GERMS最新文献_第4页

Acinetobacter baumannii: a known pathogen, a new problem. 鲍曼不动杆菌：已知病原体，新问题。

IF 2

GERMS Pub Date : 2023-12-31 eCollection Date: 2023-12-01 DOI: 10.18683/germs.2023.1408

Ricardo Campos Monteiro, Rogerio Caldeira Rodrigues Malta, Geovana Lacerda Rodrigues, Gustavo Luis de Paiva Anciens Ramos, Janaína Dos Santos Nascimento

引用次数: 0

Effect of dexamethasone and tenoxicam on the virulence activities of different Pseudomonas aeruginosa clinical isolates. 地塞米松和替诺昔康对不同铜绿假单胞菌临床分离株毒力活性的影响

IF 2

GERMS Pub Date : 2023-12-31 eCollection Date: 2023-12-01 DOI: 10.18683/germs.2023.1401

Heba E AboElfarh, El-Sayed E Habib, Mohamed M A El-Sokkary

{"title":"Effect of dexamethasone and tenoxicam on the virulence activities of different Pseudomonas aeruginosa clinical isolates.","authors":"Heba E AboElfarh, El-Sayed E Habib, Mohamed M A El-Sokkary","doi":"10.18683/germs.2023.1401","DOIUrl":"10.18683/germs.2023.1401","url":null,"abstract":"Introduction: This study aimed to examine the effect of commonly used non-antibiotic drugs (dexamethasone and tenoxicam), on treatment of Pseudomonas aeruginosa infections, antibiotic resistance and virulence in this pathogen.Methods: Four antibiotics (gentamicin, cefepime, ciprofloxacin and meropenem) were investigated. The proteolysis and hemolysis were selected as virulence factors for investigation. In this work, we selected the following final concentrations: dexamethasone (0.0052 μg/mL) and tenoxicam (2.7 μg/mL) to be used in combination with antibiotics or alone for investigation of their effects on antibiotic resistance and virulence in P. aeruginosa isolates.Results: The drugs either increased or decreased antibiotic resistance in only 0-3 isolates, which indicates that the investigated drugs did not significantly affect the antibiotic resistance. Interestingly, our study demonstrated that both dexamethasone and tenoxicam increased the hemolytic activity of the investigated isolates. On the other hand, our results indicated that no overall final increasing or decreasing effect could be observed for dexamethasone on the proteolytic activity, while tenoxicam increased the proteolytic activity of the investigated isolates. Interestingly, by real-time PCR dexamethasone has shown significant down-regulation of virulence genes namely algD, plcH and toxA, apparently, in case of combination with ciprofloxacin and with gentamicin in one isolate. However, a negative influence was observed in another isolate. Unfortunately, in the case of tenoxicam the only positive effect was observed in the combination with gentamicin in one isolate.Conclusions: Resistance of P. aeruginosa against gentamicin and ciprofloxacin may be affected by combining these antibiotics with dexamethasone or tenoxicam.","PeriodicalId":45107,"journal":{"name":"GERMS","volume":"13 4","pages":"321-331"},"PeriodicalIF":2.0,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10866164/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139742224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Changing clinical patterns and ear-nose-throat complications of seasonal viral respiratory tract infections. 季节性病毒性呼吸道感染不断变化的临床模式和耳鼻喉并发症。

IF 2

GERMS Pub Date : 2023-12-31 eCollection Date: 2023-12-01 DOI: 10.18683/germs.2023.1399

Mihai Săndulescu, Oana Săndulescu

引用次数: 0

Fosfomycin: A potential oral option for treatment of urinary tract infections in Sri Lanka in the context of high antibiotic resistance. 磷霉素：在斯里兰卡抗生素耐药性高发的情况下，治疗尿路感染的一种潜在口服选择。

IF 2

GERMS Pub Date : 2023-12-31 eCollection Date: 2023-12-01 DOI: 10.18683/germs.2023.1400

Nishadi Jayathilaka, Tharushi Pathirana, Chathurika Kumari, Varuna Navaratne, Samanmalee Gunasekara, Dilini Nakkawita, Thamarasi Senaratne

