Annals of Geriatric Medicine and Research最新文献

{"title":"Prediction of Postoperative Hypokalemia in Patients with Severe Carotid Artery Stenosis undergoing Standard Carotid Endarterectomy: A Retrospective Cohort Study.","authors":"Suiyuan Hu, Xuan Lai, Yunfeng Han","doi":"10.4235/agmr.25.0164","DOIUrl":"10.4235/agmr.25.0164","url":null,"abstract":"<p><strong>Background: </strong>Postoperative hypokalemia is a common electrolyte disturbance associated with adverse outcomes, particularly in older adults. This study aimed to identify risk factors and develop predictive models for hypokalemia within 24 hours after carotid endarterectomy (CEA) for severe carotid artery stenosis, a condition that primarily affects older patient populations.</p><p><strong>Methods: </strong>A retrospective cohort of 1,076 CEA patients (October 2021 to May 2023) was analyzed. Risk factors were identified using univariate and multivariate logistic regression. A predictive nomogram was developed and internally validated via bootstrapping. Machine learning models (Random Forest and XGBoost) were developed and interpreted using SHAP (SHapley Additive exPlanations) analysis. Subgroup analyses were performed in patients aged ≥70 years and by comparing postoperative potassium levels &gt;4.0 mmol/L versus 3.5-4.0 mmol/L.</p><p><strong>Results: </strong>The cohort had a median age of 65 years. Multivariate analysis identified preoperative potassium (odds ratio [OR]=0.60, 95% confidence interval [CI] 0.50-0.72), hemoglobin (OR=0.74, 95% CI 0.63-0.88), BMI (OR=0.74, 95% CI 0.63-0.88), and postoperative visual analogue scale score (OR=1.28, 95% CI 1.09-1.51) as independent predictors. Frailty showed borderline significance (OR=1.56, 95% CI 1.00-2.44, p=0.05). The nomogram achieved an area under the curve (AUC) of 0.710, demonstrating good discrimination and calibration. Machine learning models similarly performed well (AUC 0.707-0.709).</p><p><strong>Conclusion: </strong>We developed a validated tool to predict postoperative hypokalemia after CEA. The model highlights that in addition to biochemical and surgical factors, geriatric syndromes like frailty and nutritional status are pivotal risk determinants. This facilitates early, individualized management, including tailored potassium supplementation, nutritional support, and pain control, especially for vulnerable older adults, to mitigate complications and promote recovery.</p>","PeriodicalId":44729,"journal":{"name":"Annals of Geriatric Medicine and Research","volume":"30 1","pages":"18-27"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13054564/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147595366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Growing Burden of Fall-Related Injuries among Older Adults: A Seven-Year Study from a Tertiary Medical Center in Taiwan.","authors":"Yu-Chieh Tsai, Shey-Ying Chen, Ya-Mei Chen, Edward Pei-Chuan Huang, Feng-Ping Lu","doi":"10.4235/agmr.25.0128","DOIUrl":"10.4235/agmr.25.0128","url":null,"abstract":"<p><strong>Background: </strong>As Taiwan's population ages, falls among older adults have become a critical public health concern. However, limited data exist regarding temporal trends and injury patterns in fall-related emergency department (ED) visits. This study aimed to examine trends in fall-related ED visits and hospitalizations among older adults in Taiwan and to explore injury distributions by age group.</p><p><strong>Methods: </strong>We conducted a retrospective cohort study using data from the National Taiwan University Hospital between 2011 and 2017. Patients aged ≥65 years were compared with those aged 20-64 years. Fall-related visits were identified using chief complaints and the International Classification of Diseases 9th/10th revision (ICD-9/ICD-10) codes. Outcomes included hospitalization rates, length of stay, and 30-day mortality.</p><p><strong>Results: </strong>A total of 22,471 fall-related ED visits were analyzed. While visits among younger adults declined (annual growth rate, -1.34%), visits among older adults increased (2.37% annually), with the steepest rise in those aged ≥85 years. Hospitalization occurred in 27.1% of older adults, nearly double that of younger adults (14.4%). Older adults also had longer hospital stays and higher 30-day mortality rates, findings consistent even when restricted to lower limb fractures.</p><p><strong>Conclusion: </strong>Fall-related ED visits and hospitalizations are rising disproportionately among Taiwan's older population. Targeted prevention strategies and transitional care interventions are urgently needed to address the growing clinical and economic burden of falls in aging societies.