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[Medical interventions for the therapy of obesity]. [治疗肥胖症的医疗干预措施]。
IF 0.2
THERAPEUTISCHE UMSCHAU Pub Date : 2024-06-01 DOI: 10.23785/TU.2024.03.007
Bernd Schultes, Barbara Ernst, Marco Bueter
{"title":"[Medical interventions for the therapy of obesity].","authors":"Bernd Schultes, Barbara Ernst, Marco Bueter","doi":"10.23785/TU.2024.03.007","DOIUrl":"https://doi.org/10.23785/TU.2024.03.007","url":null,"abstract":"<p><strong>Introduction: </strong>Obesity is a chronic disease characterized by increased body fat mass and adipose tissue dysfunction, the pathogenesis of which is based on a neurobiological regulatory disorder of energy homeostasis. The primary aim of medical obesity therapy is to reduce the pathologically increased body fat mass and thus prevent secondary diseases and improve comorbidities. In this sense, bariatric-metabolic surgery is currently the most effective obesity therapy. In addition, new agents, which are essentially based on GLP-1 receptor agonism, are making pharmacological therapy increasingly effective. It is important to note that both bariatric-metabolic surgery as well as the pharmacological obesity therapy have direct effects on the central nervous regulation of energy homeostasis and, in particular, hunger and appetite, and therefore represent pathogenetically causal therapies. In this overview, we aim to shed light on the aforementioned medical interventions for obesity therapy and place them in the context of a pathogenetic disease concept.</p>","PeriodicalId":44874,"journal":{"name":"THERAPEUTISCHE UMSCHAU","volume":"81 3","pages":"99-104"},"PeriodicalIF":0.2,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141564779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adipositas: eine Einführung. 肥胖症：简介。
IF 0.2
THERAPEUTISCHE UMSCHAU Pub Date : 2024-06-01 DOI: 10.23785/TU.2024.03.001
Bernd Schultes
{"title":"Adipositas: eine Einführung.","authors":"Bernd Schultes","doi":"10.23785/TU.2024.03.001","DOIUrl":"10.23785/TU.2024.03.001","url":null,"abstract":"<p><strong>Introduction: </strong></p>","PeriodicalId":44874,"journal":{"name":"THERAPEUTISCHE UMSCHAU","volume":"81 3","pages":"68"},"PeriodicalIF":0.2,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141564783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Heart failure with preserved left ventricular ejection fraction (HFpEF)]. [左心室射血分数保留型心力衰竭（HFpEF）]。
IF 0.2
THERAPEUTISCHE UMSCHAU Pub Date : 2024-04-01 DOI: 10.23785/TU.2024.02.002
Micha T Maeder, Hans Rickli, Eva Scheler, Peter Ammann, Marc Buser
{"title":"[Heart failure with preserved left ventricular ejection fraction (HFpEF)].","authors":"Micha T Maeder, Hans Rickli, Eva Scheler, Peter Ammann, Marc Buser","doi":"10.23785/TU.2024.02.002","DOIUrl":"10.23785/TU.2024.02.002","url":null,"abstract":"<p><strong>Introduction: </strong>Heart failure with preserved left ventricular ejection fraction (HFpEF) is a common and very important disease entity because of its association with frequent repeat hospitalization and high mortality. Hallmarks of the underlying pathophysiology include a small left ventricular cavity due to concentric remodeling, impaired left ventricular compliance and left atrial dysfunction. This leads to an increase in left atrial and pulmonary pressure on exertion and in advanced stages of the disease already at rest with consecutive exertional dyspnea and exercise intolerance. Additional cardiovascular mechanisms including atrial fibrillation, chronotropic incompetence and coronary artery disease as well as non-cardiac co-morbidities contribute to a variable extent to the clinical picture. The diagnostic work-up is demanding and complex but the concepts have significantly improved during the last years. The study results of the Sodium Glucose cotransporter-2 inhibitors (SGLT-2-inhibitors) have revolutionized the treatment of HFpEF. In the present article, we provide an overview about the current understanding of the pathophysiology of HFpEF, the principles of the diagnostic pathways and a summary of the intervention studies in the field, and we propose an approach for the treatment in clinical practice.</p>","PeriodicalId":44874,"journal":{"name":"THERAPEUTISCHE UMSCHAU","volume":"81 2","pages":"31-40"},"PeriodicalIF":0.2,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141080984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Heart failure with reduced left ventricular ejection fraction (HFrEF, HFmrEF)]. [左心室射血分数降低的心力衰竭（HFrEF、HFmrEF）]。
