Turkish Journal of Obstetrics and Gynecology最新文献

{"title":"The role of inflammation, oxidation and Cystatin-C in the pathophysiology of polycystic ovary syndrome.","authors":"Özden Özdemir Başer,&nbsp;Ayşe Yeşim Göçmen,&nbsp;Demet Aydoğan Kırmızı","doi":"10.4274/tjod.galenos.2022.29498","DOIUrl":"https://doi.org/10.4274/tjod.galenos.2022.29498","url":null,"abstract":"<p><strong>Objective: </strong>The relationship between Cystatin-C levels and inflammatory, oxidant, and antioxidant markers in polycystic ovary syndrome (PCOS) was investigated.</p><p><strong>Materials and methods: </strong>A total of 96 participants were included in the study as PCOS (n=58) and control (n=38) groups. Tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1B), interleukin 6 (IL-6), malondialdehyde (MDA), superoxide dismutase (SOD), and Cystatin-C were evaluated by ELISA method. Relationships metabolic and endocrine parameters seen in PCOS were examined. Univariate and multivariate logistic regression analyzes were performed to identify risk factors that may affect the PCOS group. Bivariate correlations were investigated by the Spearman's correlation analysis.</p><p><strong>Results: </strong>While Cystatin-c, TNF-α, IL-1B, IL-6, MDA were found to be higher in patients with PCOS compared with the control group, SOD was found to be lower than the control group (p<0.05). In the correlation analysis, increased Cystatin-C levels were found to be associated with high IL-6 (r=0.214, p=0.037) and low SOD levels (r=-0.280, p=0.006).</p><p><strong>Conclusion: </strong>In our study, it was found that the increase in Cystatin-C levels was associated with an increase in IL-6 and a decrease in SOD. These results may bring up different treatment options to reduce cardiovascular risks for treating PCOS.</p>","PeriodicalId":45340,"journal":{"name":"Turkish Journal of Obstetrics and Gynecology","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2022-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/91/5a/TJOG-19-229.PMC9511937.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33479759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of asymptomatic COVID-19 infection on the placenta in the third trimester of pregnancy: A prospective case-control study.","authors":"Orhan Şahin,&nbsp;Ali Yılmaz Altay,&nbsp;Emine Aydın,&nbsp;Helin Bağcı,&nbsp;Özben Yalçın","doi":"10.4274/tjod.galenos.2022.94984","DOIUrl":"https://doi.org/10.4274/tjod.galenos.2022.94984","url":null,"abstract":"<p><p>To clarify the effect of asymptomatic coronaviruse disease-2019 (COVID-19) positivity on the placenta in the third trimester of pregnancy.</p><p><strong>Materials and methods: </strong>This prospective, case-control study included 30 pregnant women diagnosed with asymptomatic COVID-19 between April 30, 2021 and July 20, 2021 who delivered after the 34^th gestational week, and a control group of 30 pregnant women without COVID-19, who delivered between April 2021 and July 2021, matched to the study group regarding age, gestational age and body mass index. Outcomes were compared in terms of demographic characteristics, serum blood outcomes, neonatal results, complications and placental histopathological findings.</p><p><strong>Results: </strong>The mean age of the study population was 28.8 years and the mean gestational week was 38.2 weeks. The C-reactive protein levels (38.2 mg/L vs 5.8 mg/L, p=0.001) and ferritin levels (266.4 μg/L and 40.5 μg/L, p=0.001) were significantly higher in the COVID-19-positive pregnant women. The lymphocyte level was significantly higher in the non-COVID-19 pregnant women (p=0.040). Mural hypertrophy was determined at a significantly higher rate in COVID-positive pregnant women (83.3% vs 30.0%, p=0.001). Multivariate regression analysis showed that only COVID-19 positivity increased the presence of mural hypertrophy in pregnant women with asymptomatic COVID-19 (4.716-fold, 95% confidence interval=1.012-22.251).</p><p><strong>Conclusion: </strong>The results of this study demonstrated that asymptomatic COVID-19 had no significant effect on pregnancy and neonatal complications. However, mural hypertrophy in the placenta was found at a significantly higher rate in pregnant women with asymptomatic COVID-19.</p>","PeriodicalId":45340,"journal":{"name":"Turkish Journal of Obstetrics and Gynecology","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2022-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a9/36/TJOG-19-178.PMC9511936.