</p>","PeriodicalId":44729,"journal":{"name":"Annals of Geriatric Medicine and Research","volume":"30 1","pages":"70-76"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13054568/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147595301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impaired Daily Activities due to Cognitive Decline among Older Koreans Living with a Family Member with Dementia.","authors":"Inmyung Song","doi":"10.4235/agmr.25.0206","DOIUrl":"10.4235/agmr.25.0206","url":null,"abstract":"<p><strong>Background: </strong>Cohabiting with a family member with dementia may be associated with declines in the caregiver's own cognitive function. However, existing studies have been focused solely on spousal caregivers, highlighting the need for broader research across more diverse populations.</p><p><strong>Methods: </strong>This cross-sectional study used data from the 2024 Korea Community Health Survey. The analysis included individuals aged 50 years and older who had a family member with dementia (n=17,596). The dependent variable was self-reported impairment in daily activities due to cognitive decline. The main independent variable was cohabitation with a family member with dementia. Multiple logistic regression analysis was conducted to estimate the association between cohabiting with a family member with dementia and impaired daily activities due to cognitive decline.</p><p><strong>Results: </strong>Of the 17,596 participants, 52.3% were women, 17.6% cohabited with a family member with dementia, and 9.4% reported impairments in daily activities due to cognitive decline. The prevalence of impaired daily activities due to cognitive decline was 23.3% among individuals cohabiting with a family member with dementia, compared to 7.8% among those who were not (p&lt;0.0001). After adjusting for sociodemographic and health and behavioral factors, cohabiting with a family member with dementia remained significantly associated with increased risk of impaired daily activities due to cognitive decline (odds ratio=1.86, p&lt;0.0001).</p><p><strong>Conclusion: </strong>Cohabiting with a family member with dementia is associated with impaired daily functioning due to cognitive decline. These findings underscore the need for policy measures to monitor and support the cognitive health of family caregivers of individuals with dementia.</p>","PeriodicalId":44729,"journal":{"name":"Annals of Geriatric Medicine and Research","volume":"30 1","pages":"120-127"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13054570/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147595324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utility of Self-Rated vs. Informant-Rated Ascertain Dementia-8 for Detection of Early Cognitive Impairment: Experience of a \"Real-World\" Memory Clinic.","authors":"Khin Khin Win, Justin Chew, Jun Pei Lim, Esther Ho, Noorhazlina Ali, Mark Chan, Wee Shiong Lim","doi":"10.4235/agmr.25.0082","DOIUrl":"10.4235/agmr.25.0082","url":null,"abstract":"<p><strong>Background: </strong>The Ascertain Dementia 8-item Questionnaire (AD8) is a validated informant-based interview for early dementia detection. Research suggests the utility of self-rated AD8 to identify milder dementia forms in research settings. This study compares the factor structure, reliability, and diagnostic performance between AD8-Self and AD8-Informant for early cognitive impairment (ECI) in a clinical setting.</p><p><strong>Methods: </strong>Five hundreds fifteen patient-informant dyads (43 cognitively intact and 472 ECI) from a tertiary memory clinic completed both self-reported and informant AD8. We conducted exploratory factor analysis to determine the factor structure, Cronbach's alpha for internal consistency, and receiver operating characteristic (ROC) curve analysis for ECI, including a subgroup analysis for mild cognitive impairment (MCI).</p><p><strong>Results: </strong>The mean age and education of ECI participants were 75.61 years (range, 51-95) and 5.6 years (range, 0-20), respectively, and 72.6 years (range, 51-89) and 6.8 years (range, 0-16) in the MCI subgroup. Unlike AD8-Informant's one-factor structure, AD8-Self had a two-factor structure corresponding to memory and non-memory domains. AD8-Self demonstrated lower reliability (Cronbach's alpha: ECI 0.666 vs. 0.764; MCI 0.663 vs. 0.709). In ECI, AD8-Informant (cutoff score ≥3) showed better diagnostic performance (sensitivity 89%, specificity 79%) than AD8-Self (cutoff score ≥4; sensitivity 27.1%, specificity 95.3%) (AUC 0.915 vs. 0.593; p&lt;0.001). Similar results were found in MCI (sensitivity 64.7% vs. 26.5%; specificity 79.1% vs. 95.3%; AUC 0.745 vs. 0.600; p=0.002).