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Liver abnormalities following SARS-CoV-2 infection in children 1 to 10 years of age 1 至 10 岁儿童感染 SARS-CoV-2 后出现肝脏异常
IF 6.1 3区 医学
Family Medicine and Community Health Pub Date : 2024-01-01 DOI: 10.1136/fmch-2023-002655
Pauline Terebuh, Veronica R Olaker, Ellen K Kendall, David C Kaelber, Rong Xu, Pamela B Davis
{"title":"Liver abnormalities following SARS-CoV-2 infection in children 1 to 10 years of age","authors":"Pauline Terebuh, Veronica R Olaker, Ellen K Kendall, David C Kaelber, Rong Xu, Pamela B Davis","doi":"10.1136/fmch-2023-002655","DOIUrl":"https://doi.org/10.1136/fmch-2023-002655","url":null,"abstract":"Objective Beginning in October 2021 in the USA and elsewhere, cases of severe paediatric hepatitis of unknown aetiology were identified in young children. While the adenovirus and adenovirus-associated virus have emerged as leading aetiological suspects, we attempted to investigate a potential role for SARS-CoV-2 in the development of subsequent liver abnormalities. Design We conducted a study using retrospective cohorts of deidentified, aggregated data from the electronic health records of over 100 million patients contributed by US healthcare organisations. Results Compared with propensity score matched children with other respiratory infections, children aged 1–10 years with COVID-19 had a higher risk of elevated transaminases (HR (95% CI) 2.16 (1.74 to 2.69)) or total bilirubin (HR (95% CI) 3.02 (1.91 to 4.78)), or new diagnoses of liver diseases (HR (95% CI) 1.67 (1.21 to 2.30)) from 1 to 6 months after infection. Patients with pre-existing liver abnormalities, liver abnormalities surrounding acute infection, younger age (1–4 years) or illness requiring hospitalisation all had similarly elevated risk. Children who developed liver abnormalities following COVID-19 had more pre-existing conditions than those who developed abnormalities following other infections. Conclusion These results indicate that SARS-CoV-2 may prime the patient for subsequent development of liver infections or non-infectious liver diseases. While rare (~1 in 1000), SARS-CoV-2 is a risk for subsequent abnormalities in liver function or the diagnosis of diseases of the liver. No data are available. We used a cloud-based database and cannot download the data set. In addition, the database is constantly being upgraded with new information, so the actual data from which the analysis was done will not be available at a subsequent time. That is why we indicate when the database was accessed and which specific data set was used. The EMR data are deidentified and so individual data cannot be made available to us or anyone else.","PeriodicalId":44590,"journal":{"name":"Family Medicine and Community Health","volume":null,"pages":null},"PeriodicalIF":6.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139556967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Community cancer screening at primary care level in Northern India: determinants and policy implications for cancer prevention. 印度北部初级保健层面的社区癌症筛查:癌症预防的决定因素和政策影响。
IF 6.1 3区 医学
Family Medicine and Community Health Pub Date : 2023-12-17 DOI: 10.1136/fmch-2023-002397
Priyanka Sharma, Divya Khanna, Satyajit Pradhan, Praveen Birur
{"title":"Community cancer screening at primary care level in Northern India: determinants and policy implications for cancer prevention.","authors":"Priyanka Sharma, Divya Khanna, Satyajit Pradhan, Praveen Birur","doi":"10.1136/fmch-2023-002397","DOIUrl":"10.1136/fmch-2023-002397","url":null,"abstract":"<p><strong>Objective: </strong>Despite the established cancer screening programme for oral, breast and cervical cancer by the Government of India, the screening coverage remains inadequate. This study aimed to describe the determinants for oral, breast and cervical cancer prevention in a rural community at the primary care level of Northern India and its policy implications.</p><p><strong>Design: </strong>This was a camp-based project conducted for 1 year, using oral visual examination, clinical breast examination and visual inspection of cervix by application of 5% acetic acid according to primary healthcare operational guidelines. During the project, screen-positive participants were followed through reverse navigation. Information about socio-demographic profile, clinical and behavioural history and screening were collected. Predictors for screen-positivity and follow-up compliance were identified through multivariable analysis.</p><p><strong>Settings: </strong>Based on the aim of project, one of the remotely located and low socioeconomic rural blocks, having 148 villages (estimated population of 254 285) in Varanasi district, India was selected as the service site. There is an established healthcare delivery and referral system as per the National Health Mission of Government of India. Oral, breast, gallbladder and cervical cancers are the leading cancers in the district.