Interventional Medicine and Applied Science最新文献

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P wave dispersion in patients with erectile dysfunction. 勃起功能障碍患者的P波离散度。
Interventional Medicine and Applied Science Pub Date : 2019-06-01 DOI: 10.1556/1646.11.2019.10
Can Ramazan Öncel, Ali Akkoç
{"title":"P wave dispersion in patients with erectile dysfunction.","authors":"Can Ramazan Öncel,&nbsp;Ali Akkoç","doi":"10.1556/1646.11.2019.10","DOIUrl":"https://doi.org/10.1556/1646.11.2019.10","url":null,"abstract":"<p><strong>Background and aims: </strong>P wave dispersion (PWD) has been reported to be a non-invasive electrocardiographic predictor for atrial fibrillation. The aim of this study is to evaluate PWD between men with erectile dysfunction (ED) and healthy controls in order to investigate whether PWD was prolonged in patients with ED and related to severity of the disease.</p><p><strong>Methods: </strong>This study included a total of 72 men (42 patients with ED and 30 healthy controls). Demographic data and clinical features were recorded on admission. An electrocardiographic evaluation was obtained to measure PWD values for both patients and controls.</p><p><strong>Results: </strong>Maximum P wave duration was 108.5 ± 4.7 and 108.3 ± 4.3 in ED group and control group, respectively (<i>p</i> = 0.748). Minumum P wave duration was significantly higher in the control group than in the ED group. PWD was 48.1 ± 5.9 in the ED group. As a result, PWD was prolonged in patients with ED (48.1 ± 5.9 vs. 38.0 ± 3.9, <i>p</i> < 0.05). A significant negative correlation was observed between IIEF score and PWD values (<i>p</i> < 0.05, <i>r</i> = -0.662).</p><p><strong>Conclusions: </strong>Patients with ED exhibited prolonged PWD values compared with normal controls. In addition, PWD was found to be associated with severity of the disease.</p>","PeriodicalId":45181,"journal":{"name":"Interventional Medicine and Applied Science","volume":"11 2","pages":"101-105"},"PeriodicalIF":0.0,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1556/1646.11.2019.10","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37718304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Daikenchuto improved perioperative nutritional status of the patients with colorectal cancer: A prospective open-labeled randomized exploratory study. Daikenchuto改善结直肠癌患者围手术期营养状况:一项前瞻性开放标记随机探索性研究。
Interventional Medicine and Applied Science Pub Date : 2019-06-01 DOI: 10.1556/1646.11.2019.13
Fumihiko Fujita, Yasuhiro Torashima, Yusuke Inoue, Shinichiro Ito, Kazuma Kobayashi, Kengo Kanetaka, Mitsuhisa Takatsuki, Susumu Eguchi
{"title":"Daikenchuto improved perioperative nutritional status of the patients with colorectal cancer: A prospective open-labeled randomized exploratory study.","authors":"Fumihiko Fujita,&nbsp;Yasuhiro Torashima,&nbsp;Yusuke Inoue,&nbsp;Shinichiro Ito,&nbsp;Kazuma Kobayashi,&nbsp;Kengo Kanetaka,&nbsp;Mitsuhisa Takatsuki,&nbsp;Susumu Eguchi","doi":"10.1556/1646.11.2019.13","DOIUrl":"https://doi.org/10.1556/1646.11.2019.13","url":null,"abstract":"<p><strong>Background and aims: </strong>The aim of this study is to exploratively evaluate the effect of Tsumura Daikenchuto Extract Granules (DKT, TJ-100) on abdominal symptoms, body weight, and nutritional function following colorectal cancer surgery.</p><p><strong>Methods: </strong>The subjects included 20 patients for curative resection of colorectal cancer. A TJ-100 administration group (<i>n</i> = 10) and non-administration group (<i>n</i> = 10) were randomized and compared. In the administration group, TJ-100 was administered from 2 days prior to surgery up to 12 weeks following surgery. The endpoints included body weight gain, Gastrointestinal Symptom Rating Scale (GSRS), and blood biochemical factors. For the purpose of observing safety, drug adverse events were evaluated including liver function tests.