Journal of Neurorestoratology最新文献_第8页

Timing of single-event multilevel surgical interventions on long-term motor outcomes in children and adolescents with cerebral palsy: A systematic review and meta-analysis 单事件多水平手术干预时机对脑瘫儿童和青少年长期运动预后的影响：一项系统回顾和荟萃分析

IF 3.1 4区医学

Journal of Neurorestoratology Pub Date : 2025-02-01 Epub Date: 2024-11-27 DOI: 10.1016/j.jnrt.2024.100170

Weihong Wang , Qiang Tang , Hua Liu , Rong Xu , Lijun Zhang

{"title":"Timing of single-event multilevel surgical interventions on long-term motor outcomes in children and adolescents with cerebral palsy: A systematic review and meta-analysis","authors":"Weihong Wang , Qiang Tang , Hua Liu , Rong Xu , Lijun Zhang","doi":"10.1016/j.jnrt.2024.100170","DOIUrl":"10.1016/j.jnrt.2024.100170","url":null,"abstract":"<div><h3>Background</h3><div>The aim of this meta-analysis was to evaluate the impact of the timing of single-event multilevel surgery (SEMLS) on long-term motor outcomes in children and adolescents with cerebral palsy (CP).</div></div><div><h3>Methods</h3><div>A systematic review and meta-analysis were conducted by searching PubMed, Cochrane Library, Embase, and Web of Science databases for studies up to April 2024. Twelve eligible studies were included, from which we examined patients’ gait, stride length, walking speed, and the gross motor function measure (GMFM66).</div></div><div><h3>Results</h3><div>Gait analysis showed significant improvements in CP patients after SEMLS, which included an increased gait deviation index (<em>p</em> < 0.001), reduced Gillette gait index (<em>p</em> < 0.001), and reduced gait profile score (<em>p</em> < 0.001). Subgroup analysis showed that age at surgery (<12 years old vs. 12−18 years old) was not a factor affecting patients’ gait. Spatial and temporal parameters such as stride length (<em>p</em> < 0.001) and walking velocity (<em>p</em> = 0.02) also improved significantly after surgery. However, there were only trends towards broader motor function gains measured by the GMFM66 (<em>p</em> = 0.39).</div></div><div><h3>Conclusions</h3><div>SEMLS effectively improved key gait and mobility parameters in children and adolescents with CP, and was not affected by younger or older surgical ages (<12 years old or 12−18 years old). However, these gait improvements do not uniformly translate into broader motor function gains.</div></div>","PeriodicalId":44709,"journal":{"name":"Journal of Neurorestoratology","volume":"13 1","pages":"Article 100170"},"PeriodicalIF":3.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143170166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of long non-coding RNAs in depression: Mechanisms and potential therapeutic targets 长非编码 RNA 在抑郁症中的作用：机制和潜在治疗目标

IF 3.1 4区医学

Journal of Neurorestoratology Pub Date : 2024-12-01 Epub Date: 2024-08-14 DOI: 10.1016/j.jnrt.2024.100142

Zhanghua Ding , Juntian Shen , Chenlang Wei , Zhuocao Liu , Lina Huang , Shouhong Zhou

