THERAPEUTISCHE UMSCHAU最新文献_第2页

[Polyneuropathies - a practical overview]. [多神经病变-实用概述]。

IF 0.2

THERAPEUTISCHE UMSCHAU Pub Date : 2025-06-01 DOI: 10.23785/TU.2025.03.004

Marisa Blanquet, Andrea M Humm

引用次数: 0

[Leading neurological symptoms of stroke]. [中风的主要神经症状]。

IF 0.2

THERAPEUTISCHE UMSCHAU Pub Date : 2025-06-01 DOI: 10.23785/TU.2025.03.007

Sebastian Kaufmann, Hakan Sarikaya, Moritz Kielkopf

{"title":"[Leading neurological symptoms of stroke].","authors":"Sebastian Kaufmann, Hakan Sarikaya, Moritz Kielkopf","doi":"10.23785/TU.2025.03.007","DOIUrl":"https://doi.org/10.23785/TU.2025.03.007","url":null,"abstract":"Introduction: Stroke is a common, potentially life-threatening event that presents both acute and long-term challenges for patients and the healthcare system. The importance of educating patients about key symptoms, rapid diagnosis, and timely therapy is often underestimated. In addition to prevention through the optimal management of risk factors such as high blood pressure and diabetes, early detection of stroke symptoms is crucial. Modern and effective therapies such as thrombolysis and endovascular procedures can significantly improve outcomes if initiated promptly. Familiarity with stroke symptoms is essential for recognizing and differentiating so-called stroke mimics and stroke chameleons. In patients showing corresponding symptoms, immediate referral to a hospital is imperative. The 4-S acronym (Sehstörung, Sprachstörung, Schwäche, schnell handeln - visual disturbance, speech disturbance, weakness, act fast) serves as an easily understandable mnemonic for patients. If stroke is suspected, the emergency services (144) should be contacted immediately, as every minute counts (\"Time is Brain\"). Given that strokes can also present with atypical symptoms, rapid imaging is indispensable in uncertain cases to rule out misdiagnosis. In this context, general practitioners play a crucial role in early detection and timely referral, which again significantly improves the quality of care.","PeriodicalId":44874,"journal":{"name":"THERAPEUTISCHE UMSCHAU","volume":"82 3","pages":"100-104"},"PeriodicalIF":0.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144555285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Acute and episodic dizziness - diagnosis and treatment]. 急性和发作性头晕-诊断和治疗。

IF 0.2

THERAPEUTISCHE UMSCHAU Pub Date : 2025-06-01 DOI: 10.23785/TU.2025.03.005

Alexander A Tarnutzer

引用次数: 0

[Epileptic seizures as a key neurological symptom: diagnosis, differential diagnosis and management]. 【癫痫发作作为一种关键的神经系统症状：诊断、鉴别诊断和治疗】。

IF 0.2

THERAPEUTISCHE UMSCHAU Pub Date : 2025-06-01 DOI: 10.23785/TU.2025.03.002

Silke Biethahn

{"title":"[Epileptic seizures as a key neurological symptom: diagnosis, differential diagnosis and management].","authors":"Silke Biethahn","doi":"10.23785/TU.2025.03.002","DOIUrl":"https://doi.org/10.23785/TU.2025.03.002","url":null,"abstract":"Introduction: Epileptic seizures rank among the most striking neurological key symptoms and pose a particular diagnostic challenge, especially when occurring for the first time. Differentiating between provoked, unprovoked seizures and epilepsy is essential for making appropriate therapeutic decisions. A thorough medical history, supported by EEG, MRI, and laboratory tests, usually allows for a well-founded classification and helps exclude important differential diagnoses such as syncope or psychogenic non-epileptic seizures. The International League Against Epilepsy (ILAE) classifies seizures based on their origin into focal, generalized, and seizures of unknown onset, which facilitates therapeutic categorization. Acute management is particularly indicated in cases of seizure clusters or status epilepticus. The decision to initiate long-term antiseizure therapy should be made on an individual basis and depends on seizure type, etiology, risk of recurrence, comorbidities, and the patient's individual life circumstances. Patient education is a central aspect of management and should cover trigger factors, therapy adherence, everyday safety risks, and driving eligibility. Early and differentiated diagnostics combined with an individually tailored treatment approach can significantly improve the prognosis - around two-thirds of affected individuals achieve seizure freedom with antiseizure therapy.","PeriodicalId":44874,"journal":{"name":"THERAPEUTISCHE UMSCHAU","volume":"82 3","pages":"70-75"},"PeriodicalIF":0.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144555283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Focus on MS - visual loss as a cardinal symptom of multiple sclerosis]. [关注多发性硬化症-视力丧失作为多发性硬化症的主要症状]。

