensuring equity and fair distribution of resources and rigorously evaluating the real-world impacts of integrated community-institutional approaches. Ultimately, these strategies can foster collective action to improve community health and well-being and shift the paradigm from institutional reliance to community-centric resilience.</p>","PeriodicalId":45684,"journal":{"name":"AIMS Public Health","volume":"13 1","pages":"240-272"},"PeriodicalIF":4.0,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13084393/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147724280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vietnam biobanking feasibility study: An overview of biobanking landscape, infrastructure, and capacity.","authors":"Hanh Vu, Io Hong Cheong, Jasper Hoi Chun Luong, Daniel Simeon-Dubach, Duyen Le, Thi Hong Xuan Pham, Nguyen Trung Thanh, Nguen Quoc Dat","doi":"10.3934/publichealth.2026013","DOIUrl":"10.3934/publichealth.2026013","url":null,"abstract":"<p><p>Within Southeast Asia, there are still some challenges in managing non-communicable diseases and public health. Vietnam's government has supported its biotech research and pharmaceutical capacity for many years, including creating research infrastructure such as biobanks. To better understand the situation of biobanks in Vietnam, a feasibility study adapted from previous biobank work in Southeast Asia was conducted to analyze the knowledge gap for biobanking in Vietnam. The questionnaire was redefined for the purpose of the Vietnamese research climate, with 66 items categorized into 8 sections. Specifically, the study analyzed the following information: 1) General Information, (2) Biobank Information, (3) Sample and Storage Management, (4) Biobank Infrastructure, (5) Operational Resources and Personnel, (6) Laboratory Information Management Systems (LIMS), (7) Quality Management Systems (QMS), and (8) Risk Management Systems. The results showed that most biobanks in Vietnam have good energy supplies and backup power. Internet access was more critical, and backup sources were rare. Human resource management and training programs were well established. The QMS and LIMS were widespread, thus promoting confidence in the quality of biobanking, while waste management was also in place. However, reliable and available dry ice was hard to find, and sensitive data/documents lacked confidentiality. Most biobanks have a contingency plan, but alert systems/breach procedures raised questions about the quality of the contingency plans. To our knowledge, this is the first feasibility study of the biobank infrastructure in Vietnam. Our results, based on a selected group of biobanks, suggest there are well-established; however, there are critical challenges that should be addressed in the near future. Ultimately, the findings in this study should provide a foundation for future policy work, informed strategic planning, and resource allocation for the sustainable development and operation of biobanks in Vietnam. Additionaly, another survey with a broader group of biobanks should be planned.</p>","PeriodicalId":45684,"journal":{"name":"AIMS Public Health","volume":"13 1","pages":"222-239"},"PeriodicalIF":4.0,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13084478/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147724278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the public health risk from ESKAPE pathogens including MRSA and VRE on high-touch shopping cart surfaces.","authors":"Ziad Jaradat, Batool Khataybeh, Qutaiba Ababneh, Anas Al Nabulsi, Ragad Musa, Lamice Shurafa, Nisrina Ali, Maram Zahrawi, Farah Harbieh, Jude Nassar, Abeer Idrees, Bara'ah Eyadat, Ekhlas Al-Rousan","doi":"10.3934/publichealth.2026012","DOIUrl":"10.3934/publichealth.2026012","url":null,"abstract":"<p><p>Increased antimicrobial resistance (AMR) poses a significant threat to global health. This study investigated the prevalence, antibiotic susceptibility, and biofilm-forming ability of ESKAPE pathogens on shopping cart handles in Jordan. Swab samples were collected from 820 shopping carts used in grocery stores, and ESKAPE bacteria were identified using microbiological and molecular methods. The most prevalent species isolated was <i>Staphylococcus aureus</i>, which was recovered from 4.8% of the samples, followed by <i>Acinetobacter baumannii</i> (2.1%), <i>Escherichia coli</i> (2%), and <i>Enterococcus spp</i>. (0.73%). Most isolates were sensitive to antibiotics, though two <i>E. faecium</i> isolates showed resistance to vancomycin (VRE), and 17 <i>S. aureus</i> isolates were methicillin-resistant (MRSA). The ability of the isolates to form biofilm varied, with most <i>S. aureus</i> being non-formers (53.8%), whereas <i>A. baumannii</i> isolates were predominantly strong formers (53%). The presence of ESKAPE pathogens, including clinically significant strains like MRSA and VRE, on frequently touched shopping cart handles highlights the role played by these surfaces as potential reservoirs for transmission in the community.