</p><p><strong>Results: </strong>Excluding one patient, we compared 9 cases in the administration group and 10 cases in the non-administration group. No obvious adverse events were observed in any of the cases. In the comparison of body weight gain, the TJ-100 administration group showed significantly higher values at 2, 4, and 12 weeks following the surgery. There was a tendency for lower stable GSRS scores in the administration group overall, with no statistically significant difference.</p><p><strong>Conclusion: </strong>It is suggested that TJ-100 can be safely administered in the perioperative period for cases undergoing colorectal cancer surgery, potentially preventing weight loss during the early postoperative period.</p>","PeriodicalId":45181,"journal":{"name":"Interventional Medicine and Applied Science","volume":"11 2","pages":"84-88"},"PeriodicalIF":0.0,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1556/1646.11.2019.13","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37718301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Evaluation of contrast nephropathy in percutaneous treatment of chronic total occlusions. 经皮治疗慢性全闭塞造影剂肾病的评价。
Interventional Medicine and Applied Science Pub Date : 2019-06-01 DOI: 10.1556/1646.11.2019.15
Erdal Aktürk, Lütfü Aşkın, Hakan Taşolar, Ertuğrul Kurtoğlu, Serdar Türkmen, Okan Tanrıverdi, Kader Eliz Uzel
{"title":"Evaluation of contrast nephropathy in percutaneous treatment of chronic total occlusions.","authors":"Erdal Aktürk,&nbsp;Lütfü Aşkın,&nbsp;Hakan Taşolar,&nbsp;Ertuğrul Kurtoğlu,&nbsp;Serdar Türkmen,&nbsp;Okan Tanrıverdi,&nbsp;Kader Eliz Uzel","doi":"10.1556/1646.11.2019.15","DOIUrl":"https://doi.org/10.1556/1646.11.2019.15","url":null,"abstract":"<p><strong>Background: </strong>Contrast-induced nephropathy (CIN) is a leading cause of morbidity and mortality in patients undergoing percutaneous coronary intervention (PCI). Chronic total occlusions (CTO) are frequently observed among patients undergoing coronary angiography.</p><p><strong>Methods: </strong>A total of 128 CTO patients were included. Mehran score, lesion characteristics, interventional procedure, serological specimens and devices were recorded. The first group was administered with 1 ml · kg<sup>-1</sup> · h<sup>-1</sup> saline (0.9% NaCl) infusion that started 12 h before the procedure and continued 12 h post procedure as recommended by the guidelines. The second group was administered with saline infusion of 12 ml · kg<sup>-1</sup> · h<sup>-1</sup> only during CTO-PCI procedure, which is called as intensive infusion.</p><p><strong>Results: </strong>CIN development was similar in two groups (four patients in standard hydration group and five patients in intensive hydration group). The amount of saline was significantly higher in the standard group (1,767 ± 192.2 vs. 1,043.6 ± 375; <i>p</i> < 0.001). Patients with higher creatinine levels prior to PCI had a higher rate of CIN development after procedure. Interestingly, age, left ventricular ejection fraction, and diabetes mellitus independently predicted CIN.</p><p><strong>Conclusion: </strong>Intensive hydration administration appears to be an effective and cost-effective method in CTO-PCI patients, especially in patients without left ventricular function failure.</p>","PeriodicalId":45181,"journal":{"name":"Interventional Medicine and Applied Science","volume":"11 2","pages":"95-100"},"PeriodicalIF":0.0,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1556/1646.11.2019.15","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37718303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Evaluation of homocystein and asymmetric dimethyl arginine levels in patients with coronary slow flow phenomenon. 冠状动脉慢血流患者同型半胱氨酸和非对称二甲基精氨酸水平的评价。
Interventional Medicine and Applied Science Pub Date : 2019-06-01 DOI: 10.1556/1646.11.2019.07
Erkan Demirci, Oğuzhan Çelik, Macit Kalçık, Lütfü Bekar, Mucahit Yetim, Tolga Doğan
