Middle East Journal of Cancer最新文献

{"title":"Impact of Cox2, CD163, and Microvessel Density Expression on the Prediction of Relapse and Patients’ Outcome in Classical Hodgkin Lymphoma","authors":"Rania Makboul, A. Refaiy, R. Mohamed, Alia M. A. Attia, Dalia Osama, Amany N El Emary, A. Ibrahim","doi":"10.30476/MEJC.2021.87421.1418","DOIUrl":"https://doi.org/10.30476/MEJC.2021.87421.1418","url":null,"abstract":"Background: Tumor microenvironment, specifically tumor-associated macrophages, plays an important role in tumor initiation and progression. CD163 has been recognized as a valuable specific macrophage marker. Cyclooxygenase-2 (Cox2) plays a role in tumor progression. CD31 is reliable for estimation of the density of microvesseles (MVD), which has prognostic importance in several malignant tumors. Thus, the current study was conducted to test the association between CD163, Cox2, and CD31 expression with the prognosis of classical Hodgkin lymphoma (cHL) patients and their potential correlation with clinicopathological variables. \u0000Method: CD163, Cox2, and CD31 expressions were examined in newly diagnosed patients with cHL through immunohistochemistry on tissue biopsy and the results were correlated with the patients’ outcome after the median follow-up, which was about 35 months. \u0000Results: 104 patients were included in this study. High CD163 was found in 32.7 % of the patients. Cox2 was positive in 42.3% of them. CD 31 with high MVD (≥10%) was found in 51% of the subjects. A significant association was detected between CD163 and Cox2 with tumor stage (P=0.001, and P= 0.001) and IPS score. Regarding CD31, we could not find any significant associations with disease parameters, except with histological subtype (P=0.001). A significant relationship was observed between Cox2 and CD163 expression and the relapse rate (P=0.001, P=0.01 respectively). Regarding survival, only Cox2 showed a significant association with disease-free survival (DFS) (P=0.0379). \u0000Conclusion: These findings suggested that Cox2 and CD163 expression can be used as predicator for early relapse and as new therapeutic targets in cHL.","PeriodicalId":44005,"journal":{"name":"Middle East Journal of Cancer","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2021-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49488878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinicopathological and Prognostic values of Gankyrin, Snail1, and IDH1 Expression in Renal Cell Carcinoma Patients","authors":"R. Kaf, O. Harb, Magid M. Ali, N. Salama, T. Baiomy, Marwa I Abdelgawad, L. Abdelaziz.","doi":"10.30476/MEJC.2021.86762.1370","DOIUrl":"https://doi.org/10.30476/MEJC.2021.86762.1370","url":null,"abstract":"Background: Gankyrin is an oncoprotein incriminated in cancer growth, invasion, and spread. Snail1 is associated with mesenchymal features acquisition that is related to invasion and metastasis of malignant cells. Isocitrate dehydrogenase 1(IDH1) has been found to be mutated in several cancers, which leads to altered cellular metabolism and tumorgenesis. The present study aimed to assess Gankyrin, Snail1, and IDH1 expression patterns and compare them to clinicopathological and prognostic parameters. \u0000Method: In our prospective cohort study, the samples taken from 60 RCC patients were processed, diagnosed, graded, staged, and subjected to immunohistochemistry for Gankyrin, Snail1, and IDH1. The patients were chosen, treated, and followed up from January 2015 to December 2019. Overall, the survival (OS) and progression-free survival (PFS) were assessed. \u0000Results: High expression levels of Gankyrin were positively associated with high grade (P=0.003), stage (P =0.033), and size of the tumor (P=0.049), in addition to lymph nodes metastasis (P =0.01), distant metastases (P=0.007), higher incidence of tumor progression, unfavorable 5-year progression-free survival, and overall survival rates (P<0.001). High expression levels of Snail1 were positively associated with high grade (P=0.004) and stage (P=0.023) of the tumors, on top of lymph nodes metastasis (P=0.003), distant metastases (P=0.002), higher incidence of tumor progression, poorer five-year progression-free survival, and overall survival rates (P<0.001). High expression levels of IDH1 were negatively associated with low grade (P = 0.002), stage, and size of the tumor and lymph nodes metastasis (P<0.001), distant metastases (P =0.041), lower incidence of tumor progression (P=0.013), better five-year progression-free