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[Premenopausal osteoporosis]. 绝经前的骨质疏松症。
IF 0.2
THERAPEUTISCHE UMSCHAU Pub Date : 2025-02-01 DOI: 10.23785/TU.2025.01.004
Elena Tsourdi
{"title":"[Premenopausal osteoporosis].","authors":"Elena Tsourdi","doi":"10.23785/TU.2025.01.004","DOIUrl":"10.23785/TU.2025.01.004","url":null,"abstract":"<p><strong>Introduction: </strong>Premenopausal osteoporosis is often overlooked because fragility fractures and low bone mass are uncommon in premenopausal women. The definition and diagnostic criteria for premenopausal osteoporosis are less well defined than for postmenopausal women. Diagnostic procedures should be initiated in premenopausal women with existing fragility fractures or diseases and drug therapies that cause bone loss. Recent studies have shown that lifestyle and dietary habits influence bone mass in the premenopausal phase. Bone mass can be improved by an adequate intake of calcium and vitamin D in combination with increased physical activity in premenopausal women with idiopathic osteoporosis. Secondary causes of osteoporosis should be corrected or treated if possible. In women with recurrent fractures or secondary causes that cannot be reversed, e.g. glucocorticoids or oncological treatments, pharmacological intervention with bisphosphonates or teriparatide (the latter not in patients with carcinomas) may be considered. Antiresorptive and osteoanabolic agents have been shown to effectively increase bone mass; however, no studies have been conducted to date with fractures as the primary endpoint.</p>","PeriodicalId":44874,"journal":{"name":"THERAPEUTISCHE UMSCHAU","volume":"82 1","pages":"13-19"},"PeriodicalIF":0.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Vitamin D - What is the current advice?] [维生素D -目前的建议是什么？]］
IF 0.2
THERAPEUTISCHE UMSCHAU Pub Date : 2025-02-01 DOI: 10.23785/TU.2025.01.003
Heike A Bischoff-Ferrari
{"title":"[Vitamin D - What is the current advice?]","authors":"Heike A Bischoff-Ferrari","doi":"10.23785/TU.2025.01.003","DOIUrl":"10.23785/TU.2025.01.003","url":null,"abstract":"<p><strong>Introduction: </strong>We have gained new insights into vitamin D. High quality studies of over 36,000 people have shown that daily vitamin D supplementation of 800 IU reduces the risk of hip fracture and falling in older adults with vitamin D deficiency and existing falling risk. We have also learnt that vitamin D supplementation in healthy middle-aged and elderly people without vitamin D deficiency and without osteoporosis offers no additional protection. Also, large intermittent bolus doses of vitamin D either show no protection against fractures or even lead to an increase in fracture risk and fall risk in vulnerable elderly people and are therefore obsolete. In recent years, however, large randomised studies on daily vitamin D supplementation with 2000 IU in healthy people without vitamin D deficiency at the age of 50 (VITAL) and at the age of 70 (DO-HEALTH) have shown a benefit on the immune system in terms of reducing advanced cancers, cancer mortality and autoimmune diseases.</p>","PeriodicalId":44874,"journal":{"name":"THERAPEUTISCHE UMSCHAU","volume":"82 1","pages":"10-12"},"PeriodicalIF":0.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Osteoporosis therapy - Update 2025, Part 1: Antiresorptive and osteoanabolic therapy options]. [骨质疏松治疗-更新2025，第1部分：抗骨吸收和骨合成代谢治疗选择]。
IF 0.2
THERAPEUTISCHE UMSCHAU Pub Date : 2025-02-01 DOI: 10.23785/TU.2025.01.006
Serge Ferrari, Judith Everts-Graber, Christian Meier
{"title":"[Osteoporosis therapy - Update 2025, Part 1: Antiresorptive and osteoanabolic therapy options].","authors":"Serge Ferrari, Judith Everts-Graber, Christian Meier","doi":"10.23785/TU.2025.01.006","DOIUrl":"10.23785/TU.2025.01.006","url":null,"abstract":"<p><strong>Introduction: </strong>Osteoporosis is a chronic disease that requires lifelong therapy management that includes both preventive measures and pharmacological approaches. The medical treatment of osteoporosis has changed considerably in recent years, particularly due to the availability of new substances, especially osteoanabolic drugs. The wide range of antiresorptive (estrogens, raloxifene, bisphosphonates, denosumab) and osteoanabolic (teriparatide, romosozumab) preparations for the treatment of osteoporosis makes it possible today to use them in a targeted manner based on the individual fracture risk. The uncertainty in their use can contribute to the underuse and lack of treatment of patients with osteoporosis, especially patients with a high fracture risk. This review article will summarize the mechanisms of action and clinical efficacy of antiresorptive and, in particular, anabolic agents and discuss its value for osteoporosis therapy.</p>","PeriodicalId":44874,"journal":{"name":"THERAPEUTISCHE UMSCHAU","volume":"82 1","pages":"26-31"},"PeriodicalIF":0.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Introduction: Osteoporosis]. (简介:骨质疏松症)。
