Clinica e Investigacion en Arteriosclerosis最新文献

{"title":"Nutrición, riesgo de enfermedad cardiovascular y cambio climático","authors":"Carlos A. González Svatetz","doi":"10.1016/j.arteri.2022.06.001","DOIUrl":"https://doi.org/10.1016/j.arteri.2022.06.001","url":null,"abstract":"","PeriodicalId":45230,"journal":{"name":"Clinica e Investigacion en Arteriosclerosis","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49817731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Análisis geoestadístico desde el laboratorio clínico en prevención cardiovascular para atención primaria","authors":"Salomón Martín Pérez ,&nbsp;Teresa Arrobas Velilla ,&nbsp;Juan Fabiani de la Iglesia ,&nbsp;Ignacio Vázquez Rico ,&nbsp;Gema Varo Sánchez ,&nbsp;Antonio León-Justel","doi":"10.1016/j.arteri.2022.08.003","DOIUrl":"https://doi.org/10.1016/j.arteri.2022.08.003","url":null,"abstract":"<div><h3>Introduction and objectives</h3><p>Cardiovascular diseases continue to lead the ranking of mortality in Spain. The implementation of geostatistical analysis techniques in the clinical laboratory are innovative tools that allow the design of new strategies in primary prevention of cardiovascular disease. The aim of this study was to study the prevalence and geolocation of severe dyslipidemia in the health areas under study in order to implement prevention strategies in primary care. A retrospective cohort study of low-density protein-bound cholesterol, triglyceride and lipoprotein (a) levels in the years 2019 and 2020 were carried out. In addition, a geostatistical analysis was performed including representation in choropleth maps and the detection of clustering clusters, using geographic information in zip code format included in the demographic data of each analytic.</p></div><div><h3>Results</h3><p>The analytical data included in the study were triglycerides (<em>n</em> <!-->=<!--> <!-->365,384), low density protein-bound cholesterol (<em>n</em> <!-->=<!--> <!-->289,594) and lipoprotein to lipoprotein (a) (<em>n</em> <!-->=<!--> <!-->502). Areas with the highest and lowest percentage of cases were identified for the established cut-off points of LDL-C<!--> <!-->&gt;<!--> <!-->190<!--> <!-->mg/dL and TG<!--> <!-->&gt;<!--> <!-->150<!--> <!-->mg/dL. Two clustering clusters with statistical significance were detected for cLDL<!--> <!-->&gt;<!--> <!-->190<!--> <!-->mg/dL and a total of 6 clusters for TG values<!--> <!-->&gt;<!--> <!-->150<!--> <!-->mg/dL.</p></div><div><h3>Conclusions</h3><p>The detection of clusters, as well as the representation of choropleth maps, can be of great help in detecting geographic areas that require greater attention to intervene and improve cardiovascular risk.</p></div>","PeriodicalId":45230,"journal":{"name":"Clinica e Investigacion en Arteriosclerosis","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49833126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Documento de consenso para la determinación e informe del perfil lipídico en laboratorios clínicos españoles","authors":"Teresa Arrobas Velilla ,&nbsp;Carlos Guijarro ,&nbsp;Raquel Campuzano Ruiz ,&nbsp;Manuel Rodríguez Piñero ,&nbsp;José Francisco Valderrama Marcos ,&nbsp;Antonio Pérez Pérez ,&nbsp;Manuel Antonio Botana López ,&nbsp;Ana Morais López ,&nbsp;José Antonio García Donaire ,&nbsp;Juan Carlos Obaya ,&nbsp;Luis Castilla Guerra ,&nbsp;Vicente Pallares Carratalá ,&nbsp;Isabel Egocheaga Cabello ,&nbsp;Mercedes Salgueira Lazo ,&nbsp;María Mar Castellanos Rodrigo ,&nbsp;José María Mostaza Prieto ,&nbsp;Juan José Gómez Doblas ,&nbsp;Antonio Buño Soto ,&nbsp;en representación del Grupo Multidisciplinar de Trabajo de Lípidos y Riesgo Vascular","doi":"10.1016/j.arteri.2022.10.002","DOIUrl":"https://doi.org/10.1016/j.arteri.2022.10.002","url":null,"abstract":"<div><p>Cardiovascular diseases (CVD) continue to be the main cause of death in our country. Adequate control of lipid metabolism disorders is a key challenge in cardiovascular prevention that is far from being achieved in real clinical practice. There is a great heterogeneity in the reports of lipid metabolism from Spanish clinical laboratories, which may contribute to its poor control. For this reason, a working group of the main scientific societies involved in the care of patients at vascular risk, has prepared this document with a consensus proposal on the determination of the basic lipid profile in cardiovascular prevention, recommendations for its realization and unification of criteria to incorporate the lipid control goals appropriate to the vascular risk of the patients in the laboratory reports.