International Journal of Burns and Trauma最新文献

{"title":"The role of macrophages in thermal injury.","authors":"Julia A Penatzer,&nbsp;Shruthi Srinivas,&nbsp;Rajan K Thakkar","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Macrophages, first discovered for their phagocytic ability, are a complicated and heterogeneous cell type. The unique properties of macrophages allow them to perform a vast array of functions, including phagocytosis, cytokine production, antigen presentation, and wound healing. Some macrophage populations are derived from monocytes and are induced into specific phenotypes by the local tissue microenvironment, while other macrophages form during early embryonic development. The exposure of the host to local pathogens and/or traumatic injury alters the tissue microenvironment and, in turn, influences changes in macrophage phenotype and function. Perhaps the most significant change in the local tissue microenvironment and subsequent macrophage phenotype occurs after thermal injury, which causes localized tissue damage and a massive systemic inflammatory response. However, few studies have explored the influence of burn injury on the host macrophages and macrophage function in burn wounds. Furthermore, the literature is scant regarding the impact macrophage function has on outcomes in thermal injury. This review will focus on the current knowledge of macrophage function in burn wounds and the phenotypic changes in macrophages during thermal injury while identifying knowledge gaps.</p>","PeriodicalId":45488,"journal":{"name":"International Journal of Burns and Trauma","volume":"12 1","pages":"1-12"},"PeriodicalIF":0.8,"publicationDate":"2022-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8918762/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40308316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of functional outcome and comparison of three different surgical modalities for management of intertrochanteric fractures in elderly population.","authors":"Abhishek Garg,&nbsp;Pradeep Kamboj,&nbsp;Pankaj Kumar Sharma,&nbsp;Umesh Yadav,&nbsp;Ram Chander Siwach,&nbsp;Virender Kadyan","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>The purpose of this study was to compare the role of the various surgical modalities ie, Hemiarthroplasty (HA), Dynamic Hip Screw (DHS), Cephalo-medullary nail (CMN) in the management of intertrochanteric fractures in elder patients with comparison of the results and assessment of the complications encountered with each method.</p><p><strong>Methods: </strong>Total 105 adult patients having intertrochanteric fractures managed during July 2013 to December 2018 at tertiary trauma care centre and followed for minimum 12 months were included in the study. Patients were divided into three groups. Primary hemiarthroplasty was done in 35 patients (group A) while DHS and PFN was done in 35 patients each in group B and group C respectively. Functional evaluation was done using Modified Harris Hip score (HHS) at different intervals while ambulatory function was measured using the Parker Mobility Score.</p><p><strong>Results: </strong>The mean age of patients was 72.14±2.9 years. Mean operative time and blood loss in group A was significantly higher than the other two groups. Hemiarthroplasty group could ambulate earlier than DHS/PFN group. Mean HHS at final follow up was 85.40±7 in group A while in group B and group C these values were 76.36±16.45 and 86.85±10.52 respectively. HHS was significantly higher (P, 0.01) in hemiarthroplasty group in comparison to DHS group. Post-operative complications were comparable in all the groups.</p><p><strong>Conclusion: </strong>We support the use of hemiarthroplasty for unstable intertrochanteric fracture in elderly patients with lesser failure rates, early mobilization and better functional outcomes. Early mobilization and less hospital stay should be the goal of every surgical procedure in the elder population.</p>","PeriodicalId":45488,"journal":{"name":"International Journal of Burns and Trauma","volume":"12 1","pages":"13-22"},"PeriodicalIF":0.8,"publicationDate":"2022-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8918764/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40308318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of patterns, cause and risk factors of burns in patients with seizure.","authors":"Seyyed Mahdi Zia Ziabari,&nbsp;Mohammad Reza Mobayen,&nbsp;Sheyda Rimaz,&nbsp;Daniel Rahimi Nejat,&nbsp;Siamak Rimaz","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Burns following convulsion could be an important problem for patients with epilepsy. In the present study we aimed to identify the pattern and the cause of burns in these patients.