{"title":"Evaluation of homocystein and asymmetric dimethyl arginine levels in patients with coronary slow flow phenomenon.","authors":"Erkan Demirci,&nbsp;Oğuzhan Çelik,&nbsp;Macit Kalçık,&nbsp;Lütfü Bekar,&nbsp;Mucahit Yetim,&nbsp;Tolga Doğan","doi":"10.1556/1646.11.2019.07","DOIUrl":"https://doi.org/10.1556/1646.11.2019.07","url":null,"abstract":"<p><strong>Background: </strong>Previous studies have demonstrated that homocysteine and asymmetric dimethyl arginine (ADMA) levels were strongly associated with cardiovascular diseases including coronary artery disease. The aim of this study was to investigate the role of plasma homocysteine and ADMA levels in the pathogenesis of coronary slow flow (CSF) phenomenon.</p><p><strong>Methods: </strong>Twenty-three patients with CSF and 25 controls with normal coronary flow were included in this study. The quantitative measurement of coronary blood flow was performed using the thrombolysis in myocardial infarction frame count method. Plasma homocysteine and ADMA levels were determined using enzymatic assays from venous blood samples.</p><p><strong>Results: </strong>The patients with CSF had significantly higher plasma homocysteine levels than controls (16.2 ± 7.6 vs. 12.2 ± 2.2 μM/L; <i>p</i> = 0.023). The uric acid levels were significantly higher in CSF group than controls (5.4 ± 1.1 vs. 4.6 ± 0.9 mg/dl; <i>p</i> = 0.011). Plasma ADMA levels were also higher in the CSF group; however, this was not statistically significant (0.6 ± 0.1 vs. 0.5 ± 0.2 μM/L; <i>p</i> = 0.475).</p><p><strong>Conclusions: </strong>Increased homocysteine and uric acid levels may play an important role in the pathogenesis of CSF. Further large scale studies are required to determine the relationship between ADMA levels and CSF.</p>","PeriodicalId":45181,"journal":{"name":"Interventional Medicine and Applied Science","volume":"11 2","pages":"89-94"},"PeriodicalIF":0.0,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1556/1646.11.2019.07","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37718302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Echocardiographic measurement of epicardial adipose tissue thickness in patients with microvascular angina. 微血管性心绞痛患者心外膜脂肪组织厚度的超声心动图测量。
Interventional Medicine and Applied Science Pub Date : 2019-06-01 DOI: 10.1556/1646.11.2019.12
Macit Kalçık, Mahmut Yesin, Ahmet Güner, Emrah Bayam, Mucahit Yetim, Tolga Doğan, Lütfü Bekar, Oğuzhan Çelik, Yusuf Karavelioğlu
{"title":"Echocardiographic measurement of epicardial adipose tissue thickness in patients with microvascular angina.","authors":"Macit Kalçık,&nbsp;Mahmut Yesin,&nbsp;Ahmet Güner,&nbsp;Emrah Bayam,&nbsp;Mucahit Yetim,&nbsp;Tolga Doğan,&nbsp;Lütfü Bekar,&nbsp;Oğuzhan Çelik,&nbsp;Yusuf Karavelioğlu","doi":"10.1556/1646.11.2019.12","DOIUrl":"https://doi.org/10.1556/1646.11.2019.12","url":null,"abstract":"<p><strong>Introduction: </strong>Impaired coronary microcirculation, inflammation, and endothelial dysfunction were reported etiological factors for microvascular angina (MVA). Recently, increased epicardial adipose tissue (EAT) thickness has been associated with hypertension, metabolic syndrome, and coronary artery disease in general population. In this study, we aimed to evaluate the EAT thickness in patients with MVA.</p><p><strong>Methods: </strong>This study enrolled 200 patients (83 males; mean age: 55.4 ± 8.2 years) who have been diagnosed with MVA and 200 controls (89 males; mean age: 54.4 ± 8.5 years). All patients underwent transthoracic echocardiography, and EAT thickness was measured from a parasternal long-axis view as the hypoechoic space on the right ventricular free wall.</p><p><strong>Results: </strong>The mean EAT thickness was significantly higher in MVA patients than the controls (5.5 ± 1.1 vs. 4.9 ± 0.7 mm; <i>p</i> < 0.001). Multiple logistic regression analysis showed that increased EAT thickness was an independent predictor of MVA (OR = 1.183, 95% CI = 1.063-1.489; <i>p</i> = 0.023). In receiver operating characteristic curve analyses, EAT thickness above 5.3 mm predicted MVA with a sentivity of 68% and a specificity of 63% (AUC = 0.711, 95% CI = 0.659-0.762; <i>p</i> < 0.001).