</p></div>","PeriodicalId":45230,"journal":{"name":"Clinica e Investigacion en Arteriosclerosis","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49817728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evolocumab como tratamiento de la dislipemia secundaria a lorlatinib","authors":"Laura Pérez Alonso ,&nbsp;Raquel Cervera Calero ,&nbsp;María Ángeles Campos Fernández de Sevilla ,&nbsp;Miguel Ángel Moreno Palanco ,&nbsp;Jorge Francisco Gómez Cerezo","doi":"10.1016/j.arteri.2022.12.003","DOIUrl":"https://doi.org/10.1016/j.arteri.2022.12.003","url":null,"abstract":"<div><p>Anti-PCSK9 monoclonal antibodies have reduced the risk of cardiovascular events in patients with atheroesclerosis cardiovascular disease. However, its use has not been described in hyperlipidemia associated with lorlatinib, a third-generation ALK tyrosin kinasa inhibitor approved as treatment for ALK-positive non-small cell lung cancer.</p></div>","PeriodicalId":45230,"journal":{"name":"Clinica e Investigacion en Arteriosclerosis","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49817730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of rs662799 and rs5070 genetic polymorphisms with hypertriglyceridemia and atherogenic dyslipidemia in pediatric patients in Southeast Mexico","authors":"Valeria Ovando Gómez ,&nbsp;Soraya Amalí Zavaleta Muñiz ,&nbsp;Héctor Ochoa-Díaz-López ,&nbsp;José Armando Camilo Hernández Contreras ,&nbsp;Cesar Antonio Irecta Nájera","doi":"10.1016/j.arteri.2022.06.005","DOIUrl":"10.1016/j.arteri.2022.06.005","url":null,"abstract":"<div><h3>Background and aims</h3><p>Triglycerides are the initiators of the metabolic changes that lead to atherogenic dyslipidemia (AD). The APOA5 and APOA1 genes are involved in the response and metabolism of serum lipids and lipoproteins, where single nucleotide polymorphisms (SNP) rs662799 (promoter region) and rs5070 (intronic region) have been associated with the susceptibility to dyslipidemia. Until now, few studies evaluate the association of these polymorphisms with the presentation of hypertriglyceridemia and AD among Mexican children. Therefore, the objective was to determine the association between rs662799 and rs5070 with hypertriglyceridemia and AD in a pediatric population of southeastern Mexico.</p></div><div><h3>Materials and methods</h3><p>A case–control analysis was performed including 268 infants aged 2–16 years, anthropometric, clinical variables, and serum lipid profiles were analyzed. DNA was extracted from blood samples and genotyping of polymorphisms was executed with the TaqMan SNP genotyping assay. Allele and genotypic frequencies were calculated. For genetic association analysis, logistic regression models were fitted according to models of inheritance.</p></div><div><h3>Results</h3><p>The SNP rs662799 (C) was significantly associated with hypertriglyceridemia in the overdominant model (OR<!--> <!-->=<!--> <!-->3.89, <em>p</em> <!-->=<!--> <!-->0.001) and AD in the dominant model (OR<!--> <!-->=<!--> <!-->4.01, <em>p</em> <!-->=<!--> <!-->0.001). The SNP rs5070 (T) has a protective effect against hypertriglyceridemia in the additive risk model (OR<!--> <!-->=<!--> <!-->0.68, <em>p</em> <!-->=<!--> <!-->0.03).</p></div><div><h3>Conclusion</h3><p>Polymorphism rs662799 was significantly associated with cases of hypertriglyceridemia and AD in minors in southeastern Mexico. On the other hand, rs5070 polymorphism was not associated with cases of hypertriglyceridemia or AD.</p></div>","PeriodicalId":45230,"journal":{"name":"Clinica e Investigacion en Arteriosclerosis","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9683149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tasas de prevalencia de enfermedad renal crónica y su asociación con factores cardiometabólicos y enfermedades cardiovasculares. Estudio SIMETAP-ERC","authors":"Antonio Ruiz-Garcia ,&nbsp;Ezequiel Arranz-Martínez ,&nbsp;Nerea Iturmendi-Martínez ,&nbsp;Teresa Fernández-Vicente ,&nbsp;Montserrat Rivera-Teijido ,&nbsp;Juan Carlos García-Álvarez","doi":"10.1016/j.arteri.2022.07.002","DOIUrl":"https://doi.org/10.1016/j.arteri.2022.07.002","url":null,"abstract":"<div><h3>Introduction</h3><p>Chronic kidney disease (CKD) is a major health problem that contributes to the development of cardiovascular disorders such as heart failure and arteriosclerotic cardiovascular disease (ACVD). The aims of this study were to determine the prevalence of CKD and to assess its association with ACVD and cardiometabolic risk factors.