Annals of Pediatric Endocrinology & Metabolism最新文献_第3页

Long-term efficacy of a triptorelin 3-month depot in girls with central precocious puberty. 对中枢性性早熟女孩使用曲普瑞林 3 个月去势药物的长期疗效。

IF 2.8

Annals of Pediatric Endocrinology & Metabolism Pub Date : 2024-06-01 Epub Date: 2024-01-29 DOI: 10.6065/apem.2346132.066

Kyu Hyun Park, Si-Hwa Gwag, Yu Jin Kim, Lindsey Yoojin Chung, Eungu Kang, Hyo-Kyoung Nam, Young-Jun Rhie, Kee-Hyoung Lee

{"title":"Long-term efficacy of a triptorelin 3-month depot in girls with central precocious puberty.","authors":"Kyu Hyun Park, Si-Hwa Gwag, Yu Jin Kim, Lindsey Yoojin Chung, Eungu Kang, Hyo-Kyoung Nam, Young-Jun Rhie, Kee-Hyoung Lee","doi":"10.6065/apem.2346132.066","DOIUrl":"10.6065/apem.2346132.066","url":null,"abstract":"Purpose: Three-month gonadotropin-releasing hormone agonists (GnRHas) are expected to achieve better compliance in patients with central precocious puberty (CPP) compared to the monthly formulation. However, 1-month depot remains the dominant choice for conventional treatment worldwide. Our study aimed to investigate the long-term efficacy of a 3-month GnRHa for CPP treatment.Methods: In this retrospective study, 69 Korean girls with CPP were prescribed either triptorelin pamoate (TP) 3-month depot (n=29) or triptorelin acetate (TA) 1-month depot (n=40) and were followed for 1 year after the end of treatment. Auxological, radiological, and biochemical data were collected every 6 months.Results: Baseline characteristics were similar between the 2 groups. In the TP 3-month depot group, 27 of 29 patients (93.1%) exhibited suppressed luteinizing hormone level (below 2.5 IU/L) after 6 months of treatment, and this suppression level was reserved until the final injection. The degree of bone age advancement in the TP 3-month depot group decreased from 1.8±0.4 years at the start of treatment to 0.6±0.5 years at 1-year posttreatment. The gain in predicted adult height (PAH) 1 year after the end of treatment was similar between the TP 3-month and TA 1-month depot groups (5.2±3.1 and 5.3±2.4 cm, respectively; p=0.875).Conclusion: A 3-month depot of triptorelin effectively inhibited gonadal and sex hormones, suppressed bone maturation, and increased PAH. For patient convenience, we suggest a 3-month GnRHa regimen as a promising CPP treatment option.","PeriodicalId":44915,"journal":{"name":"Annals of Pediatric Endocrinology & Metabolism","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11220399/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139643108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical characteristics and outcomes of COVID-19 in children and adolescents with diabetes in Daegu, South Korea. 韩国大邱儿童和青少年糖尿病患者 COVID-19 的临床特征和结果。

IF 2.8

Annals of Pediatric Endocrinology & Metabolism Pub Date : 2024-06-01 Epub Date: 2024-06-30 DOI: 10.6065/apem.2346124.062

Na-Won Lee, You-Min Kim, Young-Hwan Kim, Seok-Jin Kang, Kyung-Mi Jang, Hae-Sook Kim, Jung-Eun Moon, Jin-Kyung Kim