</p>","PeriodicalId":45684,"journal":{"name":"AIMS Public Health","volume":"13 1","pages":"204-221"},"PeriodicalIF":4.0,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13084352/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147724077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The long-term impact of Spain's 2010 Anti-Smoking Law: A counterfactual and prospective time-series analysis.","authors":"Juan Manuel Martín-Álvarez, Aida Galiano, Brenda Vázquez-La Hoz, Serhiy Lyalkov","doi":"10.3934/publichealth.2026011","DOIUrl":"10.3934/publichealth.2026011","url":null,"abstract":"<p><p>This study evaluated the impact of Spain's 2010 Anti-Smoking Law on cigarette sales using a hybrid counterfactual and forecasting framework that combines econometric and machine learning models. Monthly provincial data observed from January 2005 to August 2025 are used to estimate the historical effects of the law (2011-2013) and to generate prospective projections under alternative scenarios for the period 2025-2027. Six time-series models-ETS, Harmonic, NNAR, SARIMA, STL_AR, and STLM-were compared using a multi-metric validation scheme to ensure robustness. Results indicate that the 2010 law generated an immediate and persistent reduction in cigarette sales throughout Spain. Across models, the cumulative national decline over 2011-2013 ranged between 0.37 and 2.45 billion cigarette packs, equivalent to a 15%-30% contraction in the tobacco market. Projections from September 2025 to December 2027 suggest continued stabilization or slight decreases in cigarette sales, indicating the long-term persistence of the law's impact. Methodologically, the study demonstrates that hybrid time-series and machine learning ensembles outperform single-model approaches in capturing structural breaks, nonlinearities, and seasonality shifts associated with behavioral regulation. The results confirm the effectiveness of comprehensive tobacco control policies in achieving sustained public health gains. Overall, Spain's experience exemplifies how evidence-based regulation can produce lasting declines in harmful consumption and provides a replicable framework for evaluating future public health interventions.</p>","PeriodicalId":45684,"journal":{"name":"AIMS Public Health","volume":"13 1","pages":"178-203"},"PeriodicalIF":4.0,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13084742/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147724267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Forging a global shield against HMPV: Uniting healthcare systems and community action to counter a silent respiratory epidemic.","authors":"Mona Gamal Mohamed, Shaimaa Hashem Elsalous","doi":"10.3934/publichealth.2026010","DOIUrl":"10.3934/publichealth.2026010","url":null,"abstract":"<p><strong>Background: </strong>Human metapneumovirus (HMPV) has emerged as a significant global cause of acute respiratory infections, disproportionately affecting vulnerable populations such as young children, the elderly, and immunocompromised individuals. Despite its considerable impact, contributing to 5%-15% of pediatric respiratory hospitalizations and 10% of respiratory deaths in children under five, HMPV often remains underdiagnosed and receives insufficient attention within public health frameworks. The absence of specific antiviral treatments and preventative vaccines further exacerbates its clinical consequences.</p><p><strong>Aim: </strong>This review aims to consolidate current understanding regarding HMPV's epidemiology, clinical manifestations, diagnostic approaches, and management strategies, while also identifying existing gaps in prevention and research efforts.</p><p><strong>Methods: </strong>A systematic review of peer-reviewed literature published between 2001 and 2024 was conducted. The search encompassed databases such as PubMed, Web of Science, and those maintained by the World Health Organization (WHO). Keywords utilized for the search included \"human metapneumovirus\", \"HMPV epidemiology\", and \"HMPV treatment\". Studies selected for inclusion were rigorously assessed for their epidemiological data, diagnostic methodologies, clinical management protocols, and preventative measures. The collected data were then synthesized to pinpoint critical knowledge deficiencies and areas requiring future research focus.</p><p><strong>Results: </strong>Our comprehensive analysis indicates that HMPV contributes significantly to global morbidity, exhibiting seasonal patterns that vary geographically with hemisphere and climate. Diagnostic challenges persist due to the symptomatic overlap with other common respiratory viruses like RSV and influenza, and current treatment approaches remain primarily supportive. Promising advancements in vaccine development, including candidates targeting the F-protein and utilizing mRNA technology, are underway but necessitate further clinical evaluation. Populations at high risk, particularly those in resource-limited settings, experience a disproportionately higher burden of disease due to inadequate diagnostic capabilities and underdeveloped healthcare infrastructure.</p><p><strong>Conclusions: </strong>HMPV represents a substantial, yet frequently underestimated, respiratory pathogen demanding immediate public health attention. Key priorities for addressing this include (1) the development of rapid and accessible diagnostic tools, (2) accelerating vaccine candidates through rigorous clinical trials, (3) establishing evidence-based treatment guidelines, and (4) strengthening global surveillance systems. A coordinated international effort is imperative to mitigate the considerable health and economic repercussions of HMPV infection.