Turkish Journal of Obstetrics and Gynecology最新文献

{"title":"Comparative analysis of laparoendoscopic single-site surgery and versus conventional laparoscopic surgery in adnexectomy: A systematic review and metaanalysis of surgical outcome.","authors":"Greg J Marchand, Hollie Ulibarri, Amanda Arroyo, Daniela Gonzalez, Brooke Hamilton, Kate Ruffley, Marissa Dominick, Ali Azadi","doi":"10.4274/tjod.galenos.2025.09804","DOIUrl":"10.4274/tjod.galenos.2025.09804","url":null,"abstract":"<p><p>Although the removal of the adnexa technically removes more tissue, it may require less fine manipulation and dissection than cystectomy. Secondary to this, we sought to measure the effectiveness and safety of laparoendoscopic single-site surgery (LESS) versus conventional laparoscopy (CLS). We search six databases to find studies comparing LESS and CLS for ovarian lesions where removal of the entire ovary, with or without the fallopian tube, is necessary. Criteria used for study eligibility: both controlled trials and observational studies were included in this analysis. Study appraisal and synthesis methods: we used the Cochrane risk of bias assessment tool for the randomized clinical trials and the national heart, lung, and blood quality assessment tools for the observational studies. The statistical analysis was done using the review manager software. LESS showed a significantly longer operative time [mean difference (MD)=2.96 (-1.97, 7.90), p=0.24], but with moderate heterogeneity. Estimated blood loss was significantly lower for LESS [MD=-18.62 (-33.83, -3.42), p=0.02]. The length of patient hospital stay was comparable [MD=-0.02 (-0.50, 0.47), p=0.95]. Visual analog scale (VAS) pain scores at 24 hours [MD=0.23 (-0.09, 0.56), p=0.16] and 6 hours postoperatively [MD=0.15 (-0.04, 0.33), p=0.12] were similar. The LESS group required less postoperative analgesia [risk ratios (RR)=0.47 (0.32, 0.68), p=0.001]. The change in hemoglobin was comparable [MD=-0.11 (-0.26, 0.03), p=0.14]. Perioperative complications were higher in the LESS group [RR=2.236 (1.031, 4.851), p=0.04]. Compared with CLS, LESS required more operative time but resulted in significantly less blood loss and lower postoperative analgesic use. Hospital stays and VAS pain scores were similar. LESS had a higher incidence of perioperative complications, which questions the feasibility of its use in some situations.</p>","PeriodicalId":45340,"journal":{"name":"Turkish Journal of Obstetrics and Gynecology","volume":"22 1","pages":"83-95"},"PeriodicalIF":1.0,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11894769/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of sympathetic denervation via paraaortic lymphadenectomy on blood pressure in endometrial cancer patients.","authors":"Selçuk Erkılınç, Serhan Can İşcan, Sena Özcan, Betül Öztürk, Ufuk Atlıhan, Can Ata, Hüseyin Aytuğ Avşar, Tevfik Berk Bildacı, İlker Çakır","doi":"10.4274/tjod.galenos.2025.32654","DOIUrl":"10.4274/tjod.galenos.2025.32654","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the effect of para-aortic lymphadenectomy on blood pressure changes in endometrial cancer patients.</p><p><strong>Materials and methods: </strong>This retrospective study included patients with endometrial cancer treated surgically between 2017 and 2023. Patients undergoing para-aortic lymphadenectomy, up to the renal artery, in a non-nerve-sparing fashion, were compared with those undergoing pelvic lymphadenectomy or sentinel lymph node mapping. Data collected included age, body mass index, comorbidities including hypertension, diabetes mellitus, coronary artery disease, operative time, number of lymph nodes removed, tumor size, and postoperative complications. Preoperative blood pressure was recorded during outpatient visits, and postoperative measurements were collected daily during hospitalization and at follow-up visits. Statistical analyses assessed differences in systolic and diastolic blood pressure changes, operative outcomes, and complications.