</p></div><div><h3>Methods</h3><p>Cross-sectional observational study conducted in primary care setting. Population-based random sample: 6,588 people between 18 and 102 years old (response rate: 66%). Crude and sex- and age-adjusted prevalence rates of CKD according to KDIGO were determined by assessing albuminuria and estimated glomerular filtration rate according to CKD-EPI, and their associations with cardiometabolic factors and ACVD were determined.</p></div><div><h3>Results</h3><p>The crude prevalence of CKD was 11.48% (95%CI: 10.72–12.27%), without significant difference between men (11.64% [95%CI: 10.49–12.86%]) and women (11.35% [95%CI: 10.34–12.41%]). The age- and sex-adjusted prevalence rate of CKD was 9.16% (men: 8.61%; women: 9.69%). The prevalence of low estimated glomerular filtration rate (&lt;<!--> <!-->60<!--> <!-->mL/min/1.73<!--> <!-->m²) and albuminuria (≥<!--> <!-->30<!--> <!-->mg/g) were 7.95% (95%CI: 7.30–8.61) and 5.98% (95%CI: 5.41–6.55), respectively. Hypertension, diabetes, prediabetes, increased waist-to-height ratio, heart failure, atrial fibrillation, and ACVD were independently associated with CKD (<em>P</em> <!-->&lt;<!--> <!-->.001). Very high cardiovascular risk according to SCORE was found in 77.51% (95%CI: 74.54–80.49) of the population with CKD.</p></div><div><h3>Conclusions</h3><p>The adjusted prevalence of CKD was 9.2% (low estimated glomerular filtration rate: 8.0%; albuminuria: 6.0%). Most of the patients with CKD had very high cardiovascular risk. Hypertension, diabetes, prediabetes, increased waist-to-height ratio and ACVD were independently associated with CKD.</p></div>","PeriodicalId":45230,"journal":{"name":"Clinica e Investigacion en Arteriosclerosis","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49791864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vascular smooth muscle cell phenotype is modulated by ligands of the lymphotoxin β receptor and the tumor necrosis factor receptor","authors":"Susana Martín-Vañó ,&nbsp;Alejandra Miralles-Abella ,&nbsp;Pascual Castaño ,&nbsp;Gema Hurtado-Genovés ,&nbsp;María Aguilar-Ballester ,&nbsp;Andrea Herrero-Cervera ,&nbsp;Angela Vinué ,&nbsp;Sergio Martínez-Hervás ,&nbsp;Herminia González-Navarro","doi":"10.1016/j.arteri.2022.05.003","DOIUrl":"10.1016/j.arteri.2022.05.003","url":null,"abstract":"<div><h3>Objective</h3><p>Vascular smooth muscle cells (VSMCs) undergo a phenotypic-switching process during the generation of unstable atheroma plaques. In this investigation, the potential implication of the tumor necrosis factor superfamily (TNFSF) ligands, in the gene expression signature associated with VSMC plasticity was studied.</p></div><div><h3>Material and methods</h3><p>Human aortic (ha)VSMCs were obtained commercially and treated with the cytokine TNFSF14, also called LIGHT, the lymphotoxin alpha (LTα), the heterotrimer LTα₁β₂ or with vehicle for 72<!--> <!-->h. The effect of the different treatments on gene expression was analyzed by quantitative PCR and included the study of genes associated with myofibroblast-like cell function, osteochondrogenesis, pluripotency, lymphorganogenesis and macrophage-like cell function.</p></div><div><h3>Results</h3><p>HaVSMCs displayed a change in myofibroblast-like cell genes which consisted in reduced <em>COL1A1</em> and <em>TGFB1</em> mRNA levels when treated with LTα or LIGHT and with augmented <em>MMP9</em> expression levels when treated with LTα. LTα and LIGHT treatments also diminished the expression of genes associated with osteochondrogenesis and pluripotency <em>SOX9</em>, <em>CKIT</em>, and <em>KLF4.</em> By contrary, all the above genes were no affected by the treatment with the trimer LTα₁β₂. In addition, haVSMC treatment with LTα, LTα₁β₂ and LIGHT altered lymphorganogenic cytokine gene expression which consisted of augmented <em>CCL20</em> and <em>CCL21</em> mRNA levels by LTα and a reduction in the gene expression of <em>CCL21</em> and <em>CXCL13</em> by LIGHT and LTα₁β₂ respectively. Neither, LTα or LIGHT or LTα₁β₂ treatments affected the expression of macrophage-like cell markers in haVSMC.</p></div><div><h3>Conclusions</h3><p>Altogether, indicates that the TNFSF ligands through their interconnected network of signaling, are important in the preservation of VSMC identity against the acquisition of a genetic expression signature compatible with functional cellular plasticity.