</p><p><strong>Participants: </strong>We invited all men and women aged 30-65 years residing in the selected block for the last 6 months for the screening camps. Unmarried women, women with active vaginal bleeding, those currently pregnant and those who have undergone hysterectomy were excluded from cervical cancer screening.</p><p><strong>Results: </strong>A total of 14 338 participants were screened through 190 camps and the majority (61.9%) were women. Hindu religion, tobacco use, intention to quit tobacco and presence of symptoms were significantly associated with screen-positivity. Nearly one-third (220; 30.1%) of the screened-positives complied with follow-up. Young age and illiteracy were significantly associated with lower compliance.</p><p><strong>Conclusion: </strong>Poor follow-up compliance, despite the availability of tertiary cancer care, patient navigation, free transportation and diagnostic services, calls for research to explore the role of contextual factors and develop pragmatic interventions to justify 'close the care gap'. Community cancer screening needs strengthening through cancer awareness, establishing referral system and integration with the National Tobacco Control and Cancer Registry Programmes.</p>","PeriodicalId":44590,"journal":{"name":"Family Medicine and Community Health","volume":null,"pages":null},"PeriodicalIF":6.1,"publicationDate":"2023-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10729271/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138811467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Should I take aspirin? A qualitative study on the implementation of a decision aid on taking aspirin for bowel cancer prevention. 我应该吃阿司匹林吗?服用阿司匹林预防肠癌决策辅助实施的定性研究。
IF 6.1 3区 医学
Family Medicine and Community Health Pub Date : 2023-11-30 DOI: 10.1136/fmch-2023-002423
Shakira Onwuka, Jennifer McIntosh, Lucy Boyd, Napin Karnchanachari, Finlay Macrae, George Fishman, Jon Emery
{"title":"Should I take aspirin? A qualitative study on the implementation of a decision aid on taking aspirin for bowel cancer prevention.","authors":"Shakira Onwuka, Jennifer McIntosh, Lucy Boyd, Napin Karnchanachari, Finlay Macrae, George Fishman, Jon Emery","doi":"10.1136/fmch-2023-002423","DOIUrl":"10.1136/fmch-2023-002423","url":null,"abstract":"<p><strong>Objectives: </strong>Australian guidelines recommend 50-70 years consider taking aspirin to reduce their bowel cancer risk. We trialled a decision aid in general practice to facilitate the implementation of these guidelines into clinical practice. This publication reports on the qualitative results from the process evaluation of the trial. We aimed to explore general practitioners' (GPs) and their patients' approach to shared decision-making (SDM) about taking aspirin to prevent bowel cancer and how the decision aids were used in practice.</p><p><strong>Methods: </strong>Semistructured interviews were conducted with 17 participants who received the decision aid and 12 GPs who participated in the trial between June and November 2021. The interviews were coded inductively, and emerging themes were mapped onto the Revised Programme Theory for SDM.</p><p><strong>Results: </strong>The study highlighted the dynamics of SDM for taking aspirin to prevent bowel cancer. Some participants discussed the decision aid with their GPs as advised prior to taking aspirin, others either took aspirin or dismissed it outright without discussing it with their GPs. Notably, participants' trust in their GPs, and participants' diverse worldviews played pivotal roles in their decisions. Although the decision aid supported SDM for some, it was not always prioritised in a consultation. This was likely impacted during the trial period as the COVID-19 pandemic was the focus for general practice.</p><p><strong>Conclusion: </strong>In summary, this study illustrated the complexities of SDM through using a decision aid in general practice to implement the guidelines for low-dose aspirin to prevent bowel cancer. While the decision aid prompted some participants to speak to their GPs, they were also heavily influenced by their unwavering trust in the GPs and their different worldviews. In the face of the COVID-19 pandemic, SDM was not highly prioritised. This study provides insights into the implementation of guidelines into clinical practice and highlights the need for ongoing support and prioritisation of cancer prevention in general practice consultations.</p><p><strong>Trial registration number: </strong>ACTRN12620001003965.</p>","PeriodicalId":44590,"journal":{"name":"Family Medicine and Community Health","volume":null,"pages":null},"PeriodicalIF":6.1,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10689404/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138463297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Supporting and retaining competent primary care workforce in low-resource settings: lessons learned from a prospective cohort study. 在资源匮乏的环境中支持和留住合格的初级保健劳动力:从前瞻性队列研究中吸取的教训。