</p><p><strong>Results: </strong>A total of 264 patients were analyzed. Patients in the para-aortic group had significantly longer operative times. Tumor size was larger in the paraaortic group than in another group. Systolic blood pressure decreased significantly in the para-aortic group compared to the control group (para-aortic: -17 mmHg vs. non-para-aortic: -1.10 mmHg, p<0.05), with a similar trend for diastolic pressure (-8.00 mmHg vs. -0.80 mmHg, p<0.05). Chylous ascites (15.6% vs. 5.6%) and ileus (0% vs. 12%) were more common in the para-aortic group, along with the administration of radiotherapy and chemotherapy. Both systolic and diastolic blood pressures were significantly lower in paraaortic group, in both early and late postoperative follow-up measures (p<0.005).</p><p><strong>Conclusion: </strong>Aortic lymphadenectomy is associated with decreased blood pressure and may have therapeutic potential for hypertensive patients, highlighting the need for prospective randomized studies to explore this effect further.</p>","PeriodicalId":45340,"journal":{"name":"Turkish Journal of Obstetrics and Gynecology","volume":"22 1","pages":"13-18"},"PeriodicalIF":1.0,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11894776/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association of the FOXE1 polyalanine tract length with the occurrence of premature ovarian insufficiency in the Greek population: A pilot, case-control study.","authors":"Andreas Kalampalikis, Michail Panagiotopoulos, Sophia Ivanidou, Depy Mavrogianni, Peter Drakakis, Lina Michala","doi":"10.4274/tjod.galenos.2025.94024","DOIUrl":"10.4274/tjod.galenos.2025.94024","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the relationship between the FOXE1 gene polyalanine tract length and premature ovarian insufficiency (POI) in the Greek population.</p><p><strong>Materials and methods: </strong>Peripheral blood was collected from 28 women with POI and 29 healthy controls. DNA was extracted and the gene was amplified using the polymerase chain reaction (PCR) technique. The PCR product was sequenced and the number of alanine tracts and the genotypes was recorded. Statistical analysis examined differences in allele and genotype frequencies between the groups.</p><p><strong>Results: </strong>The patients' group mean age was 31.68 years with a mean age of POI diagnosis of 25.18 years. Five alleles (8, 12, 14, 16, 17 comprising alanine residues) and seven genotypes (14/14, 14/16, 16/16, 14/17, 16/17, 8/16, 12/14) were identified. The 8-alanine allele was exclusive to patients, while the 12-alanine allele appeared only in controls. The most common genotype in the study group was 14/16 (64.29%), whereas the most common genotype in the control group was 14/14 (41.4%). No differences of statistical significance were observed in the prevalences of the allele with 14 (p=0.590) and 16 (p=0.594) residues or the genotype prevalences between the two groups (p=0.066).</p><p><strong>Conclusion: </strong>Our preliminary findings suggest no correlation between FOXE1 polyalanine tract length and POI, but given the study's small sample size, they should be interpreted with caution. Further research is deemed necessary.</p>","PeriodicalId":45340,"journal":{"name":"Turkish Journal of Obstetrics and Gynecology","volume":"22 1","pages":"41-45"},"PeriodicalIF":1.0,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11894772/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of <i>TAB2</i> gene polymorphism with endometrial cancer susceptibility and clinical analysis.","authors":"Siyu Long, Yayun Wang","doi":"10.4274/tjod.galenos.2025.24983","DOIUrl":"10.4274/tjod.galenos.2025.24983","url":null,"abstract":"<p><strong>Objective: </strong>Transforming growth factor-β-activated kinase 1 binding protein 2 (TAB2) plays a vital role in inflammatory pathways. It has also been considered a potential target for the enhancement of the the antiestrogen effects. Previous evidence has indicated that TAB2 gene variants are associated with several diseases, whereas their potential correlation with endometrial cancer (EC) is unclear. This study aims to initially explore the association between TAB2 gene polymorphisms (rs237028 /AG, rs521845 T/G, and rs652921 T/C) and EC.