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33478133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the localization of intrauterine adhesions in pregnant and infertile women.","authors":"Rukiye Ada Bender,&nbsp;Canan Özcan,&nbsp;Bertan Akar,&nbsp;Eray Çalışkan","doi":"10.4274/tjod.galenos.2022.69705","DOIUrl":"https://doi.org/10.4274/tjod.galenos.2022.69705","url":null,"abstract":"<p><strong>Objective: </strong>Intrauterine adhesion (IUA) is the formation of band-shaped fibrotic tissues in the endometrial cavity due to uterine procedures. Most adhesions remain asymptomatic and do not affect fertility or pregnancy conditions. However, they may lead to infertility and pregnancy complications in some women. This study aimed to determine which localization and type of IUA may lead to infertility.</p><p><strong>Materials and methods: </strong>Seventy-six women with IUA were retrospectively scanned. Thirty-nine women with IUA with uterine factor-related infertility were included in the infertility group. Thirty-seven pregnant women, who had adhesions in the second-trimester ultrasonography and who had a live birth via cesarean section at term, were included in the pregnancy group. The localization of adhesions was determined as the fundus, corpus, isthmus, and cornu. Concerning the type of adhesion, the adhesions were classified as dense- and film-type adhesions.</p><p><strong>Results: </strong>The infertility group was compared with the pregnancy group according to the type and localization of the adhesions. Fundal adhesions were significantly higher in the infertility group compared to the pregnancy group (p<0.05). The isthmic adhesions, however, were more common in the pregnancy group than in the infertility group (p<0.05). Dense-type adhesions were more common in the infertility group than in the pregnancy group (p<0.05).</p><p><strong>Conclusion: </strong>According to the localization and types of adhesions, fundal and dense-type adhesions are among the features of uterine factor-related infertility. However, isthmus-located and film-type adhesions may not cause infertility.</p>","PeriodicalId":45340,"journal":{"name":"Turkish Journal of Obstetrics and Gynecology","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2022-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/bb/76/TJOG-19-195.PMC9511928.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33478527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The predictive role of second trimester uterocervical angle measurement in obstetric outcomes.","authors":"Merve Şişecioğlu,&nbsp;Emin Üstünyurt,&nbsp;Burcu Dinçgez Çakmak,&nbsp;Serkan Karasin,&nbsp;Nefise Nazlı Yenigül","doi":"10.4274/tjod.galenos.2022.64176","DOIUrl":"https://doi.org/10.4274/tjod.galenos.2022.64176","url":null,"abstract":"<p><strong>Objective: </strong>Uterocervical angle has been suggested as a marker to predict preterm birth. However, the literature has limited data about its predictive role in preterm delivery. Moreover, no evidence is present to clarify the role of second-trimester uterocervical angle in induction success and postpartum hemorrhage. Here, it was aimed to compare the role of uterocervical angle with cervical length in predicting preterm labor and assess the utility of the second-trimester uterocervical angle in induction success and postpartum hemorrhage.</p><p><strong>Materials and methods: </strong>A total of 125 pregnant women, hospitalized with a diagnosis of preterm labor were included in the study. Sonographic measurements of cervical length and uterocervical angle were performed between 16 and 24 weeks of gestation. The demographic, obstetric, laboratory, and sonographic features of the participants were recorded. Patients were divided into subgroups as preterm and term; with and without induction success; with and without postpartum hemorrhage. Additionally, preterm cases were divided into subgroups as early and late preterm. Variables were evaluated between the groups.</p><p><strong>Results: </strong>Cervical length was shorter in the preterm group (30.74±6.37 and 39.19±5.36, p<0.001). The uterocervical angle was 100.85 (85.2-147) in preterm and 88 (70-131) degrees in terms that were statistically significant (p<0.001). Furthermore, the uterocervical angle was wider [126 (100.7-147) and 98 (85.2-114), p<0.001] in the early preterm group. When the groups with and without postpartum bleeding were compared, no significant difference was detected in terms of uterocervical angle [96.5 (71-131) and 88 (70-147), p=0.164]. Additionally, the uterocervical angle was wider in the successful induction group (p<0.001). An a uterocervical angle >85 degrees predicted preterm delivery with 100% sensitivity and 45.54% specificity [area under the curve (AUC)=0.743, p<0.001]. When the cervical length and uterocervical angle were evaluated together to predict preterm delivery, no significant difference was found (p=0.086). An a uterocervical angle >88 degrees predicted induction success with 84.78% sensitivity and 79.75% specificity (AUC=0.887, p<0.001).