IF 0.2

THERAPEUTISCHE UMSCHAU Pub Date : 2025-06-01 DOI: 10.23785/TU.2025.03.003

Stefanie Müller

引用次数: 0

Leitsymptome in der Neurologie – eine Übersicht für die Grundversorgung. 神经病学的基本原理。

IF 0.2

THERAPEUTISCHE UMSCHAU Pub Date : 2025-06-01 DOI: 10.23785/TU.2025.03.001

Andreas R Gantenbein

引用次数: 0

[Phosphatidyethanol in the diagnosis and treatment of alcohol-related disorders]. [磷脂乙醇在酒精相关疾病诊断和治疗中的应用]。

IF 0.2

THERAPEUTISCHE UMSCHAU Pub Date : 2025-04-01 DOI: 10.23785/TU.2025.02.003

Philippe Pfeifer, Panagiota Ntinopoulou, Matthias Bantle, Wolfgang Weinmann

{"title":"[Phosphatidyethanol in the diagnosis and treatment of alcohol-related disorders].","authors":"Philippe Pfeifer, Panagiota Ntinopoulou, Matthias Bantle, Wolfgang Weinmann","doi":"10.23785/TU.2025.02.003","DOIUrl":"https://doi.org/10.23785/TU.2025.02.003","url":null,"abstract":"Introduction: The diagnosis and treatment of alcohol use disorders often pose complex questions and challenges for healthcare professionals. In addition to the established indirect biomarkers (e. g. carbohydrate-deficient transferrin [CDT]), clinical research in recent years has produced increasingly valuable findings on the use of direct biomarkers. In this regard, the marker phosphatidyltethanol (PEth), a lipid metabolite that is formed during the breakdown of ethanol, is stored in the erythrocytes, should be emphasized in particular. The advantage of targeted use of PEth in general medical and psychiatric practice to improve diagnostics and therapy has been demonstrated in clinical studies in recent years. Together with the established screening instruments (e. g. AUDIT), PEth can lead to greater validity in the diagnosis of alcohol use disorders. Targeted use of PEth can be used to control treatment goals (e. g. abstinence vs. controlled drinking) and monitor them longitudinally. The determination of PEth generally facilitates and improves communication with patients and can contribute to a destigmatization of the clinical picture, as certain feelings of shame and inhibitions in doctor-patient contact could be diminished.","PeriodicalId":44874,"journal":{"name":"THERAPEUTISCHE UMSCHAU","volume":"82 2","pages":"48-52"},"PeriodicalIF":0.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143990952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Interventional psychiatric procedures and novel substances for the treatment of affective disorders: An overview and outlook]. [介入精神病学程序和治疗情感性障碍的新物质：综述和展望]。

IF 0.2

THERAPEUTISCHE UMSCHAU Pub Date : 2025-04-01 DOI: 10.23785/TU.2025.02.005

Tobias Bracht, Daniela Hubl, Kristina Adorjan, Gianluca Florineth, Leila M Soravia, Bogdan Draganski, Sebastian Olbrich, Annette Brühl, Niklaus Denier

{"title":"[Interventional psychiatric procedures and novel substances for the treatment of affective disorders: An overview and outlook].","authors":"Tobias Bracht, Daniela Hubl, Kristina Adorjan, Gianluca Florineth, Leila M Soravia, Bogdan Draganski, Sebastian Olbrich, Annette Brühl, Niklaus Denier","doi":"10.23785/TU.2025.02.005","DOIUrl":"https://doi.org/10.23785/TU.2025.02.005","url":null,"abstract":"Introduction: Depression is one of the most common mental disorders. The effectiveness of pharmacological and psychotherapeutic treatments is well documented. Remission rates are around 67 % for pharmacological antidepressant initial and secondary treatment of a depressive episode in unipolar disorders. However, patients with a depressive episode who do not respond to at least two successive attempts at pharmacological antidepressant treatment have significantly lower remission rates. Particularly in this subgroup with difficult-to-treat depression, brain stimulation procedures and treatment with novel substances represent innovative and effective treatment options that complement pharmacotherapy and psychotherapy. The aim of this paper is to provide an overview and outlook on the following treatment procedures: repetitive transcranial magnetic stimulation (rTMS), electroconvulsive therapy (ECT), ketamine/esketamine, transcranial direct current stimulation (tDCS), deep brain stimulation (DBS), and psychedelic-assisted psychotherapy (PAT). An outlook on selected current developments with the aim of a procedure-specific, individualized indication will be given.","PeriodicalId":44874,"journal":{"name":"THERAPEUTISCHE UMSCHAU","volume":"82 2","pages":"57-61"},"PeriodicalIF":0.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144029329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[ASSIP flex sustainable suicide prevention: a treatment programme for people who have attempted suicide]. [assp灵活的可持续自杀预防：针对有自杀企图的人的治疗方案]。