</p><p><strong>Materials and methods: </strong>Polymerase chain reaction-restriction fragment length polymorphism was applied to determine the genotype composition and the allele frequencies of TAB2 gene variant polymorphisms in 270 EC patients and 294 healthy controls.</p><p><strong>Results: </strong>The G allele of rs521845 was related to the increase of EC risk [p=0.08, odds ratio (OR): 0.72, 95% confidence interval (CI): 0.56-0.91]. Moreover, EC risk was associated with rs521845 in different genetic models (p=0.017, OR: 0.63, 95% CI: 0.44-0.91 in the codominant model; p=0.0051, OR: 0.61, 95% CI: 0.43-0.87 in the dominant model). For rs237028, the percentage of AG genotype in patients with highly differentiated tumours (G1) was significantly higher than that in moderately, poorly differentiated patients (G2/G3) (p=0.031, OR: 0.77, 95% CI: 0.45-1.30).</p><p><strong>Conclusion: </strong>Our results showed that the rs521845 polymorphism of TAB2, was associated with EC risk, suggesting that TAB2 may play a crucial role in EC prognosis.</p>","PeriodicalId":45340,"journal":{"name":"Turkish Journal of Obstetrics and Gynecology","volume":"22 1","pages":"1-12"},"PeriodicalIF":1.0,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11894771/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glutathione S-transferase polymorphisms and their role in recurrent pregnancy loss: A genetic risk assessment.","authors":"Nejmiye Akkus, Hande Kucuk Kurtulgan","doi":"10.4274/tjod.galenos.2025.57609","DOIUrl":"10.4274/tjod.galenos.2025.57609","url":null,"abstract":"<p><strong>Objective: </strong>The frequency of recurrent pregnancy loss in society is 3-5%. Experts suggest that genetics account for over 80% of unexplained recurrent pregnancy loss. Glutathione S-transferase (GST) enzymes, regulated by GST genes, facilitate the detoxification of a variety of naturally occurring metabolites as well as environmentally derived chemicals. This research aimed to investigate GST gene polymorphisms as a potential risk factor in recurrent pregnancy loss etiology in the Turkish population.</p><p><strong>Materials and methods: </strong>This study involved 107 recurrent pregnancy loss patients who sought treatment at the Sivas Cumhuriyet University Faculty of Medicine, Department of Medical Genetics, along with a control group of 107 individuals who had a successful birth and no previous history of miscarriage. The multiplex polymerase chain reaction and restriction fragment length polymorphism techniques were employed to analyze <i>GSTM1, GSTT1</i> and <i>GSTP1</i> gene polymorphisms in these cases.</p><p><strong>Results: </strong>GSTT1 null genotype (X²=4.74; p=0.029) and GSTT1/GSM1 null genotype (X²=3.333; p=0.047) were associated with statistically significant differences between the study groups. No statistical significance was detected when considering the GSTM1 null genotype (X²=3.326; p=0.068) or the <i>GSTM1/GSTP1</i> and <i>GSTT1/GSTP1</i> gene polymorphisms.</p><p><strong>Conclusion: </strong>A statistically significant association was observed between the GSTT1 null genotype and the diseased group. Our research demonstrated a substantial increase in the risk of recurrent pregnancy loss in the Turkish population, specifically among individuals with the GSTM1-null genotype. No statistical correlation was found between the <i>GSTM1</i> and <i>GSTP1</i> gene polymorphisms and recurrent pregnancy loss. Furthermore, no statistical significance was observed when they were assessed together.</p>","PeriodicalId":45340,"journal":{"name":"Turkish Journal of Obstetrics and Gynecology","volume":"22 1","pages":"19-25"},"PeriodicalIF":1.0,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11894774/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive value of homocysteine levels in embryo culture media for embryo selection in infertile patients with endometriosis.","authors":"Metehan İmamoğlu, Mahmut Öncül, Abdullah Tüten, Levent M Şentürk","doi":"10.4274/tjod.galenos.2025.43669","DOIUrl":"10.4274/tjod.galenos.2025.43669","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the possible ability of homocysteine (Hcy) levels in embryo culture media for estimating better invitro fertilization outcomes in endometriosis patients.