</p><p><strong>Conclusion: </strong>Our study revealed that the uterocervical angle can be a useful marker in predicting preterm labor and induction success, although it does not predict postpartum hemorrhage.</p>","PeriodicalId":45340,"journal":{"name":"Turkish Journal of Obstetrics and Gynecology","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2022-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/1a/57/TJOG-19-187.PMC9511929.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33490186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative serum determination of CD3, CD4, CD8, CD16, and CD56 in women with primary infertility: The role of cell-mediated immunity.","authors":"Behzad Shakerian,&nbsp;Sahar Irvani,&nbsp;Sara Mostafavi,&nbsp;Mozhgan Moghtaderi","doi":"10.4274/tjod.galenos.2022.47527","DOIUrl":"https://doi.org/10.4274/tjod.galenos.2022.47527","url":null,"abstract":"<p><strong>Objective: </strong>Cellular adaptive immunity plays an essential role in the etiology of primary infertility. This study aimed to measure the T-lymphocyte subpopulations and natural killer (NK) cells in infertile women compared with healthy ones.</p><p><strong>Materials and methods: </strong>From January to September 2021, we conducted this cross-sectional study among women with primary infertility, and healthy women were referred to Isfahan Fertility and Infertility Center affiliated with Najafabad University of medical sciences in Isfahan, Iran for immunological investigations. For each person, we determined quantitative serum measurements of CD3, CD4, CD8, CD4/CD8, CD16, CD56, and CD56+16.</p><p><strong>Results: </strong>This study included one hundred and fifty-one infertile women with a mean age of 31.4±4.7 years and 46 healthy women with a mean age of 31.5±3.4 years. Compared to the controls, immunophenotyping findings in infertile patients revealed a significant drop in CD8 T cells [p=0.01, 95% confidence interval (CI) 0.53 to 4.57] and the percentage of CD 56 NK cells (p=0.005, 95% CI 0.74 to 4.03) in infertile patients.</p><p><strong>Conclusion: </strong>Despite having a normal quantity of CD3 T cells, infertile women had lower CD8 T cells and CD56 NK cells than the controls. More studies are needed to confirm the role of cell-mediated assessments as a screening test in patients with primary infertility.</p>","PeriodicalId":45340,"journal":{"name":"Turkish Journal of Obstetrics and Gynecology","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2022-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/17/1c/TJOG-19-242.PMC9511930.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33490192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fertility preservation strategies for cancerous women: An updated review.","authors":"Fatemeh Anbari,&nbsp;Mohammad Ali Khalili,&nbsp;Maryam Mahaldashtian,&nbsp;Alireza Ahmadi,&nbsp;Maria Grazia Palmerini","doi":"10.4274/tjod.galenos.2022.42272","DOIUrl":"https://doi.org/10.4274/tjod.galenos.2022.42272","url":null,"abstract":"<p><p>Due to the increase in cancer among young women, the risk of premature ovarian insufficiency with subsequent infertility has been raised. Fertility preservation restores reproductive potential along with increasing life expectancy in these patients. Given the articles on new options for treating cancerous women, we searched the keywords, including fertility preservation, in vitro maturation (IVM), and ovarian cryopreservation. This review focuses on the currently available procedures, including in (IVM) of retrieved immature oocytes, oocyte, embryo, and ovarian tissue cryopreservation (OTC). OTC is a helpful procedure that restores ovarian function and natural pregnancy. Also, we summarized the literature that reported the qualification of using the abovementioned procedures, comparing the cryopreservation methods including vitrification and slow freezing. Due to the impressive clinical development of OTC in cancerous patients, it is recommended as a standard treatment in cryopreservation strategies.</p>","PeriodicalId":45340,"journal":{"name":"Turkish Journal of Obstetrics and Gynecology","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2022-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/12/17/TJOG-19-152.PMC9249358.