</p><p><strong>Methods: </strong>This is a cross-sectional study that was performed in 2017-2019 in Guilan on 40 patients with burns following seizure. The information in the records of patients were reviewed. We collected data including age, sex, marital status, occupation, place of residence, length of hospital stay, anatomy of the burn site, percentage of burn, degree of burns, cause of burns and disease outcome.</p><p><strong>Results: </strong>The mean age of the patients was 42.2±2.99 years. Seven cases (17.5%) had burns due to fire, 5 cases (12.5%) due to gas explosion, 3 cases (7.5%) due to electrocution, 15 cases (37.5%) with hot water, 1 case (2.5%) with hot liquids, 5 cases (12.5%) with hot surface, 1 case (2.5%) with hot bath, 2 cases (5%) with hot food and 1 case (2.5%) with hot glue. The mean burning percentage of patients was 19.3±3.18%. The most common patterns of burns were observed as 7 (17.5%) upper limbs and 7 (17.5%) lower limbs. The mean duration of hospitalization was 5.05±0.69 days ranging from 1 to 18 days. 37 patients (92.5%) recovered partially and 3 patients (7.5%) died.</p><p><strong>Conclusion: </strong>Hot water, fire and hot surface are most common causes of burns and there were significant direct correlations between age with percentage of burns and duration of hospitalization. We believe further studies should evaluate the preventive strategies in this regard.</p>","PeriodicalId":45488,"journal":{"name":"International Journal of Burns and Trauma","volume":"12 1","pages":"23-27"},"PeriodicalIF":0.8,"publicationDate":"2022-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8918765/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40308315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of berberine-loaded albumin nanoparticles in infections of traumatic wounds.","authors":"Zhenqiang Liu,&nbsp;Yanchao Liu,&nbsp;Ting Fang,&nbsp;Jianhua Xia,&nbsp;Ning Ma,&nbsp;Yanhong Wang","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In recent years, the morbidity of infections in traumatic wounds has been on the increase. There are not many kinds of drugs for clinical treatment of infections, and their efficacy and safety are limited. Plant antimicrobial drugs are increasingly popular in mainstream medicine due to the challenges of traditional antibiotics abuse. Berberine has a scavenging effect on infections, however, berberine was restricted from using as a drug preparation with poor stability and bioavailability. Due to the low toxicity of nanoparticles, the green-synthetic, size-controlled approach of nanoparticles has been paid more attention. Therefore, based on the intermolecular disulfide bond network platform built earlier, we designed and developed a strategy to assemble molecular bovine serum albumin into large-sized nanostructures through the reconstructed intermolecular disulfide bond and hydrophobic interaction, and berberine with poor water solubility was encapsulated in it. Nanoassembly with bovine serum albumin increased biostability of berberine and significantly improved its activity against Staphylococcus Aureus (<i>S.aureus</i>) activity, which gives some new insights into the preparation and development of anti-infectives for Chinese medicine.</p>","PeriodicalId":45488,"journal":{"name":"International Journal of Burns and Trauma","volume":"12 1","pages":"28-34"},"PeriodicalIF":0.8,"publicationDate":"2022-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8918763/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40308317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of keratinocyte function on the defected diabetic wound healing.","authors":"Navid Hosseini Mansoub","doi":"10.5603/dk.a2022.0004","DOIUrl":"https://doi.org/10.5603/dk.a2022.0004","url":null,"abstract":"Non-healing wounds are a major complication of diabetes that can lead to limb amputation and disability in patients. The normal process of wound repair progresses through well-defined stages including hemostasis, inflammation, proliferative, and remodeling, which may be impaired in diabetic wounds. In recent years, it has been reported that keratinocytes, a major cell type in human skin, play a key role in the healing process of wounds. In this overview, firstly, a summary of the wound healing process is provided and the role of keratinocytes in wound healing is briefly reviewed. Then, a set of evidence about the impaired keratinocytes activities in diabetic wounds and clinical trials focused mainly on improving keratinocytes in the context of diabetic wound therapeutics are summarized. Keratinocytes can produce signaling molecules that act in a paracrine and autocrine way, causing pleiotropic effects on various cell types. The affected cells respond to keratinocytes by creating several signaling molecules, which also adjust keratinocyte activation through wound healing. In diabetic wounds, disruption of various biological mechanisms leads to dysfunction of keratinocytes including impaired migration, adhesion, and