{"title":"Clinical characteristics and outcomes of COVID-19 in children and adolescents with diabetes in Daegu, South Korea.","authors":"Na-Won Lee, You-Min Kim, Young-Hwan Kim, Seok-Jin Kang, Kyung-Mi Jang, Hae-Sook Kim, Jung-Eun Moon, Jin-Kyung Kim","doi":"10.6065/apem.2346124.062","DOIUrl":"10.6065/apem.2346124.062","url":null,"abstract":"Purpose: Children with comorbidities have a higher risk of severe, coronavirus disease 2019 (COVID-19). This study investigated the clinical features and outcomes of COVID-19 in children and adolescents with diabetes between January and March 2022.Methods: We retrospectively reviewed the medical records of 123 children and adolescents (73 with type 1 diabetes and 50 with type 2 diabetes, 59 males and 64 females) aged <18 years who had been diagnosed with diabetes. Data were collected from 7 academic medical centers in Daegu, South Korea.Results: Thirty-five children with diabetes were diagnosed with COVID-19 (18 with type 1 and 17 with type 2 diabetes). Eighteen of the 35 children with diabetes and COVID-19 and 50 of the 88 children with diabetes alone received a COVID-19 vaccination. No significant differences were observed between patients with diabetes and COVID-19 and patients with diabetes alone in the type of diabetes diagnosed, sex, age, body mass index, hemoglobin A1c, or vaccination status. All children with diabetes and COVID-19 had mild clinical features and were safely managed in their homes. Fourteen children had a fever of 38℃ or higher that lasted for more than 2 days, 11 of whom were not vaccinated (p=0.004). None experienced post-COVID-19 conditions.Conclusion: All children and adolescents with pre-existing diabetes had mild symptoms of COVID-19 due to low disease severity, high vaccination rates, uninterrupted access to medical care, and continuous glucose monitoring. Unvaccinated children with diabetes who experienced COVID-19 presented with higher and more frequent fevers compared to vaccinated children.","PeriodicalId":44915,"journal":{"name":"Annals of Pediatric Endocrinology & Metabolism","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11220390/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141493887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gamma-aminobutyric acid for delaying type 1 diabetes mellitus: an update. γ-氨基丁酸用于延缓 1 型糖尿病：最新进展。

IF 2.8

Annals of Pediatric Endocrinology & Metabolism Pub Date : 2024-06-01 Epub Date: 2024-06-30 DOI: 10.6065/apem.2346184.092

Jane Carissa Sutedja, Bryan Gervais de Liyis, Made Ratna Saraswati

{"title":"Gamma-aminobutyric acid for delaying type 1 diabetes mellitus: an update.","authors":"Jane Carissa Sutedja, Bryan Gervais de Liyis, Made Ratna Saraswati","doi":"10.6065/apem.2346184.092","DOIUrl":"10.6065/apem.2346184.092","url":null,"abstract":"The current gold-standard management of hyperglycemia in individuals with type 1 diabetes mellitus (T1DM) is insulin therapy. However, this therapy is associated with a high incidence of complications, and delaying the onset of this disease produces a substantially positive impact on quality of life for individuals with a predisposition to T1DM, especially children. This review aimed to assess the use of gamma-aminobutyric acid (GABA) to delay the onset of T1DM in children. GABA produces protective and proliferative effects in 2 ways, β cell and immune cell modulation. Various in vitro and in vivo studies have shown that GABA induces proliferation of β cells, increases insulin levels, inhibits β-cell apoptosis, and suppresses T helper 1 cell activity against islet antigens. Oral GABA is safe as no serious adverse effects were reported in any of the studies included in this review. These findings demonstrate promising results for the use of GABA treatment to delay T1DM, specifically in genetically predisposed children, through immunoregulatory effects and the ability to induce β-cell proliferation.","PeriodicalId":44915,"journal":{"name":"Annals of Pediatric Endocrinology & Metabolism","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11220392/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141493889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Waist-height ratio and body mass index as indicators of obesity and cardiometabolic risk in Korean children and adolescents. 腰高比和体重指数是韩国儿童和青少年肥胖和心脏代谢风险的指标。

IF 2.8

Annals of Pediatric Endocrinology & Metabolism Pub Date : 2024-06-01 Epub Date: 2024-06-30 DOI: 10.6065/apem.2346090.045