IF 0.2
THERAPEUTISCHE UMSCHAU Pub Date : 2024-04-01 DOI: 10.23785/TU.2024.02.003
Thomas Seiler, Matthias Paul
{"title":"[Heart failure with reduced left ventricular ejection fraction (HFrEF, HFmrEF)].","authors":"Thomas Seiler, Matthias Paul","doi":"10.23785/TU.2024.02.003","DOIUrl":"10.23785/TU.2024.02.003","url":null,"abstract":"<p><strong>Introduction: </strong>Heart failure is the final stage of most heart diseases and, with over 64 million people affected worldwide, is considered a global pandemic. The prevalence is expected to continue to rise. The prevention and treatment of cardiovascular diseases and the early detection of patients suffering from heart failure are essential. Different therapies are available depending on the extent of the reduction in left ventricular ejection fraction (LVEF). Optimal treatment prevents unnecessary admissions to hospital, reduces mortality and improves quality of life. In the following article, we discuss the diagnosis of heart failure and explain the various treatment options for heart failure with reduced LVEF (HFrEF, HFmrEF).</p>","PeriodicalId":44874,"journal":{"name":"THERAPEUTISCHE UMSCHAU","volume":"81 2","pages":"41-46"},"PeriodicalIF":0.2,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141081078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Rhythm management in patients with heart failure]. [心力衰竭患者的节律管理]。
IF 0.2
THERAPEUTISCHE UMSCHAU Pub Date : 2024-04-01 DOI: 10.23785/TU.2024.02.005
Richard Kobza, Benjamin Berte
{"title":"[Rhythm management in patients with heart failure].","authors":"Richard Kobza, Benjamin Berte","doi":"10.23785/TU.2024.02.005","DOIUrl":"10.23785/TU.2024.02.005","url":null,"abstract":"<p><strong>Introduction: </strong>Arrhythmias manifest frequently in individuals with heart failure, posing a notable threat of mortality and morbidity. While the prevention of sudden cardiac death through ICD therapy remains pivotal, accurate risk stratification remains a challenging task even in 2024. Recent data underscore the early consideration of catheter ablation for ventricular tachycardias. Although antiarrhythmic drug therapy serves as an ancillary measure for symptomatic patients, it does not confer prognostic advantages. The holistic management of arrhythmias in heart failure necessitates a systematic, multidimensional approach that initiates with evidence-based medical therapy for heart failure and integrates device-based and interventional therapies. Noteworthy clinical studies have illustrated the positive prognostic impact of early rhythm control strategies, particularly catheter ablation, in individuals managing heart failure and atrial fibrillation.</p>","PeriodicalId":44874,"journal":{"name":"THERAPEUTISCHE UMSCHAU","volume":"81 2","pages":"54-59"},"PeriodicalIF":0.2,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141081502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Introduction: Heart failure]. [导言：心力衰竭]。
IF 0.2
THERAPEUTISCHE UMSCHAU Pub Date : 2024-04-01 DOI: 10.23785/TU.2024.02.001
Christophe Wyss
{"title":"[Introduction: Heart failure].","authors":"Christophe Wyss","doi":"10.23785/TU.2024.02.001","DOIUrl":"https://doi.org/10.23785/TU.2024.02.001","url":null,"abstract":"<p><strong>Introduction: </strong></p>","PeriodicalId":44874,"journal":{"name":"THERAPEUTISCHE UMSCHAU","volume":"81 2","pages":"30"},"PeriodicalIF":0.2,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141081422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Cardiomyopathies: a practical approach to the assessment and management of patients and their families]. [心肌病：评估和管理患者及其家属的实用方法]。
IF 0.2
THERAPEUTISCHE UMSCHAU Pub Date : 2024-04-01 DOI: 10.23785/TU.2024.02.006
Roxana Hiestand, Christiane Gruner