IF 6.1 3区 医学
Family Medicine and Community Health Pub Date : 2023-11-01 DOI: 10.1136/fmch-2023-002421
Mingyue Li, Haoqing Tang, Huixian Zheng, Yiran Tian, Xiaoran Cheng, Haozhe Cheng, Xiaotian Zhang, Dan Hu, Xiaoyun Liu
{"title":"Supporting and retaining competent primary care workforce in low-resource settings: lessons learned from a prospective cohort study.","authors":"Mingyue Li, Haoqing Tang, Huixian Zheng, Yiran Tian, Xiaoran Cheng, Haozhe Cheng, Xiaotian Zhang, Dan Hu, Xiaoyun Liu","doi":"10.1136/fmch-2023-002421","DOIUrl":"10.1136/fmch-2023-002421","url":null,"abstract":"<p><strong>Objective: </strong>Assess whether local health facilities can adequately support the performance of general practitioners (GPs) trained by China's national compulsory services programme (CSP).</p><p><strong>Design: </strong>Prospective cohort study.</p><p><strong>Setting: </strong>Health facilities in middle and western rural areas in China, 2015-2022.</p><p><strong>Participants: </strong>Cohorts of CSP graduates from 2015 to 2019 in four major medical universities.</p><p><strong>Main outcomes: </strong>Job performance measured by a 12-item Job Performance Scale; productivity measured by outpatient volume per day; turnover measured by ever changing jobs within the past year.</p><p><strong>Results: </strong>91.2%, 92.0% and 90.5% GPs working in township health centres reported inadequate medication, equipment and external assistance from higher level hospitals, while CSP graduates working in secondary or tertiary hospitals reported a lower rate of less than 60%. The top three tests reported as lacking were blood gases (67.7%), microbiology (61.6%) and cancer biomarkers (49.7%); the top three lacked procedures were CT scan (64.8%), MRI scan (58.1%) and ambulatory BP monitoring (55.8%); and the top three lacked drugs were drugs for cardiovascular diseases (23.3%), systematic hormonal preparations (17.7%) and traditional Chinese medicines (13.0%). Multivariable analysis showed that facility support was positively associated with job performance-adequate medication increased job performance by 2.2 points (95% CI 0.7 to 3.8), and adequate external assistance increased job performance by 3.3 points (95% CI 1.8 to 4.8). Facility support was also positively associated with productivity-adequate medication increased outpatients seen per day by 20% (95% CI 0.1 to 0.3), and adequate equipment increased outpatients seen per day by 12% (95% CI 0.0 to 0.2). Facility support did not have significant impact on turnover, but GPs who changed jobs in the past year were 1.9-2.3 times more likely to report adequate facility support.</p><p><strong>Conclusion: </strong>GPs in township health centres experienced a high prevalence of shortage in facility support. The identification of a positive association between facility support and performance and productivity has implications for future research and resources deployment in primary healthcare.</p>","PeriodicalId":44590,"journal":{"name":"Family Medicine and Community Health","volume":null,"pages":null},"PeriodicalIF":6.1,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10632899/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71487204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Health-related quality of life among adolescents with type 1 diabetes since the second wave of the COVID-19 pandemic in Germany. 自德国第二波COVID-19大流行以来,青少年1型糖尿病患者的健康相关生活质量
IF 6.1 3区 医学
Family Medicine and Community Health Pub Date : 2023-11-01 DOI: 10.1136/fmch-2023-002415
Juliane Regina Framme, Su-Jong Kim-Dorner, Bettina Heidtmann, Thomas Michael Kapellen, Karin Lange, Olga Kordonouri, Heike Saßmann
{"title":"Health-related quality of life among adolescents with type 1 diabetes since the second wave of the COVID-19 pandemic in Germany.","authors":"Juliane Regina Framme, Su-Jong Kim-Dorner, Bettina Heidtmann, Thomas Michael Kapellen, Karin Lange, Olga Kordonouri, Heike Saßmann","doi":"10.1136/fmch-2023-002415","DOIUrl":"10.1136/fmch-2023-002415","url":null,"abstract":"<p><strong>Objective: </strong>The COVID-19 pandemic had an impact on everyday life and in general, reduced the health-related quality of life (HRQoL) of adolescents. In this study, we assess the HRQoL of adolescents with type 1 diabetes (T1D) in Germany since the second wave of the COVID-19 pandemic by using self-report and parent-proxy reports, to identify risk factors, to compare to peers and to examine the agreement of HRQoL between parents and their children.