survival, and overall survival rates (P<0.041). \u0000Conclusion: We indicated the associations between poor RCC pathological parameters, unfavorable patients’ outcome, high Gankyrin, high Snail1, and reduced IDH1 expression.","PeriodicalId":44005,"journal":{"name":"Middle East Journal of Cancer","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2021-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46781869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human Papillomavirus Status of Head and Neck Squamous Cell Carcinoma Patients and its Association with Expression of PIK3CA and CRNDE","authors":"Laleh Karimi Sani, Abbas Shakoori Garakani, S. Jafari, E. Razmpa","doi":"10.30476/MEJC.2021.84958.1247","DOIUrl":"https://doi.org/10.30476/MEJC.2021.84958.1247","url":null,"abstract":"Background: Human papillomavirus (HPV) positive head and neck squamous cell carcinoma (HNSCC) have distinctive molecular features. We conducted the present work to evaluate the HPV status of HNSCC patients and its association with expression of PIK3CA and CRNDE genes. Method: In the present case-control study, 50 fresh frozen tissue samples of HNSCC patients were collected from the patients referred to hospital for tumor removal. HPV typing was performed on DNA samples using a one-step polymerase chain reaction (PCR) followed by Reverse Line Blot method. Relative expression of PIK3CA and CRNDE genes was evaluated utilizing a real-time PCR method. Results: Out of 50 patients, 14 (28%) were HPV positive and the most prevalent type was HPV 16. Both PIK3CA and CRNDE genes were upregulated in tumoral tissues compared to adjacent non-cancerous tissues (ANCTs) (P=0.0322 and 0.0005, respectively). Based on the area under curve (AUC) values, the diagnostic power of CRNDE (AUC= 0.676) was higher than that of PIK3CA (AUC= 0.604). Finally, the expression level of PIK3CA was significantly associated with HPV+ HNSCC (P=0.01). Conclusion: We showed that the prevalence of HPV in HNSCC was within our local prevalence range. Moreover, the association of PIK3CA overexpression with HPV status implied distinctive molecular characteristics of HPV(+) HNSCC.","PeriodicalId":44005,"journal":{"name":"Middle East Journal of Cancer","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2021-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47917887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cancer and COVID-19: The Synergistic Burden on Mental Health Status of Patients with Cancer","authors":"M. Azizi, M. Kamali, E. Zaboli, F. Elyasi","doi":"10.30476/MEJC.2021.88707.1489","DOIUrl":"https://doi.org/10.30476/MEJC.2021.88707.1489","url":null,"abstract":"Dear Editor, Over the recent decades, there have been more than 30 emerging infectious diseases appeared as pandemics. 1 In December 2019, the outbreak of coronavirus disease 2019 (COVID-19) was initially observed in the city of Wuhan, China. 2, 3 COVID-19, the novel member of the coronavirus family, can cause acute respiratory diseases and death among infected individuals. 4 In this regard, the World Health Organization (WHO) declared this condition as a global major public health emergency. 2, 5, 6","PeriodicalId":44005,"journal":{"name":"Middle East Journal of Cancer","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2021-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49599914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Value of King's Score as a Predictor of Risk of Hepatocellular Carcinoma among Egyptian Patients with Hepatitis C Virus-Related Cirrhosis","authors":"A. Metwally, Amal A Jouda","doi":"10.30476/MEJC.2021.85341.1275","DOIUrl":"https://doi.org/10.30476/MEJC.2021.85341.1275","url":null,"abstract":"Background: Hepatocellular carcinoma (HCC) is the fifth most prevalent cancer and the second leading cause of cancer-related deaths worldwide. Egypt is one of the African countries with a high incidence of HCC. The process of carcinogenesis in the liver, particularly in post-hepatitic necrosis, is related to the severity of liver damage and fibrosis. The present study aimed to investigate the utility of King’s score to identify patients at higher risk of developing HCC among patients with hepatitis C virus-related cirrhosis. \u0000Method: 58 patients were included in this retrospective case-control study. They were divided into two groups; group I included 29 patients diagnosed with HCC and group II comprised 29 patients without HCC. King’s score was calculated for all the patients based on their pararmeters at