proliferation. The function of abnormal keratinocytes can lead to poor diabetic wound healing. Taken together, clarification of molecular and functional disturbances of keratinocyte cells and applying them in diabetic wounds can contribute to enhanced treatment of diabetic wounds. Based on the location of keratinocytes in the epidermis and the central role of keratinocytes in the diabetic wound healing process, applying keratinocytes has great potential for the treatment of diabetic burn wounds.","PeriodicalId":45488,"journal":{"name":"International Journal of Burns and Trauma","volume":"11 6 1","pages":"430-441"},"PeriodicalIF":0.8,"publicationDate":"2022-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44435705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Initial treatment strategies in new-onset atrial fibrillation in critically ill burn patients.","authors":"Mithun R Suresh,&nbsp;Alexander C Mills,&nbsp;Garrett W Britton,&nbsp;Wilson B Pfeiffer,&nbsp;Marissa C Grant,&nbsp;Julie A Rizzo","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Atrial fibrillation is associated with increased morbidity and mortality in critically ill patients. Few studies have specifically examined this arrhythmia in burn patients. Given the significant clinical implications of atrial fibrillation, understanding the optimal management strategy of this arrhythmia in burn patients is important. Consequently, the purpose of this study was to examine rate- and rhythm-control strategies in the management of new onset atrial fibrillation (NOAF) and assess their short term outcomes in critically ill burn patients.</p><p><strong>Methods: </strong>We identified all patients admitted to our institution's burn intensive care unit between January 2007 and May 2018 who developed NOAF. Demographic information and burn injury characteristics were captured. Patients were grouped into two cohorts based on the initial pharmacologic treatment strategy: rate-(metoprolol or diltiazem) or rhythm-control (amiodarone). The primary outcome was conversion to sinus rhythm. Secondary outcomes included relapse or recurrence of atrial fibrillation, drug-related adverse events, and complications and mortality within 30 days of the NOAF episode.</p><p><strong>Results: </strong>There were 68 patients that experienced NOAF, and the episodes occurred on median days 8 and 9 in the rate- and rhythm-control groups, respectively. The length of the episodes was not significantly different between the groups. Conversion to sinus rhythm occurred more often in the rhythm-control group (P = 0.04). There were no differences in the incidences of relapse and recurrence of atrial fibrillation, and the complications and mortality between the groups. Hypotension was the most common drug-related adverse event and occurred more frequently in the rate-control group, though this difference was not significant.</p><p><strong>Conclusions: </strong>Conversion to sinus rhythm occurred more often in the rhythm-control group. Outcomes were otherwise similar in terms of mortality, complications, and adverse events. Hypotension occurred less frequently in the rhythm-control group, and although this difference was not significant, episodes of hypotension can have important clinical implications. Given these factors, along with burn patients having unique injury characteristics and a hypermetabolic state that may contribute to the development of NOAF, when choosing between rate- and rhythm control strategies, rhythm-control with amiodarone may be a better choice for managing NOAF in burn patients.</p>","PeriodicalId":45488,"journal":{"name":"International Journal of Burns and Trauma","volume":"12 6","pages":"251-260"},"PeriodicalIF":0.8,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9845808/pdf/ijbt0012-0251.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10544823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of clinical findings and CT scan in children with minor head trauma.","authors":"Seyyed Mahdi Zia Ziabari,&nbsp;Payman Asadi,&nbsp;Zoheir Reihanian,&nbsp;Aryan Rafieezadeh,&nbsp;Nazanin Noori Roodsari,&nbsp;Ilnaz Tavakoli,&nbsp;Habib Eslami-Kenarsari,&nbsp;Golnoosh Seifi","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>The most common cause of death or severe impairment in children older than one-year-old is traumatic brain injury (TBI). Assessing TBI in children with minor head trauma (MHT) using clinical findings from history-taking and a physical exam is crucial to minimizing unnecessary brain CTs and more accurately predicting TBI. We aimed to evaluate the findings of brain CT scans in children with mild head trauma and their relationship with clinical signs and symptoms to avoid unnecessary interventions in many children with MHT.