International Journal of Life Science and Pharma Research最新文献

{"title":"Curcumin's Role in Dentistry: A Review of Herbal Drugs","authors":"Sakshi Pramod Nathani, Dr. Ravikant Sune, Dr Vidya Lohe, Dr Priyanka Paul Madhu","doi":"10.22376/ijlpr.2023.13.6.p120-p126","DOIUrl":"https://doi.org/10.22376/ijlpr.2023.13.6.p120-p126","url":null,"abstract":"Before antiquated duration, seasonings had been a substantial wellspring of medication. Turmeric (diferuloylmethane) is a tangerine-brown part of Curcumin (Curcuma aromatica),a flavor frequently originated in powdered curry. Generally remembered for its calming impacts, Curcumin longa possess extended past of therapeutic usage in Ayurveda and frameworks ofmedication from China. Curcumin can be used as a mouthwash, pit and gap filler, and subgingival irritant in various combinations. It has also been connected to a variety of pharmacologicalactions such as cancer prevention, antimicrobial properties, and soothing effects. Haldi is the local drug delivery system in clotting structure. The following article presents with an elevatedperspective mostly on the organic exercises of the miswak and conceivable restorative and dental applications. Turmeric is one of the most well-known spices that has been used for a longtime and is an important component of ancient medicine. It's harmless and has a variety of restorative applications, including dental use. The purpose of this essay is to look at the other oralcavity uses of turmeric because of lack of data and study of the area. The motive of the following write-up is to assess the potency of Curcumin longa spice for maintaining dental wellbeingspecifically, as well as overall wellbeing. Haldi or Indian saffron, is a spice with therapeutic characteristics and is reliable and reasonable choice. It also shown cancer-prevention, antibacterial,germ-free activities. It is also highly useful in dentistry because of these qualities. It aids in the treatment of periodontal disease and other dental illnesses. Turmeric can be used in a variety ofways, including as a pit and crevice sealer, mouthwash, and subgingival irritant. It can be additionally used a topical application in a coagulant format. Turmeric (Curcumin) is a well-known spicewith ancient medicinal uses, particularly in Ayurveda and Chinese medicine. Its tangerine-brown component, Curcumin longa, has been extensively utilized for its anti-inflammatory properties.In dentistry, Curcumin has found various applications, including as a mouthwash, pit and gap filler, and subgingival irritant in different combinations. Additionally, it exhibits pharmacologicalactions such as cancer prevention, antimicrobial effects, and soothing properties. The present article provides an overview of the organic activities of Curcumin, particularly its potentialtherapeutic and dental applications. Turmeric has a long history of safe use and has been a crucial component of traditional medicine. However, research on its oral cavity uses is limited,warranting further investigation in this area. The focus of this essay is to evaluate the efficacy of Curcumin in maintaining dental and overall wellbeing. As Haldi or Indian saffron, it offersreliable and affordable therapeutic benefits. Its demonstrated cancer-preventive, antibacterial, and germicidal activities make it highly valuab","PeriodicalId":44665,"journal":{"name":"International Journal of Life Science and Pharma Research","volume":"314 ","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134902850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concept of Sangyaharana (Anaesthesia) and Pain Management in Ayurveda: A Critical Review","authors":"Dr. Shivam Sharma, Dr. Sheetal Asutkar","doi":"10.22376/ijlpr.2023.13.6.l286-l292","DOIUrl":"https://doi.org/10.22376/ijlpr.2023.13.6.l286-l292","url":null,"abstract":"Despite highly developed scientific studies, pain continues to be the leading cause of disability that affects a sizable portion of theglobal population. An integrated approach to pain management may alleviate the distress associated with treating this symptom, which can bepresent in various degrees. The Sushruta Samhita is the only complete work that addresses the difficulties of actual surgery and midwifery.Sushruta was a deeply skilled surgeon. Since the beginning, doctors have recognized the importance of anesthesia and have worked to createthis pain-free surgical environment. Sushruta utilized Sangyaharana for painless surgery. The Sushruta Samhita is where we first see asystematic approach to organizing the surgical expertise of more experienced surgeons. Some dravyas, such as Madya (wine), have beendescribed by Sushruta, while mohachurna has been discussed in Bhojaprabandha. According to Charaka, the tikshna sura should beadministered to the patient before surgery. Some study experts have also detailed the use of Ayurvedic medications, including Vacha,Ashwagandha, Bramhi, Parijata, and Parasika yavani, postoperatively to reduce pain, edema, and anxiety in patients.A major herbal anestheticis still needed, though. This review