THERAPEUTISCHE UMSCHAU最新文献_第3页

[Preventing dementia in an ageing society]. [在老龄化社会中预防痴呆症]。

IF 0.2

THERAPEUTISCHE UMSCHAU Pub Date : 2026-02-01 DOI: 10.23785/TU.2026.01.007

Stefanie Steininger, Franziskos Xepapadakos

引用次数: 0

[Diagnosis and treatment of obsessive compulsive disorder]. [强迫症的诊断与治疗]。

IF 0.2

THERAPEUTISCHE UMSCHAU Pub Date : 2026-02-01 DOI: 10.23785/TU.2026.01.004

Christine Poppe

{"title":"[Diagnosis and treatment of obsessive compulsive disorder].","authors":"Christine Poppe","doi":"10.23785/TU.2026.01.004","DOIUrl":"10.23785/TU.2026.01.004","url":null,"abstract":"Introduction: Obsessive-compulsive disorders (OCD) are common and often chronic mental illnesses, characterized by recurring, intrusive thoughts, ideas and impulses (obsessions) and repetitive, stereotypical behaviors (compulsions). Etiopathogenetically, OCD is explained by a complex interplay of genetics and epigenetics, neurotransmission, imbalances in cortico-striato-thalamo-cortical circuits, as well as learning mechanism and environmental factors. In ICD-11, OCD is now classified in the chapter \"Obsessive-compulsive and related disorders\", which share compulsive and impulsive behavioral patterns. This article provides diagnostic recommendations, common psychiatric comorbidities, and key differential diagnoses. In terms of psychotherapy, disorder-specific cognitive behavioral therapy (CBT) with exposure and response prevention is highly effective and recommended as first-line treatment. New approaches describe intensified and internet-based formats as well as modern developments in CBT. Pharmacologically, serotonin inhibitors (SSRIs and Clomipramin) are recommended at high dosages. Atypical antipsychotics may be used in low dosages for augmentation. For treatment-resistant cases, brain stimulation techniques such as repetitive transcranial magnetic stimulation and bilateral deep brain stimulation may be considered following a careful risk-benefit analysis.","PeriodicalId":44874,"journal":{"name":"THERAPEUTISCHE UMSCHAU","volume":"83 1","pages":"19-26"},"PeriodicalIF":0.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147515490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Optimisation of psychopharmacological treatment strategies by using therapeutic drug monitoring]. [利用药物监测优化精神药物治疗策略]。

IF 0.2

THERAPEUTISCHE UMSCHAU Pub Date : 2026-02-01 DOI: 10.23785/TU.2026.01.002

Michael Paulzen, Georgios Schoretsanitis

{"title":"[Optimisation of psychopharmacological treatment strategies by using therapeutic drug monitoring].","authors":"Michael Paulzen, Georgios Schoretsanitis","doi":"10.23785/TU.2026.01.002","DOIUrl":"10.23785/TU.2026.01.002","url":null,"abstract":"Introduction: The effect of a (neuro-)psychopharmacological drug is determined by its interaction with its target structure in the brain (pharmacodynamics). A number of pharmacokinetic factors determine whether a drug is capable of reaching its site of action in a sufficient concentration. The concentration of the active compound can be significantly affected by its metabolism, which is genetically determined in each individual (known as the pharmacokinetic genotype), and by potential interactions with other prescribed drugs (known as the pharmacokinetic phenotype). For example, changes in drug metabolism inevitably lead to changes in the concentration of active compounds and thus to changes in the exposure of the drug. Therapeutic drug monitoring (TDM) is a tool for individualized pharmacotherapy that helps to optimize pharmacological treatment. On the one hand, TDM helps to detect deviations from expected drug concentrations and individualize treatment by adjusting doses. On the other hand, looking at the ratio of the parent compound and its metabolite (known as the metabolic ratio) helps to identify any abnormalities or peculiarities in drug metabolism supporting dose adjustments. This article provides a clinically oriented overview of how changes in drug metabolism can lead to treatment failure and which tools can be used to optimize treatment.","PeriodicalId":44874,"journal":{"name":"THERAPEUTISCHE UMSCHAU","volume":"83 1","pages":"3-13"},"PeriodicalIF":0.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147515479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Sleep disorders and mental health]. [睡眠障碍和心理健康]。

IF 0.2

THERAPEUTISCHE UMSCHAU Pub Date : 2026-02-01 DOI: 10.23785/TU.2026.01.005

Benedikt Habermeyer, Michael Huber, Marc Spielmanns

{"title":"[Sleep disorders and mental health].","authors":"Benedikt Habermeyer, Michael Huber, Marc Spielmanns","doi":"10.23785/TU.2026.01.005","DOIUrl":"10.23785/TU.2026.01.005","url":null,"abstract":"Introduction: Sleep disorders occur in almost one out of three people and are therefore among the most common disorders that physicians encounter in their practice. They often also present in the context of mental disorders. While it was previously assumed that they were merely a symptom of mental illness, current literature emphasizes the bidirectional connection between sleep and mental disorders. Even in the most common sleep disorders, namely sleep-related breathing disorders, insomnia, and restless legs syndrome / periodic limb movement disorder, reciprocal and sometimes complex interactions between sleep and the mental health are found. A diagnostic classification is often successful based on a targeted and sleep-specific medical history and can then be efficiently narrowed down using a step-by-step diagnostic approach. Due to the bidirectional connection between sleep and mental disorders, it is crucial to also inquire about mental symptoms in sleep disorders and to consider sleep in mental disorders. If a sleep disorder occurs together with a mental disorder, it is essential to treat both disorders specifically. While nocturnal continuous positive airway pressure therapy is the primary treatment for sleep-related breathing disorders, insomnia is ideally treated with cognitive behavioural therapy. Interestingly, this treatment also shows effects on the associated mental disorder. Restless legs syndrome and periodic limb movement disorder, on the other hand, are usually treated pharmacologically, with particular attention to the association with psychotropic medications.","PeriodicalId":44874,"journal":{"name":"THERAPEUTISCHE UMSCHAU","volume":"83 1","pages":"27-32"},"PeriodicalIF":0.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147515504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Precision psychiatry: Transforming mental health care - an introduction for practitioners]. [精确精神病学：转变精神卫生保健-从业人员介绍]。

