International Journal of Life Science and Pharma Research最新文献

{"title":"Evaluation and Comparison of Removable Dentures Constructed with The SR-IVOCAP System and The Traditional System.","authors":"Prof. Edit Xhajanka, Dr. Neada Hysenaj, Prof. Dr. Vergjini Mulo, Dr. Dorina Mele, Dr. Tedi Verçani, Dr. Endrit Paparisto","doi":"10.22376/ijlpr.2023.13.5.l302-l310","DOIUrl":"https://doi.org/10.22376/ijlpr.2023.13.5.l302-l310","url":null,"abstract":"The treatment of edentulous patients is still a challenging problem. Acrylic resin is the most used material forconstructing removable denture bases. The main disadvantage of this material is resin shrinkage, which occurs during and afterpolymerization. Our study aimed to evaluate the denture parameters regarding patient satisfaction regarding the removabledentures constructed with two different processing techniques: compression molding and injection. 80 patients, who came in theUniversity Dental Clinic, Tirana were examined and evaluated. Those who fulfilled the criteria were treated with removabledentures. The patients were divided into two groups: in the first group, 40 patients were treated with removable denturesconstructed with the compression molding technique, and in the second group, 40 patients were treated with removable denturesconstructed with the injection molding technique. All the clinical and laboratory procedures until the processing technique wereidentical. After denture delivery, all the patients were re-scheduled to fulfill a questionnaire regarding four parameters of theremovable dentures: denture stability, mastication efficiency, denture comfort, and quality of dentures in general. Results. Thedescriptive statistics of the data were done. Sample t-test showed that the SR IVOCAP dentures had higher mean values for allthe parameters than the traditional dentures. Based on our study, the satisfaction of the patients treated with removable dentureswith the SR-IVOCAP system for all the parameters evaluated was higher compared to the patient satisfaction treated withtraditional removable dentures.","PeriodicalId":44665,"journal":{"name":"International Journal of Life Science and Pharma Research","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49086903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relevance of Ayurveda Management in Duchenne Muscular Dystrophy to Augment the Quality of Life- A Pediatric Case Report","authors":"Renu Rathi, Sakshi Shirbhate, Bharat Rathi, Sadhana Misar, Monali Kurhadkar, Prasad Yewle","doi":"10.22376/ijlpr.2023.13.5.l322-l330","DOIUrl":"https://doi.org/10.22376/ijlpr.2023.13.5.l322-l330","url":null,"abstract":"Muscular dystrophy is a myopathy that stakes clinical characteristics of progressive muscular feebleness. Duchenne muscular dystrophy (DMD) is the most common X-linked disorder of muscular dystrophy in children, present in early childhood, and characterized by proximal muscle weakness and calf hypertrophy in affected boys. This case aims to make Ayurveda pediatricians aware of planning a protocol for DMD. The objective is to provide instant relief in motor function to some extent and to augment the quality of life. An 11 years old boy was presented with an in ability to stand, gross muscle weakness, difficulty in movements of lower limbs, and particularly in all vigorous physical activities. He also had decreased strength, stamina, and progressive debility with positive Gower's sign, which suggested DMD. Confirmed economic treatment options are unavailable to prevent progressive illness and mortality. The family members were counselled and assured of improving their quality of life. He was started with multiple pre-panchakarma procedures of alternate Rukshan and Brihan to pacify internal Ayurveda medicines with the support of occupational therapy and physiotherapy in different sittings for three months. His CPK -creatinine kinase was 8335 U/L (NV= 55 to 170 U/L) which became4741U/L post-treatment. He could stand with support for 15 minutes on his own with ease in body movements due to a reduction in contractures & increase in the range of motions measured by the goniometer, as this genetic disease has no medicinal cure. However, by adopting a multi-dimensional integrative approach, family support, and willpower, the quality of life can be augmented to much extent. Ayurveda plays a crucial role in the drastic improvement because of panchkarma shaman procedures, medicines, Yog, physiotherapy, traction, and counselling at regular intervals for lifelong.","PeriodicalId":44665,"journal":{"name":"International Journal of Life Science and Pharma Research","volume":"78 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135298147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Evaluation of Microleakage of G-Aenial, Bis-GMA Nanohybrid and Bis- GMA Microhybrid Flowable Composites in Class I Cavities – An in Vitro Study.","authors":"Mrinal Nadgouda, Aditya Patel, Shraddha Patel, Pradnya Nikhade, Manoj Chandak, Ladusingh Rajpurohit, Swayangprabha Sarangi","doi":"10.22376/ijlpr.2023.13.5.p116-p122","DOIUrl":"https://doi.org/10.22376/ijlpr.2023.13.5.p116-p122","url":null,"abstract":"The most vulnerable area while restoring a tooth surface lies at the interphase between the restoration and the tooth margins.This area is the weakest junction in a tooth and serves as a potential pathway for microorganisms to invade into the tooth. This leads tofailures in