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40410879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elevated serum YKL-40 levels as a diagnostic and prognostic marker in the placenta accreta spectrum.","authors":"Neslihan Bayramoğlu Tepe,&nbsp;Denizhan Bayramoglu,&nbsp;İbrahim Taşkum","doi":"10.4274/tjod.galenos.2022.94884","DOIUrl":"https://doi.org/10.4274/tjod.galenos.2022.94884","url":null,"abstract":"<p><strong>Objective: </strong>Placenta accreta spectrum (PAS) is an important problem with increasing cesarean section (CS) rates recently. There is still no serum marker for the diagnosis. We determined whether serum YKL-40 levels can be used in the diagnosis and prognosis of PAS.</p><p><strong>Materials and methods: </strong>The study was conducted with 50 patients with a PAS diagnosis, 27 individuals without PAS, and 33 normal pregnant women. The operations (CS + placental bed suture, CS + excision of the lower segment, CS-hysterectomy) and for individuals who had the excision of the lower segment /CS-hysterectomy, the histopathological diagnoses (accreta, increta, percreta) were recorded. Serum YKL-40 levels were analyzed.</p><p><strong>Results: </strong>The individuals with PAS possessed significantly greater serum YKL-40 grades (p=0.001). The surgical interventions included 4 CS + excision of the lower segment, 9 CS + placental bed sutures, and 37 CS-hysterectomy. The histopathological outcomes of the individuals who had the excision of the lower segment, CS-hysterectomy and diagnosed 6, 9, and 26 patients with accreta, increta, and percreta, respectively. The accreta, increta, and percreta groups showed statistically significant different serum YKL-40 grades (p=0.001). The receiver operating characteristic analysis was performed to discriminate the cut-off serum YKL-40 level as 32.81 ng/mL with a sensitivity of 66% and specificity of 70.37%. The positive and negative predictive values of YKL-40 in the indicator of PAS were 80.5% and 52.8%, respectively.</p><p><strong>Conclusion: </strong>Elevated serum YKL-40 grades were correlated with the diagnosis and severity of PAS. If our findings are corroborated and elaborated by larger patient series, the YKL-40 levels should be used along with ultrasonography to construct a model identical to that used in aneuploidy screening.</p>","PeriodicalId":45340,"journal":{"name":"Turkish Journal of Obstetrics and Gynecology","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2022-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ab/8b/TJOG-19-98.PMC9249364.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40410357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does \"no-touch\" technique hysteroscopy increase the risk of infection?","authors":"Evrim Ebru Kovalak","doi":"10.4274/tjod.galenos.2022.04272","DOIUrl":"https://doi.org/10.4274/tjod.galenos.2022.04272","url":null,"abstract":"<p><strong>Objective: </strong>Today, thanks to its many advantages, hysteroscopy with a vaginoscopic approach (no-touch) is increasingly being used more in outpatient diagnoses and treatments. However, there are concerns that the \"no-touch\" technique increases ascending genital tract infections since a speculum is not inserted, and disinfection of the cervix cannot achieve.</p><p><strong>Materials and methods: </strong>Between 2011 and 2017, 302 patients who underwent office hysteroscopy with the vaginoscopic approach (group 1) and 254 patients who underwent hysteroscopy with the standard method under anesthesia in the operating room (group 2) were compared in terms of early complications (within two weeks postoperatively). The primary outcome was early postoperative infection, and the secondary outcome was other early complications, such as bleeding and rupture.</p><p><strong>Results: </strong>In this study, the success rate of hysteroscopy with the vaginoscopic approach was 96.4%. According to the visual analog scale scoring system, 88.7% of the patients described mild-to-moderate pain. When group 1 and 2 were compared in terms of postoperative infection (3% and 2.4%, respectively) and other early complication rates (0% and 0.8%, respectively), no statistically significant difference was found (p>0.05).</p><p><strong>Conclusion: </strong>Hysteroscopy with a vaginoscopic approach continues to be the gold standard method that is safe and well-tolerated by patients.</p>","PeriodicalId":45340,"journal":{"name":"Turkish Journal of Obstetrics and Gynecology","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2022-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/63/07/TJOG-19-145.PMC9249365.