V.F.Snegirev Archives of Obstetrics and Gynecology最新文献

{"title":"Retroplacental blood biochemical parameters in preeclampsia","authors":"Anastasia Samusevich, L.M. Samokhodskaya, Elena Proskurnina, I. Ignatko, O. B. Panina","doi":"10.17816/aog630248","DOIUrl":"https://doi.org/10.17816/aog630248","url":null,"abstract":"The effectiveness of existing methods for predicting preeclampsia is far from 100%, which dictates the need to search for new additional markers. Retroplacental blood is a unique almost unexplored biological substrate, the composition of which possibly affects the course of pregnancy. \u0000The purpose of our research was to study retroplacental blood biochemical parameters in preeclampsia. \u0000The research included 53 pregnant women who were divided in two groups: physiological pregnancy (n = 28) and severe preeclampsia (n = 25). All pregnant women were delivered by caesarean section. The materials of our research were peripheral and retroplacental blood sera. Samples were taken immediately after the mechanical placenta abruption and delivery of afterbirth. Using a Beckman Coulter AU480 biochemical analyzer (Germany), we determined the levels of ALT, AST, LDH, total protein, albumin, urea, creatinine, total and direct bilirubin, glucose, uric acid. \u0000According to the results of our research, the biochemical parameters of retroplacental and peripheral blood had significant differences (p 0.05). In physiological pregnancy, ALT, AST, LDH, urea, creatinine, direct bilirubin, and uric acid levels were 1.9; 20,1; 11.4; 1.14; 1.19; 2; 1.15 times, respectively, significantly (p 0.05) higher in retroplacental blood, and the glucose level was 1.5 times lower. In patients with severe preeclampsia, the levels of AST, LDH, creatinine, total and direct bilirubin, and uric acid in the in the retroplacental blood were 11.5; 1.3; 1.2; 2.2; 1.11 times, respectively, significantly increased (p 0.05), and the glucose level was 1.57 times lower again. \u0000When compared peripheral blood biochemical parametres of the main and control groups, significant differences (p 0.05) were detected for ALT, AST, total protein, albumin, urea and creatinine. In contrast, in retroplacental blood during physiological pregnancy and preeclampsia, significant differences (p 0.05) were detected only for urea, creatinine and uric acid. \u0000Thus, studying retroplacental blood biochemical parametres can provide more information of preeclampsia pathogenesis.","PeriodicalId":448378,"journal":{"name":"V.F.Snegirev Archives of Obstetrics and Gynecology","volume":"36 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141382930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE ROLE OF EPILEPSY IN WOMEN'S REPRODUCTIVE FUNCTION","authors":"Anastasia V. Orchinskaya, Kristina V. Degtereva, Svetlana A. Zotova, Niyaz M. Aminov, Ilseyar F. Korotkova, Azaliya Zh. Vagapova, Alina S. Zavidova, Yana S. Poplavskaya, Anastasia V. Usova, Vladlena V. Aleksandrova, Ekaterina P. Zhukova, Asya A. Aslanyan, Lale M. Muradova","doi":"10.17816/aog627031","DOIUrl":"https://doi.org/10.17816/aog627031","url":null,"abstract":"According to the World Health Organization, epilepsy is one of the most common neurological diseases in the world, affecting about 50 million people. The overall prevalence of epilepsy in the Russian Federation in 2020 was 2.49 patients per 1,000 people, and the total number of registered epilepsy patients in Russia was 366,134 people. About 40% of epilepsy patients are women of reproductive age. The course of epilepsy in women of reproductive age has its own characteristics, which are associated with daily and monthly cyclic rhythms. Epilepsy has a wide range of physiological consequences due to antiepileptic pharmaceutical therapy. The purpose of the review is to summarize up-to-date information on the impact of epilepsy on women's reproductive health. The authors conducted a search for publications in the electronic databases PubMed, eLibrary and Google Scholar. The search strategy included the presence of the following keywords and their combinations: \"epilepsy\", \"reproductive health\", \"sex hormones\", \"pregnancy\", \"menstrual cycle\", \"fetal\", \"neonatal\", \"epilepsy\", \"reproductive health\", \"sex hormones\", \"pregnancy\", \"menstrual cycle\", \"fetal\", \"neonatal\". The search was conducted among studies published before December 2023. Women are particularly concerned about epilepsy throughout their reproductive years. Infertility rates increase as a result of the psychological stress faced by people with epilepsy and impaired physiological processes that support reproductive health. Finally, the doctor should examine the physiological effects of antiepileptic and anticonvulsant drugs. The main goal of therapy is to provide women with epilepsy with a seizure-free life, excellent overall well-being and improved health. The current plan is achievable if the practitioner is familiar with the sexual differences in the course of epilepsy at the molecular level. The limitation is that modern treatment methods cannot be available to every woman in conditions of limited resources.","PeriodicalId":448378,"journal":{"name":"V.F.Snegirev Archives of Obstetrics and Gynecology","volume":"8 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141267572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical treatment in a patient with giant uterine fibroids of reproductive age (Clinical case)","authors":"Anatoliy Ishchenko, Anton Ishchenko, Irina Khokhlova, T. Dzhibladze, Oksana Gorbanko, I. Gadaeva, Yuri Chushkov, Ekaterina Tevlina, Anna Komarova, Mikhail Ageev, D.E. Samgurova, Adelina Ozdemir","doi":"10.17816/aog626391","DOIUrl":"https://doi.org/10.17816/aog626391","url":null,"abstract":"Presented clinical case of organ-preserving surgical treatment for giant uterine fibroid with secondary alterations in 36-year-old women with an unrealized reproductive function indicates an individual approach to each patient with benign tumor both during examination and in the process of intra- and postoperative treatment.","PeriodicalId":448378,"journal":{"name":"V.F.Snegirev Archives of Obstetrics and Gynecology","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141266641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delivery and organ-preserving surgery in a woman with high-risk uterine myoma","authors":"Maria Klyavlina","doi":"10.17816/aog595918","DOIUrl":"https://doi.org/10.17816/aog595918","url":null,"abstract":"This article presents a clinical case from the practice of the State Budgetary Healthcare Institution of the Republic of Belarus \"GKPTs\" in Ufa regarding organ-conserving surgery in a woman with high-risk uterine fibroids of isthmus localization with transition to the posterior wall of the uterus. In May 2023, at 39 weeks of pregnancy, patient T. was scheduled for planned surgical delivery by cesarean section, with subsequent expansion of the scope of the operation to conservative myomectomy. The indication for surgery was uterine fibroids of gigantic size and isthmus localization with transition to the posterior wall of the uterus, as a result of which delivery through the natural birth canal is impossible. Uterine fibroids in this patient were discovered during pregnancy. Instrumental research methods used during the examination: ultrasound, magnetic resonance imaging (MRI). During routine ultrasound screenings, uterine fibroids of isthmus localization measuring 123x99x112 mm without disruption of the node's nutrition were diagnosed. According to MRI, the diagnosis of large uterine fibroids was confirmed. A transverse suprapubic laparotomy was performed. The first stage of the combined operation was a cesarean section in the lower segment. As a result, a live full-term boy weighing 3480 g, 53 cm, with 7-8-9 points on the Apgar scale was recovered. Then, during an inspection of the pelvic organs, a myomatous node was discovered in the isthmus area with a transition to the posterior wall of the uterus measuring 10x12 cm, without signs of necrosis. A conservative myomectomy was performed without penetration into the uterine cavity. The bed is sutured with separate sutures. Hemostasis has been achieved. The weight of the myomatous node will be 570 grams. Our clinical case shows that a favorable full-term pregnancy with high-risk, large size, atypical localization uterine fibroids is possible. Also, organ-preserving, combined operations are currently being carried out, which enable a woman to preserve the organ and further realize her reproductive potential.","PeriodicalId":448378,"journal":{"name":"V.F.Snegirev Archives of Obstetrics and Gynecology","volume":"13 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141266492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound examination in antenatal diagnosis of placenta accreta spectrum","authors":"Viktoriya А. Efimova, Andrei V. Murashko","doi":"10.17816/aog626559","DOIUrl":"https://doi.org/10.17816/aog626559","url":null,"abstract":"The rise in caesarean section rates worldwide has led to a great increase in placenta accreta spectrum cases. Accurate diagnostics of placenta accreta before delivery is still difficult, as one-half to two-thirds of placenta accreta cases remain undiagnosed until delivery. Domestic and foreign sources use the diagnostic accuracy of ultrasonography (US) as the most commonly used method for placenta accreta image because of its inexpensiveness, non invasiveness, and rapidness. In this review, we highlighted the possibilities of prenatal ultrasound diagnosis of placenta accreta. Diagnostic accuracy may be reduced due to posterior wall placenta location and a higher body mass index (BMI). US and MRI are highly specific and useful in diagnosing or ruling out placenta accreta. Unlike MRI, the accuracy of ultrasound depends on the qualification, and therefore single-center studies often overestimate the accuracy of ultrasound. It is necessary to continue studying diagnostic methods for placenta accreta in order to select logical obstetric tactics for managing pregnant women with this pathology.","PeriodicalId":448378,"journal":{"name":"V.F.Snegirev Archives of Obstetrics and Gynecology","volume":"2 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141267159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The experience of metroplasty at the stage of delivery in pregnant \u0000women with two cesarean section operations in the anamnesis","authors":"Kristina Tarasova, I. I. Musin, A. Yaschuk","doi":"10.17816/aog624957","DOIUrl":"https://doi.org/10.17816/aog624957","url":null,"abstract":"The purpose of our