Min Yeong Kim, Sejin An, Young Suk Shim, Hae Sang Lee, Jin Soon Hwang

{"title":"Waist-height ratio and body mass index as indicators of obesity and cardiometabolic risk in Korean children and adolescents.","authors":"Min Yeong Kim, Sejin An, Young Suk Shim, Hae Sang Lee, Jin Soon Hwang","doi":"10.6065/apem.2346090.045","DOIUrl":"10.6065/apem.2346090.045","url":null,"abstract":"Purpose: We assessed the clinical relevance of waist-height ratio (WHtR) as an indicator of cardiometabolic risk and body fat mass measured by dual-energy x-ray absorptiometry (DXA) among Korean children and adolescents.Methods: Data from 1,661 children and adolescents aged 10-18 years who participated in the Korea National Health and Nutrition Examination Survey were analyzed. Unadjusted Pearson correlation, age- and sex-adjusted Pearson correlation, and multiple linear regression analyses were performed to investigate the relationships between WHtR standard deviation score (SDS) and cardiometabolic risk factors, as well as DXA-assessed parameters.Results: WHtR SDS was correlated with cardiometabolic risk factors, including systolic blood pressure, glucose, total cholesterol, high-density lipoprotein cholesterol, triglyceride, and low-density lipoprotein cholesterol, as well as DXA-assessed parameters such as lean mass SDS, fat mass SDS, and fat mass percentage SDS in both whole body and trunk using an adjusted Pearson correlation analyses among all participants (p<0.001). WHtR SDS was strongly correlated with whole-body fat mass and trunk fat mass (r=0.792, p<0.001 and r=0.801, p<0.001, respectively) whereas WHtR SDS had a low correlation coefficient with whole-body lean mass and trunk lean mass SDS (r=0.512, p<0.001 and r=0.487, p<0.001, respectively). In multiple linear regression analyses, WHtR SDS was significantly associated with whole-body and trunk fat mass after adjustment for confounders.Conclusion: Cardiometabolic risk factors and body fat mass assessed by DXA in Korean children and adolescents were highly correlated with WHtR. Additionally, WHtR has an advantage in distinguishing fat-free mass. WHtR can be a useful and convenient clinical indicator of cardiometabolic risk factors.","PeriodicalId":44915,"journal":{"name":"Annals of Pediatric Endocrinology & Metabolism","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11220395/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141493893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 2.8

Annals of Pediatric Endocrinology & Metabolism Pub Date : 2024-06-01 Epub Date: 2024-06-30 DOI: 10.6065/apem.2448028.014

Yoko Kuroki, Atsushi Hattori, Keiko Matsubara, Maki Fukami

引用次数: 0

Factors affecting bone mineral density in children and adolescents with systemic lupus erythematosus. 影响系统性红斑狼疮儿童和青少年骨矿物质密度的因素。

IF 2.8

Annals of Pediatric Endocrinology & Metabolism Pub Date : 2024-06-01 Epub Date: 2024-01-28 DOI: 10.6065/apem.2346060.030

Su Jin Park, Soo Yeun Sim, Dae Chul Jeong, Byung-Kyu Suh, Moon Bae Ahn

{"title":"Factors affecting bone mineral density in children and adolescents with systemic lupus erythematosus.","authors":"Su Jin Park, Soo Yeun Sim, Dae Chul Jeong, Byung-Kyu Suh, Moon Bae Ahn","doi":"10.6065/apem.2346060.030","DOIUrl":"10.6065/apem.2346060.030","url":null,"abstract":"Purpose: Patients with juvenile-onset systemic lupus erythematosus (JSLE) are at a high risk of entering adulthood with disease-related morbidities like reduced bone mass and osteoporosis. This study aimed to evaluate the clinical characteristics of JSLE and to analyze the factors associated with low bone mineral density (BMD) in these patients.Methods: Children and adolescents diagnosed with JSLE at a single institution in Korea were included. Demographic, clinical, and laboratory data as well as details about the use of glucocorticoids (GCs) and disease-modifying antirheumatic drugs were collected. The lumbar spine (LS) BMD z-score was measured using dual energy x-ray absorptiometry, and lateral thoracolumbar spine radiographs were collected.Results: A total of 29 patients with JSLE were included in this study. Of these patients, 7 had a BMD z-score of -2.0 or lower and were designated as the low BMD group. The differences in the clinical parameters and treatment variables between the low BMD and non-low BMD groups were compared. Higher cumulative GC dose, longer GC exposure, and higher cumulative hydroxychloroquine (HCQ) dose were all associated with low BMD; among them, the main factor was the duration of GC exposure. There was no significant correlation between BMD and clinical profile, disease activity, or bone-metabolism markers.Conclusion: The duration of GC exposure, cumulative GC dose, and cumulative HCQ dose were risk factors for low BMD in patients with JSLE, with the main factor being the duration of GC exposure. Thus, patients with JSLE should be routinely monitored for low BMD and potential fracture risks, and GC-sparing treatment regimens should be considered.","PeriodicalId":44915,"journal":{"name":"Annals of Pediatric Endocrinology & Metabolism","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11220398/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139643106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Commentary on "Long-read next-generation sequencing for molecular diagnosis of pediatric endocrine disorders". 关于 "用于儿科内分泌疾病分子诊断的长读数新一代测序 "的评论。