</p>","PeriodicalId":45684,"journal":{"name":"AIMS Public Health","volume":"13 1","pages":"158-177"},"PeriodicalIF":4.0,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13084423/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147724286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Before the algorithm: An exemplar case of the necessity of statistical testing for epidemiological consistency in public health data.","authors":"Marco Roccetti","doi":"10.3934/publichealth.2026008","DOIUrl":"10.3934/publichealth.2026008","url":null,"abstract":"<p><p>The adoption of sophisticated analytical tools, including Machine Learning and massive data processing, has accelerated health research. However, a foundational principle asserts that the rigor of these complex methods is dependent on the integrity and validity of the underlying statistical design. I posit that advanced analyses, particularly in epidemiology, must be subsequent to the rigorous verification of methodological coherence. In this study, I used an exploratory case to demonstrate a crucial cautionary principle: Complex models amplify, rather than correct, substantial methodological limitations. To demonstrate this, I applied standard descriptive and inferential statistical methods (Z-tests, Confidence Intervals, and t-tests) alongside established national epidemiological benchmarks to a published cohort study on vaccine outcomes and psychiatric events. Through this approach, I identified multiple, statistically significant inconsistencies within the source data, including implausible incidence rates and relevant baseline group imbalances. These findings, supported by inferential statistical evidence, demonstrated that the observed effects (e.g., contradictory Hazard Ratios) are not biological but are mathematical artifacts stemming from uncorrected selection and classification biases in the cohort construction. These paradoxes arise from the exclusion of prevalent psychiatric cases in the vaccinated group and the misclassification of pre-existing conditions as new incident events in the control group. Our analysis serves as a robust demonstration that the validity of any conclusion drawn from subsequent advanced ML or statistical modeling sourced from public health data rests on first passing the test of basic epidemiological consistency.</p>","PeriodicalId":45684,"journal":{"name":"AIMS Public Health","volume":"13 1","pages":"121-134"},"PeriodicalIF":4.0,"publicationDate":"2026-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13084459/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147724123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between burnout, sociodemographic factors, health behaviors, and obesity indices in Spanish employees.","authors":"Aina Gabriela Valiente Pizá, Pedro Juan Tárraga López, Ángel Arturo López-González, Irene Coll Campayo, Carla Busquets-Cortés, José Ignacio Ramírez Manent","doi":"10.3934/publichealth.2026009","DOIUrl":"10.3934/publichealth.2026009","url":null,"abstract":"<p><strong>Background: </strong>Obesity remains a major global health concern, and psychosocial stressors such as burnout may contribute to its development. While lifestyle and sociodemographic factors are recognized determinants, their interaction with burnout has been less studied, especially using advanced adiposity indices. In this study, we assessed the associations between burnout, sociodemographic variables, lifestyle habits, and obesity in a large cohort of Spanish employees.</p><p><strong>Methods: </strong>We performed a cross-sectional analysis of Spanish workers undergoing occupational health examinations. Burnout was classified into low, moderate, and high levels. Obesity was assessed using body mass index (BMI), waist-to-height ratio (WtHR), the Clínica Universidad de Navarra Body Adiposity Estimator (CUN-BAE), and the Metabolic Score for Visceral Fat (METS-VF). Logistic regression models adjusted for sociodemographic and behavioral variables were applied, including interaction analyses.</p><p><strong>Results: </strong>Burnout showed a strong and graded association with obesity across all indices. Compared with low burnout, high burnout was associated with up to a 40% higher odds of obesity by BMI, and even stronger associations when using CUN-BAE and METS-VF. Women, older employees, and those from lower social classes were disproportionately affected. Adherence to a Mediterranean diet and engagement in regular physical activity were associated with lower obesity risk among participants with higher burnout levels.</p><p><strong>Conclusions: </strong>Burnout is a significant and independent correlate of obesity in working populations, particularly when measured with indices capturing visceral fat. Vulnerable groups, women, older workers, and lower social classes, -require targeted interventions. Workplace health programs should integrate stress management with lifestyle promotion as dual strategies to combat obesity. Longitudinal research is needed to confirm causality and assess intervention effectiveness.