双胞胎研究是解决初级医疗机构癌症护理研究问题的一种创新方法。

IF 2.6 3区 医学 Q1 PRIMARY HEALTH CARE
Monalisha Sahu
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引用次数: 0

摘要

本文提出利用双生子研究作为一种新颖而强大的方法论,来调查与初级保健中的癌症预防、筛查、诊断、治疗和存活相关的关键研究问题。单卵双生(MZ)(同卵)双胞胎之间固有的遗传相似性为我们提供了一个独特的机会,可以将癌症相关结果的遗传和环境影响因素区分开来。MZ 双胞胎的遗传组成几乎完全相同,这为辨别遗传和环境因素对癌症相关结果的相对贡献提供了独特的机会。相比之下,异卵双胞胎(DZ)又称异卵双胞胎,由两个不同的精子受精而成,平均共享 50%的遗传物质,与非双胞胎兄弟姐妹的遗传相似程度相同。通过比较 MZ 双胞胎和 DZ 双胞胎,研究人员可以将遗传因素与共同的环境影响因素区分开来。这种方法有可能促进我们对癌症护理中遗传易感性、生活方式因素和医疗干预之间多方面相互作用的理解。本文概述了基于初级保健的癌症研究中双生子研究的原理、设计考虑因素和潜在应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Twin studies as an innovative approach to address research questions in cancer care within primary care settings.

This paper proposes the utilisation of twin studies as a novel and powerful methodological approach to investigate critical research questions pertaining to cancer prevention, screening, diagnosis, treatment and survivorship within primary care contexts. The inherent genetic similarity between monozygotic (MZ) (identical) twins provides a unique opportunity to disentangle genetic and environmental influences on cancer-related outcomes. MZ twins share virtually identical genetic makeup, offering a unique opportunity to discern the relative contributions of genetic and environmental factors to cancer-related outcomes. In contrast, dizygotic (DZ) twins, also known as fraternal twins, develop from two separate eggs fertilised by two different sperm and share on average 50% of their genetic material, the same level of genetic similarity found in non-twin siblings. Comparisons between MZ and DZ twins enable researchers to disentangle hereditary factors from shared environmental influences. This methodology has the potential to advance our understanding of the multifaceted interplay between genetic predisposition, lifestyle factors and healthcare interventions in the context of cancer care. This paper outlines the rationale, design considerations and potential applications of twin studies in primary care-based cancer research.

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来源期刊
CiteScore
9.70
自引率
0.00%
发文量
27
审稿时长
19 weeks
期刊介绍: Family Medicine and Community Health (FMCH) is a peer-reviewed, open-access journal focusing on the topics of family medicine, general practice and community health. FMCH strives to be a leading international journal that promotes ‘Health Care for All’ through disseminating novel knowledge and best practices in primary care, family medicine, and community health. FMCH publishes original research, review, methodology, commentary, reflection, and case-study from the lens of population health. FMCH’s Asian Focus section features reports of family medicine development in the Asia-pacific region. FMCH aims to be an exemplary forum for the timely communication of medical knowledge and skills with the goal of promoting improved health care through the practice of family and community-based medicine globally. FMCH aims to serve a diverse audience including researchers, educators, policymakers and leaders of family medicine and community health. We also aim to provide content relevant for researchers working on population health, epidemiology, public policy, disease control and management, preventative medicine and disease burden. FMCH does not impose any article processing charges (APC) or submission charges.
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