existing restorations paving way for the initiation of secondary caries progression. An advanced restorative material bridges thisgap and seals off the weak interphasic junctions. Flowable composites having adequate strength and lesser polymerisation shrinkage werechosen. The aim of this study was to find a material having lesser microleakage deemed suitable for restorative purposes. Three types offlowable composites were chosen, which had the objective of being tested as a flowable material for evaluation of microleakage amongstthe three tested groups. Dye penetration test was carried out to evaluate the amount of microleakage occurring under flowable resinswhich were then evaluated under a light reflecting digital compound microscope. A total of 45 extracted human premolars were selectedfor the study; scoring of specimens was done with the help of an Ordinal scale to detect microleakage. The results obtained from thestudy was that G-aenial Universal Flo, performed superior than Tetric N flow which was then followed by Kulzer Charisma Flo whichshowed highest dye penetration. The amount of dye penetration reflects directly the microleakage occuring at the interphases ofrestoration. The novelty of this study lies in the fact that this is one of its kind of study evaluating the amount of microleakage occurringbetween three different flowable composites. It was concluded that G-aenial Universal Flo, showed the least amount of microleakagewhen compared against two similar flowable composites to provide an adequate marginal seal.Keywords: , , , , ,","PeriodicalId":44665,"journal":{"name":"International Journal of Life Science and Pharma Research","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136236509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Early Molecular Biomarker Study in Pre-eclampsia","authors":"Vinaya Vijayan, R. Kannan, B. R. Reddy","doi":"10.22376/ijlpr.2023.13.5.l293-l301","DOIUrl":"https://doi.org/10.22376/ijlpr.2023.13.5.l293-l301","url":null,"abstract":"Preeclampsia (PE), a hypertension condition associated with pregnancy that manifests after 20 weeks of pregnancy,may be brought on by faulty placental development and poses a serious risk to both the mother and the fetus. The disease can bedetected only once the symptoms arise, there is a need for a biomarker, which makes early detection of the disease possible, andproper management of the disease can be done at an early stage of pregnancy. Even though many studies were done globallyregarding the role of microRNAs as molecular biomarkers in pre-eclampsia, no literature showed the effect of microRNA inpreeclampsia in the Indian population. The aim of the study was to find an early molecular marker that can detect the disease atan early stage, even before the symptoms arise. Placental MicroRNAs were studied using Next-generation Sequencing of 60Preeclamptic groups ( 30 Early Onset,30Late onset preeclampsia), and 30 control groups were selected; miRNA profiling wasdone by Illumina sequencing, and the quantifier did downstream analysis for identification, quantification, and expression profiling.pl, script, and miRDeep2.pl, script. Total RNAs were extracted from placental tissues and cells by TRIzol reagent and purified. Therelative expression of miR-483-5p in tissues or cells was determined: micro-RNA 483-5p was expressed in significant quantity inEarly Onset preeclamptic placental samples compared to Late Onset and normal samples. miR 483-5p was analyzed, and the genetargets were found using computational methods. From this study, it was found that microRNA 483-5p can be used as an earlybiomarker for the identification of preeclampsia.","PeriodicalId":44665,"journal":{"name":"International Journal of Life Science and Pharma Research","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46828981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epithelioid Glioblastoma in A 15-Year-Old Boy: A Rare Case Report","authors":"Dr.Poornima Pandey, Dr.Hanish Kumar Chawda, Dr.Parth Shah","doi":"10.22376/ijlpr.2023.13.5.l316-l321","DOIUrl":"https://doi.org/10.22376/ijlpr.2023.13.5.l316-l321","url":null,"abstract":"Epithelioid glioblastoma (E-GBM), one of the rarest intrusive forms of Glioblastoma multiforme (GBM), was consigned in the World Health Organization (WHO) categorization of the Central nervous system (CNS) in the year 2016. The current article reports a rare epithelioid glioblastoma described for its histomorphological character and clinical finding for its medical rarity. The present case deals with a 15-year-old boy complaining of headaches and multiple episodes of vomiting. The investigatory procedures revealed hypo-intense multiple lesions in the left medial frontal lobe extending to a Sylvian fissure. The case is being discussed to distinguish the development of secondary glioblastomas, which usually occur due to pre-existing lesions, which were not present in our discussed case. The patient had come from a rural background with no previous investigations, ophthalmological examination revealed the presence of bilateral papilledema, and the hematological reports were within normal range. The patient was managed with magnetic resonance imaging (MRI) and computed tomography (CT), which depicted a multifocal tumor. Further left fronto temporal craniotomy and ablation of the lesion were done. The surgical procedure upshot divulged that the patient was conscious with improved right