</p><p><strong>Conclusions: </strong>The EAT thickness was observed significantly higher in MVA patients as compared to controls. Increased EAT thickness may be associated with mechanisms that play a major role in the pathogenesis of MVA.</p>","PeriodicalId":45181,"journal":{"name":"Interventional Medicine and Applied Science","volume":"11 2","pages":"106-111"},"PeriodicalIF":0.0,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1556/1646.11.2019.12","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37718305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Copeptin levels in patients with coronary artery ectasia. 冠状动脉扩张患者的Copeptin水平。
Interventional Medicine and Applied Science Pub Date : 2019-06-01 DOI: 10.1556/1646.11.2019.08
Ozkan Yavcin, Lutfu Askin, Ozlem Seçen, Serdar Turkmen, Erdal Akturk, Okan Tanriverdi, Mustafa Necati Dagli
{"title":"Copeptin levels in patients with coronary artery ectasia.","authors":"Ozkan Yavcin,&nbsp;Lutfu Askin,&nbsp;Ozlem Seçen,&nbsp;Serdar Turkmen,&nbsp;Erdal Akturk,&nbsp;Okan Tanriverdi,&nbsp;Mustafa Necati Dagli","doi":"10.1556/1646.11.2019.08","DOIUrl":"https://doi.org/10.1556/1646.11.2019.08","url":null,"abstract":"<p><strong>Background and aims: </strong>The etiology and pathophysiology of coronary artery ectasia (CAE) has not been fully elucidated. A rapid rise in plasma copeptin has been observed in cardiovascular diseases, stroke, sepsis, and shock. This increase has diagnostic and prognostic value. The aim of this study was to investigate whether copeptin has a relationship with CAE.</p><p><strong>Methods: </strong>This observational prospective study was carried out between October 2012 and March 2013 in the cardiology catheter laboratory with the inclusion of 44 subjects with a diagnosis of CAE and 44 age- and gender-matched individuals with normal coronary arteries. Blood samples obtained from the patients were stored at -70 °C until analysis and copeptin levels in sera were measured by ELISA.</p><p><strong>Results: </strong>This study comprised 88 study participants, among whom 44 were patients meeting ectasia criteria [mean age: 58.0 ± 11.5 years; 59% (<i>n</i> = 26) male], and 44 were control subjects with angiographically normal coronary anatomy [mean age: 49.2 ± 10.1 years; 30% (<i>n</i> = 13) male]. Copeptin levels were similar between the groups (<i>p</i> > 0.05). In addition, there was no correlation between copeptin levels and CAE.</p><p><strong>Conclusion: </strong>In this study, it is examined that copeptin levels were not elevated in CAE patients.</p>","PeriodicalId":45181,"journal":{"name":"Interventional Medicine and Applied Science","volume":"11 2","pages":"112-116"},"PeriodicalIF":0.0,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1556/1646.11.2019.08","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37718306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
In situ reconstruction of an MRSA-infected paravisceral aortic pseudoaneurysm with cryopreserved aortic allograft. 低温保存同种异体主动脉移植原位重建mrsa感染的内脏旁主动脉假性动脉瘤。
Interventional Medicine and Applied Science Pub Date : 2019-06-01 DOI: 10.1556/1646.11.2019.11
Peter Banga, Peter Legeza, Zoltán Szeberin