provides a historical overview of the Sangyaharana (Anaesthesia) practiced by ancient surgeons. Thisarticle highlights the concept of sangyaharana (anesthesia) and pain management in Ayurveda. The main objective of this article was to collectdata from different articles and textual concepts and present it systematically. This review article covers a combination of all the drugs andayurvedic herbal methods for sangyaharana and pain management. Most previous articles had very little information about the drugs andmethods of sangyaharn, and the data was very discrete and in random order. This article covers all the details in a systematic and orderlymanner. This article provides information regarding various Ayurvedic treatment modalities for pain management. It also shows the need foran effective Ayurvedic anesthetic drug having sangyaharan properties in the present era, and scientists and researchers have to work on thison a priority basis. The article concludes with how the sangyaharna was given in old times and old literature about sangyaharna and drugs thathelp pain management in pre-sangyaharna and their work in the modern era.","PeriodicalId":44665,"journal":{"name":"International Journal of Life Science and Pharma Research","volume":"119 9","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134956825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report On Abnormal Uterine Bleeding with Multi-System Disorders","authors":"Dr. Niranjani S, Dr. T.G. Revathy, Dr. Varrshine.R","doi":"10.22376/ijlpr.2023.13.6.l182-l185","DOIUrl":"https://doi.org/10.22376/ijlpr.2023.13.6.l182-l185","url":null,"abstract":"Autoimmune disease is a condition that attacks the immune system and leads to multi-system disorders like systemiclupus erythematosus and rheumatoid disorders, which initiates self-directed immune responses that result in clinical diseases,mainly in obstetrics conditions like recurrent pregnancy loss, pre-eclampsia are common. The study aimed to identify therelationship between connective tissue disorders and abnormal uterine bleeding patterns. A rare case of abnormal uterinebleeding with a past history of recurrent pregnancy loss was presented in the casualty with excessive menstrual bleeding in astate of hypovolemic shock. The patient complained of generalised malaise, giddiness, breathlessness, and palpitations for thepast 2 months. She suffered recurrent epistaxis for the past 2 months and experienced symptoms like loss of appetite, recurrentvomiting for the past 15 – 20 days, and rashes over the face and cheeks for 6 months. Her haemoglobin was 2.4g/dL, and theplatelets were less than 10,000 with bicytopenia at the time of admission She was shifted to ICU and haemodynamicallystabilized by packed red blood cells, fresh frozen plasma, and platelets. Following this, she was treated with antifibrinolytics, andsevere anaemia was corrected with multiple PRBC transfusions. Multiple single-donor platelet transfusions were also done. Afterrecovery, the patient was discharged with an advice to continue hydroxychloroquine. Immune dysregulation and inflammationtogether contribute to the development of menstrual disorders among women with Rheumatoid Disorders which can be wellmanaged with systematic therapeutic plans at the initial stage.","PeriodicalId":44665,"journal":{"name":"International Journal of Life Science and Pharma Research","volume":"122 2","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134957262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial Intelligence: An Overview of Dental Applications","authors":"Gagan Agrawal, Dr.Aarati Panchbhai, Dr. Amit Reche, Radha Deshmukh, Vaidehi Borkar","doi":"10.22376/ijlpr.2023.13.6.l104-l108","DOIUrl":"https://doi.org/10.22376/ijlpr.2023.13.6.l104-l108","url":null,"abstract":"Artificial intelligence (AI) is emerging as a promising modality and could be anticipated to shape the future of dental health caredelivery. Artificial intelligence is the solution that assists doctors rather than replaces them, and hence is more likely to be accepted byhealthcare professionals. Artificial Intelligence has several clinical applications and has encompassed almost all the specialties of the dentalfield. Common dental diseases such as dental caries, pulpal pathologies, bone loss, cysts, salivary gland disease, lymph node metastasis, etc.,are easily diagnosed and well treated with the help of AI and robotics. AI and Machine learning has made an excellent and impactful way ofchanging dentistry. In dentistry, AI helps predict the future of disease, that is, prognosis and treatment planning. Additionally, it will opennew avenues in research and development. Since the last few centuries, AI has shown significant growth and progress in digital technology.The applications of AI have been tremendously increased in terms of data sciences, robotic field machine intelligence and deep learning,and computer sciences. Now a day's, expert human minds get replaced by computer data, or the mind gets filled with robotic fields. Whentalking in the field of medicine and dentistry has various