</p><p><strong>Materials and methods: </strong>Nineteen women with endometriosis who were admitted to Cerrahpaşa Medical Faculty, Department of Obstetrics and Gynecology, Infertility Outpatient Clinic with the diagnosis of infertility were included in the study. The results of intracytoplasmic sperm injection treatments were recorded and Hcy levels in the embryo culture were evaluated. The results were compared with those of the control patients without endometriosis, who had previously been admitted to our clinic for assisted reproductive technology.</p><p><strong>Results: </strong>Mean Hcy levels in the culture media of the endometriosis group and non-endometriosis group were 4.31±0.48 µmol/L and 4.15±1.44 µmol/L, respectively (p>0.05). Pregnancy was achieved in 3 patients in the endometriosis group, while 13 pregnancies were obtained in the non-endometriosis group (p>0.05). When all cases were evaluated, the mean value of Hcy in the culture medium was found to be 3.60±0.84 µmol/L in the patients with a pregnancy and 4.21±0.84 µmol/L in the group that failed to achieve a pregnancy, and this difference was statistically significant (p<0.05).</p><p><strong>Conclusion: </strong>Difference between mean Hcy levels in the culture media of the endometriosis group and non-endometriosis group was statistically non-significant. Further studies with larger groups are needed for evaluating the association of Hcy with infertility in endometriosis patients. Mean Hcy levels in the group of patients who succeeded in conceiving were statistically higher than the group of patients who failed to conceive. It may be suggested that Hcy levels in the embryo culture media can predict the achievement of a pregnancy independently from some conditions which may adversely affect the embryo quality, such as endometriosis.</p>","PeriodicalId":45340,"journal":{"name":"Turkish Journal of Obstetrics and Gynecology","volume":"22 1","pages":"26-34"},"PeriodicalIF":1.0,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11894767/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PERİDER-TJOD joint review on threatened abortion and guideline for its treatment.","authors":"Süleyman Cansun Demir, İbrahim Polat, Dilek Şahin, Ali Gedikbaşı, Cihan Çetin, Hakan Timur, Atakan Tanaçan","doi":"10.4274/tjod.galenos.2025.36926","DOIUrl":"10.4274/tjod.galenos.2025.36926","url":null,"abstract":"<p><strong>Objective: </strong>Although there are several guidelines in the literature on \"recurrent abortion\", there is no comprehensive guideline on \"threatened abortion\". The overall purpose of this guideline is to provide healthcare providers with the best available evidence for examination and treatment of pregnant women with threatened abortion.</p><p><strong>Materials and methods: </strong>The scope of the guideline and the first version of the questions were prepared by the Perinatology and High Risk Pregnancies Association (PERİDER) guideline development group in January 2024. Meetings were held to discuss key questions and redefine them. A final list of 8 key questions was created. Keywords were defined for each question and ranked in order of importance and used in searches for all English-language publications in PubMed/Medline and Cochrane libraries. These databases were thoroughly scanned for publications that were published until February 1, 2024. Literature reviews were conducted as an iterative process. In the first step, systematic reviews and meta-analyses were collected. If no results were found, the research was expanded to randomized controlled trials and then to cohort studies and case reports, following the hierarchy of evidence levels.</p><p><strong>Results: </strong>This guideline was presented to the board of directors of the Turkish Gynecology and Obstetrics Society (TJOD). With their suggestions, guideline was finalized, and it was decided to be published as a joint guideline of PERİDER-TJOD.</p><p><strong>Conclusion: </strong>This guideline provides an overview of threatened abortion and the recommended treatments. In addition, by recognizing the deficiencies in the literature, suggestions were made regarding research that could help clinicians' decisions in the future.