IF 0.2
THERAPEUTISCHE UMSCHAU Pub Date : 2025-02-01 DOI: 10.23785/TU.2025.01.001
Christian Meier
{"title":"[Introduction: Osteoporosis].","authors":"Christian Meier","doi":"10.23785/TU.2025.01.001","DOIUrl":"10.23785/TU.2025.01.001","url":null,"abstract":"<p><strong>Introduction: </strong></p>","PeriodicalId":44874,"journal":{"name":"THERAPEUTISCHE UMSCHAU","volume":"82 1","pages":"1"},"PeriodicalIF":0.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Metatarsalgia]. [跖骨痛］
IF 0.2
THERAPEUTISCHE UMSCHAU Pub Date : 2024-12-01 DOI: 10.23785/TU.2024.07.002
Fabienne Inglin, Markus Knupp
{"title":"[Metatarsalgia].","authors":"Fabienne Inglin, Markus Knupp","doi":"10.23785/TU.2024.07.002","DOIUrl":"10.23785/TU.2024.07.002","url":null,"abstract":"<p><strong>Introduction: </strong>Metatarsalgia is a generic term for complaints in the forefoot and the metatarsophalangeal joints II-IV. However, it does not describe a specific clinical picture but rather a complex of symptoms, which can have different causes. There are mechanical causes, e.g. due congenital or acquired malformations of the foot. Splayfeet with a bunion malformation combined with transfer a common cause. Other examples include brachimetatarsalgia or an instability of the first ray. Other, non-mechanical causes are Morton's neuroma, stress fractures, systemic diseases (rheumatoid arthritis, gout) or infections and aseptic necrosis. Metatarsalgia is described as stress-dependent pain in the ball of the forefoot, which often has a burning or stabbing character. Sometimes a foreign body feeling is reported, as if one were walking on a «pebble». Wearing tight and hard shoes further provokes the symptoms. The therapy depends on the causes and should initially cover conservative options. This includes wearing proper shoes, foot gymnastic/stretching exercise, orthopedic insoles or even orthopedic shoes. Surgical options comprise of Morton's neuroma removal, deformity correction and ligament reconstruction.</p>","PeriodicalId":44874,"journal":{"name":"THERAPEUTISCHE UMSCHAU","volume":"81 7","pages":"240-244"},"PeriodicalIF":0.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143626264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Osteochondral lesions of the talus]. [距骨骨软骨病变]。
IF 0.2
THERAPEUTISCHE UMSCHAU Pub Date : 2024-12-01 DOI: 10.23785/TU.2024.07.005
Doria Juric, Nicola Krähenbühl
{"title":"[Osteochondral lesions of the talus].","authors":"Doria Juric, Nicola Krähenbühl","doi":"10.23785/TU.2024.07.005","DOIUrl":"10.23785/TU.2024.07.005","url":null,"abstract":"<p><strong>Introduction: </strong>The talus has a comparatively high occurrence of osteochondral lesions (OCL), largely due to its unique anatomic characteristics. These lesions can occur post-traumatic or primary. Patients often present with non-specific symptoms, making a thorough clinical examination essential. This examination should include assessing hindfoot alignment, performing antero-lateral and antero-medial palpation with the ankle joint slightly plantar-flexed and evaluating stability. Beyond standard X-ray examinations, additional imaging modalities such as magnetic resonance imaging (MRI) and arthro-computed tomography (CT) are valuable diagnostic tools. Surgical intervention is recommended for symp-tomatic patients with unstable OCL. Besides cartilage reconstructive procedures, options like fusion or prosthetic treatments are available for managing recurring pain.</p>","PeriodicalId":44874,"journal":{"name":"THERAPEUTISCHE UMSCHAU","volume":"81 7","pages":"254-257"},"PeriodicalIF":0.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143626267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Introduction: Foot]. (简介:脚)。
IF 0.2
THERAPEUTISCHE UMSCHAU Pub Date : 2024-12-01 DOI: 10.23785/TU.2024.07.001
Markus Knupp
{"title":"[Introduction: Foot].","authors":"Markus Knupp","doi":"10.23785/TU.2024.07.001","DOIUrl":"10.23785/TU.2024.07.001","url":null,"abstract":"<p><strong>Introduction: </strong></p>","PeriodicalId":44874,"journal":{"name":"THERAPEUTISCHE UMSCHAU","volume":"81 7","pages":"239"},"PeriodicalIF":0.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143626261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Chronic exertional compartment syndrome - an overlooked diagnosis of exercise related leg pain]. 慢性运动筋膜室综合征——一种被忽视的与运动相关的腿部疼痛诊断。
IF 0.2