study is to evaluate the effectiveness of metroplasty at the stage of abdominal delivery in women with a history of two cesarean section operationsMaterials and methods. From 2020 to 2022, 150 pregnant women were examined. The patients were divided into 3 groups: the first group - pregnant women with a history of cesarean section, the second group – pregnant women with two cesarean sections. In these groups, metroplasty was performed at the stage of delivery. The third control group consisted of pregnant women with a history of two cesarean sections who underwent surgical delivery without excision of scar tissue in the lower segment.Metroplasty was performed before fetal extraction with a whole fetal bladder in accordance with the patent \"Method of metroplasty during operative delivery in women with two or more cesarean sections\".In order to study the dynamics of changes in scar thickness, all women underwent ultrasound examination 2 hours later, on the third day after delivery, and 6 months after delivery.The results of the study. Resection of the scar area on the uterus during repeated cesarean section improves the residual thickness of the myometrium, which is determined by ultrasound 6 months after surgery. This technique allows you to form a functionally consistent scar on the uterus after two cesarean section operations.","PeriodicalId":448378,"journal":{"name":"V.F.Snegirev Archives of Obstetrics and Gynecology","volume":"5 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141266568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An original method of surgical correction of enterocele using a titanium implant with transobturator-sacrospinal fixation","authors":"Anna Komarova, Anton Kazantsev, Anton Ishchenko, Irina Хохлова, T. Dzhibladze, O. Gorbenko, Yuri Chushkov, I. Gadaeva, D.E. Samgurova, Adelina Ozdemir, A.P. Moskvicheva","doi":"10.17816/aog626388","DOIUrl":"https://doi.org/10.17816/aog626388","url":null,"abstract":"Aim: to optimize the results of surgical treatment of enterocele using the original model of “Titanium Silk” mesh implants with their transobturator-sacrospinal fixation. \u0000Materials and methods: a comprehensive clinical examination and surgical treatment of 22 patients aged 53 to 68 years for enterocele, who had previously undergone surgical interventions for various forms of POP, were carried out. All patients underwent a developed surgical technique for enterocele correction using an original “Titanium Silk” mesh implant model with transobturator-sacrospinal fastening. Outpatient monitoring of patients in the early and delayed postoperative periods was carried out after 1–6–12–24 months. \u0000Results: during dynamic follow-up, patients were satisfied with the results of surgical treatment, stable leveling of POP symptoms, and no signs of relapse and mesh-associated complications. \u0000Conclusion: the study showed the effectiveness and safety of a new developed surgical technique for correction of enterocele using an original model of a mesh implant “Titanium silk” with transobturator-sacrospinal fixation in patients with enterocele who had undergone surgery in the past for various forms of POP, which indicates the need for further research in this direction.","PeriodicalId":448378,"journal":{"name":"V.F.Snegirev Archives of Obstetrics and Gynecology","volume":"2 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141265823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anorexia nervosa – A New Look at an Old Problem","authors":"E. A. Sosnova, Rafael A Sarkisyan, Emil R Ahmetgaryaev, E. Svidinskaya, M. B. Ageev","doi":"10.17816/aog623869","DOIUrl":"https://doi.org/10.17816/aog623869","url":null,"abstract":"In Russia, according to Rosstat, about 2.5% of adolescents suffer from anorexia, in Moscow, according to 2015 data, at least 5% of young women suffered from anorexia, but most experts believe the true figures are much higher, since only advanced cases are recorded. The relevance of the problem of anorexia nervosa is associated with the potential threat to the lives of patients, eating disorders, concomitant mental diseases and, in general, the deterioration of the mental status of the patient. Despite the seeming simplicity of diagnosis, patients with advanced stages that require long-term therapy are more likely to turn to the doctor. Treatment of anorexia requires a comprehensive approach, including psychopharmacotherapy, psychological influence, diet therapy, therapy of somatic pathology and concomitant complications. It is important that all these aspects of treatment are carried out at the same time. The key to success is the constant monitoring of therapy by a psychiatrist. As a result of the patient's malnutrition, there is a deterioration in the general somatic state of health, as a result of which specifically in girls there are menstrual disorders, complications associated with conception and gestation, and a difficult pregnancy. In this regard, it is especially important to consider this disease from the point of view of psychiatry, obstetrics and gynecology.","PeriodicalId":448378,"journal":{"name":"V.F.Snegirev Archives of Obstetrics and Gynecology","volume":"84 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141268081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genital