the time of diagnosis and their records of one year prior to the diagnosis. \u0000Results: King’s score was significantly higher in group I, not only at the time of diagnosis (95.4±45.2 vs 24.23±7.4 P<0.001), but also when calculated from the patients’ records a year before the diagnosis (70.4±41.8 vs 17.46±8.2 P<0.001). \u0000Conclusion: King’s score can diagnose higher risk of developing HCC up to one year before the appearance of focal lesion.","PeriodicalId":44005,"journal":{"name":"Middle East Journal of Cancer","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2021-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45120655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Another Evidence of an Increasing Trend in the Incidence of Breast Cancer in Developing Countries over the Recent Years","authors":"R. Zahedi, H. Vardanjani, M. Baneshi, A. Haghdoost, R. M. Afshar, Farzaneh Zolala","doi":"10.30476/MEJC.2021.85250.1263","DOIUrl":"https://doi.org/10.30476/MEJC.2021.85250.1263","url":null,"abstract":"Background: We examined and estimated the trend of breast cancer incidence in Kerman, the largest province in Iran. \u0000Method: Having compiling the data of new cases from three sources (cancer registry, pathology, radiotherapy) in this longitudinal study, the number of untouched cases was estimated using log-linear model. We estimated the annual age-standardized rate (ASR) per 100 000 women in 2001-2015. We utilized joint point regression method to estimate the trend of breast cancer incidence during the examined years. \u0000Results: The ASR of breast cancer increased from 25 in 2001-2005 to 37 in 2011-2015, showing that the annual average percentage increased by 5.9% (95%Confidence Interval: 3.5, 8.4, P<0.001). Moreover, during this period, the completeness of the cancer registry increased from 16% in the first five years to 70% in the last five years. \u0000Conclusion: Our findings revealed that the coverage of the cancer registry increased significantly. It seems that part of the increasing trend of the reported cancer incidence was attributed to the enhancement of the cancer registry scheme, but our findings suggested that the real incidence of breast cancer had a growing trend.","PeriodicalId":44005,"journal":{"name":"Middle East Journal of Cancer","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2021-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43220974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sexual Experience of Iranian Women with Cancer: A Qualitative Content Analysis","authors":"S. Hosseini, Mahnaz Ilkhani, C. Rohani, A. Nasrabadi","doi":"10.30476/MEJC.2021.90027.1561","DOIUrl":"https://doi.org/10.30476/MEJC.2021.90027.1561","url":null,"abstract":"Background: Cancer diagnosis and treatments cause sexual dysfunction in patients. Sexual function is one of the most important aspects of quality of life. However, in previous studies, qualitative methods have been less accentuated to explore in to the sexual experiences and feelings of cancer patients. The aim of the present study was to investigate the experiences of Iranian women affected with cancer about their sexual quality of life. \u0000Method: A qualitative descriptive study with a conventional content analysis approach was performed on a targeted sample of 28 Iranian women with cancer from October 2018 to February 2020. Data were collected through face to face and in depth semi structured interviews until data saturation was attained. \u0000Results: Data analysis revealed four themes and eleven categories. The emerged themes were entitled: “Changing sexual capacity”, “physical consequences”, “sexual self-sacrifice” and “Changing woman’s identity”. \u0000Conclusion: Women with cancer experience many sexual problems such as reduced orgasm, lack of pleasure, and pain during sex. Due to the taboo of sexual issues, especially for women, many of them are embarrassed to ask their questions to the medical staff and for this reason, their problems will remain unresolved. The support of their spouses and the social can play an important role in facilitating coping. Health care providers have an important role in assessing and improving patients' quality of life. It is recommended to adopt strategies for appropriate interventions, education and counseling to improve sexual quality of life in cancer patients.","PeriodicalId":44005,"journal":{"name":"Middle East Journal of