IF 2.8

Annals of Pediatric Endocrinology & Metabolism Pub Date : 2024-06-01 Epub Date: 2024-06-30 DOI: 10.6065/apem.24224014edi03

Won Kyoung Cho

引用次数: 0

Idiopathic ketotic hypoglycemia in children: an update. 儿童特发性酮症性低血糖：最新进展。

IF 2.8

Annals of Pediatric Endocrinology & Metabolism Pub Date : 2024-06-01 Epub Date: 2024-01-29 DOI: 10.6065/apem.2346156.078

Kotb Abbass Metwalley, Hekma Saad Farghaly

{"title":"Idiopathic ketotic hypoglycemia in children: an update.","authors":"Kotb Abbass Metwalley, Hekma Saad Farghaly","doi":"10.6065/apem.2346156.078","DOIUrl":"10.6065/apem.2346156.078","url":null,"abstract":"Idiopathic ketotic hypoglycemia (IKH) is defined as bouts of hypoglycemia with increased blood or urine ketones in certain children after prolonged fasting or during illness. IKH is divided into physiological IKH, which is most frequently observed in normal children with intercurrent acute illness, and pathological IKH, which occurs in children who lack counter-regulatory hormones, have a metabolic disease, or have Silver-Russell syndrome. The typical patient is a young child between the ages of 10 months and 6 years. Episodes nearly always occur in the morning after overnight fasting. Symptoms include those of neuroglycopenia, ketosis, or both. IKH may be diagnosed after ruling out various metabolic and hormonal conditions associated with ketotic hypoglycemia. Sufficient amounts of carbohydrates and protein, avoidance of prolonged fasting, and increased frequency of food ingestion are the main modes of treating IKH. It is crucial to understand the pathogenesis of IKH and to distinguish physiological IKH from pathological IKH. In this mini-review, we present a brief summary of IKH in terms of its definition, types, clinical presentation, diagnosis, and therapeutic approach in children.","PeriodicalId":44915,"journal":{"name":"Annals of Pediatric Endocrinology & Metabolism","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11220389/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139643107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impacts of COVID-19 on childhood obesity: prevalence, contributing factors, and implications for management. COVID-19 对儿童肥胖症的影响：流行率、诱因及对管理的影响。

IF 2.8

Annals of Pediatric Endocrinology & Metabolism Pub Date : 2024-06-01 Epub Date: 2024-01-29 DOI: 10.6065/apem.2346094.047