</p>","PeriodicalId":45340,"journal":{"name":"Turkish Journal of Obstetrics and Gynecology","volume":"22 1","pages":"96-105"},"PeriodicalIF":1.0,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11894778/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Which urinary incontinence inquiry form should be used in women with urinary incontinence?","authors":"Önder Tosun, Çetin Kılıççı, Pınar Kumru, Sultan Seren Karakuş, Reyyan Gökçen İşcan, Zeynep Tosun, Ali Aras, Çağla Yıldırım Varol, Andrea Tinelli","doi":"10.4274/tjod.galenos.2024.08566","DOIUrl":"10.4274/tjod.galenos.2024.08566","url":null,"abstract":"<p><strong>Objective: </strong>To determine urinary incontinence (UI) inquiry forms to be used in the follow-up of incontinence according to UI type.</p><p><strong>Materials and methods: </strong>This prospective cohort study was conducted at the University of Health Science Hospital between 2020 and 2022. A total of 449 patients referred for urodynamic evaluation for UI were included herein, and clinical results regarding UI types were collected and reviewed. The validated urogenital distress inventory 6 (UDI-6), incontinence impact questionnaire (IIQ-7), and incontinence quality of life (I-QOL) questionnaires were completed by all patients. The demographic data of the patients, total questionnaire scores, and urodynamic results were compared between the groups according to UI type.</p><p><strong>Results: </strong>Forty-nine percent of the participants were in the menopausal period, and 41% required regular ped use. A total of 52.1% of patients experienced 5 years of UI. Stress incontinence was reported in 4.2% of patients, urge incontinence in 10%, stress-predominant mixed UI in 59.2%, and urge-predominant mixed UI in 24.7%. The mean ± standard deviation values were 59.62±20.62 for the UDI-6, 54.72±24.84 for the IIQ-7, 62.41±23.52 for the total I-QOL, 21.85±8.55 for the I-QOL limitation of behaviors subscale, 27.99±10.86 for the I-QOL psychological influence subscale, and 12.64±5.72 for the I-QOL social isolation subscale. A statistically significant difference was assessed between the urodynamics results and the UDI-6, IIQ-7, total I-QOL, I-QOL limitation of behaviors subscale, I-QOL psychological influence subscale, and I-QOL social isolation subscale scores (p<0.001 for all variables).</p><p><strong>Conclusion: </strong>In patients diagnosed with UI, when each of the 3 questionnaires for UI diagnosis was compared, the best inquiry questionnaire for the prediction of mixed-type UI was the UDI-6.</p>","PeriodicalId":45340,"journal":{"name":"Turkish Journal of Obstetrics and Gynecology","volume":"22 1","pages":"65-74"},"PeriodicalIF":1.0,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11894773/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of prenatal and postnatal outcomes of fetuses with intrauterine cardiac anomalies: Tertiary center experience.","authors":"Gözde Miray Yılmaz, Süleyman Cansun Demir, Serdar Aykut, İsmail Cüneyt Evrüke, Mete Sucu","doi":"10.4274/tjod.galenos.2025.60894","DOIUrl":"10.4274/tjod.galenos.2025.60894","url":null,"abstract":"<p><strong>Objective: </strong>Fetal cardiac anomalies are among the leading causes of infant mortality due to congenital anomalies. The prenatal diagnosis of congenital heart diseases allows for the acquisition of prognostic information before birth and provides insights into treatment options either before or after delivery. This study aims to observe the correlation between the prenatal and postnatal diagnoses of fetuses with cardiac anomalies detected in our perinatology clinic. The goal, by tracking postnatal outcomes and identifying risk factors, is to assist in selecting the most appropriate approach, prioritizing maternal and fetal health.</p><p><strong>Materials and methods: </strong>The records of 188 fetuses diagnosed during the prenatal period by the Perinatology Department of Obstetrics and Gynecology at Çukurova University Faculty of Medicine, delivered and admitted to the Çukurova University Neonatal Intensive Care Unit, and undergoing fetal echocardiography by the Pediatric Cardiology Clinic between January 2016 and December 2021, were retrospectively evaluated. Postnatal transthoracic echocardiography results of the infants were also reviewed.