International Journal of Life Science and Pharma Research最新文献

{"title":"Anti-Alzheimer’s and Anti-Fungal Activities of Pyrrolo[1,2-a] Quinoline Derivatives","authors":"Pramod N Patil, Vijayakumar Uppar, Basavaraj Padmashali, Rangappa Keri","doi":"10.22376/ijlpr.2023.13.6.p1-p11","DOIUrl":"https://doi.org/10.22376/ijlpr.2023.13.6.p1-p11","url":null,"abstract":"Psychiatrists have described the protein deposits in the brain that causes various diseases such as cerebral, functional,physiological dysfunction, and neurodegenerative diseases. Although Alzheimer's disease is detectable, its treatment remainsunattainable. More than 4.6 million new patients are recorded yearly, who are affected by Alzheimer's disease and only a fewdrugs are currently in use for treatment with side effects. Hence, there is a clinical need for new drugs, design, and development.On the other hand, despite the development of antifungal therapeutics over the last three decades, antifungal resistance is still amajor cause. Regularly using inappropriate antimicrobials has become a major healthcare problem globally in the 21st century andhas been titled a \"silent tsunami facing modern medicine.\" It has been estimated that over 8,000,000 die yearly, which providesscope for developing novel antifungal drugs. In this research paper, we describe the synthesized dimethyl-1-(4-substitutedbenzoyl)-5-methylpyrrolo[1,2-a] quinoline-2,3-dicarboxylate 1a-c and ethyl-1-(4-substituted benzoyl) 5-methylpyrrolo[1,2-a]quinoline-3-carboxylate 1d-f were evaluated for in vitro antifungal and anti-Alzheimer’s activities. The derivatives1a-f wereobtained by 1,3-dipolar cycloaddition reaction by treating quaternary salt with dimethyl acetylene dicarboxylate and ethylpropiolate respectively, in the presence of K2CO3 and DMF as a solvent. Among all compounds, 1a, 1d, and 1e showed thehighest inhibitory capacity with IC50 values of 0.28, 0.32, and 0.30 μM, respectively. On the other hand, derivatives were alsoscreened for antifungal activity that displayed moderate activity, whereas 1a and 1f derivatives showed good activity.","PeriodicalId":44665,"journal":{"name":"International Journal of Life Science and Pharma Research","volume":"330 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134902834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Vitro and in Silico Analysis of Phytochemicals from Asteraceae Plant Species Against Wound-Infecting Pathogens","authors":"K.S. Shanmugam, L. Ramkumar, R. Jagadeesan","doi":"10.22376/ijlpr.2023.13.6.l1-l10","DOIUrl":"https://doi.org/10.22376/ijlpr.2023.13.6.l1-l10","url":null,"abstract":"The idea of polyherbal combinations has a strong foundation in modern medicine and has had amazing success, givingpatients new hope. Polyherbal mixtures have managed various conditions, from cancer to autoimmune disorders. Given that it hasalready been shown to be secure and efficient, this therapeutic approach is gaining popularity. In alternative, complementarytherapies, polyherbal formulations blend many herbs to provide an additive effect. Physicians are accepting this strategy, which hasbeen used for generations. Numerous research papers in the pharmaceutical field demonstrate the efficacy of combining plants andthe present study aimed to evaluate antibacterial phytochemicals from a polyherbal extract. Phytoconstituents extracted with ethanoland ethyl acetate by conventional soxhlet method and chemical constituents were analyzed by qualitative and GC-MS. Antibacterialactivity of extracts tested by disc diffusion method against wound infecting pathogens. MIC was done by Alamar blue assay. Inhibitionof ESBL enzyme predicted by in silico docking using Autodock. Extraction with ethanol shows less significant positive results thanethylacetate in qualitative and antibacterial studies. GC-MS analysis showed the presence of 35 bioactive compounds from ethylacetate and 45 compounds from ethanol. Cyclononasiloxane, Octodecane, hexadecanoic acid, and Benzenedicarboxylic werecommonly found in both extracts. The ethylacetate PHE exhibited strong antibacterial activity and was more effective than thestandard. From GCMS, three compounds were predicted to have good ADME characteristics with high gastrointestinal absorptionand metabolic activity. Compound 6-(3-fluorobenzylamino) purine has been selected and investigated by in silico method, showingthat it has a greater binding affinity with ESBL, ompC, and murA after being