Gynecology and Minimally Invasive Therapy-GMIT最新文献

{"title":"Pedunculated Adenomyoma with Osseous Metaplasia: A Case Report.","authors":"Luay Ibrahim Abu Atileh, Nouf Khalifeh, Caroline Sabanekh, Lina Amairi, Bayan Al Omari","doi":"10.4103/gmit.GMIT-D-24-00026","DOIUrl":"10.4103/gmit.GMIT-D-24-00026","url":null,"abstract":"<p><p>We report a case of a pedunculated adenomyoma with osseous metaplasia, which mimics a dermoid cyst on magnetic resonance imaging (MRI) making it a considerable differential diagnosis. A 40-year-old female presented with chronic lower abdomen pain for a year. Pelvic MRI revealed a right-sided pelvic mass measuring 8.4 cm × 5.7 cm. The mass appeared isointense, with hyperintense contents similar to calcifications and fatty content. These results strongly indicated a dermoid cyst. During laparoscopy, a massive pedunculated uterine myoma was seen on the right posterior-fundal part of the uterus. During laparoscopic myomectomy, calcified tissues were discovered during manual morcellation. The histopathological examination confirmed the diagnosis of adenomyoma with widespread calcification and localized osseous metaplasia. Osseous metaplasia is an uncommon cytomorphological transformation seen mostly in the endometrium. Adenomyomas are rare, benign uterine tumors that are frequently misdiagnosed. In this case, the preoperative diagnosis suggested a dermoid cyst, broadening the differential diagnosis for calcified uterine tumors detected on MRI.</p>","PeriodicalId":45272,"journal":{"name":"Gynecology and Minimally Invasive Therapy-GMIT","volume":"14 2","pages":"185-188"},"PeriodicalIF":1.4,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12165686/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144303194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Potential Value of Modulation of Cell Death in Immunotherapy of Gynecological Tumors.","authors":"Jiajun Wang, Ning Luo, Yuliang Wu, Zhongping Cheng","doi":"10.4103/gmit.GMIT-D-24-00005","DOIUrl":"10.4103/gmit.GMIT-D-24-00005","url":null,"abstract":"<p><p>Cell death plays a pivotal role in a multitude of biological processes, including embryonic development, organ maintenance, aging, immune response, and autoimmunity. These processes are underpinned by distinct molecular mechanisms and have significant implications for biological systems. Currently, research on regulatory cell death (RCD) is primarily focused on apoptosis, necroptosis, pyroptosis, ferroptosis, cuproptosis, and autophagy. These pathways have been shown to play a crucial role in regulating the tumor microenvironment (TME) and influencing the clinical outcome of cancer immunotherapy. RCD exerts a dual regulatory effect on TME, releasing intracellular components and regulating the distribution of immune cells. These cells are involved in fine-tuning the antitumor immune response in the TME. The treatment of gynecological tumors frequently presents a challenge due to the lack of immunotherapeutic responsiveness. This review will focus on apoptosis, necroptosis, pyroptosis, ferroptosis, cuproptosis, and autophagy. It will explore how the molecular messengers released during these processes are involved in regulating their complex interactions with tumor tissues as well as with the immune response. It will also analyze the immunological consequences of regulated cell death and its potential impact on the future development of gynecological oncology therapy. By investigating the mechanisms of cell death, we can gain insight into their role in the development of gynecological tumors and potentially identify new therapeutic strategies to enhance the efficacy of existing treatments and advance cancer care.</p>","PeriodicalId":45272,"journal":{"name":"Gynecology and Minimally Invasive Therapy-GMIT","volume":"14 2","pages":"109-117"},"PeriodicalIF":1.4,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12165680/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144303188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ruptured Pedunculated Adnomyoma with Cystic Degeneration in a Postmenopausal Woman: A Case Report and Literature Review.","authors":"Mohammad Zeiter, Chuan-Chi Kao, Kuan-Gen Huang, Chyi-Long Lee, Luay Abu Atileh","doi":"10.4103/gmit.gmit_56_24","DOIUrl":"10.4103/gmit.gmit_56_24","url":null,"abstract":"<p><p>Endometriosis, adenomyosis, and uterine adenomyomas prevail most frequently in reproductive-age women. However, about 2%-4% of postmenopausal women may suffer from endometriosis symptoms, while adenomyosis does not occur frequently after menopause in the absence of exogenous hormones. While cystic adenomyosis is an uncommon variant of adenomyosis, it is even rarer to be pedunculated. Usually, degeneration is a feature of uterine leiomyoma, 4% of which might be cystic, while ruptured adenomyoma with cystic degeneration is only reported few times in the literature. We present a case of a 50-year-old menopausal woman, with a ruptured pedunculated adenomyoma with endometriotic cystic degeneration, with a literature review.