</p><p><strong>Conclusion: </strong>AD8-Self has a distinct factor structure, lower reliability, and inferior diagnostic performance compared to AD8-Informant for ECI/MCI detection. Our result do not support AD8-Self as a standalone tool for detecting ECI or MCI.</p>","PeriodicalId":44729,"journal":{"name":"Annals of Geriatric Medicine and Research","volume":" ","pages":"109-119"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13054566/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145655931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between Dietary Variety, Oral Function, and Body Composition among Outpatients at a Community Dental Clinic.","authors":"Emi Akama, Wataru Fujii, Sayaka Nishio, Yumeko Sumino, Erika Matsumoto, Kosuke Akama, Toshiyuki Tsujisawa, Shirou Tabe","doi":"10.4235/agmr.25.0184","DOIUrl":"10.4235/agmr.25.0184","url":null,"abstract":"<p><strong>Background: </strong>Japan's rapidly aging population has increased the urgency of addressing frailty among older adults. Oral hypofunction and malnutrition are recognized as key contributors to frailty, and both are considered reversible through early interventions. However, little is known about the effectiveness of integrating nutritional guidance and oral function training in community dental clinics. This study aimed to examine the association between dietary variety, oral function, and body composition among outpatients aged 50 years and older, and to evaluate the effects of targeted interventions over a 1-year period.</p><p><strong>Methods: </strong>A total of 74 outpatients (mean age 72.3±9.6 years) were assessed at baseline and after 1 year. Dietary variety was evaluated using the Dietary Variety Score (DVS), and oral function was assessed using seven standardized parameters. Body composition, including weight, body fat percentage, and muscle mass, was assessed using a bioelectrical impedance analyzer. Based on DVS results, registered dietitians provided nutritional counseling, while dental hygienists delivered tailored oral function training. Statistical analyses included the Wilcoxon signed-rank and McNemar's tests.</p><p><strong>Results: </strong>Significant improvements were observed in eight of the ten DVS food groups, resulting in a higher total DVS score. Tongue coating index and tongue pressure also improved significantly, and the prevalence of oral hypofunction declined. No significant changes were found in body composition.</p><p><strong>Conclusion: </strong>Integrating nutritional guidance and oral function training in a community dental setting improved dietary variety and oral function in older adults. These findings suggest that multidisciplinary care in community dental clinics may contribute to health promotion and frailty prevention.</p>","PeriodicalId":44729,"journal":{"name":"Annals of Geriatric Medicine and Research","volume":"30 1","pages":"101-108"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13054563/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147595345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sarcopenia: From Global Consensus to Korean Implementation - A Narrative Review and Standpoint.","authors":"Geon Young Jang, Sunghwan Ji, Heewon Jung, Ji Yeon Baek, Il-Young Jang, Kyoung Min Kim, Miji Kim, Clara Yongjoo Park, Kwang-Pyo Lee, Dongryeol Ryu, Sang Yoon Lee, Ok Hee Jeon, Sunyoung Kim","doi":"10.4235/agmr.25.0182","DOIUrl":"10.4235/agmr.25.0182","url":null,"abstract":"<p><p>Sarcopenia is a major geriatric syndrome characterized by progressive loss of muscle mass and strength, resulting in disability and mortality. This narrative review synthesizes international consensus recommendations and Korean evidence to guide context-specific sarcopenia management strategies. PubMed, Embase, Cochrane Library, and KoreaMed (January 2000-November 2025) were searched, focusing on randomized trials, meta-analyses, systematic reviews, clinical practice guidelines, and large observational studies. Global diagnostic frameworks have evolved from muscle mass-based definitions toward multidimensional models that incorporate muscle strength and physical performance. Exercise and nutrition remain the mainstay treatments, with resistance-based training and adequate protein intake. Currently, pharmacologic options with proven clinical benefit are limited. In Korea, growing evidence supports the effectiveness of community-based sarcopenia interventions, underscoring the need for standardized, integrated delivery models that bridge the fragmented healthcare system and enable sustainable implementation.