</p><p><strong>Methods: </strong>A total of 445 adolescents (12-18 years) and 413 parents participated in an anonymous cross-sectional survey conducted at three German diabetes centres from January 2021 to June 2022. Inclusion criteria were diabetes duration ≥1 year and German-speaking. Teen HRQoL was assessed by using self-report and parent-proxy report versions of the KIDSCREEN-10 index.</p><p><strong>Results: </strong>The majority of adolescents reported average (75.5%) HRQoL. Approximately 11.3% of teens reported high and 13.2% low HRQoL. Teen's female gender, older age, higher diabetes burden and parental depression symptoms contributed to lower self-reported HRQoL among teens. For parent-proxy reports, increasing diabetes burdens, parental depression symptoms, non-migrant status, high education and ketoacidosis contributed to lower scores on teen HRQoL. The mean scores of the KIDSCREEN-10 index for adolescents did not differ from the German norm. In comparison to healthy peers during the first wave of the pandemic, adolescents in the current study reported higher HRQoL. The overall teen-parent agreement was fair although parents reported significantly lower teen HRQoL than adolescents did.</p><p><strong>Conclusions: </strong>HRQoL of most adolescents with T1D during the COVID-19 pandemic was average with parents reporting significantly lower scores. Self-reported and parent-proxy-reported HRQoL and the level of agreement due to different perspectives can provide important information for clinical care and intervention planning.</p>","PeriodicalId":44590,"journal":{"name":"Family Medicine and Community Health","volume":null,"pages":null},"PeriodicalIF":6.1,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10660822/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134650154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Service evaluation: identification of gaps in choking prevention advice for children in the South Coast of England, UK. 服务评估:确定英国英格兰南海岸儿童窒息预防建议的差距。
IF 6.1 3区 医学
Family Medicine and Community Health Pub Date : 2023-10-01 DOI: 10.1136/fmch-2022-001966
Saira Khan, Karen Patterson, Katy Fidler
{"title":"Service evaluation: identification of gaps in choking prevention advice for children in the South Coast of England, UK.","authors":"Saira Khan,&nbsp;Karen Patterson,&nbsp;Katy Fidler","doi":"10.1136/fmch-2022-001966","DOIUrl":"https://doi.org/10.1136/fmch-2022-001966","url":null,"abstract":"© Author(s) (or their employer(s)) 2023. Reuse permitted under CC BYNC. No commercial reuse. See rights and permissions. Published by BMJ. INTRODUCTION Choking, also known as foreign body airway obstruction, is the blockage of respiration by a foreign body in the airway including the trachea, hypopharynx and pharynx. Among young children, choking is one of the leading causes of death among unintentional injuries, thus making it a significant public health issue. Children under 5 have the highest risk of choking compared with other children and adults. In 2016, of the approximately 1900 choking episodes resulting in emergency calls in London, 40% were for children under 5. Common items that children may choke on include food, toys and coins. Round objects that can adapt to the shape of a child’s airway are most likely to cause complete obstruction of the airways such as grapes, peanuts and hard sweets. To reduce the incidence of these events, choking prevention advice for parents/ caregivers is critical. One study showed that parents who lacked awareness of food choking hazards were more likely to give foods to their children that increase choking risk. Conversely, studies conducted in Israel and Crete showed a decline in choking cases in children after implementing educational choking prevention programmes. Healthcare professionals (HCPs) such as general practitioners (GPs), paediatric nurses and health visitors play a significant role in providing choking prevention advice to parents/caregivers. Examples of choking prevention advice recommended by the Child Accident Prevention Trust are shown in box 1. During their professional training, these HCPs have typically received choking prevention and management teaching. However, in clinical practice, it is unclear how routinely these roles are being carried out. Aims and objectives Our service evaluation had a primary objective to identify the type of HCPs providing choking prevention advice and how consistently this advice was delivered. Secondary objectives included assessing the use of choking prevention resources by HCPs and determining where HCPs think choking prevention advice is best placed.","PeriodicalId":44590,"journal":{"name":"Family Medicine and Community Health","volume":null,"pages":null},"PeriodicalIF":6.1,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/39/11/fmch-2022-001966.PMC10565162.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41215453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of COVID-19 with respiratory syncytial virus (RSV) infections in children aged 0-5 years in the USA in 2022: a multicentre retrospective cohort study. 2022年美国0-5岁儿童新冠肺炎与呼吸道合胞病毒(RSV)感染的关联:一项多中心回顾性队列研究。