</p>","PeriodicalId":45684,"journal":{"name":"AIMS Public Health","volume":"13 1","pages":"135-157"},"PeriodicalIF":4.0,"publicationDate":"2026-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13084453/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147724082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of digital health education intervention on stress, anxiety and depression of patients with polycystic ovarian syndrome: study protocol for a single blinded randomized controlled trial.","authors":"Sadia Akter, Farkhanda Mahjebin, Mohammad Delwer Hossain Hawlader, Md Moshiur Rahman, Sanmei Chen, Saori Kashima, Sheuly Akter, Shamit Dasgupta, Yoko Shimpuku","doi":"10.3934/publichealth.2026007","DOIUrl":"10.3934/publichealth.2026007","url":null,"abstract":"<p><strong>Background: </strong>Polycystic ovarian syndrome (PCOS) is an endocrine disorder that is connected to a range of gynecological symptoms. The disorder has both physical and mental health outcomes. While the physical symptoms are often expressed and diagnosed, the mental health outcomes are ignored and undiagnosed. To the best of our knowledge, in Bangladesh, although women are affected by the disease, research exploring the impact of digital health interventions on the mental health burden is scarce. Emerging evidence suggests that smartphone-based health education interventions could be helpful in alleviating the psychological burden associated with PCOS by improving awareness and self-management among patients.</p><p><strong>Objective: </strong>The aim of the study is to explore the impact of digital health education on the stress, anxiety, and depression levels among PCOS patients in Bangladesh.</p><p><strong>Methods: </strong>A single blinded, randomized controlled trial was being conducted at the Enayetpur of Sirajganj district at Khwaja Yunus Ali Medical College and Hospital. A total of 212 participants were randomly assigned to either the intervention group or the control group in the study. The intervention group received PCOS related health education via a mobile application reinforced with app notifications and bi-monthly phone calls from the researcher. Baseline Data collection was completed in April 2025. Endline data collection started in November 2025. The intervention was a six-month intervention that ran from May to October. The primary outcome, depression, stress and anxiety was measured using the DASS21 questionnaire. The secondary outcomes were serum hormone levels (cortisol and testosterone), body mass index (BMI), and knowledge about PCOS.</p><p><strong>Results: </strong>The baseline data collection was completed in April 2025. A total of 212 patient provided their consent to participate in the study. The participants were divided into groups of 106 individuals for the control and intervention groups.</p><p><strong>Trial registration: </strong>Japan Registry of Clinical Trials (jRCT2062240073), https://jrct.mhlw.go.jp/en-latest-detail/jRCT2062240073 and North South University Institutional Review Board approved this study (#2024/0RNSU/IRBII 002).</p>","PeriodicalId":45684,"journal":{"name":"AIMS Public Health","volume":"13 1","pages":"105-120"},"PeriodicalIF":4.0,"publicationDate":"2026-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13084743/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147724067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between ketone body levels and chronic liver disease: Epidemiological studies and potential mechanisms.","authors":"Zeping Liu, Yihu Zheng, Yi Li","doi":"10.3934/publichealth.2026006","DOIUrl":"10.3934/publichealth.2026006","url":null,"abstract":"<p><p>Chronic liver disease encompasses conditions such as metabolic dysfunction-associated steatotic liver disease, metabolic dysfunction-associated steatohepatitis, alcohol-related liver disease, and chronic viral hepatitis, being a major cause of cirrhosis and hepatocellular carcinoma. Ketone bodies, crucial hepatic energy substrates, may serve as biomarkers in CLD progression. This review investigated the association between chronic liver diseases and ketone body levels. Studies indicate that ketone body levels may serve as biomarkers for chronic liver diseases. Patients with metabolic dysfunction-associated steatotic liver disease have elevated ketone levels. However, findings are inconsistent in obese populations and metabolic dysfunction-associated steatohepatitis. The relationship between ketone body levels and other chronic liver diseases, such as alcohol-related liver disease and chronic viral hepatitis, remains unclear, necessitating further research. The review also discussed potential mechanisms linking ketone metabolism abnormalities to chronic liver disease pathogenesis. Understanding the role of ketone bodies in chronic liver disease is essential for developing targeted interventions, and future research should employ large-scale databases and causal inference methods to clarify these associations.</p>","PeriodicalId":45684,"journal":{"name":"AIMS Public Health","volume":"13 1","pages":"82-104"},"PeriodicalIF":4.0,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13084475/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147724072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}