{"title":"Role of long non-coding RNAs in depression: Mechanisms and potential therapeutic targets","authors":"Zhanghua Ding , Juntian Shen , Chenlang Wei , Zhuocao Liu , Lina Huang , Shouhong Zhou","doi":"10.1016/j.jnrt.2024.100142","DOIUrl":"10.1016/j.jnrt.2024.100142","url":null,"abstract":"<div><h3>Background</h3><p>Depression, also known as major depressive disorder, is a mental disorder caused by multiple factors. The cause of depression remains unclear, but a growing number of studies have reported a link between depression and long non-coding RNAs (lncRNAs). In the present study, we reviewed the relationships between depression and four lncRNAs, focusing on the differential expression of these lncRNAs in patients with depression, how to regulate depression, and how to use lncRNAs for the diagnosis, prevention, and treatment of clinical depression.</p></div><div><h3>Methods</h3><p>A systematic review of 23 studies published between 2011 and 2021 was conducted using Pubmed. Selection criteria included publication date and relevance to topic: Only articles published after 2010 were included to ensure the review reflects the most recent research, and all articles are selected strictly on their research topic.</p></div><div><h3>Results</h3><p>The short communication has summarized the relationships between depression and four lncRNAs, especially antisense lncRNAs and lincRNAs, and their potential in the diagnosis of depression and its targeted therapy.</p></div><div><h3>Conclusions</h3><p>The study found that these four lncRNAs, particularly antisense lncRNAs and lincRNAs, are closely associated with various aspects of depression. These findings suggest new therapeutic targets and could contribute to improving the accuracy of depression diagnosis.</p></div>","PeriodicalId":44709,"journal":{"name":"Journal of Neurorestoratology","volume":"12 4","pages":"Article 100142"},"PeriodicalIF":3.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2324242624000494/pdfft?md5=708764b86b1cf3042edff88a03ceae08&pid=1-s2.0-S2324242624000494-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142087978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Topographic and temporal patterns of dyskinesia in multiple system atrophy with predominant parkinsonism 多系统萎缩伴主要帕金森病患者运动障碍的地形和时间模式

IF 3.1 4区医学

Journal of Neurorestoratology Pub Date : 2024-12-01 Epub Date: 2024-08-17 DOI: 10.1016/j.jnrt.2024.100145

Hong Sun , Chong Dong , Yuan Li , Miaomiao Li , Hui Zhang , Xitong Xu , Wei Mao , Piu Chan

{"title":"Topographic and temporal patterns of dyskinesia in multiple system atrophy with predominant parkinsonism","authors":"Hong Sun , Chong Dong , Yuan Li , Miaomiao Li , Hui Zhang , Xitong Xu , Wei Mao , Piu Chan","doi":"10.1016/j.jnrt.2024.100145","DOIUrl":"10.1016/j.jnrt.2024.100145","url":null,"abstract":"<div><h3>Background</h3><p>Although dyskinesia is well recognized in Parkinson's disease, it is generally under acknowledged in multiple system atrophy (MSA). Reported cases of dyskinesia primarily manifest in patients with MSA with predominant parkinsonism (MSA-P), and characteristically present as orofacial dystonia. However, we have observed other manifestations of dyskinesia in our clinical practice. The current report aims to present the specific manifestations of dyskinesia in MSA-P, with videos.</p></div><div><h3>Methods</h3><p>We enrolled six patients with MSA-P with dyskinesia from Xuanwu Hospital. Of these, four had clinically established MSA-P and two had clinically probable MSA-P according to the 2022 Movement Disorder Society criteria for MSA diagnosis. All six patients underwent an acute levodopa challenge test, and videos were recorded during the process.</p></div><div><h3>Results</h3><p>Dyskinesia had a unilateral distribution in four patients. Three patients presented with peak-dose orofacial dystonia; of these, two were associated with blepharospasm and two were associated with limb dystonia. In addition, we observed that one patient had peak-dose distal lower limb dystonia with upper limb chorea, one patient had wearing-off dystonia of the eyelids, and one patient had diphasic generalized chorea mimicking that of Parkinson's disease.</p></div><div><h3>Conclusions</h3><p>In addition to orofacial dystonia, the topographic patterns of dyskinesia in MSA-P can manifest as limb dystonia, blepharospasm, and generalized chorea. Moreover, the temporal patterns of dyskinesia in MSA-P can be peak-dose, wearing-off, or diphasic.</p></div>","PeriodicalId":44709,"journal":{"name":"Journal of Neurorestoratology","volume":"12 4","pages":"Article 100145"},"PeriodicalIF":3.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2324242624000524/pdfft?md5=43131876dd7e488e868ce0d326075d36&pid=1-s2.0-S2324242624000524-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142128500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bilateral hypertrophic olivary degeneration caused by unilateral midbrain infarction: A case report 单侧中脑梗塞导致的双侧肥大性橄榄变性：病例报告