{"title":"[Cardiomyopathies: a practical approach to the assessment and management of patients and their families].","authors":"Roxana Hiestand, Christiane Gruner","doi":"10.23785/TU.2024.02.006","DOIUrl":"10.23785/TU.2024.02.006","url":null,"abstract":"<p><strong>Introduction: </strong>The new 2023 European Society of Cardiology (ESC) Guidelines for the management of cardiomyopathies addresses all cardiomyopathies in a single document for the first time. The focus is on a phenotype-oriented diagnostic approach, multimodal imaging and genetic testing to establish the most accurate diagnosis possible. Additionally, new recommendations for risk stratification for sudden cardiac death in various cardiomyopathy phenotypes are provided. MRI and genetic testing have significantly gained importance in this context. Recommendations for comprehensive clinical and genetic cascade screening in relatives of individuals with cardiomyopathies have been revised. This article presents the most important innovations of these guidelines in a practice-oriented approach.</p>","PeriodicalId":44874,"journal":{"name":"THERAPEUTISCHE UMSCHAU","volume":"81 2","pages":"60-66"},"PeriodicalIF":0.2,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141080883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Acute heart failure (AHF)]. [急性心力衰竭（AHF）]。
IF 0.2
THERAPEUTISCHE UMSCHAU Pub Date : 2024-04-01 DOI: 10.23785/TU.2024.02.004
Stefanie Boll, Eleonora Lupi, Thomas Wolters, Tobias Höfflinghaus, Mattia Arrigo
{"title":"[Acute heart failure (AHF)].","authors":"Stefanie Boll, Eleonora Lupi, Thomas Wolters, Tobias Höfflinghaus, Mattia Arrigo","doi":"10.23785/TU.2024.02.004","DOIUrl":"10.23785/TU.2024.02.004","url":null,"abstract":"<p><strong>Introduction: </strong>Acute heart failure (AHF) is a frequent cause for emergency consultations, leads to long hospital stays and is characterized by high mortality and rehospitalization rates, with the first months after hospitalization having the highest risk («vulnerable phase»). The clinical presentation is usually characterized by fluid accumulation. Over the last three decades, few advances have been achieved in the treatment of AHF, as most studies with diuretics or vasodilators failed to show positive effects in terms of mortality and rehospitalization rates. In this context, the treatment of AHF must have an integrative approach, consisting of rapid correction of systemic congestion on the one hand, and specific therapies for the precipitating factors, the underlying cardiac pathology, and non-cardiac comorbidities on the other. Recently, it has been shown that a rapid and intensive up-titration of oral heart failure medical therapy during and immediately after hospitalization can improve the prognosis during the vulnerable phase after AHF. In this article, the principles of optimization and personalization of diuretic therapy and oral heart failure medication during hospitalization and the early outpatient phase after AHF are discussed.</p>","PeriodicalId":44874,"journal":{"name":"THERAPEUTISCHE UMSCHAU","volume":"81 2","pages":"47-53"},"PeriodicalIF":0.2,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141080803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Interstitial lung disease: an introduction]. [间质性肺病：简介]。
IF 0.2
THERAPEUTISCHE UMSCHAU Pub Date : 2024-02-01
Katrin Hostettler
{"title":"[Interstitial lung disease: an introduction].","authors":"Katrin Hostettler","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong></p>","PeriodicalId":44874,"journal":{"name":"THERAPEUTISCHE UMSCHAU","volume":"81 1","pages":"1-3"},"PeriodicalIF":0.2,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140866123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Progressive pulmonary Fibrosis]. [进行性肺纤维化］
IF 0.2
THERAPEUTISCHE UMSCHAU Pub Date : 2024-02-01
Rebekka Kleiner, Susanne Pohle
{"title":"[Progressive pulmonary Fibrosis].","authors":"Rebekka Kleiner, Susanne Pohle","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Progressive pulmonary Fibrosis Abstract: Cough and dyspnea on excertion are common and early symptoms of interstitial lung diseases (ILD). Thoracic imaging (particularly computed tomography) detects such lung structural alterations early in the disease course. Knowledge of these diseases and their management is necessary in the daily business. The term \"progressive pulmonary fibrosis\" subsumes a heterogene group of interstitial lung diseases with a similar course of progressive fibrosis. The management of these diseases should be discussed interdisciplinary, similar to the management of the Idiopathic pulmonary fibrosis (IPF). Antifibrotic drugs are new therapeutic options.</p>","PeriodicalId":44874,"journal":{"name":"THERAPEUTISCHE UMSCHAU","volume":"81 1","pages":"12-15"},"PeriodicalIF":0.2,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140852870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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