</p><p><strong>Methods: </strong>This cross-sectional-analytical study was performed to evaluate the findings of brain CT scans in children with MHT and their relationship with clinical signs and symptoms that were referred to Poursina Hospital in Rasht in the first half of 2021. Children were divided into two age groups: under two years and 2-12 years, and analyzed separately. Initially, a list containing all demographic information, patients' clinical signs, and symptoms were prepared. The collected data were then analyzed using SPSS software version 26.</p><p><strong>Results: </strong>According to the results, the mean age of patients was 66.01 months and 88 were boys (56.4%). The most common mechanism of injury was falling from a height. Most patients had isolated head injuries. Among the accompanying injuries, facial injuries were the most common. Among the clinical factors studied, cranial fracture on CT scan and GCS less than 15 were significantly associated with the occurrence of traumatic brain injury on CT scan. In addition, cranial fracture on CT scan, injury severity, and history of vomiting had the highest positive predictive value, respectively.</p><p><strong>Conclusion: </strong>Standard history and clinical examination are sufficient to identify high-risk cases of pediatric head injuries. GCS is the most important risk factor for pediatric MHT. Requesting a CT scan is not recommended without these risk factors.</p>","PeriodicalId":45488,"journal":{"name":"International Journal of Burns and Trauma","volume":"12 6","pages":"261-268"},"PeriodicalIF":0.8,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9845804/pdf/ijbt0012-0261.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10551723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response of a single European burn center to Centelles mass casualty burn disaster: enzymatic debridement utility.","authors":"Jon Ander Aguirrezabala,&nbsp;Jorge Aguilera-Sáez,&nbsp;Marc Illa-Boixaderas,&nbsp;Jordi Serracanta,&nbsp;Alejandra Monte-Soldado,&nbsp;Danilo Rivas-Nicolls,&nbsp;Juan P Barret","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Mass burn casualty disasters present with a big challenge due to the complex multidisciplinary management of severely burned patients and the limited capacity of the specialized centers. Literature is scarce, and so is the management of these disasters with enzymatic debridement (ED).</p><p><strong>Methods: </strong>Retrospective observational analysis of nine patients admitted to the Vall d'Hebron University Hospital Burn Center (Barcelona, Spain), as a consequence of a bell tower explosion on December 30, 2019. The patients with intermediate-deep second-degree burns, either in circumferential or affecting highly functional areas as hands, feet or face, were included in the ED group. Continuous variables are expressed as mode and standard deviation and quantitative ones as percentages.</p><p><strong>Results: </strong>Fourteen people were injured after the explosion of gunpowder-containing bags in a bell tower during a cultural celebration. Nine casualties (6 men and 3 women) suffered burn injuries that required assessment and admission in our Burn Center. The mean age was 44.33 years (range 19-61 years), with burns covering a mean total body surface area (TBSA) of 15% (range 5-48% TBSA). One patient required invasive mechanical ventilation and intensive care management. Seven patients required ED, with an average debrided TBSA of 6.1% (range 3-10% TBSA). Seven out of 9 patients required at least one surgery. The average hospital stay was 23.33 days (range 2-53 days). No escharotomy was required and no patient died.</p><p><strong>Conclusions: </strong>This experience brought out the weak and strong features of our center when facing a situation that implies an important care stress. It can be useful for other Burn Centers in similar situations in the future. We found that new tools, such as ED, can be advantageous in such situations.</p>","PeriodicalId":45488,"journal":{"name":"International Journal of Burns and Trauma","volume":"12 6","pages":"224-231"},"PeriodicalIF":0.8,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9845805/pdf/ijbt0012-0224.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10551720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical versus conservative management of distal radius fracture with coronal shift; a randomized controlled trial.","authors":"Mohammad Dehghani,&nbsp;Hadi Ravanbod,&nbsp;Mohammadreza Piri Ardakani,&nbsp;Mohammad Hossein Tabatabaei Nodushan,&nbsp;Shakiba Dehghani,&nbsp;Meghdad Rahmani","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Coronal shift is one of the most critical complications related to distal radius fracture (DRF), leading to instability in the distal radioulnar joint (DRUJ). Nevertheless, there is no unified approach for the managing DRF with coronal shift; therefore, the current study aims to compare the surgical versus conservative approach for the coronal shift due to DRF treatment.