THERAPEUTISCHE UMSCHAU Pub Date : 2024-12-01 DOI: 10.23785/TU.2024.07.003
Anja Hirschmüller, Kerstin Recktenwald, Roman Gähwiler, Lukas Weisskopf
{"title":"[Chronic exertional compartment syndrome - an overlooked diagnosis of exercise related leg pain].","authors":"Anja Hirschmüller, Kerstin Recktenwald, Roman Gähwiler, Lukas Weisskopf","doi":"10.23785/TU.2024.07.003","DOIUrl":"10.23785/TU.2024.07.003","url":null,"abstract":"<p><strong>Introduction: </strong>Chronic exertional compartment syndrome (CECS) is an underdiagnosed clinical condition primarily affecting young, physically active people between the ages of 15 and 25. Pathophysiologically, there is an activity associated pressure increase in one or more muscle compartments of the lower leg, usually triggered by sports including running or jumping. The lower legs are most affected, but compartment syndromes of arms, thighs, feet and even the paravertebral muscles have also been described. Typically, CECS manifests as bilateral exercise related leg pain, quickly subsiding after the end of activity. Intracompartmental pressure measurement is required to make a definitive diagnosis. Vascular entrapments, spinal pathologies and myopathies should be considered in the differential diagnosis. Conservative therapy measures include activity modifications, detonation of the muscles, gait retraining, optimization of biomechanics, compression stockings, dry needling and Botulinum toxin injections. If symptoms persist, an endoscopically assisted fasciotomy is a surgical procedure with few complications and a high success rate.</p>","PeriodicalId":44874,"journal":{"name":"THERAPEUTISCHE UMSCHAU","volume":"81 7","pages":"245-248"},"PeriodicalIF":0.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143626087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Foot Ulcers in Orthopedics]. [骨科中的足部溃疡]。
IF 0.2
THERAPEUTISCHE UMSCHAU Pub Date : 2024-12-01 DOI: 10.23785/TU.2024.07.004
Felix Waibel, Madlaina Schöni
{"title":"[Foot Ulcers in Orthopedics].","authors":"Felix Waibel, Madlaina Schöni","doi":"10.23785/TU.2024.07.004","DOIUrl":"10.23785/TU.2024.07.004","url":null,"abstract":"<p><strong>Introduction: </strong>Foot ulcers are most often vascular, pressure-related or diabetes-related. The presence of neuropathy with loss of protective sensation and/or peripheral arterial disease are essential risk factors for diabetic foot ulcers. Prevention aims at identifying the foot at risk, regularly checking the foot at risk, educating patients, relatives and healthcare professionals, ensuring the routine wearing of appropriate footwear and treating risk factors for ulceration. In the presence of a diabetic foot ulcer, therapy consists of a combination of mechanical relief (gold standard during the ulcer phase: total contact cast), treatment of peripheral arterial disease, treatment of infections, metabolic control and treatment of comorbidities, local ulcer control and education of patients and relatives. Infected ulcers must be examined for the presence of osteomyelitis. Without osteomyelitis, therapy consists of local debridement and 1-2 weeks of antibiotic therapy. If osteomyelitis is present, therapy consists either of a combination of surgical therapy (amputation vs. internal resection) with accompanying short antibiotic therapy or of purely conservative therapy with 6 weeks of antibiotics. After the ulcer has healed, orthopedic shoe care is indicated to prevent recurrence.</p>","PeriodicalId":44874,"journal":{"name":"THERAPEUTISCHE UMSCHAU","volume":"81 7","pages":"249-253"},"PeriodicalIF":0.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143626257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Flatfoot in Children - A Look at Myths and Their Evidence]. [儿童扁平足--误解及其证据]。
IF 0.2
THERAPEUTISCHE UMSCHAU Pub Date : 2024-12-01 DOI: 10.23785/TU.2024.07.006
Bernhard Speth
{"title":"[Flatfoot in Children - A Look at Myths and Their Evidence].","authors":"Bernhard Speth","doi":"10.23785/TU.2024.07.006","DOIUrl":"10.23785/TU.2024.07.006","url":null,"abstract":"<p><strong>Introduction: </strong>In connection with children's flat feet, one encounters many general statements whose truthfulness is unknown. Some of these myths concerning epidemiology, natural history, long-term progression and non-surgical interventions are examined in more detail in this article with regard to their evidence.</p>","PeriodicalId":44874,"journal":{"name":"THERAPEUTISCHE UMSCHAU","volume":"81 7","pages":"258-262"},"PeriodicalIF":0.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143626071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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