docked. The ethyl acetate extract demonstrated goodaction against certain pathogenic bacteria in the current experiment, while the ethanol extract exhibited no activity. Our findingsconclude that the polyherbal extracts have broad-spectrum activity against bacteria and depend on the solvent used.","PeriodicalId":44665,"journal":{"name":"International Journal of Life Science and Pharma Research","volume":"6 ","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134956790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Raktadushti in Madatyaya Vyadhi: A Cross Sectional Observational Study","authors":"Sumant M. Pande, Maheshwari D Joshi, Seema H Thakare","doi":"10.22376/ijlpr.2023.13.6.l246-l257","DOIUrl":"https://doi.org/10.22376/ijlpr.2023.13.6.l246-l257","url":null,"abstract":"All over the world, alcohol consumption is becoming a lifestyle. The fashion of alcohol ingestion leads to habits of chronicalcoholism. Alcoholism (Madyapaan) is a behavioral disorder characterized by repetitive and excessive consumption of alcohol (Madya). It isobserved that long-term consumption of alcohol damages the liver to a very large extent, leading to either Alcoholic liver disease or livercirrhosis. In Ayurveda, this condition can be correlated with 'Madatyaya.' Madya is described as the main etiological factor of various diseasesat multiple places in Ayurvedic classics, but madatyaya is a primary one. Ayurved explains the etiology, pathogenesis, and treatment ofmadatyaya, but the specific srotodushti is not explained. When characteristics of madya and causative moolasthanavikruti (Hepatotoxicity) areconsidered, it is assumed that madya may cause raktadushti also. Hence this topic is an attempt to evaluate raktadushti in madatyaya vyadhi. Itis a cross-sectional observational study performed on 50 patients of Madatyaya. Patients were examined thoroughly, and all the details werenoted in a specially designed case record format. A comparative study of madatyaya and raktadushti was conducted; also assessment ofraktadushti was done based on symptoms of raktadushti observed in those patients. Collected data and the observations are then analyzed bystatistical tests such as the chi-square test and correlation regression. This study proves the positive correlation between madyatyaya andraktadushti. It may be the alcohol metabolized primarily in the liver, which is getting damaged by long-term consumption. Ayurveda explainsYakrita and pleeha as the moolasthana (roots) of Raktavaha srotas. This moolasthana dushti (damage to the root) causes damage to the wholesystem (Raktavaha srotas); hence madatyaya vyadhi can be labeled as a disease of Raktavaha srotas.","PeriodicalId":44665,"journal":{"name":"International Journal of Life Science and Pharma Research","volume":"42 ","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134957356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ksharkarmaas A Management of Charmakeela(Warts) – A Review","authors":"Dr. Naveen Singh, Dr. Devyani Dasar, Dr. PavithraJaivarshaa Gv, Dr. Akshay Kumar, Dr. Abhishek","doi":"10.22376/ijlpr.2023.13.6.l110-l113","DOIUrl":"https://doi.org/10.22376/ijlpr.2023.13.6.l110-l113","url":null,"abstract":"Anything resembling a nail or bound to the skin is called charmakeela in Ayurveda. Charmakeela is a condition that hasexisted since ancient times and requires more attention for cosmetic reasons. Acharya Sushrutha mentions Charmakeela as akshudraroga. The pathogenesis of this disease is caused by vitiation of vyanavata and kapha over the skin, resulting in the formationof a hard, hard nail-like structure known as Charmakeela. They exhibit different characteristics depending on the dominant dosha.Vata dominant Charmakila (Warts) are ruksha and ruja; Pitta dominant Charmakila (Warts) are Krishna varna; and Kapha dominantCharmakila (Warts) are kwacha varna, snigdha, and granthi. Sushruta Samhita, AstangaHridaya, MadhavNidana, Yogratnakara, andBhavapraksha all mention Charamkeela. Based on the signs and symptoms described in the classics, Charmakeelacan be comparedto Warts. Warts, also known as verrucae, are a common skin condition caused by the Human Papillomavirus (HPV). Sushruthamentioned Charmakeela while describing the indication of KsharKar main SushruthaSamhitha. Kshara is composed of several drugsin their most concentrated and subtle forms; it has kshanana and shodana propertiesand uses tikshnaguna, which aids in the externaldesquamation