</p><p><strong>Methods: </strong>This is a randomized clinical trial conducted on 50 patients with distal radius fracture (type 1 based on Fernandez Classification of Distal Radius Fractures) with a coronal shift in 2014-17. The patients were randomly allocated to treatment conservatively (n=25) by a long arm casting or surgically (n=25) using a volar plate fixation. The patients were followed for 24 months, and primary outcomes included a functional score on the Disabilities of the Arm, Shoulder, and Hand (DASH) questionnaire; pain score based on the Visual Analogue Scale (VAS), and handgrip strength (HGS) measured via a dynamometer were assessed and compared.</p><p><strong>Results: </strong>Both approaches led to significant improvement in range of motion, pain complaint, DASH scores, and HGS at the end of the two-year follow-up (<i>P</i>-value <0.05). The comparison of the trend of changes in the two groups generally revealed a remarkable better range of motions, VAS, and HGS among the operated cases (<i>P</i>-value <0.05); however, DASH score did not differ (<i>P</i>-value >0.05).</p><p><strong>Conclusion: </strong>The long-term outcomes of volar plate fixation for DRF management (bending fracture of metaphysis) plus coronal shift are notably superior to the conservative treatment; however, due to the limited information in this regard, further evaluations are strongly recommended.</p>","PeriodicalId":45488,"journal":{"name":"International Journal of Burns and Trauma","volume":"12 2","pages":"66-72"},"PeriodicalIF":0.8,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9123450/pdf/ijbt0012-0066.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10600167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effectiveness of skin allografts in survival rate of patients with major burns.","authors":"Maryam Azizian,&nbsp;Nadia Ghasemi Darestani,&nbsp;Linda Mohammadzadeh Boukani,&nbsp;Kimia Ghahremanloo,&nbsp;Sayed Mohammad Amin Nourian","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Burns are still one of the most prevalent injuries in the world. Allograft is in high demand as a biological dressing for any superficial open wounds, not just burn victims. Skin allograft is the gold standard for treating burns in people who do not have enough skin to cover all of the injured areas of their bodies. Studies have shown that skin allografts are superior to topical antimicrobial dressings in partial thickness burns and can reduce complications and length of hospital stay in burn patients. However, to the best of our knowledge very few studies have investigated these results in our country. The aim of the current study is to evaluate and report the outcomes of skin allograft on burn patient survival in Iran.</p><p><strong>Method: </strong>This prospective clinical trial study was performed on patients admitted to the burn center of Imam Khomeini Hospital in Tehran between July 15, 2017 and April 27, 2021. The control group consisted of patients admitted to the burn ward who were not undergoing skin allografts. This group was matched with the case group in terms of sex, age, and percentage of burns. We compared the outcome of the study was the duration of hospitalization, and status of patients at discharge. The study protocol was approved by Iranian Registry of Clinical Trials (IRCT) under the code of IRCT2016112431074N1 (https://fa.irct.ir/trial/24517).</p><p><strong>Result: </strong>Overall, 112 patients in the case group and 224 patients in the control group were studied. The length of hospital stay in the case group (41.13±11.7) was considerably longer than the control group (24.6±12.1) (P<0.001), but the mortality rate in the two groups was not statistically different (P=0.633). The average survival time of case group (53 days, 95% CI=45-56) was higher than the control group (49 days, 95% CI=39-58) (P=0.012). Number of allograft usage (OR=0.038, 95% CI=0.142-0.945) and also Age (OR=1.03, 95% CI=1.005-1.070) were predictors of death.</p><p><strong>Conclusion: </strong>Although the use of skin allografts in large burns (more than 50%) reduced mortality in burn patients, their use in burns less than 50% has not been effective in reducing patient mortality. Due to the limited access to this valuable product, its use in burns less than 50% should be done with caution and, due to the limited access to skin allografts in most burn centers in Iran, patients with extensive burns (more than 50%) should be used as a priority.</p>","PeriodicalId":45488,"journal":{"name":"International Journal of Burns and Trauma","volume":"12 2","pages":"45-51"},"PeriodicalIF":0.8,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9123452/pdf/ijbt0012-0045.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10600169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}