side weakness but a remnant motor aphasia, but within a short span, he could walk with support. The incidence of E-GBM that too in adolescent children is minuscule, and due to its poor prognosis, it's very crucial to acknowledge the attributable features of epithelioid glioblastoma, inclusive of functional outset, neuro-imaging, and the hazards of surgical measures.","PeriodicalId":44665,"journal":{"name":"International Journal of Life Science and Pharma Research","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135248859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Updated Detailed Review of Trachyspermum Ammi: Composition, Applications and Pharmacological Profile","authors":"Kamal Nabi, None Imanshu, Saswat Swarup, Deepika Bhatia, Manisha Bhatti, Lovedeep Singh","doi":"10.22376/ijlpr.2023.13.5.p221-p238","DOIUrl":"https://doi.org/10.22376/ijlpr.2023.13.5.p221-p238","url":null,"abstract":"Trachyspermum Ammi (T. Ammi) is a traditional medicinal plant belonging to the family Apiaceae. It, also known asAjacine or Ajwain, is an herb with Egyptian origins. It is distributed all over India and mainly cultivated in Rajasthan and Gujarat.This review is designed to discuss the updated pharmacological activities of T. Ammi, its phytochemistry, herbal formulations,and patents filed on its novel formulations and their actions. Until now, no such review has discussed the above mentionedparticulars on the same platform. The review aims to provide the updated traditional and pharmacological activities of T. Ammi,along with its phytochemistry, herbal formulations, and microwave-assisted extraction method. The microwave-assistedextraction method is less time-consuming, cost-effective, and gives more extractive value than other methods. We have alsoadded the latest novel patents of the T.ammi. It is an annual plant with tall growth that is fragrant and bears white blooms andlittle brownish berries, small, grey, bitter, and peppery. The seeds or fruit of this plant are the parts that are used mostfrequently. Ajwain's fruits have 5% essential oil in them. Ancient researchers highly influenced the use of this herb. The essentialoil brings on Ajwain's aroma and flavor. Ajwain is a potent traditional medicine that is frequently used to cure a variety ofillnesses in both humans and animals. To include literature evidence to support the article's theme, a search was performed onfive electronic databases, including PubMed, Scopus, Web of Science, Embase, and Google Scholar, by using specific keywords.","PeriodicalId":44665,"journal":{"name":"International Journal of Life Science and Pharma Research","volume":"127 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135098958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Periodontal Tissue Engineering: A Literature Review","authors":"Dr. Shrishti Salian, Dr. Prasad V. Dhadse, Dr Ruchita Patil","doi":"10.22376/ijlpr.2023.13.5.l331-l339","DOIUrl":"https://doi.org/10.22376/ijlpr.2023.13.5.l331-l339","url":null,"abstract":"Periodontal regeneration is the formation of new cementum, periodontal ligament, and alveolar bone followingperiodontal surgery. It is widely believed that tissues formed during regeneration are more resistant to deterioration than thosegained when healing occurs through repair, which is why regeneration is so important. The two main goals of periodontal therapyare controlling the infection and rebuilding the architecture and function of periodontal tissues. Due to the periodontium's highlyhierarchical organization, which calls for a highly coordinated spatiotemporal healing response to enable regeneration, theregeneration of the periodontal apparatus with the formation of the bone-PDL-cementum complex at the same time continues topresent challenges. The final goal of periodontal therapy for tissues destroyed by periodontal diseases is the regeneration of theattachment apparatus, composed of the development of new alveolar bone, periodontal ligament, and cementum. With a clearunderstanding of the periodontal disease process, the regeneration of the periodontium is one of the major goals of periodontaltherapy. This review is an update on the current tissue engineering knowledge as a possible periodontal regeneration technique.","PeriodicalId":44665,"journal":{"name":"International Journal of Life Science and Pharma Research","volume":"57 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135255332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of Parshnishool (Heel Pain) Due to Vatakantaka (Calcaneal Spur) With Agnikarma (Therapeutic Burn). – A Case Report.","authors":"Divya Jadhav, Mayuri Amol Deshpande, Amol Madhav Deshpande, Minakshi Urkude","doi":"10.22376/ijlpr.2023.13.5.l358-l363","DOIUrl":"https://doi.org/10.22376/ijlpr.2023.13.5.l358-l363","url":null,"abstract":"Pain is the commonest symptom due to which patients come to the Physician. Every patient wants instant relief from such type ofunwanted feelings. Conventional therapies have many painkillers that instantly give the desired effect with a byproduct of many side effects.Parshnishool (Heel pain) occurring due to Vatakantaka (calcaneal spur) is a common type of pain nowadays. It hampers day-to-day life choresaffecting the physical as well as mental status of an individual. Ayurveda has solutions for all types of diseases occurring in every Era. Thecalcaneum has tiny osteophyte projections known as calcaneal spurs. It is not an acute