IF 6.1 3区 医学
Family Medicine and Community Health Pub Date : 2023-10-01 DOI: 10.1136/fmch-2023-002456
Lindsey Wang, Pamela B Davis, Nathan Berger, David C Kaelber, Nora Volkow, Rong Xu
{"title":"Association of COVID-19 with respiratory syncytial virus (RSV) infections in children aged 0-5 years in the USA in 2022: a multicentre retrospective cohort study.","authors":"Lindsey Wang, Pamela B Davis, Nathan Berger, David C Kaelber, Nora Volkow, Rong Xu","doi":"10.1136/fmch-2023-002456","DOIUrl":"10.1136/fmch-2023-002456","url":null,"abstract":"<p><strong>Objective: </strong>To investigate whether COVID-19 infection was associated with increased risk for incident respiratory syncytial virus (RSV) infections and associated diseases among young children that might have contributed to the 2022 surge of severe paediatric RSV cases in the USA.</p><p><strong>Design: </strong>This is a retrospective population-based cohort study. Five outcomes were examined, including overall RSV infection, positive lab test-confirmed RSV infection, clinically diagnosed RSV diseases, RSV-associated bronchiolitis and unspecified bronchiolitis. Risk ratio (RR) and 95% CI of the outcomes that occurred during the 2022 and 2021 RSV seasons were calculated by comparing propensity-score matched cohorts.</p><p><strong>Setting: </strong>Nationwide multicentre database of electronic health records (EHRs) of 61.4 million patients in the USA including 1.7 million children 0-5 years of age, which was accessed through TriNetX Analytics that provides web-based and secure access to patient EHR data from hospitals, primary care and specialty treatment providers.</p><p><strong>Participants: </strong>The study population consisted of 228 940 children of 0-5 years with no prior RSV infection who had medical encounters in October 2022. Findings were replicated in a separate study population of 370 919 children of 0-5 years with no prior RSV infection who had medical encounters in July 2021-August 2021 during a non-overlapping time period.</p><p><strong>Results: </strong>For the 2022 study population (average age 2.4 years, 46.8% girls, 61% white, 16% black), the risk for incident RSV infection during October 2022<b>-</b>December 2022 was 6.40% for children with prior COVID-19 infection, higher than 4.30% for the matched children without COVID-19 (RR 1.40, 95% CI 1.27 to 1.55); and among children aged 0<b>-</b>1 year, the overall risk was 7.90% for those with prior COVID-19 infection, higher than 5.64% for matched children without (RR 1.40, 95% CI 1.21 to 1.62). For the 2021 study population (average age 2.2 years, 46% girls, 57% white, 20% black), the risk for incident RSV infection during July 2021<b>-</b>December 2021 was 4.85% for children with prior COVID-19 infection, higher than 3.68% for the matched children without COVID-19 (RR 1.32, 95% CI 1.12 to 1.56); and 7.30% for children aged 0<b>-</b>1 year with prior COVID-19 infection, higher than 4.98% for matched children without (RR 1.47, 95% CI 1.18 to 1.82).</p><p><strong>Conclusion: </strong>COVID-19 was associated with a significantly increased risk for RSV infections among children aged 0-5 years in 2022. Similar findings were replicated for a study population of children aged 0-5 years in 2021. Our findings suggest that COVID-19 contributed to the 2022 surge of RSV cases in young children through the large buildup of COVID-19-infected children and the potential long-term adverse effects of COVID-19 on the immune and respiratory system.</p>","PeriodicalId":44590,"journal":{"name":"Family Medicine and Community Health","volume":null,"pages":null},"PeriodicalIF":6.1,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b2/27/fmch-2023-002456.PMC10582888.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41215451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Trustworthy evidence-based versus untrustworthy guidelines: detecting the difference. 值得信赖的循证指南与不值得信赖的指南:检测差异。
IF 6.1 3区 医学
Family Medicine and Community Health Pub Date : 2023-10-01 DOI: 10.1136/fmch-2023-002437
João Pedro Lima, Wimonchat Tangamornsuksan, Gordon H Guyatt