</p></div>","PeriodicalId":45230,"journal":{"name":"Clinica e Investigacion en Arteriosclerosis","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9233748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ENVEJECIMIENTO ARTERIAL Y RIESGO ARTERIOSCLEROTICO: NUEVAS PERSPECTIVAS","authors":"Vicente Lahera Juliá ,&nbsp;Ana M. Lahera García","doi":"10.1016/j.arteri.2023.01.001","DOIUrl":"https://doi.org/10.1016/j.arteri.2023.01.001","url":null,"abstract":"","PeriodicalId":45230,"journal":{"name":"Clinica e Investigacion en Arteriosclerosis","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49787882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clonal hematopoiesis and atherosclerotic cardiovascular disease: A primer","authors":"María A. Zuriaga ,&nbsp;José J. Fuster","doi":"10.1016/j.arteri.2021.09.006","DOIUrl":"10.1016/j.arteri.2021.09.006","url":null,"abstract":"<div><p>Despite current standards of care, a considerable risk of atherosclerotic cardiovascular disease remains in both primary and secondary prevention. In this setting, clonal hematopoiesis driven by somatic mutations has recently emerged as a relatively common, potent and independent risk factor for atherosclerotic cardiovascular disease and other cardiovascular conditions. Experimental studies in mice suggest that mutations in <em>TET2</em> and <em>JAK2</em>, which are among the most common in clonal hematopoiesis, increase inflammation and are causally connected to accelerated atherosclerosis development, which may explain the link between clonal hematopoiesis and increased cardiovascular risk. In this review, we provide an overview of our current understanding of this emerging cardiovascular risk factor.</p></div>","PeriodicalId":45230,"journal":{"name":"Clinica e Investigacion en Arteriosclerosis","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10655612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eating frequency has an inverse correlation with adiposity measures and non-invasive arterial stiffness parameters in healthy adult people","authors":"Sajjad Arefinia ,&nbsp;Lida Jarahi ,&nbsp;Hamed Khedmatgozar ,&nbsp;Saeed Eslami Hasan Abadi ,&nbsp;Mohammad Reza Shadmand Foumani Moghadam ,&nbsp;André Tchernof ,&nbsp;Hosein Soleimaninia ,&nbsp;Reza Rezvani","doi":"10.1016/j.arteri.2022.06.004","DOIUrl":"10.1016/j.arteri.2022.06.004","url":null,"abstract":"<div><h3>Background</h3><p>Lifestyle modifications have been recommended as an essential treatment approach for cardiovascular diseases. Recent studies have shown that eating frequency (EF) correlates with hypertension and related risk of organ damage. This study aimed to examine critical clinical implications to evaluate the association of EF with arterial stiffness parameters as an early marker of atherosclerosis manifestations.</p></div><div><h3>Methods</h3><p>A cross-sectional descriptive study was performed on 658 participants of the PERSIAN Organizational Cohort study in Mashhad, aged 30–70 years. Arterial stiffness was assessed by measurement markers of arteriosclerosis, including arterial age, augmentation index (AIx), augmentation pressure (AP), carotid-femoral pulse wave velocity (Cf-PWV), and central blood pressure. Differences in anthropometric indices, blood indices, and arterial stiffness parameters were evaluated across EF groups.</p></div><div><h3>Results</h3><p>Our data demonstrate that EF was positively correlated with total daily energy intake, and favourable profiles of adiposity and blood lipids. Subjects with an increased EF, had significantly lower AIx, AP, Arterial Age and Central blood pressure (<em>P</em> for trend<!--> <!-->&lt;<!--> <!-->0.001) as compared to Lowest EF and not significant with PWV (<em>P</em> for trend, 0.19). Arterial stiffness was also significantly lower in those with increased EF compared with subjects with low EF. By Linear regression analysis, after adjustment for Confounding factors, except PWV, EF showed the associations with all of the non-invasive arterial stiffness parameters.</p></div><div><h3>Conclusion</h3><p>Increased EF is associated with a lower wave reflection and blood pressure in the central arteries.</p></div>","PeriodicalId":45230,"journal":{"name":"Clinica e Investigacion en Arteriosclerosis","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10662930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}