illness with abrupt onset. It takes place as a result ofprogressive changes in that area. Calcaneal spurs are often seen in two regions: the inferior and posterior ones. The lower one is placed onthe calcaneum's inferior side and frequently reacts to plantar fasciitis over time. Calcaneal spur and its symptoms can be easily treated withAgnikarma means therapeutic heat application. Vata is the causative factor in all types of pain. There are a total of 80 diseases that occur due tothe vitiation of Vata. Vata and Agni have exactly opposite properties. In this case, we use Loha shalaka (Iron lancet) for therapeutic burns. Lohashalaka gives more relief from pain than any other shalakas. The patient got complete relief after three sittings. He was advised with someinternal medication as supplements. Agnikarma is the easy, less time-consuming, and financially affordable treatment in Pashnishool occurring inVatakantaka with no side effects.","PeriodicalId":44665,"journal":{"name":"International Journal of Life Science and Pharma Research","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135298287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of Zoonotic Bacterial Pathogens Associated with Rodents in Rural Areas of Nellore, India","authors":"Manohar B. Vadela, Satyanagalakshmi Karri, Daveedu Thathapudi, Devi Bogireddy, Vijay A.K.B. Gundi","doi":"10.22376/ijlpr.2023.13.5.l339-l407","DOIUrl":"https://doi.org/10.22376/ijlpr.2023.13.5.l339-l407","url":null,"abstract":"Rodent species are known to harbour and host various zoonotic pathogens, including bacterial, viral, fungal, and protozoal species. Several investigations proved that commensal rats (Rattus spp.) are potential to transmit drug-resistant and hyper-virulent bacterial pathogens to humans. India's rapid urbanization and developmental activities facilitated rats to live near the human population. However, few information was known about bacterial species associated with rodents and their role in zoonotic risk to humans in India. The present study aimed to (i) investigate the presence of bacterial pathogens associated with rodents and (ii) infer the prevalence and diversity of potential bacterial pathogens in Nellore district, India. Bacterial prevalence was determined by isolation and identification techniques. The isolated bacterial cultures were submitted for phenotypic observation, biochemical identification using the VITEK 2 compact automated system, and molecular detection by DNA extraction and amplification of the 16S rRNA gene. A diversified bacterial community belonging to 14 species was detected from all collected animals. Bacterial species' prevalence was comparatively higher in black rats (n=66) than brown rats (n=27). 46 rats out of 93 were found to be positive (49.4%) for bacterial presence. A significant variation was found in the prevalence of bacterial species between both rodent species. The highest bacterial prevalence was recorded for Bacillus spp. (36%) followed by E. coli (29%). The prevalence of Klebsiella pneumoniae was found as 17%, of which 18% in black rats and 14% in brown rats. Listeria spp.'s prevalence was 23.6%, but a higher prevalence was observed in black rats (25.7%). Surprisingly, an uncommon pathogen, Sphingomonas paucimobilis, was detected in both rodent species. These results suggest that Rattus rats in Nellore were suspected to be potential carriers of transmitting zoonotic bacterial species to humans.","PeriodicalId":44665,"journal":{"name":"International Journal of Life Science and Pharma Research","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135433417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of Non-Hormonal Intervention On Lipid Profile Among Perimenopausal Women.","authors":"Muthulakshmi. C, Dr. S. Kalabarathi, Dr. Nithisharma","doi":"10.22376/ijlpr.2023.13.5.l260-l266","DOIUrl":"https://doi.org/10.22376/ijlpr.2023.13.5.l260-l266","url":null,"abstract":"This study aims to find the effect of a non-hormonal therapy to help solve dyslipidemia among perimenopausalwomen. The objective of achieving this aim was to find the effect of soya supplementation on low-density lipoprotein (LDL),high-density lipoprotein (HDL), and total cholesterol (TCL) levels among perimenopausal women with dyslipidemia. This singleblindedquasi-experimental study was conducted in a rural community in southern India with 54 perimenopausal women in 40-55 age. The subjects were randomized into a control group that received only structured health education and an experimentalgroup that received structured health education, and soya supplements 50 grams of soya meal curry on alternative days for 3days a week for 16 weeks. The three-outcome analysis for the study HDL, LDL, and TCL levels was analyzed as a part ofbaseline selection criteria (Pre-test), following 8 weeks (Post-test 1) and 16th weeks (Post-test 2), respectively. The study resultsshowed that all three biomarkers normalized significantly better in the experimental group than in the control group. The studysupports the statement that a soya diet can be an adjunct to estrogen therapy. Hence, the study favors using a soya diet as atreatment choice for managing dyslipidemia among perimenopausal women.","PeriodicalId":44665,"journal":{"name":"International Journal of Life Science and Pharma Research","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44698883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}