{"title":"<i>In situ</i> reconstruction of an MRSA-infected paravisceral aortic pseudoaneurysm with cryopreserved aortic allograft.","authors":"Peter Banga,&nbsp;Peter Legeza,&nbsp;Zoltán Szeberin","doi":"10.1556/1646.11.2019.11","DOIUrl":"https://doi.org/10.1556/1646.11.2019.11","url":null,"abstract":"<p><strong>Objectives: </strong>Treatment of paravisceral aortic infections poses several challenges because standard therapy with excision of all infected tissues and extraanatomic reconstruction is frequently not possible without jeopardizing visceral perfusion. <i>In situ</i> reconstruction with rifampin-soaked prosthetic graft or endovascular repair with stent grafts runs the risk of reinfection. We present a case of a paravisceral aortic infection, where cryopreserved allograft was used for the reconstruction of the aorta.</p><p><strong>Methods: </strong>Medical documentation and CT angiography studies were retrospectively reviewed for a patient in a tertiary care center.</p><p><strong>Results: </strong>A 62-year-old male patient presented with an infected pseudoaneurysm of the paravisceral aorta at the level of the celiac artery. He had previously undergone multiple orthopedic surgical interventions and developed methicillin-resistant <i>Staphylococcus aureus</i> infections. We successfully repaired the paravisceral pseudoaneurysm with excision of all infected tissues and <i>in situ</i> aortic replacement with a cryopreserved allograft.</p><p><strong>Conclusion: </strong>In case of infected aortic pseudoaneurysm, the use of cryopreserved aortic allograft is a reliable choice for reconstruction of the aorta.</p>","PeriodicalId":45181,"journal":{"name":"Interventional Medicine and Applied Science","volume":"11 2","pages":"122-124"},"PeriodicalIF":0.0,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1556/1646.11.2019.11","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37718308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Anthropometric, body composition, and somatotype characteristics of Japanese young women: Implications for normal-weight obesity syndrome and sarcopenia diagnosis criteria. 日本年轻女性的人体测量、身体组成和体型特征:对正常体重肥胖综合征和肌肉减少症诊断标准的影响
Interventional Medicine and Applied Science Pub Date : 2019-06-01 DOI: 10.1556/1646.11.2019.14
Tomohiro Yasuda
{"title":"Anthropometric, body composition, and somatotype characteristics of Japanese young women: Implications for normal-weight obesity syndrome and sarcopenia diagnosis criteria.","authors":"Tomohiro Yasuda","doi":"10.1556/1646.11.2019.14","DOIUrl":"https://doi.org/10.1556/1646.11.2019.14","url":null,"abstract":"<p><strong>Aims: </strong>The purpose of this study was to examine the anthropometric, body composition, and somatotype characteristics of Japanese young women and to focus on normal-weight obesity syndrome and sarcopenia diagnosis criteria.</p><p><strong>Methods: </strong>A total of 124 Japanese university freshmen women were measured at body mass index (BMI), percent body fat and skeletal muscle index (SMI), usual gait test, and handgrip strength. The subjects were divided into obesity (≥30% body fat; BMI: ≥25.0 kg/m<sup>2</sup>), normal-weight obesity (≥30% body fat; BMI: 18.5-24.9 kg/m<sup>2</sup>), sarcopenia (handgrip, <18 kg; gait speed: ≤0.8 m/s; SMI: <5.7 kg/m<sup>2</sup>), or presarcopenia (SMI: <5.7 kg/m<sup>2</sup>). There were no subjects below the sarcopenia diagnosis criteria in usual gait speed, but not for handgrip (0.8%) and SMI (36.3%).</p><p><strong>Results: </strong>The prevalence of presarcopenia group (36.3%) is higher than in the normal-weight obesity (16.9%) and obesity (4.8%) groups. Anthropometry and sarcopenia diagnosis assessments were significantly higher in normal-weight obesity and standard groups compared with presarcopenia group.</p><p><strong>Discussion: </strong>The number of young women was higher in the presarcopenia group than in the normal-weight obesity group, suggesting that the improvement of intrinsic skeletal muscle mass rather than fat mass is important for Japanese young women.</p>","PeriodicalId":45181,"journal":{"name":"Interventional Medicine and Applied Science","volume":"11 2","pages":"117-121"},"PeriodicalIF":0.0,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1556/1646.11.2019.14","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37718307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 17
Neuroprotection against stroke and encephalopathy after cardiac surgery. 心脏手术后对中风和脑病的神经保护。