</p>","PeriodicalId":44729,"journal":{"name":"Annals of Geriatric Medicine and Research","volume":"30 1","pages":"3-17"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13054565/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147595306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microscopic Polyangiitis in a Nonagenarian: Diagnostic and Therapeutic Challenges in Geriatric Vasculitis.","authors":"Leila C Tou, Colleen Doyle, Gregory Payne, Robert Buntyn, James Lamb","doi":"10.4235/agmr.25.0156","DOIUrl":"10.4235/agmr.25.0156","url":null,"abstract":"<p><p>Microscopic polyangiitis (MPA) is a rare antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis that poses unique diagnostic and therapeutic challenges in seniors. We describe a 90-year-old female with diabetes, hypertension and heart failure who presented with anasarca and rapid renal failure. Evaluation revealed myeloperoxidase-ANCA positivity, and renal biopsy confirmed pauci-immune crescentic glomerulonephritis. Her course was complicated by anemia and deep vein thrombosis. She was managed with high-dose corticosteroids, rituximab, and supportive hemodialysis, achieving improvement in renal function. This case highlights how comorbidities may obscure recognition of vasculitis and how assessment of frailty and baseline function are essential in weighing risks of immunosuppression in older adults. Clinicians should maintain vigilance for ANCA-associated vasculitis in older adults with unexplained renal decline and tailor therapy to balance disease control with vulnerability to treatment toxicity.</p>","PeriodicalId":44729,"journal":{"name":"Annals of Geriatric Medicine and Research","volume":" ","pages":"137-141"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13054583/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145655947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The World Health Organization Integrated Care for Older People (ICOPE) Framework and the Association with Frailty in Older Adults.","authors":"Wan-Yun Chou, Kun-Pei Lin, Chiung-Jung Wen, Ding-Cheng Derrick Chan, Su-I Hou","doi":"10.4235/agmr.25.0125","DOIUrl":"10.4235/agmr.25.0125","url":null,"abstract":"<p><strong>Background: </strong>The World Health Organization published the 2019 Integrated Care for Older People (ICOPE) framework to guide, assess, and promote the intrinsic capacity (IC) of older adults, referring to their physical and mental health. This study aims to investigate the relationship between IC and frailty among older adults.</p><p><strong>Methods: </strong>This cross-sectional study was conducted in a medical center in Taiwan in 2021. Two hundred ten patients over 65 admitted to the geriatric ward were invited to participate. The questionnaire included an IC measure, Fried Frailty Scale, and demographic items. The IC measure was ascertained using the six domains of ICOPE (cognition, mobility, nutrition, visual, hearing, and depressive symptoms). The Fried Frailty Scale was used to categorize participants as robust (Fried Frailty Scale=0), prefrail (Fried Frailty Scale=1-2), or frail (Fried Frailty Scale ≥3). Multinomial logistic regression was used to analyze the association between individual ICOPE domains and frailty stages, while adjusting for confounders.</p><p><strong>Results: </strong>Among the participants, 39.0% were prefrail, and 28.6% were frail. Limited mobility and depressive symptoms were significantly associated with prefrail (adjusted odds ratio [aOR]=4.44, 95% confidence interval [CI] 1.82-10.82; aOR=8.41, 95% CI 1.75-40.37) and frail (aOR=11.57, 95% CI 3.63-36.93; aOR=13.77, 95% CI 2.62-72.49) individuals, respectively. Malnutrition (aOR=4.01, 95% CI 1.18-13.62) and hearing loss (aOR=4.37, 95% CI 1.09-19.66) were significantly associated with frail older adults.</p><p><strong>Conclusion: </strong>Limited mobility and depressive symptoms occurring at the prefrail stage could be used as assessment items for early detection of prefrail.