Tuberculosis as a Socially Significant Disease (Literature Review)","authors":"Maksim V Verbitsky, Sofia A Permyakova, Alena V Paskannaia, E. Svidinskaya, Dmitrii V. Baburin, E. A. Sosnova","doi":"10.17816/aog625916","DOIUrl":"https://doi.org/10.17816/aog625916","url":null,"abstract":"Globally, TB is the second leading cause of death from infectious diseases after COVID-19. Tuberculosis of the female genital organs is a type of extrapulmonary tuberculosis.It is known that both clinically pronounced and latent forms of this disease can cause both primary and secondary infertility due to pathogenetically caused disruption of the structure of the fallopian tubes and changes in the susceptibility of the uterine endometrium. It can be assumed that the problem of genital tuberculosis in Russia is still very relevant, although its true prevalence is unknown. This assumption is based on the facts of the projected growth of indicators the incidence of extrapulmonary tuberculosis, the obvious discrepancy between the real incidence and the official figures, as well as the increasing incidence of tubal-peritoneal infertility, which is often caused by genital tuberculosis. It is known that tuberculosis of the female genital organs is a difficult disease to diagnose. This is determined, in particular, by the fact that it does not have specific (so-called \"marker\") manifestations. Low rates of diagnosis of extrapulmonary forms of TB create a false sense of well-being, which does not reflect its true epidemiological picture. An obvious need today is the development of an optimal diagnostic complex, the use of which would contribute to accelerating the diagnosis of genital tuberculosis in women and, as a result, preventing the occurrence of irreversible changes in the female reproductive system caused by it. \u0000The authors used the scientific databases CyberLeninka, ELibrary and PubMed. Articles were searched for the following keywords: \"tuberculosis\", \"genital tuberculosis\", \"infertility and tuberculosis\". The paper analyzes articles published over the past 10 years.","PeriodicalId":448378,"journal":{"name":"V.F.Snegirev Archives of Obstetrics and Gynecology","volume":"5 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141267533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MECHANISMS OF EPIGENETIC REGULATION IN THE DEVELOPMENT OF PREECLAMPSIA","authors":"Ekaterina Morozova, Natalya A. Nikitina, I. S. Sidorova, M. Raygorodskaya, Sergej A. Timofeev, M. B. Ageev, Nigar Amiraslanova","doi":"10.17816/aog623622","DOIUrl":"https://doi.org/10.17816/aog623622","url":null,"abstract":"Introduction. The etiology and pathophysiology of pre-eclampsia (PE) are unclear. Effective methods of its prognosis, prevention and treatment have not still been devised. Of great interest have been the prospects for the use microRNA molecules that epigenetically control the expression of target genes at the post-transcriptional level and of key importance in proliferation, differentiation, invasion, migration, apoptosis of trophoblast cells, regulation of angiogenesis, immune response and other processes which occur during pregnancy \u0000Aim. The objective of the study is to investigate the epigenetic development mechanisms of PE based on the evaluation of the expression of pathogenetically significant microRNAs in women’s blood plasma. \u0000Materials and methods. The study include 62 female patients divided into the main study group (42 pregnant women with PE) and the control group (20 healthy women with uncomplicated pregnancy, childbirth and post-natal period). All patients have undergone a general clinical, laboratory, instrumental examination. The expression 15 micRroNAs level in blood plasma has been evaluated using a quantitative real-time polymerase chain reaction.The software DIANA miRPath v. 3.0 has been used to evaluate the effect of differentially expressed microRNAs on the signalling pathways functioning . The statistical data processing has been carried out using the licensed software package Statistica 6.0. \u0000Results. The women with PE have been detected to have multidirectional changes in the expression of 13 out of 15 plasma microRNAs compared with the control group; however, there has been a statistically significant decrease in the expression levels of 8 microRNAs: hsa-miR-146a-5p, hsa-miR-181a-5p , hsa-miR-210-3p, hsa-miR-517a-3p , hsa-miR-517c-3p, hsa-miR-574-3p, hsa-miR-574-5p, hsa-miR-1304-5p . The subgroup of pregnant women having PE proceeding with the symptoms of fetal growth retardation (FGR), has shown a significant decrease in the expression of hsa-miR-20a-5p and hsa-miR-143-3p molecules compared with the subgroup without FGR. Dysregulation of more than 40 signalling pathways has been shown. \u0000Conclusion. The development of PE proceeds alongside with significant epigenetic changes accompanied by changes in the microRNA expression profile which are associated with cardiovascular, cerebrovascular diseases, placental disorders. The detected differentially expressed microRNAs may be potential diagnostic markers of PE","PeriodicalId":448378,"journal":{"name":"V.F.Snegirev Archives of Obstetrics and Gynecology","volume":"8 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141267575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}