IF 0.2

THERAPEUTISCHE UMSCHAU Pub Date : 2025-04-01 DOI: 10.23785/TU.2025.02.006

Adriana Frei, Lara Marie Aschenbrenner, Marie-Anna Sedlinskà, Franziska von Strauss Und Torney, Katja Cattapan, Laurent Michaud, Stéphane Saillant, Sebastian Olbrich, Stephanie Homan, Sophia Werdin, Kaspar Wyss, Kristina Adorjan, Sebastian Walther, Anja Gysin-Maillart

{"title":"[ASSIP flex sustainable suicide prevention: a treatment programme for people who have attempted suicide].","authors":"Adriana Frei, Lara Marie Aschenbrenner, Marie-Anna Sedlinskà, Franziska von Strauss Und Torney, Katja Cattapan, Laurent Michaud, Stéphane Saillant, Sebastian Olbrich, Stephanie Homan, Sophia Werdin, Kaspar Wyss, Kristina Adorjan, Sebastian Walther, Anja Gysin-Maillart","doi":"10.23785/TU.2025.02.006","DOIUrl":"10.23785/TU.2025.02.006","url":null,"abstract":"Introduction: Background: ASSIP flex is a structured, low-threshold brief therapy for individuals with suicidal behavior. As a flexible treatment approach, it can be delivered in inpatient, outpatient, and home settings. This study examines its feasibility, acceptability, and clinical application in routine practice. Method: In an observational pre-post study, 105 patients (53.8 % women; M = 38.8 years, SD = 15.2) were interviewed before (t0) and after (t1) the ASSIP flex brief intervention. Sociodemographic characteristics, feasibility aspects, and clinical variables were assessed. In addition, nine therapists evaluated implementation and acceptability. Results: ASSIP flex was mainly recommended by professionals (57.3 %) and showed high acceptability, with its adaptability across different treatment settings cited as a key advantage. Patients demonstrated a significant reduction in suicidal ideation (t104 = 4.5, p 0.001) and depressive symptoms (t104 = 6.0, p 0.001), as well as an increase in self-efficacy (t104 = -2.3, p 0.05). Higher perceived effectiveness of ASSIP flex correlated with lower suicidal ideation (r = -0.28, p 0.01) and depressive symptoms (r = -0.29, p 0.01), as well as increased self-efficacy (r = 0.22, p 0.05). Conclusion: ASSIP flex is a versatile treatment option for individuals with suicidal behavior. The results confirm its potential as a promising addition to existing care structures and its ability to address a critical gap in post-attempt care.","PeriodicalId":44874,"journal":{"name":"THERAPEUTISCHE UMSCHAU","volume":"82 2","pages":"62-68"},"PeriodicalIF":0.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144029327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Personalised treatment planning for patients with depression - a guide that takes into account biological, psychological and social aspects]. [抑郁症患者的个性化治疗计划——一个考虑生物、心理和社会方面的指南]。

IF 0.2

THERAPEUTISCHE UMSCHAU Pub Date : 2025-04-01 DOI: 10.23785/TU.2025.02.002

Katja Cattapan, Paul Lukas, Debora Verciglio, Tobias Ballweg, Kristina Adorjan

{"title":"[Personalised treatment planning for patients with depression - a guide that takes into account biological, psychological and social aspects].","authors":"Katja Cattapan, Paul Lukas, Debora Verciglio, Tobias Ballweg, Kristina Adorjan","doi":"10.23785/TU.2025.02.002","DOIUrl":"https://doi.org/10.23785/TU.2025.02.002","url":null,"abstract":"Introduction: The diagnosis of \"depression\" encompasses very heterogeneous clinical pictures. There are different treatment methods for depression, with psychopharmacological and psychotherapeutic treatment strategies being particularly relevant. There is increasing evidence that a personalised therapeutic approach, which takes into account individual biological, psychological and social vulnerability factors and resources, is useful. The article describes the specific impact factors that are important for treatment planning. In the presence of stressful childhood experiences, which are particularly relevant for the development of chronic depression, these should be specifically considered in therapy. As the inadequate satisfaction of basic psychological needs is a central factor in the development and maintenance of depression, the individual case concept helps to analyse psychological conflicts and motivational goals in greater depth. Two checklists are presented as instruments for this purpose, which - taking into account the biological and psychosocial dimensions, both in regard of deficits and resources - identify the factors relevant for treatment planning.","PeriodicalId":44874,"journal":{"name":"THERAPEUTISCHE UMSCHAU","volume":"82 2","pages":"42-47"},"PeriodicalIF":0.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144051569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0