numbers of applications that improve the outcomes of the patient. In dentistry, AIhas played a major role in diagnosis, identifying abnormal and normal structures, and resulting in the best treatment output. This reviewgives light on the importance of the robotic field in dentistry. This review covers a combination of all aspects of artificial intelligence indentistry that should have been included in some articles. Most of the review studies focus on intelligence networks and the applications ofartificial intelligence in dentistry. The article concludes that the implementation of sources of artificial intelligence in dentistry as well as inmedical sciences with more precise results and minimum amount of error.","PeriodicalId":44665,"journal":{"name":"International Journal of Life Science and Pharma Research","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135272173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Meditation On Self-Control of Mind","authors":"Dr. Kavita R. Bhagat, Dr. Deepa R. Kale, Dr. Rajkumar Gupta, Dr. Sudeep Menon","doi":"10.22376/ijlpr.2023.13.6.l522-l530","DOIUrl":"https://doi.org/10.22376/ijlpr.2023.13.6.l522-l530","url":null,"abstract":"Anxiety neurosis is common due to today's lifestyle challenges. People often cannot handle their emotions and getangry, depressed, and anxious. Meditation Helps to eliminate negative emotions and develop positive emotions, increaseconcentration, enhance memory, give clarity of thoughts, and improve willpower. The current research work discusses the Karmasof Manasa such as Indriyabhigraha and Swasyanigraha (self-control), the Sattvavajaya Chikitsa, anxiety neurosis as a result of abnormalSwasya Nigraha, the utility of meditation for control on self, i.e., Swasyanigraha. The present study was carried out to study theself-control function of the mind and the effect of Twin Heart Meditation in anxiety neurosis subjects. In the present single-armstudy, 114 young adults (aged 18-35 years) with diagnosed anxiety neurosis based on Ayurvedic Sattva Parikshana criteria and theHamilton anxiety rating scale were selected. They were prescribed Meditation or Dhyana for 90 days. Follow-up was taken every30 days to assess anxiety symptoms according to the Hamilton anxiety rating scale. All the 114 participants showed improvement.Moderate improvement was observed in most of the participants. (91%) Based on the results of the present study done throughthe Hamilton Anxiety Rating Scale and Ayurvedic Satva Parikshana Scale, it can be inferred that the Twin–Hearts Meditation forconsecutive 90 days in individuals suffering from mild to moderate anxiety neurosis enhances Swasyanigraha Karma (Self Control).","PeriodicalId":44665,"journal":{"name":"International Journal of Life Science and Pharma Research","volume":"227 6","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135371907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Phytochemicals, and Pharmacological Efficiency Studies of Nyctanthes Arbor-Tristis Linn","authors":"Ponnusamy Kiruba, Kuppusamy Palanisamy, Ponnuswamy Selvamaleeswaran, Michael Helan Soundra Rani, Edward Gnanaraj Wesely","doi":"10.22376/ijlpr.2023.13.6.p142-p153","DOIUrl":"https://doi.org/10.22376/ijlpr.2023.13.6.p142-p153","url":null,"abstract":"Nyctanthes arbor-tristis is a member of the Oleaceae family with various therapeutic characteristics. Different plant components are used intraditional medicine to treat illnesses such as sciatica, chronic fever, and skin diseases. It is today regarded as a rich source of numerous uniquecompounds for creating medicines against various diseases and certain industrial products. In general, the leaves, roots, flowers, and seeds of Parijatare used to cure several ailments in various dose forms, including juice and powder. The current paper discusses the Plant Profile of N. arbor-tristisLinn., as well as the Phytochemical Screening of Extract of N. arbor-tristis Leaves, physicochemical parameters, and the Extraction Procedure andPharmacological Activities conducted on N. arbor-tristis Leaves. The study aims to analyze the antioxidant, antibacterial, and anti-inflammatory potentialof petroleum ether extract of N. arbor-tristis leaves. DPPH scavenging assays and in vitro anti‐inflammatory activity was evaluated using Albumindenaturation, Proteinase inhibitory assay and was subjected to GC-MS analysis to identify its active components. The antibacterial potential wasanalyzed using the agar well diffusion method against Gram-negative and Gram-positive bacteria. Preliminary phytochemical screening confirmed thepresence of alkaloids, flavonoids, phenols, tannins, triterpenoids, Amino acids, Carbohydrate, and the absence of alkaloids, Anthraquinone, Phenols,Saponin, and tannin. Remarkably, free radicals scavenging ability was observed in DPPH with the IC50 of 610.71±13.6μg/mL, and the anti-inflammatoryassay also observed Albumin denaturation with the IC50 of 781.93±13.6μg/mL and the proteinase inhibitory activity with the IC50 of 652.98±32.5μg/mL.In the antibacterial assay, the zone of inhibition was