IF 0.2

THERAPEUTISCHE UMSCHAU Pub Date : 2026-02-01 DOI: 10.23785/TU.2026.01.008

Thomas D Szucs

{"title":"[Precision psychiatry: Transforming mental health care - an introduction for practitioners].","authors":"Thomas D Szucs","doi":"10.23785/TU.2026.01.008","DOIUrl":"10.23785/TU.2026.01.008","url":null,"abstract":"Introduction: Mental disorders are common in primary care and impose substantial societal costs. Current psychiatric care still relies largely on trial-and-error prescribing, often delaying response and increasing adverse effects. Precision psychiatry aims to shift practice toward data-driven, individualized decisions by integrating biological markers, clinical phenotypes and contextual factors. This article introduces practical tools with an emphasis on real-world use in general practice: RNA-editing blood biomarkers (the EDIT-B test) to support the differentiation of bipolar disorder from unipolar major depression; genomic approaches targeting the AVP/V1B pathway as a proxy for HPA-axis hyperactivity and as a potential companion diagnostic for V1B-receptor antagonists; and pharmacogenomics (CYP2D6/CYP2C19) to guide antidepressant selection and dosing. Additional emerging components include inflammatory markers such as hsCRP, digital phenotyping with wearables for longitudinal monitoring, and metabolomic/lipidomic signatures for stratification. Finally, key implementation issues in primary care are discussed, including training needs, workflow and EHR integration, reimbursement, and data protection/informed consent.","PeriodicalId":44874,"journal":{"name":"THERAPEUTISCHE UMSCHAU","volume":"83 1","pages":"45-52"},"PeriodicalIF":0.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147515483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Einführung: Tauch- und Höhenmedizin, Aviatik, hyperbare Sauerstofftherapie. 介绍：潜水和高空医学，航空，高压氧治疗。

IF 0.2

THERAPEUTISCHE UMSCHAU Pub Date : 2025-12-01 DOI: 10.23785/TU.2025.06.001

Tsogyal Daniela Latshang

引用次数: 0

[Clinical value of hyperbaric oxygen therapy for the treatment of chronic wounds]. [高压氧治疗慢性伤口的临床价值]。

IF 0.2

THERAPEUTISCHE UMSCHAU Pub Date : 2025-12-01 DOI: 10.23785/TU.2025.06.003

Andrea Will, Christian Wölfel, Kujtim Veseli, Marco Gelsomino, Luise Adam

引用次数: 0

[High-altitude exposure in chronic lung deseases - fundamentals, current evidence, and practical recommendations]. [慢性肺部疾病的高海拔暴露——基础、现有证据和实用建议]。

IF 0.2

THERAPEUTISCHE UMSCHAU Pub Date : 2025-12-01 DOI: 10.23785TU.2025.06.005

Dinah Hertig, Vincent Grunder, Michael Furian, Laura Mayer, Silvia Ulrich, Mona Lichtblau

引用次数: 0

[Overview of the most important (patho)physiological mechanisms of high-altitude acclimatization in healthy individuals]. [健康个体高原适应最重要（病理）生理机制综述]。

IF 0.2

THERAPEUTISCHE UMSCHAU Pub Date : 2025-12-01 DOI: 10.23785/TU.2025.06.006

Kay von Grünigen, Silvia Ulrich, Mona Lichtblau, Laura Mayer, Michael Furian

{"title":"[Overview of the most important (patho)physiological mechanisms of high-altitude acclimatization in healthy individuals].","authors":"Kay von Grünigen, Silvia Ulrich, Mona Lichtblau, Laura Mayer, Michael Furian","doi":"10.23785/TU.2025.06.006","DOIUrl":"10.23785/TU.2025.06.006","url":null,"abstract":"Introduction: More and more people are spending time at high altitudes, either recreationally or permanently. As altitude increases, the partial pressure of inspired oxygen decreases, leading to hypobaric hypoxia and triggering a wide range of physiological adaptations. This article discusses the most relevant (patho)physiological acclimatization effects at high altitudes in healthy subjects. Hypobaric hypoxia primarily affects respiration, circulation, blood, as well as sleep and brain function. Respiration responds immediately with increased ventilation (hypoxic ventilatory response), reducing CO₂ levels and causing respiratory alkalosis, which is later compensated renally. Above approximately 2500 m, periodic breathing often occurs, disrupting sleep. Cardiac output initially rises due to an increased heart rate but decreases later as stroke volume declines. Plasma volume contracts rapidly, raising hematocrit and increasing blood viscosity. In the long term, erythropoietin stimulates red blood cell production, enhancing oxygen transport capacity. Physical performance begins to decline linearly from around 1500 m, and maximum oxygen uptake remains limited despite acclimatization.","PeriodicalId":44874,"journal":{"name":"THERAPEUTISCHE UMSCHAU","volume":"82 6","pages":"202-208"},"PeriodicalIF":0.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146020125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Hypoxia in aviation: list of possible causes]. [航空缺氧：可能的原因]。

IF 0.2

THERAPEUTISCHE UMSCHAU Pub Date : 2025-12-01 DOI: 10.23785/TU.2025.06.004

Basil Kopp, Denis Bron

引用次数: 0