</p>","PeriodicalId":44729,"journal":{"name":"Annals of Geriatric Medicine and Research","volume":" ","pages":"41-50"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13054569/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145655907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Performance of Arm Circumference Compared to Other Indicators for Detecting Sarcopenia in Older Adults.","authors":"Brena Leticia Gomes de Paiva, Claudia Porto Sabino Pinho Ramiro, Cyro Rego Cabral Junior, Fabiana Andrea Moura, Enaiane Cristina Menezes, Gabriel Soares Bádue, Müller Ribeiro-Andrade, João Araújo Barros-Neto","doi":"10.4235/agmr.25.0090","DOIUrl":"10.4235/agmr.25.0090","url":null,"abstract":"<p><strong>Background: </strong>To evaluate the accuracy of arm circumference (AC) compared with other anthropometric and functional indicators as a predictor of sarcopenia risk in community-dwelling older adults.</p><p><strong>Methods: </strong>This was a cross-sectional, analytical, population-based study derived from a household survey involving individuals aged 60 years or older. Measurements of AC, calf circumference (CC), and variables related to muscle strength, muscle mass, and functional performance were collected, including the Timed Up and Go test, sit-to-stand test, and gait speed.</p><p><strong>Results: </strong>The sample comprised 708 older adults, predominantly female (64.7%), aged between 60 and 94 years. The prevalence of sarcopenia was 14.7%, with 4.9% classified as severe. AC showed a negative association with sarcopenia (β=-0.01, 95% confidence interval [CI] 0.75-0.92, p&lt;0.01) and reduced the odds of sarcopenia by 17% for each additional centimeter (odds ratio=0.83, 95% CI 0.75-0.92). The comparison of the areas under the receiver operating characteristic curves (AUC) indicated similar performance between AC and CC (z=0.24, p=0.81). The diagnostic accuracy of AC was slightly higher than that of CC in male (27.1% vs. 26.6%) and female (43.0% vs. 37.6%).</p><p><strong>Conclusion: </strong>Both AC and CC demonstrated high discriminative capacity for sarcopenia, with cutoff points that balanced sensitivity and specificity. AC stands out as a viable, simple, and effective alternative for sarcopenia screening in community-dwelling older adults.</p>","PeriodicalId":44729,"journal":{"name":"Annals of Geriatric Medicine and Research","volume":"30 1","pages":"92-100"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13058735/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147595319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased Phase Angle Reflects Improvement in Activities of Daily Living and Muscle Health in Post-stroke Rehabilitation.","authors":"Kouki Yoneda, Yoshihiro Yoshimura, Hidetaka Wakabayashi, Ayaka Matsumoto, Fumihiko Nagano, Sayuri Shimazu, Yoshifumi Kido, Takahiro Bise, Takenori Hamada, Ai Shiraishi","doi":"10.4235/agmr.25.0083","DOIUrl":"10.4235/agmr.25.0083","url":null,"abstract":"<p><strong>Background: </strong>Phase angle (PhA) reflects cellular integrity and muscle quality. However, evidence is limited regarding whether an increase in PhA is associated with improvements in activities of daily living (ADL) and skeletal muscle mass. This study aimed to investigate the association between change in PhA and prognosis in terms of ADL and skeletal muscle mass in post-stroke patients undergoing rehabilitation.</p><p><strong>Methods: </strong>This retrospective cohort study was conducted at a convalescent rehabilitation hospital in Japan. Patients with a PhA at admission below the cutoff values (4.76° for male and 4.11° for female) were included. Patients were categorized into a PhA-increase group (&gt;0) and a non-increase group (≤0). Outcomes included the Functional Independence Measure (FIM)-motor score and skeletal muscle mass index (SMI) at discharge. Multivariate regression was used to assess associations.</p><p><strong>Results: </strong>A total of 253 patients were included (mean age 78.0±10.9 years; 51% females). The median PhA at admission was 3.70° (interquartile range [IQR], 3.20-4.10), and the median change during hospitalization was 0.00° (IQR, -0.20- 0.30). Of these, 119 patients had increased PhA and 134 did not. Change in PhA was independently associated with higher FIM-motor scores (β=0.078, p=0.040) and greater SMI (β=0.454, p&lt;0.001) at discharge.</p><p><strong>Conclusions: </strong>In post-stroke patients, an increase in PhA during hospitalization was associated with better functional and muscular outcomes. PhA may therefore serve as a valuable biomarker for assessing the efficacy of rehabilitation.</p>","PeriodicalId":44729,"journal":{"name":"Annals of Geriatric Medicine and Research","volume":" ","pages":"62-69"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13054585/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145655909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}