of warts. Because of their cleansing and antiseptic properties, Ksharaaids in the Ropana (healing process). The aimis Ksharkarma as a management of Charmakeela(Warts) – A Review. Material collected from many Ayurvedic texts, such as theSamhita, online resources, journal papers, and books, are available. It can be concluded that Kshar Karma is an effectiveayurvedictreatment forcharmakeelathat has no side effects. Because it does not leave scars or cause recurrence, this non-invasive indigenoustherapeutic technique is more effective in treating Charmakeela.","PeriodicalId":44665,"journal":{"name":"International Journal of Life Science and Pharma Research","volume":"92 3-4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135161990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevention of Pressure Injury from Elastic Ear Loop of Face Masks: A Technical Report with Review of Literature","authors":"Fareedi Mukram Ali, Abdullah Saeed Wasli, Abbas Hasan Hobani, Samira Hussain Al Faraj, Essa Hamoud Mashiakhy, Ali Mohammed Alkhayrat, Reem Abdullah Khawaji","doi":"10.22376/ijlpr.2023.13.6.l235-l240","DOIUrl":"https://doi.org/10.22376/ijlpr.2023.13.6.l235-l240","url":null,"abstract":"Protective masks are widely used today to prevent the spread of microorganisms, especially masks used duringsurgery with elastic loops. When the mask is worn for several hours a day, these stretching bands constantly press against theskin, resulting in pressure on the cartilage of the auricle, resulting in erythematous and painful lesions on the skin behind theauricle. Wearing masks for extended periods is now common with patients and members of the public. There is pressure harmto the ear while using this mask often over time. As a result, individuals continually change the mask to release the pressure,which raises their risk of contracting infection. The damage to the ears and auricles can be a side effect of continued use andshould be recognized by doctors and other health care professionals. This article focuses on a new technique to reduce strainon the ear loops of surgical masks. Also, it reviews the common ear injuries or pressure injuries on the ear published in theliterature related to prolonged use of masks and their preventive strategies.","PeriodicalId":44665,"journal":{"name":"International Journal of Life Science and Pharma Research","volume":"232 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135372041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral Manifestations in Diabetes Mellitus and Management Considerations: A Review","authors":"Dr. Prasanna R. Sonar, Dr. Aarati S. Panchbhai, Dr. Sunil Mishra, Dr. Suwarna B. Dangore","doi":"10.22376/ijlpr.2023.13.6.l349-l357","DOIUrl":"https://doi.org/10.22376/ijlpr.2023.13.6.l349-l357","url":null,"abstract":"Diabetes mellitus is a chronic metabolic disorder defined as an increase in sugar levels in the bloodstream brought onby either insufficient insulin secretion, resistance to insulin's effects, or both. All age groups are affected by the chronic conditionknown as diabetes mellitus. It is among the world's major causes of mortality and morbidity. Xerostomia, dental caries,periodontal disease, gingivitis, candidiasis, other oral infections, burning mouth syndrome, taste dysfunction, oral mucosalalterations, delayed wound healing, and localized osteitis are common oral manifestations of diabetes mellitus. Majorcomplications impacting a patient's quality of life include oral complications in diabetic individuals. Long-term oral problems inthese patients’ harm blood glucose regulation, making oral complications care and prevention important. The dental professionalshould be familiar with DM's oral manifestations to identify this disease complication. This article not only discusses the oralmanifestations but also discusses management considerations in diabetic patients which will help future dental professionals indental practice. This article aims to spread knowledge and awareness about the potential oral manifestations of diabetes mellitusand treatment considerations.Keywords: , , , , ,","PeriodicalId":44665,"journal":{"name":"International Journal of Life Science and Pharma Research","volume":"36 4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135456553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study On Association of Thyroid Hormone and Intensive Care Unit Mortality in Central India.","authors":"DrPravin Gulab Dandekar, Dr