Min-Ji Kim, Minji Kim, Ju Young Yoon, Chong Kun Cheon, Sukdong Yoo

{"title":"The impacts of COVID-19 on childhood obesity: prevalence, contributing factors, and implications for management.","authors":"Min-Ji Kim, Minji Kim, Ju Young Yoon, Chong Kun Cheon, Sukdong Yoo","doi":"10.6065/apem.2346094.047","DOIUrl":"10.6065/apem.2346094.047","url":null,"abstract":"Purpose: This study aimed to identify changes in the prevalence of obesity and related diseases among children and adolescents during the coronavirus disease 2019 (COVID-19) pandemic.Methods: This study was conducted using data from the 2016-2021 Korean National Health and Nutrition Examination Survey and included 3,861 children and adolescents aged 10-18 years. The prevalence of obesity and related diseases was adjusted for age, sex, and income. We also analyzed the socioeconomic, nutritional, and physical activity items in the survey.Results: During the COVID-19 pandemic, there was a significant increase in the prevalence of obesity (p=0.02), central obesity (p=0.001), mean body mass index (BMI, p=0.03), and hemoglobin A1c (p=0.005) among children and adolescents aged 10-18 years. The intake of food and calories was significantly reduced in the normal-weight group (p=0.001 and <0.001) but not in the obese group. Incidences of skipping breakfast increased and eating out decreased, regardless of obesity status. However, the changes in health behaviors were not significant. The prevalence of central obesity and increased BMI showed a significant linear association between children and their parents, especially in the 10-12-year-old age group. A clear increase in the proportion of metabolically unhealthy children and adolescents was observed in the obese group, and the frequency of central obesity in parents also increased.Conclusion: The number of metabolically unhealthy, obese children and adolescents increased during the COVID-19 pandemic. Age-specific strategies that consider growth, development, and genetic and social factors are required. Health strategies targeting the entire family are required to develop healthier habits.","PeriodicalId":44915,"journal":{"name":"Annals of Pediatric Endocrinology & Metabolism","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11220391/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139643111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-term endocrine sequelae after hematopoietic stem cell transplantation in children and adolescents. 儿童和青少年造血干细胞移植后的长期内分泌后遗症。

IF 2.2

Annals of Pediatric Endocrinology & Metabolism Pub Date : 2024-04-01 Epub Date: 2024-01-24 DOI: 10.6065/apem.2346046.023

Soojin Hwang, Yena Lee, Ji-Hee Yoon, Ja Hye Kim, Hyery Kim, Kyung-Nam Koh, Ho Joon Im, Han-Wook Yoo, Jin-Ho Choi

{"title":"Long-term endocrine sequelae after hematopoietic stem cell transplantation in children and adolescents.","authors":"Soojin Hwang, Yena Lee, Ji-Hee Yoon, Ja Hye Kim, Hyery Kim, Kyung-Nam Koh, Ho Joon Im, Han-Wook Yoo, Jin-Ho Choi","doi":"10.6065/apem.2346046.023","DOIUrl":"10.6065/apem.2346046.023","url":null,"abstract":"Purpose: As the survival rate from pediatric cancers has increased significantly with advances in treatment modalities, long-term endocrine complications have also risen. This study investigated the frequencies and risks of endocrine sequelae in childhood cancer survivors who received hematopoietic stem cell transplantation (HSCT).Methods: This study included 200 pediatric patients who underwent HSCT. Clinical and endocrinological findings were collected retrospectively. The median follow-up duration after HSCT was 14 years.Results: Endocrine complications occurred in 135 patients (67.5%). Children who underwent HSCT at pubertal age (n=100) were at higher risk of endocrine complications than those who received it at prepubertal age (79% vs. 56%, P=0.001). The most common complication was hypogonadism (40%), followed by dyslipidemia (22%). Short stature and diabetes mellitus were more prevalent in the prepubertal group, whereas hypogonadism and osteoporosis were more common in the pubertal group. Being female, pubertal age at HSCT, and glucocorticoid use were predictors of an increased risk for any complication. Radiation exposure increased the risk of short stature and hypothyroidism. Hypogonadism was significantly associated with being female, pubertal age at HSCT, and high-dose radiation. Pubertal age at HSCT also increased the risks of osteoporosis and dyslipidemia.Conclusion: This study demonstrates that long-term endocrine complications are common after HSCT in children and adolescents. Age at HSCT is a critical factor for endocrine complications after HSCT. These findings suggest that surveillance strategies for endocrine complications in childhood cancer survivors should be specified according to age at HSCT.","PeriodicalId":44915,"journal":{"name":"Annals of Pediatric Endocrinology & Metabolism","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11076227/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139565061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0