</p><p><strong>Results: </strong>Our study was conducted with 188 pregnant women. The most frequently detected cardiac anomalies in the fetuses were conotruncal anomalies, followed by right heart anomalies. The concordance between prenatal and postnatal findings was 88.8%, with a sensitivity of 96.55% and a specificity of 100%. Among the live-born infants with congenital heart disease, significant differences were observed between the group that survived the neonatal period and those who did not, in terms of parental consanguinity, gestational age at birth, birth weight, APGAR scores, and the rate of chromosomal anomaly assessment.</p><p><strong>Conclusion: </strong>Our study emphasized several risk factors. A high concordance was found between our prenatal and postnatal echocardiography findings. In conclusion, we believe that increasing awareness and making screening a routine practice are essential to contributing to healthier future generations. This can be achieved by reducing perinatal mortality and morbidity through appropriate management and equipment, thereby optimizing the well-being of affected individuals in society.</p>","PeriodicalId":45340,"journal":{"name":"Turkish Journal of Obstetrics and Gynecology","volume":"22 1","pages":"55-64"},"PeriodicalIF":1.0,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11894768/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association study of <i>interleukin-10</i> and <i>P53</i> polymorphisms and their influence on Iranian women with recurrent abortion.","authors":"Nastaran Rezaee Bakhtiar, Kobra Shojaei, Fariba Sharifnia, Pegah Ghandil","doi":"10.4274/tjod.galenos.2024.73780","DOIUrl":"10.4274/tjod.galenos.2024.73780","url":null,"abstract":"<p><strong>Objective: </strong>Recurrent spontaneous abortion (RSA), characterized by multiple miscarriages without a known cause, includes both genetic and non-genetic factors. In this research, we studied the association between two polymorphisms of the <i>interleukin (IL)-10</i> and <i>P53</i> genes and RSA for the first time in the southwest of Iran.</p><p><strong>Materials and methods: </strong>This was a case-control study involving 62 patients with a history of at least two RSA of unknown etiology, as well as 66 healthy individuals. Clinical factors were analyzed. Genomic DNA was extracted from whole blood. Genotyping was performed using amplification refractory mutation system-polymerase chain technique to investigate two single nucleotide polymorphisms (SNPs) of <i>P53</i> and <i>IL-10</i> genes. Gene-gene interactions were analyzed by logistic regression. Statistical analysis was performed using a significance level of p<0.05.</p><p><strong>Results: </strong>Allelic and genotypic frequencies as well as dominant, recessive and over dominant models for two SNPs, rs1042522 and rs1800871, were investigated. No significant association with RSA (p>0.05) was found. The combination of the homozygote CC for the polymorphism rs1042522 in the <i>P53</i> gene and the homozygote CC for the polymorphism rs1800871 in the homozygote CC for the polymorphism rs1800871 in the <i>IL-10</i> gene was associated with an increased risk of spontaneous abortion (p=0.01). Meanwhile, the phenotypic frequency of individuals with a history of consanguineous marriage was statistically significant between the case and control groups (p=0.003).</p><p><strong>Conclusion: </strong>Limited studies have been conducted on the association between these two polymorphisms and RSA, and conflicting results have been obtained. Further investigation with a larger sample size may confirm results. Genetic research, such as this, helps understand genetic factors associated with the risk of RSA.</p>","PeriodicalId":45340,"journal":{"name":"Turkish Journal of Obstetrics and Gynecology","volume":"22 1","pages":"46-54"},"PeriodicalIF":1.0,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11894777/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}