{"title":"Trustworthy evidence-based versus untrustworthy guidelines: detecting the difference.","authors":"João Pedro Lima,&nbsp;Wimonchat Tangamornsuksan,&nbsp;Gordon H Guyatt","doi":"10.1136/fmch-2023-002437","DOIUrl":"10.1136/fmch-2023-002437","url":null,"abstract":"<p><p>Guidelines are essential tools in healthcare decision-making. Trustworthy guidelines inform clinicians not only on the direction (against or in favour) and strength (strong or weak/conditional) of recommendations but also on the certainty of the underlying evidence. Developing trustworthy guidelines requires panellists with clinical and methodological expertise who consider patients' values and preferences. Adherence to trustworthiness standards remains variable; clinicians should, therefore, be able to distinguish trustworthy from untrustworthy guidelines. In this paper, we offer eight domains of disparities between trustworthy evidence-based guidelines and less trustworthy guidelines.</p>","PeriodicalId":44590,"journal":{"name":"Family Medicine and Community Health","volume":null,"pages":null},"PeriodicalIF":6.1,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c7/7d/fmch-2023-002437.PMC10565152.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41139475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Time trend and seasonality in medically attended respiratory syncytial virus (RSV) infections in US children aged 0-5 years, January 2010-January 2023. 2010年1月至2023年1月,美国0-5岁儿童的医学护理呼吸道合胞病毒(RSV)感染的时间趋势和季节性。
IF 6.1 3区 医学
Family Medicine and Community Health Pub Date : 2023-10-01 DOI: 10.1136/fmch-2023-002453
Lindsey Wang, Nathan Berger, Pamela B Davis, David C Kaelber, Nora Volkow, Rong Xu
{"title":"Time trend and seasonality in medically attended respiratory syncytial virus (RSV) infections in US children aged 0-5 years, January 2010-January 2023.","authors":"Lindsey Wang, Nathan Berger, Pamela B Davis, David C Kaelber, Nora Volkow, Rong Xu","doi":"10.1136/fmch-2023-002453","DOIUrl":"10.1136/fmch-2023-002453","url":null,"abstract":"<p><strong>Objective: </strong>The long-term time trend and seasonality variations of first-time medically attended respiratory syncytial virus (RSV) infections among young children are unknown. We aim to examine the time trend of medically attended first-time RSV infections among young children in the USA from January 2010 through January 2023.</p><p><strong>Design: </strong>This is a population-based cohort study using electronic health records (EHRs). Monthly incidence rate of medically attended first-time RSV infection (cases per 10 000 000 person-days). A time-series regression model was used to model and predict time trends and seasonality.</p><p><strong>Setting: </strong>Multicenter and nationwide TriNetX Network in the USA.</p><p><strong>Participants: </strong>The study population comprised children aged 0-5 years who had medical visits during the period of January 2010 to January 2023.</p><p><strong>Results: </strong>The data included 29 013 937 medical visits for children aged 0<b>-</b>5 years (46.5% girls and 53.5% boys) from January 2010 through January 2023. From 2010 through 2019, the monthly incidence rate of first-time medically attended RSV infection in children aged 0<b>-</b>5 years followed a consistent seasonal pattern. Seasonal patterns of medically attended RSV infections were significantly disrupted during the COVID-19 pandemic. In 2020, the seasonal variation disappeared with a peak incidence rate of 20 cases per 1 000 000 person-days, a decrease of 97.4% from the expected peak rate (rate ratio or RR: 0.026, 95% CI 0.017 to 0.040). In 2021, the seasonality returned but started 4 months earlier, lasted for 9 months, and peaked in August at a rate of 753 cases per 1 000 000 person-days, a decrease of 9.6% from the expected peak rate (RR: 0.90, 95% CI 0.82 to 0.99). In 2022, the seasonal pattern is similar to prepandemic years but reached a historically high rate of 2182 cases per 10 000 000 person-days in November, an increase of 143% from the expected peak rate (RR: 2.43, 95% CI 2.25 to 2.63). The time trend and seasonality of the EHR-based medically attended RSV infections are consistent with those of RSV-associated hospitalisations from the Centers for Disease Control and Prevention (CDC) survey-based surveillance system.</p><p><strong>Conclusion: </strong>The findings show the disrupted seasonality during the COVID-19 pandemic and a historically high surge of paediatric RSV cases that required medical attention in 2022. Our study demonstrates the potential of EHRs as a cost-effective alternative for real-time pathogen and syndromic surveillance of unexpected disease patterns including RSV infection.</p>","PeriodicalId":44590,"journal":{"name":"Family Medicine and Community Health","volume":null,"pages":null},"PeriodicalIF":6.1,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/09/ef/fmch-2023-002453.PMC10582996.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41239627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Priorities for research on family planning impact: recommendations of a WHO Think Tank meeting. 计划生育影响研究的优先事项:世界卫生组织智囊团会议的建议。
IF 6.1 3区 医学
Family Medicine and Community Health Pub Date : 2023-10-01 DOI: 10.1136/fmch-2023-002406
Moazzam Ali, James Kiarie, Iqbal Shah
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引用次数: 0
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