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40410880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A clinical scoring system for the diagnosis of adenomyosis.","authors":"Muhammet Yıldırır,&nbsp;Hakan Aytan,&nbsp;Hüseyin Durukan,&nbsp;İclal Gürses","doi":"10.4274/tjod.galenos.2022.88289","DOIUrl":"https://doi.org/10.4274/tjod.galenos.2022.88289","url":null,"abstract":"<p><strong>Objective: </strong>To develop a scoring system using clinical evaluation methods to predict the presence of adenomyosis.</p><p><strong>Materials and methods: </strong>A cohort of 232 patients who underwent hysterectomy for benign gynecologic disorders was prospectively enrolled. A detailed anamnesis was obtained and physical/pelvic examinations with trans-vaginal ultrasound imaging were performed one day before the hysterectomy. The diagnosis of adenomyosis was based on histopathologic examination. Findings were compared between patients with (n=55) and without (n=166) adenomyosis. Factors associated with adenomyosis were assessed with regression analysis and odds ratios (OR) were calculated. The variables found to be significant were chosen for the scoring system. Receiver operating characteristic analysis was carried out to find the cut-off values for these variables.</p><p><strong>Results: </strong>Number of parity, dyspareunia and dysmenorrhea visual analogue scale (VAS) scores, age of menarche, presence of uterine tenderness and detection of heterogeneous myometrium and myometrial cysts during ultrasonography were found to be the significant parameters. OR for the presence of myometrial heterogeneity, myometrial cysts, uterine tenderness were 27.2, 3.6 and 9.3 respectively. Cut-off values were calculated; 3 for parity (OR=2.8), 13-years for menarche (OR=1.6), 2 for dyspareunia VAS scores (OR=1.9) and 4 for dysmenorrhea VAS scores (OR=1.2). The total sum of maximum OR that a patient can obtain was calculated as 47.6 and this value was assumed to predict the presence of adenomyosis 100%. The multiplication of the sum of the OR in a patient by 2.1 (100/47.2) was found to have a predictive ability for the presence of adenomyosis.</p><p><strong>Conclusion: </strong>A scoring system is developed to predict adenomyosis non-invasively based on clinical evaluation.</p>","PeriodicalId":45340,"journal":{"name":"Turkish Journal of Obstetrics and Gynecology","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2022-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/0b/43/TJOG-19-138.PMC9249356.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40410881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the impact of laser-assisted hatching on fresh cleavage and blastocyst embryo transfer and association with pregnancy outcomes.","authors":"Selin Hazır,&nbsp;İskender Kaplanoğlu,&nbsp;Asena Ayça Özdemir,&nbsp;Oya Aldemir,&nbsp;Runa Özelci,&nbsp;İnci Kahyaoğlu,&nbsp;Serdar Dilbaz","doi":"10.4274/tjod.galenos.2022.36690","DOIUrl":"https://doi.org/10.4274/tjod.galenos.2022.36690","url":null,"abstract":"<p><strong>Objective: </strong>Assisted hatching (AH) techniques can improve live birth (LB) and clinical pregnancy (CP) rates. Since there are limited data regarding this subject, we investigated the impact of laser-assisted hatching (LAH) on fresh embryo transfer (ET) and association with pregnancy outcomes in unselected patient population.</p><p><strong>Materials and methods: </strong>This retrospective study included the fresh ETs performed at our center between April 2010 and April 2019. Among 3.782 fresh ETs, 3.286 underwent LAH (n=1.583 at cleavage stage and n=1.703 at blastocyst stage) while 496 underwent non-assisted hatching (NAH) (n=213 at cleavage stage and n=283 at blastocyst stage). The ETs were performed at the blastocyst or cleavage stages, and single or double embryos were transferred. LB rate was the primary outcome, while secondary outcomes were the pregnancy test, monozygotic twinning (MZT), and CP rates.</p><p><strong>Results: </strong>The LAH and NAH groups showed similar LB, pregnancy test, CP, and MZT rates at cleavage and blastocyst stages. On the other hand, LAH significantly affected LB rates at the blastocyst stage (20.6% at blastocyst stage vs. 16% at the cleavage stage, p=0.001).</p><p><strong>Conclusion: </strong>In conclusion, LAH does not improve reproductive outcomes of fresh blastocyst-stage and cleavage-stage ETs. However, LAH significant impacts LB rates in the blastocyst stage than the cleavage stage.</p>","PeriodicalId":45340,"journal":{"name":"Turkish Journal of Obstetrics and Gynecology","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2022-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/50/3e/TJOG-19-130.PMC9249366.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40411222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}