{"title":"Fosfomycin: A potential oral option for treatment of urinary tract infections in Sri Lanka in the context of high antibiotic resistance.","authors":"Nishadi Jayathilaka, Tharushi Pathirana, Chathurika Kumari, Varuna Navaratne, Samanmalee Gunasekara, Dilini Nakkawita, Thamarasi Senaratne","doi":"10.18683/germs.2023.1400","DOIUrl":"10.18683/germs.2023.1400","url":null,"abstract":"Introduction: Fosfomycin is an effective treatment for urinary tract infections (UTIs). It is not currently used in Sri Lanka to treat UTIs. Hence, this study was conducted to assess the fosfomycin susceptibility for E. coli in urinary isolates, with an aim to find the usability of fosfomycin in the context of high antibiotic resistance.Methods: E. coli isolates were identified by the colony appearance and by performing biochemical tests for the urinary coliform isolates collected from two different hospitals in Western Province Sri Lanka, during the period of November 2021 to February 2022. Susceptibility to fosfomycin 200 μg disc was performed following the Clinical Laboratory Standard Institute (CLSI) disc diffusion method.Results: A total of 101 E. coli isolates from both oncology patients (52.5%) and non-oncology patients (47.5%) were identified and included in the study. The study sample showed majority of females (63.3%). Ampicillin showed the highest resistance rate (72.2%) while fosfomycin was the only antibiotic that showed 100% in vitro susceptibility to all the tested clinical isolates. The overall presence of multidrug-resistant (MDR) and carbapenem-resistant (CR) E. coli were 47.5% and 9.9% respectively.Conclusions: Fosfomycin is a potential antibiotic option especially for MDR and CR organisms, with 100% in vitro susceptibility. Further studies involving multiple centers, with larger sample size and clinical efficacy studies would be important to assess the potential use of fosfomycin especially for the treatment of UTI-causing MDR and CR organisms.","PeriodicalId":45107,"journal":{"name":"GERMS","volume":"13 4","pages":"314-320"},"PeriodicalIF":2.0,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10866161/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139742281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The analysis of saliva as screening in patients with COVID-like symptoms. 分析唾液，筛查 COVID 类症状患者。

IF 2

GERMS Pub Date : 2023-12-31 eCollection Date: 2023-12-01 DOI: 10.18683/germs.2023.1410

Giorgio Novelli, Mattia Moretti, Maria Costanza Meazzini, Davide Paolo Bernasconi, Sergio Maria Ivano Malandrin, Monica Raggi, Cristina Maria Angela Cassé, Luca Arturo Pavesi, Davide Sozzi

引用次数: 0

Role of gender in hesitancy toward the COVID-19 vaccine beyond medical students: Reply to Rujittika Mungmunpuntipantip and Viroj Wiwanitkit. 性别在医学生对 COVID-19 疫苗犹豫不决中的作用：回复 Rujittika Mungmunpuntipantip 和 Viroj Wiwanitkit。

IF 2

GERMS Pub Date : 2023-12-31 eCollection Date: 2023-12-01 DOI: 10.18683/germs.2023.1409

Aris P Agouridis, Spyridon A Karageorgos, Constantinos Tsioutis

引用次数: 0

Bacterial species associated with peri-implant disease - a literature review. 与种植体周围疾病相关的细菌种类--文献综述。

IF 2

GERMS Pub Date : 2023-12-31 eCollection Date: 2023-12-01 DOI: 10.18683/germs.2023.1405

Mihai Săndulescu, Valentin Daniel Sîrbu, Ion Alexandru Popovici

引用次数: 0

Endophthalmitis caused by Enterococcus casseliflavus: a systematic review of literature. 卡氏肠球菌引起的眼内炎：文献系统回顾。

IF 2

GERMS Pub Date : 2023-12-31 eCollection Date: 2023-12-01 DOI: 10.18683/germs.2023.1404

Stylianos A Kandarakis, Nikolaos Spernovasilis, Ilias Georgalas, Michalis Mendris, Constantinos Tsioutis, Aris P Agouridis

{"title":"Endophthalmitis caused by Enterococcus casseliflavus: a systematic review of literature.","authors":"Stylianos A Kandarakis, Nikolaos Spernovasilis, Ilias Georgalas, Michalis Mendris, Constantinos Tsioutis, Aris P Agouridis","doi":"10.18683/germs.2023.1404","DOIUrl":"10.18683/germs.2023.1404","url":null,"abstract":"Introduction: Enterococcus casseliflavus is a rare pathogen in human infections, despite being widely distributed in natural environments. This systematic review aims to evaluate the evidence related to endophthalmitis caused by E. casseliflavus.Methods: A thorough search of PubMed, PubMed Central, and Scopus databases was conducted, covering the period up to October 2022.Results: A total of 53 records were identified, with 8 studies reporting a total of 21 cases meeting the inclusion criteria. Among these studies, 7 described isolated case reports, while 1 study described 14 cases. The overall quality of the reports was good, as all articles were determined to have low risk of bias. Vancomycin susceptibility was reported in only one case of isolated case reports, while the remaining cases were all vancomycin resistant. With regard to management, in most cases intravenous ampicillin and linezolid were administered, while only one study reported administration of vancomycin.Conclusions: Ophthalmologists should be aware of the potential for E. casseliflavus to cause endophthalmitis infections and the challenges associated with its intrinsic resistance to vancomycin.","PeriodicalId":45107,"journal":{"name":"GERMS","volume":"13 4","pages":"343-351"},"PeriodicalIF":2.0,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10866162/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139742278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dental pathologies of endodontic origin and subsequent bacterial involvement - a literature review. 牙髓病和随后的细菌感染--文献综述。

IF 2

GERMS Pub Date : 2023-12-31 eCollection Date: 2023-12-01 DOI: 10.18683/germs.2023.1407

Alexandru Gliga, Mihai Săndulescu, Oana Amza, Ruxandra Stănescu, Marina Imre

引用次数: 0

Erratum. 勘误。

IF 2

GERMS Pub Date : 2023-12-31 eCollection Date: 2023-12-01 DOI: 10.18683/germs.2023.1411

引用次数: 0