Pranay Anil Jain, Dr Shefali Jain","doi":"10.22376/ijlpr.2023.13.6.l51-l56","DOIUrl":"https://doi.org/10.22376/ijlpr.2023.13.6.l51-l56","url":null,"abstract":"Thyroid dysfunction has been linked to mortality in patients hospitalized in the intensive care unit (ICU). We aim tostudy the thyroid hormone level changes in critically ill ICU patients and predict mortality based on thyroid hormone levels. Thisprospective observational study was conducted on 80 consecutive patients aged over 18yrs, from November 2021 to May 2022,in patients admitted to ICU at Chirayu medical college and Hospital, Bhopal, and followed up during their ICU stay. Samples weretested for T3, T4, and TSH on day 1 and day 7. In our study of 80 participants, 46(57.5%) were male, and 34(42.5%) were female.About 32 (40%) were non-survivors. The significance value (P value) of T3 levels on day 1 was 0.083, and on day 7 was 0.001; T4levels on day 1 were 0.85, and on day 7 was 0.001. Similarly, the significance of TSH levels on day 1 was 0.085, and on day 7 was0.001. Day 1 levels of T3 are significantly correlated with APACHE II Score, and Day 7 levels of T3, T4, and TSH significantlycorrelated with APACHE II scores in predicting the outcome of the patients with the higher significance of T3 compared to T4and TSH. Our study showed that low T3 level during critical illness increases mortality risk. Thyroid profiles can be used inpredicting mortality and as an independent factor in predicting the outcome of ICU patients.","PeriodicalId":44665,"journal":{"name":"International Journal of Life Science and Pharma Research","volume":"38 12","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135456631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Vastus Medialis Oblique Strengthening Versus Mulligan Knee Taping Technique (Mcconnell Tape) on Patellofemoral Pain Syndrome: A Comparative Study.","authors":"Donicia. A. Kharsyntiew, Abhijit Dutta, Abhijit Kalita","doi":"10.22376/ijlpr.2023.13.6.l375-l386","DOIUrl":"https://doi.org/10.22376/ijlpr.2023.13.6.l375-l386","url":null,"abstract":"This study aims to determine the effectiveness of Vastus medialis oblique (VMO) strengthening and conventional therapy treatment (group A) andMulligan knee taping technique(McConnell tape) and conventional therapy treatment (group B) in patients with patellofemoral pain syndrome by VAS for pain andKPS for anterior knee pain scale is to compare VMO strengthening Versus Mulligan knee taping technique using McConnell tape in patellofemoral pain syndromeusing VAS for assessing pain and Kujala patellofemoral scale to assess knee pain and function. The most frequent cause of knee discomfort with retro patellar orperipatellar pain is patellofemoral pain syndrome (PFPS). The need for further studies to better understand the causes and treatment of PFPS is essential to provideoptimal care for individuals experiencing pain in the knee. Physical therapy is considered the most effective treatment for PFPS, but more research is needed todetermine each individual's best course of action. Proper diagnosis is the key to successful treatment and prevention of PFPS. Early intervention is also important forbetter outcomes. Patellofemoral pain syndrome (PFPS), which is often used interchangeably with \"anterior knee pain\" or \"runner's knee,\" is the clinical entity ofstiffness or pain or both on prolonged sitting with the knees flexed and pain with activities that load the patellofemoral joint, such as climbing or descending stairs,squatting, running and kneeling. Varieties of conservative treatments are suggested, like quadriceps strengthening, stretching, braces and straps, electrotherapy, footorthosis, patellar taping, etc. Hence, a comparison between the vastus medialis obliqus muscle strengthening and patellar taping was undertaken to determine theireffectiveness concerning pain and function. A well-organized research study was conducted over 12 months to investigate the impact of strengthening the vastusmedialis oblique muscle and applying conventional therapy treatment. Group A received this combination of treatments, while Group B was assigned a treatmentprotocol involving the use of McConnell tape along with conventional therapy treatment. After taking informed and written consent, 30 subjects diagnosed withunilateral or bilateral PFPS were randomly selected and allocated into two groups - Group A (VMO muscle strengthening and conventional therapy