recorded as 20.6±1.6mm, 21.3±1.8mm, 21.3±1.8mm, and 17.9±1.5mm for the strains of Escherichiacoli, Klebsiella pneumonia, Pseudomonas spp., Staphylococcus aureus, and Bacillus spp. respectively. The highest inhibition zone was observed against E. coli(24.8±1.7 and 26.6±1.4mg/mL, respectively), and the least inhibitory was observed against L. acidophilus (19.5±1.1 and 21.7±1.7mg/mL) respectively.GC-MS profile exhibited the presence of 29 components highly accountable for its pharmaceutical activities. The results suggested the presence ofphytochemicals in Nyctanthes arbor-tristis Leaves possess antioxidant and anti-inflammatory properties in the petroleum ether extract. This informationcan be used as a starting point in the search for natural-based drugs that are effective at alleviating inflammatory symptoms and antioxidant aspects.Keywords: , , , , , ,","PeriodicalId":44665,"journal":{"name":"International Journal of Life Science and Pharma Research","volume":"54 9","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135455106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Pilates and Conventional Treatment Methods in The Management of Stress Urinary Incontinence Among Women","authors":"Veena Kirthika.S, Swetha. M, Selvaraj Sudhakar, J. Arunselvi, Saravanan. V, G. Rajalakshmi, Bharaneedharan. T","doi":"10.22376/ijlpr.2023.13.6.l510-l521","DOIUrl":"https://doi.org/10.22376/ijlpr.2023.13.6.l510-l521","url":null,"abstract":"Stress Urinary Incontinence is a common condition among women that requires attention. The main aim of thisstudy was to compare the effects of Pilates and conventional treatment methods in managing stress urinary incontinence amongwomen. This study is an experimental design, comparative pre-post-test type. 30 female subjects with stress urinaryincontinence were randomly divided into groups, Group A and Group B, with 15 subjects in each group. Group A receivedPilates exercises, and Group B subjects received conventional Kegel's exercises. The study duration was 12 weeks. The pad test,cough stress test, and International Consultation on Incontinence (ICIQ) Questionnaire were outcome measures. The results ofthis study revealed that on comparing the Mean values of Group A &amp; Group B on the International Consultation onIncontinence Questionnaire (ICIQ) and Pad test, Group A (Pilates Exercise) showed 4.46 and 4.93 post-test values which weremore effective than Group B (Conventional kegel's Exercise) at 8.60 and 9.46 at P ≤ 0.001. The Pilates group experienced ahighly significant improvement on the cough stress test compared to the conventional group at P< 0. 001.Pilates exercises wereproven highly effective in managing stress urinary incontinence among women. This study is one of its kind, which demonstratedthe effect of Pilates and its clinical usage for the effective management of Stress Urinary Incontinence.","PeriodicalId":44665,"journal":{"name":"International Journal of Life Science and Pharma Research","volume":"86 12","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135456271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Yoga and Exercise for Fetal Heart Rate, Body Mass Index, And Blood Pressure of Antenatal Mothers","authors":"G. Sathiyabama, Dr. S. Kalabarathi, Dr. Nidhisharma","doi":"10.22376/ijlpr.2023.13.6.l584-l594","DOIUrl":"https://doi.org/10.22376/ijlpr.2023.13.6.l584-l594","url":null,"abstract":"oga is a traditional practice with Indian roots that has many therapeutic benefits. Pranayama and dhyana on bodymass index (BMI) and mean blood pressure (MBP) of the antenatal mother (AM) and fetal heart rate (FHR) are critical for theantenatal mothers. Our aim is to determine Asana's impact in antenatal mothers. This Single blinded placebo-controlled trial wasconducted at Saveetha Medical College and Hospital, Chennai, India. Consecutive sampling was used to select the samplesconveniently. Then, they were randomly assigned into four groups using a random number table: control (CN), yoga group (YG),and Antenatal exercise group (EG), and Yoga and Antenatal exercise group (YAE) with 33 samples in each group. The CN groupreceived conventional management, the YG and EG groups received Yoga intervention and antenatal exercises, respectively, andthe YAE group received both Yoga and antenatal. The groups received their respective treatment 2 days a week for 16 consecutiveweeks. BMI, BP of the AMs, and FHR were assessed at the end of the 4th week, 8th week, 12th week, and 16th week. A total of 132samples accounted for the study results, which showed that the YAE group subjects performed significantly better than the YG,EG, and CN groups in all temporal outcomes (P<0.001). The CN group subjects did not progress significantly compared to theYG and EG group samples. The study concluded that instead of using Yoga as an individual tool in the training AM, addingantenatal exercise will be more beneficial in normalizing BMI, BP, and FHR among AMs.","PeriodicalId":44665,"journal":{"name":"International Journal of Life Science and Pharma Research","volume":"10 