Clinical Reviews in Bone and Mineral Metabolism最新文献_第4页

Low bone mineral density in anorexia nervosa: Treatments and challenges. 神经性厌食症的低骨密度:治疗和挑战。

IF 1.8

Clinical Reviews in Bone and Mineral Metabolism Pub Date : 2019-06-01 Epub Date: 2019-04-15 DOI: 10.1007/s12018-019-09260-4

Pouneh K Fazeli

{"title":"Low bone mineral density in anorexia nervosa: Treatments and challenges.","authors":"Pouneh K Fazeli","doi":"10.1007/s12018-019-09260-4","DOIUrl":"https://doi.org/10.1007/s12018-019-09260-4","url":null,"abstract":"Anorexia nervosa, a psychiatric disease predominantly affecting women, is characterized by self- induced starvation and a resultant low-weight state. During starvation, a number of hormonal adaptations - including hypothalamic amenorrhea and growth hormone resistance - allow for decreased energy expenditure during periods of decreased nutrient intake, but these very same adaptations also contribute to the medical complications associated with chronic starvation, including low bone mass. Almost 90% of women with anorexia nervosa have bone mineral density (BMD) values more than one-standard deviation below the mean of healthy women at peak bone mineral density and this disease is associated with a significantly increased risk of fracture. Although multiple therapies have been studied for the treatment of low bone mass in anorexia nervosa, there are currently no approved therapies and few promising long-term therapeutic options. This review will outline the mediators of low bone mass in anorexia nervosa, discuss therapies that have been studied for the treatment of low BMD in this disorder, and highlight the important challenges that remain, including the differences in bone modeling in adolescents with anorexia nervosa as compared to adults, necessitating that potential therapies be tested in these two populations separately, and the paucity of long-term therapeutic strategies for treating bone loss in this disorder.","PeriodicalId":45316,"journal":{"name":"Clinical Reviews in Bone and Mineral Metabolism","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12018-019-09260-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37544069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

The Clinical Relevance of the Bone Vascular System: Age-Related Implications 骨血管系统的临床相关性:与年龄相关的含义

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Clinical Reviews in Bone and Mineral Metabolism Pub Date : 2019-03-01 DOI: 10.1007/s12018-019-09259-x

R. Prisby

引用次数: 7

Effects of Sympathetic Activity on Human Skeletal Homeostasis: Clinical Evidence from Pheochromocytoma 交感神经活动对人体骨骼稳态的影响:来自嗜铬细胞瘤的临床证据

IF 1.8

Clinical Reviews in Bone and Mineral Metabolism Pub Date : 2019-01-19 DOI: 10.1007/s12018-019-9257-4

Beom-Jun Kim, Seung Hun Lee, J. Koh

引用次数: 2

Fourier Transform Infrared Spectroscopy of Bone Tissue: Bone Quality Assessment in Preclinical and Clinical Applications of Osteoporosis and Fragility Fracture 骨组织的傅里叶变换红外光谱:骨质疏松症和脆性骨折临床前和临床应用中的骨质量评估

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Clinical Reviews in Bone and Mineral Metabolism Pub Date : 2019-01-10 DOI: 10.1007/s12018-018-9255-y

N. Kourkoumelis, Xianzuo Zhang, Zeming Lin, Jian Wang

引用次数: 27

Acknowledgement to Referees 2018 2018年裁判鸣谢

IF 1.8

Clinical Reviews in Bone and Mineral Metabolism Pub Date : 2019-01-02 DOI: 10.1007/s12018-019-9258-3

引用次数: 0

Systemic Bone Loss After Fracture 骨折后全身性骨丢失

IF 1.8

Clinical Reviews in Bone and Mineral Metabolism Pub Date : 2018-12-01 DOI: 10.1007/s12018-018-9253-0

B. Osipov, Armaun J. Emami, B. Christiansen

引用次数: 20

Tendon healing in the context of complex fractures. 复杂骨折情况下的肌腱愈合。

IF 1.8

Clinical Reviews in Bone and Mineral Metabolism Pub Date : 2018-12-01 Epub Date: 2018-12-29 DOI: 10.1007/s12018-018-9254-z

Elahe Ganji, Megan L Killian

{"title":"Tendon healing in the context of complex fractures.","authors":"Elahe Ganji, Megan L Killian","doi":"10.1007/s12018-018-9254-z","DOIUrl":"10.1007/s12018-018-9254-z","url":null,"abstract":"Tendons connect muscle to bone and play an integral role in bone and joint alignment and loading. Tendons act as pulleys that provide anchorage of muscle forces for joint motion and stability, as well as for fracture reduction and realignment. Patients that experience complex fractures also have concomitant soft tissue injuries, such as tendon damage or rupture. Tendon injuries that occur at the time of bone fracture have long-term ramifications on musculoskeletal health, yet these injuries are often disregarded in clinical treatment and diagnosis for patients with bone fractures as well as in basic science approaches for understanding bone repair processes. Delayed assessment of soft tissue injuries during evaluation of trauma can lead to chronic pain, dysfunction, and delayed bone healing even following successful fracture repair, highlighting the importance of identifying and treating damaged tendons early. Treatment strategies for bone repair, such as mechanical stabilization and biological therapeutics, can impact tendon healing and function. Because poor tendon healing following complex fracture can significantly impact the function of tendon during bone fracture healing, a need exists to understand the healing process of complex fractures more broadly, beyond the healing of bone. In this review, we explored the mechanical and biological interaction of bone and tendon in the context of complex fracture, as well as the relevance and potential ramifications of tendon damage following bone fracture, which has particular impact on patients that experience complex fractures, such as from combat, automobile accidents, and other trauma.","PeriodicalId":45316,"journal":{"name":"Clinical Reviews in Bone and Mineral Metabolism","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12018-018-9254-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36998986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Military Fractures: Overtraining, Accidents, Casualties, and Fragility 军事骨折:过度训练、事故、伤亡和脆弱性

IF 1.8

Clinical Reviews in Bone and Mineral Metabolism Pub Date : 2018-11-28 DOI: 10.1007/s12018-018-9252-1

A. Wheeler, J. Wenke

引用次数: 8

Exploring the Links Between Common Diseases of Ageing—Osteoporosis, Sarcopenia and Vascular Calcification 探讨老年常见疾病——骨质疏松症、肌肉萎缩和血管钙化之间的联系

IF 1.8

Clinical Reviews in Bone and Mineral Metabolism Pub Date : 2018-11-23 DOI: 10.1007/s12018-018-9251-2

Alexander J. Rodríguez, D. Scott, P. Ebeling

引用次数: 12

Bringing Attention to Lesser-known Bone Remodeling Pathways 关注鲜为人知的骨重塑途径

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Clinical Reviews in Bone and Mineral Metabolism Pub Date : 2018-09-01 DOI: 10.1007/s12018-018-9250-3

Mehdi Shadmand, Krista L. Jackson, Cecelia Bender, S. Donnelly, Henry Guan, Kirby Tobin, Sydni Yates, J. Hum, J. Lowery

引用次数: 2