</p>","PeriodicalId":45272,"journal":{"name":"Gynecology and Minimally Invasive Therapy-GMIT","volume":"14 2","pages":"178-181"},"PeriodicalIF":1.4,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12165685/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144303198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regarding a Cornual Pregnancy after Salpingectomy for Isthmic Pregnancy.","authors":"Ibrahim A Abdelazim, Ainur Donayeva, Ainur Amanzholkyzy","doi":"10.4103/gmit.gmit_83_24","DOIUrl":"10.4103/gmit.gmit_83_24","url":null,"abstract":"","PeriodicalId":45272,"journal":{"name":"Gynecology and Minimally Invasive Therapy-GMIT","volume":"14 2","pages":"197-198"},"PeriodicalIF":1.4,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12165684/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144303195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of the Relationship between Endometrial Cancer and Liver Fibrosis-4 Score.","authors":"Sema Yilmaz Rakici, Omer Yayla, Hanife Zeynep Yilmaz, Sefik Metin","doi":"10.4103/gmit.gmit_19_24","DOIUrl":"10.4103/gmit.gmit_19_24","url":null,"abstract":"<p><strong>Objectives: </strong>We investigated the relationship between the degree of fibrosis and endometrial cancer (EC) by calculating the fibrosis-4 (FIB-4) score, a noninvasive marker for measuring the severity of liver fibrosis.</p><p><strong>Materials and methods: </strong>Liver function tests, platelet (PLT) values, abdominal ultrasonography (USG), and magnetic resonance imaging (MRI) reports were analyzed retrospectively before, after, and at diagnosis in patients with EC.</p><p><strong>Results: </strong>The study included 38 patients diagnosed with EC. The median FIB-4 score was calculated as 1.15 (minimum: 0.46-maximum: 3.72). When endometroid (type 1 EC) and nonendometroid (type 2 EC) were compared, the FIB-4 score was higher in type one patients (1.16 [0.46-3.72] and 1.01 [0.53-2.96], respectively). However, there was no significant difference between the two groups (<i>P</i> = 0.961). There was no significant difference between the groups in terms of aspartate aminotransferase, alanine aminotransferase, and PLT parameters before diagnosis, at the time of diagnosis, and after treatment. Gamma-glutamyl transferase (GGT) level was significantly higher in the type 1 group in the prediagnosis period (<i>P</i> = 0.016). In the posttreatment period, GGT was higher in the type 2 group (<i>P</i> = 0.020). For PLT level, there was a statistically significant difference between all three periods only in the type 1 group (<i>P</i> < 0.001).</p><p><strong>Conclusion: </strong>FIB-4 score was higher in patients with type 1 EC, which is more associated with obesity and hormones. In addition, prediagnostic values of GGT and PLT were statistically significantly higher in the type 1 group. Our study needs further studies to support FIB-4 score and biochemical GGT and PLT as biochemical markers in patients with type 1 EC.</p>","PeriodicalId":45272,"journal":{"name":"Gynecology and Minimally Invasive Therapy-GMIT","volume":"14 2","pages":"118-124"},"PeriodicalIF":1.4,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12165668/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144303191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Laparoscopy for Advanced Ovarian, Fallopian Tube, and Peritoneal Cancers: A Retrospective Study.","authors":"Jongmyung Park, Takashi Seike, Haruka Sugi, Hironobu Hori, Kanako Gondo, Atsumu Terada","doi":"10.4103/gmit.gmit_32_24","DOIUrl":"10.4103/gmit.gmit_32_24","url":null,"abstract":"<p><strong>Objectives: </strong>Despite advancements in the management of advanced ovarian, fallopian tube, and peritoneal cancers, there remains a need to explore safe and effective diagnostic techniques, particularly in cases where primary debulking surgery (PDS) is challenging. This retrospective study aimed to investigate the safety and availability of diagnostic laparoscopy for patients with advanced ovarian, fallopian tube, and peritoneal cancers.</p><p><strong>Materials and methods: </strong>We analyzed data from 36 patients who underwent diagnostic laparoscopy between September 2017 and March 2023. The surgical outcomes of diagnostic laparoscopy and initial treatment outcomes were investigated.</p><p><strong>Results: </strong>The median patient age was 65 years (range, 39-82 years), with majority diagnosed with high-grade serous carcinoma (HGSC). Perioperative complications were observed in 11% of patients. Neoadjuvant chemotherapy (NAC) was administered to 92% of patients, with PDS performed in two cases. Of the 33 patients who received NAC, 30 (90%) underwent interval debulking surgery, and 23 (77%) achieved complete resection. Two patients (clear-cell carcinoma and mucinous carcinoma) died of cancer before or during the initial chemotherapy. The median follow-up duration for all patients was 26.9 months. Median progression-free survival (PFS) was 19.7 months, and median overall survival was 65.5 months. In multivariate analysis, non-HGSC (hazard ratio: 3.20, 95% confidence interval [CI]: 1.07-9.61, <i>P</i> = 0.038) and homologous recombination proficiency (hazard ratio: 7.44, 95% CI: 1.39-39.9, <i>P</i> = 0.019) were risk factors for PFS.</p><p><strong>Conclusion: </strong>Diagnostic laparoscopy is useful for intraperitoneal observation and pretreatment diagnosis in advanced ovarian, fallopian tube, and peritoneal cancers. Despite tolerable perioperative complications, further research is warranted to optimize patient outcomes.