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139292385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined Effects of Plyometric Exercise with Dynamic Taping and Kinesio Taping On Muscle Power, Speed, And Muscle Strength Among University Male Football Players – A Randomized Controlled Trial","authors":"K. Rengaramanujam, Dr S. Subbiah, Dr Khalid A. Alahmari","doi":"10.22376/ijlpr.2023.13.6.l572-l583","DOIUrl":"https://doi.org/10.22376/ijlpr.2023.13.6.l572-l583","url":null,"abstract":"Plyometric exercise (PE) is a high-intensity, short-duration training method that may offer an adequate stimulus toimprove physical fitness and sport-specific performance. The sports medicine team employs KT tapes in isolation or in conjunctionwith workout regimens to enhance athletic performance. Research has been done to find out the combined effects of plyometricswith various elements to improve sport-specific fitness performance among football players. More research needs to be examiningthe collective impact of plyometrics in conjunction with taping on fitness performances. The present randomized controlled trialstudy aims to determine the combined effect of plyometrics with dynamic taping (DT) and kinesio taping (KT) to improve musclepower, speed, and muscle strength among university football players. Forty-five university male football players between 18 and25 who fulfilled the inclusion criteria were randomly assigned to 1 of 3 groups (DT, KT, and control groups). Athletes performedPE for 6-weeks. Outcomes were measured at baseline and six weeks post-PE. Vertical jump, standing long jump, and single leg hoptests were used to measure muscle power, and the 30-meter sprint and strength dynamometers were used to measure speed andmuscle strength, respectively. Significant differences were found in the group receiving PE and DT than the other groups in all theoutcome variables (p<0.05). The combined effects of PE and DT significantly affect muscle power, speed, and muscle strengthamong university male football players compared to KT with PE and PE alone.","PeriodicalId":44665,"journal":{"name":"International Journal of Life Science and Pharma Research","volume":"10 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139292760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing Anti-Allergic Transdermal Patches Through Box-Behnken Design Approach with Chlorpheniramine Maleate","authors":"Hindustan Abdul Ahad, Siriguppa Dheeraj, Haranath Chinthaginjala","doi":"10.22376/ijlpr.2023.13.6.p366-p377","DOIUrl":"https://doi.org/10.22376/ijlpr.2023.13.6.p366-p377","url":null,"abstract":"This research focuses on developing transdermal patches incorporating chlorpheniramine maleate (CPM), an anti-allergic medication. Transdermal patches offer a convenient and effective way to administer drugs, and CPM's application in this context holds promise for improved patient care. The primary aim of this study was to utilize the Box-Behnken design to formulate transdermal patches containing CPM. These patches were developed through a solvent dispersion technique, with key ingredients including HPMC (a polymer), PEG (a plasticizer), ethanol, and a permeation enhancer. The overarching goal was to assess the impact of polymer type, permeation enhancer, and sonication time on patch formulation and performance. To achieve our aim, we conducted several tests, including folding endurance, drug content, thickness, entrapment efficiency, in vitro moisture uptake, permeation analysis, and in vitro experiments. These specific objectives allowed us to evaluate the quality and effectiveness of the transdermal patches comprehensively. In our methodology, HPMC was employed as the polymer, and PEG served as the plasticizer. The Box-Behnken design facilitated kinetic assessments to study drug release from the patches. We systematically varied the HPMC, PEG, and ethanol concentrations and the sonication time to optimize patch formulation. The outcomes of our study indicated that all formulated patches met the specified criteria for quality and performance. Folding endurance was found to follow the formula +178.00 + 5.37A + 13.25B + 1.13C - 1.75AB + 0.0000AC + 0.2500BC + 4.25A² + 8.50B² + 2.75C², while permeation at 24 hours exhibited the equation +73.00 + 2.12A + 6.37B + 0.7500C - 0.5000AB - 0.2500AC - 0.2500BC + 1.00A² + 0.0000B² + 1.25C². These findings underscore the successful development of transdermal patches containing CPM and shed light on the critical factors influencing patch formulation. In summary, this investigation accomplished the development of transdermal patches incorporating CPM and elucidated the influence of polymer type, permeation enhancer, and sonication time on the formulation process. These findings contribute to advancing transdermal drug delivery systems and offer potential benefits for patients receiving anti-allergic medication.","PeriodicalId":44665,"journal":{"name":"International Journal of Life Science and Pharma Research","volume":"266 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139298385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}