IF 3.1 4区医学

Journal of Neurorestoratology Pub Date : 2024-12-01 Epub Date: 2024-08-17 DOI: 10.1016/j.jnrt.2024.100141

Yuying Sun , Yunfei Zhang , Zhaoyang Lu , Zijie Chen , Jinggui Song , Ping Zhang

引用次数: 0

Letter to Editor: Correspondence to "Two sides of one coin: Neurorestoratology and Neurorehabilitation" 致编辑的信致 "一枚硬币的两面：神经恢复学和神经康复 "的通信

IF 3.1 4区医学

Journal of Neurorestoratology Pub Date : 2024-12-01 Epub Date: 2024-10-12 DOI: 10.1016/j.jnrt.2024.100159

Xiumin Li, Jie Wang, Yong Liu

引用次数: 0

Correspondence: “Application of deep brain stimulation and transcranial magnetic stimulation in stroke neurorestoration: A review” 通讯："脑深部刺激和经颅磁刺激在中风神经恢复中的应用：综述

IF 3.1 4区医学

Journal of Neurorestoratology Pub Date : 2024-12-01 Epub Date: 2024-08-22 DOI: 10.1016/j.jnrt.2024.100147

Xiumin Li, Bin Dong, Jie Wang

引用次数: 0

Authors’ response to correspondence regarding “Application of deep brain stimulation and transcranial magnetic stimulation in stroke neurorestoration: A review” 作者对有关 "脑深部刺激和经颅磁刺激在中风神经恢复中的应用：综述"

IF 3.1 4区医学

Journal of Neurorestoratology Pub Date : 2024-12-01 Epub Date: 2024-10-22 DOI: 10.1016/j.jnrt.2024.100161

Yanxi Chen, Wen Wang, Fangling Sun

引用次数: 0

Respondence to article “Brain iron deposition and whole-exome sequencing of non-Wilson's disease hypoceruloplasminemia in a family” 对文章 "一个家族的非威尔逊氏病低铁蛋白血症的脑铁沉积和全外显子组测序 "的回应

IF 3.1 4区医学

Journal of Neurorestoratology Pub Date : 2024-12-01 Epub Date: 2024-08-16 DOI: 10.1016/j.jnrt.2024.100146

Hui Liu, Shu-Hong Wang

引用次数: 0

Response to the Letter from Dr. Li et al. for “Two Sides of One Coin: Neurorestoratology and Neurorehabilitation” 对李博士等人就 "一枚硬币的两面：神经恢复学和神经康复"

IF 3.1 4区医学

Journal of Neurorestoratology Pub Date : 2024-12-01 Epub Date: 2024-10-19 DOI: 10.1016/j.jnrt.2024.100160

Hongyun Huang, Hari Shanker Sharma, Lin Chen, Ali Otom, John R. Bach, Wagih S. El Masri

引用次数: 0

Corrigendum to “Comparison of chronic restraint stress-and lipopolysaccharide-induced mouse models of depression: Behavior, c-Fos expression, and microglial and astrocytic activation” [J Neurorestoratol 12 (2024) 100130] 慢性束缚应激和脂多糖诱导的抑郁小鼠模型的比较：行为、c-Fos表达以及小胶质细胞和星形胶质细胞活化" [J Neurorestoratol 12 (2024) 100130] 的更正

IF 3.1 4区医学

Journal of Neurorestoratology Pub Date : 2024-12-01 Epub Date: 2024-09-27 DOI: 10.1016/j.jnrt.2024.100158

Lingyu Zhang , Caizhuo Cao , Changyi Luo , Huaqiang Ruan , Chuang Xu , Yan Wang , Xiaoxia Jiang , Gengsheng Mao

引用次数: 0