Interventional Medicine and Applied Science Pub Date : 2019-03-01 DOI: 10.1556/1646.11.2019.01
Daniel G Jovin, Karl G Katlaps, Ben K Ellis, Benita Dharmaraj
{"title":"Neuroprotection against stroke and encephalopathy after cardiac surgery.","authors":"Daniel G Jovin,&nbsp;Karl G Katlaps,&nbsp;Ben K Ellis,&nbsp;Benita Dharmaraj","doi":"10.1556/1646.11.2019.01","DOIUrl":"https://doi.org/10.1556/1646.11.2019.01","url":null,"abstract":"<p><p>Cerebral ischemia in the perioperative period is a major risk factor for stroke, encephalopathy, and cognitive decline after cardiothoracic surgery. After coronary artery bypass grafting, both stroke and encephalopathy can result in poor patient outcomes and increased mortality. Neuroprotection aims to lessen the severity and occurrence of further injury mediated by stroke and encephalopathy and to aid the recovery of conditions already present. Several pharmacological and non-pharmacological methods of neuroprotection have been investigated in experimental studies and in animal models, and, although some have shown effectiveness in protection of the central nervous system, for most, clinical research is lacking or did not show the expected results. This review summarizes the value and need for neuroprotection in the context of cardiothoracic surgery and examines the use and effectiveness of several agents and methods with an emphasis on clinical trials and clinically relevant neuroprotectants.</p>","PeriodicalId":45181,"journal":{"name":"Interventional Medicine and Applied Science","volume":"11 1","pages":"27-37"},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1556/1646.11.2019.01","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37717467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Effects of flavonol quercetin on activity of lipid peroxide oxidation in experimental bacterial-immune periodontitis. 黄酮醇槲皮素对实验性细菌免疫性牙周炎脂质过氧化活性的影响。
Interventional Medicine and Applied Science Pub Date : 2019-03-01 DOI: 10.1556/1646.10.2018.48
Andrii Demkovych
{"title":"Effects of flavonol quercetin on activity of lipid peroxide oxidation in experimental bacterial-immune periodontitis.","authors":"Andrii Demkovych","doi":"10.1556/1646.10.2018.48","DOIUrl":"https://doi.org/10.1556/1646.10.2018.48","url":null,"abstract":"<p><p>The article presents the results of lipid peroxidation activity in blood serum, which were assessed on the base changes in the level of oxidative modification of proteins, TBA-active products, and total amount of nitrogen (II) oxide metabolites (NO<sub>2</sub> <sup>-</sup> + NO<sub>3</sub> <sup>-</sup>). Indices were determined on the 14<sup>th</sup> day of development in experimental periodontitis both without correction, and in condition treatment with a water-soluble flavonol quercetin (corvitin). The treated animals take intramuscular injections of corvitin in a dose 100 mg/kg weight for 7 days. For further testing, blood serum was selected. The results were statistically analyzed using parametric and non-parametric indices. In this investigation, characterized dynamics of changes in the indices of oxidative processes activity were revealed both during the period of formation and the course of periodontitis. In particular, it was found that, for the period of the most expressed inflammatory reaction in the periodontal complex, intensive increase in the level of reactive forms of oxygen. The treatment with flavonol quercetin for 7 days resulted in stabilization of free radical processes and the suppression of the inflammatory reaction.</p>","PeriodicalId":45181,"journal":{"name":"Interventional Medicine and Applied Science","volume":"11 1","pages":"55-59"},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1556/1646.10.2018.48","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37718335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
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