treatment) andGroup B (Mulligan knee taping technique (McConnell tape) and conventional therapy treatment). Both groups received 6 therapy sessions every alternate day for 6weeks. The visual analog scale (VAS) and Kujala patellofemoral scale (KPS) measured pre and post-pain and function. \"T-Test\" was used for statistical analysis. Therewas a significant improvement in pain and function in patients with Patellofemoral pain syndrome at the end of 6 weeks regarding VAS and KPS within both groups,i.e., groups A and B (p<0.01). But there was no significant difference regarding improvement in pain and functional status in","PeriodicalId":44665,"journal":{"name":"International Journal of Life Science and Pharma Research","volume":"85 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135456282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Art of Aromatherapy: A Complementary Therapy in Healthcare Professional","authors":"Ankita Pathak, Mithilesh Dhamande, Seema Sathe, Anjali Borle, Smruti Gujjelwar","doi":"10.22376/ijlpr.2023.13.6.p355-p365","DOIUrl":"https://doi.org/10.22376/ijlpr.2023.13.6.p355-p365","url":null,"abstract":"Aromatherapy, a part of herbology, is one of today's rapid-developing treatments. Fundamental oils are best utilized asback rubs, shower oils, or inward breaths. It is often accounted for that fragrance-based treatment leaves one inclination elevated,animated, empowered, or restored, contingent upon the oil utilized. At the point when breathed in, the different smells infiltratethe circulatory system through the lungs, causing physiologic changes. Aromatherapy is a form of alternative medicine.Aromatherapy is becoming increasingly popular, and there are clear indications that it should be used. It is one of thecomplementary therapies for anxiety reduction. Derived aroma molecules from essential oils contain curative and preventive usesin the medicine department. Although the perception and reaction to essential oils appear to differ significantly between men andwomen, aromatherapy benefits people of all ages. This article mainly focuses on a narrative review of aromatherapy, Derivatives,and uses of essential oils with a widened horizon in Aromatology.","PeriodicalId":44665,"journal":{"name":"International Journal of Life Science and Pharma Research","volume":"12 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135714227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Search for Novel Antagonist/S of HIF-1α from Selected Synthetic Analgesics/ Bioactive Flavonoids: An In-Silico Approach","authors":"Moumita Saha, Rumana Rahman, Anisha Mukherjee, Chandreyi Ghosh, Sirshendu Chatterjee","doi":"10.22376/ijlpr.2023.13.6.p12-p27","DOIUrl":"https://doi.org/10.22376/ijlpr.2023.13.6.p12-p27","url":null,"abstract":"Computer aided drug designing as well as drug repurposing implies the usage of molecular modelling techniques like analysis of the structures of receptor and ligand, molecular docking, pharmacokinetics and toxicity prediction, to explain the bioactivity of the synthetic molecules or plant secondary metabolites to design more efficient drug candidates or to repurpose an old drug in new diseases. Numerous studies have demonstrated that the low oxygen environment inside the cell is a key factor in developing breast cancer metastasis. To gain insight into the spread of breast cancer, hypoxia-inducible factor 1 (HIF-1), one of the master regulators of the hypoxic response, has been intensively explored. Our current research focuses on the insilico analysis and comparative study to evaluate the effects of different cancer drugs, analgesics, and plant-derived flavonoid compounds on HIF-1α regulation of breast cancer metastasis. According to the study, Quercetin shows the maximum binding affinity, i.e., -8.2 kcal/ mol. followed by Letrozole (-7.3 kcal/mol.), Naringenin (-7.11 kcal/mol), Tamoxifen (-7.07 kcal/mol), Phenacetin (-6.16 kcal/mol), and Aspirin (-5.7 kcal/mol). The study highlighted that Quercetin has the strongest binding affinity whereas Aspirin has the least binding affinity with HIF-1α protein. Hence the least toxic compound Quercetin can be a good candidate to control breast cancer metastasis by modulating the HIF-1 pathway.","PeriodicalId":44665,"journal":{"name":"International Journal of Life Science and Pharma Research","volume":"315 ","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134902849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}