</p>","PeriodicalId":45272,"journal":{"name":"Gynecology and Minimally Invasive Therapy-GMIT","volume":"14 2","pages":"125-131"},"PeriodicalIF":1.4,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12165673/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144303186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Device Selection Contributes to Operative Time Reduction in Laparoscopic Sacrocolpopexy.","authors":"Kenji Kuroda, Koetsu Hamamoto, Kazuki Kawamura, Ayako Masunaga, Akio Horiguchi, Keiichi Ito","doi":"10.4103/gmit.gmit_155_23","DOIUrl":"10.4103/gmit.gmit_155_23","url":null,"abstract":"<p><strong>Objectives: </strong>The standard laparoscopic sacrocolpopexy (LSC) technique involves several suture fixation sites, which can prolong the operative time. This study aimed to investigate the extent to which the operative time could be shortened using devices such as tackers in sites where suture manipulation could be omitted.</p><p><strong>Materials and methods: </strong>The study enrolled 82 patients who underwent LSC at our hospital between May 2016 and May 2022. The median operative time was 3.2 h (1.78-6.5 h). Changes in symptoms before and after surgery were measured using several questionnaires and 60-min pad weight testing among patient groups based on the device used.</p><p><strong>Results: </strong>Among the preoperative factors, no factors were found to be significantly correlated with the operative time (≥3.2 h or <3.2 h). As intraoperative factors, significant associations were found between the number of tackers used on the posterior vaginal wall, anterior vaginal wall, and cervix (0-3 locations), whether a device was used in mesh retroperitonealization, whether the first needle used to fix the anterior longitudinal ligament was successful, whether adhesion dissection was performed, and the type of sealing device. Among these factors, the use of tackers on the posterior wall, anterior wall, and cervix and the use of a device in mesh retroperitonealization were significantly associated with the operative time.</p><p><strong>Conclusion: </strong>The use of easy-to-operate devices appeared to contribute to a shorter operative time in LSC.</p>","PeriodicalId":45272,"journal":{"name":"Gynecology and Minimally Invasive Therapy-GMIT","volume":"14 2","pages":"157-164"},"PeriodicalIF":1.4,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12165672/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144303185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of Cesarean Scar Ectopic Pregnancy with Hysteroscopic Resection.","authors":"Hoora Amuzegar, Fatemeh Davari Tanha, Firoozeh Akbari Asbagh, Mahbod Ebrahimi, Sareh Ezzati, Venus Hajialiakbar","doi":"10.4103/gmit.gmit_28_24","DOIUrl":"10.4103/gmit.gmit_28_24","url":null,"abstract":"<p><p>Cesarean scar pregnancy (CSP) is an ectopic that is located in the myometrium of a previous C-section of the scar. It is rare but threatening. The aim of this study was to introduce 10 cases of CSP treated with hysteroscopic resection. In the preoperative phase, the patients with beta-human chorionic gonadotropin (B-hCG) titers more than 10,000 were treated with methotrexate (MTX) to reduce B-hCG titers. Two patients did not receive MTX. All patients were treated with hysteroscopic resection except one patient, who underwent hysteroscopic resectoscopy due to a lack of reduction of B-hCG and due to unrepairable scar site of cesarean and uterine perforation eventuate hysterectomy. All patients had normal menstrual cycles as well as the negative β-hCG level after 2 months. Moreover, no recurrence was reported after 3 years. Low-invasive treatments such as hysteroscopic resection can be an important step to maintain fertility and the general health of patients.</p>","PeriodicalId":45272,"journal":{"name":"Gynecology and Minimally Invasive Therapy-GMIT","volume":"14 2","pages":"170-173"},"PeriodicalIF":1.4,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12165682/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144303200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Jain Point for First Blind Trocar Insertion: Fellows' Perspective.","authors":"Nutan Jain, Vandana Jain, Divyanee Gulati, Sakshi Srivastava, Priyanka Sureddi, Bhumika Bansal, Sweta Sareen, Sonika Mann, Chetna Agarwal, Shalini Singh, Sri Lakshmi Prasanna Bayya","doi":"10.4103/gmit.gmit_58_24","DOIUrl":"10.4103/gmit.gmit_58_24","url":null,"abstract":"","PeriodicalId":45272,"journal":{"name":"Gynecology and Minimally Invasive Therapy-GMIT","volume":"14 2","pages":"105-108"},"PeriodicalIF":1.4,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12165674/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144303192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The New Concepts from New Evidences.","authors":"Chyi-Long Lee","doi":"10.4103/gmit.GMIT-D-24-00064","DOIUrl":"10.4103/gmit.GMIT-D-24-00064","url":null,"abstract":"","PeriodicalId":45272,"journal":{"name":"Gynecology and Minimally Invasive Therapy-GMIT","volume":"14 1","pages":"1-2"},"PeriodicalIF":1.4,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11936399/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143721951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}