Cancer","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2021-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49606738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Towards Cancer Theory – Circadian and 11-Day Biological Clocks","authors":"Yuri B. Kirsta, Dmitry Y. Kirsta","doi":"10.30476/MEJC.2021.85055.1255","DOIUrl":"https://doi.org/10.30476/MEJC.2021.85055.1255","url":null,"abstract":"Background: In the current study, we used the information-hierarchical system approach to examine human metabolism. Metabolism hierarchical structure, beginning from enzyme level, is controlled by the established information principle and divine section numbers. This structure represents a key mechanism of the hierarchical biological clock (HBC) of human body. Time cycles of HBC hierarchical levels are nested into each other according to strict dynamics schemes. The cycles form the HBC scales of 1, 6, 42 seconds, 24 hours (circadian rhythm), and 11 days and jointly make up the precision HBC similar to the conventional countdown (1 s, 1 m, 1 hr, 1 day, and 1 month). \u0000Method: Diagnostic/prognostic studies of cancer require a detailed analysis of metabolic HBC disorders. We utilized the information-hierarchical system approach and the information principle in order to analyze HBC run under different dietary patterns. \u0000Results: We characterized hierarchical metabolic systems with 24-hour and 11-day operation times. The 24-hour circadian rhythm comprised citrate, pentose, and fatty acid (anabolic or catabolic) biochemical cycles individually. The 11-day cyclicity referred to these cycles combined into a ternary system of the higher-rank hierarchical level. Disorder of systems operation should lead to a radical change in HBC run with subsequent transformation of normal cells into cancer cells. \u0000Conclusion: Mutations of metabolic enzyme genes can damage HBC run, thereby leading to cancer and other chronobiological disorders. Organized rhythmicity of external factors (everyday food intake, 11-day periodical dietary pattern, and so forth) made it possible to heal cancer cells per se. Applying a particular kind of diet, the human lifespan could significantly increase. The proposed direction of cancer prevention and treatment can be called a cancer metabolism chronotherapy.","PeriodicalId":44005,"journal":{"name":"Middle East Journal of Cancer","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2021-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44275454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synchronous Hodgkin’s Lymphoma and Adenocarcinoma Lung with Metachronous Squamous Cell Carcinoma of Esophagus – A Rare Case Report","authors":"Aswin Nagarajan, G. Selvaluxmy, Ramya Ravichandar, S. Sundersingh","doi":"10.30476/MEJC.2021.85886.1314","DOIUrl":"https://doi.org/10.30476/MEJC.2021.85886.1314","url":null,"abstract":"The patients with multiple malignancies are difficult to diagnose as one malignancy may be indolent and usually diagnosed as an incidental finding, while proceeding with staging workup for the other malignancy. Treating such patients is even more difficult due to the issues related to sequencing the treatment for each of them. We report a case study where a patient was diagnosed with dual malignancies (Hodgkin’s lymphoma and adenocarcinoma lung) and was treated for both malignancies sequentially. The patient had five years of disease-free survival and was kept under follow-up. He was diagnosed with metachronous malignancy, squamous cell carcinoma of esophagus, and underwent treatment for the same condition.","PeriodicalId":44005,"journal":{"name":"Middle East Journal of Cancer","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2021-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46426404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of the Number of Fields on Radiotherapy Plans of Breast Cancer Patients in Three-Dimensionally Conformal Radiotherapy Plans: Dosimetric Studies","authors":"Zezy Mansour Bazeed, E. Attalla, I. Awad, M. Hamid, A. Sarhan","doi":"10.30476/MEJC.2021.85935.1316","DOIUrl":"https://doi.org/10.30476/MEJC.2021.85935.1316","url":null,"abstract":"Background: The objective of this study was to compare the dosimetric outcome of plans with more fields to those with fewer ones for breast cancer patients. Method: Twenty-three breast cancer patients were examined in this experimental study. Two groups of these patients were planned by treatment planning system. The number of beams was changed for each group, and the dosimetric parameters were calculated. The dose volume histogram (DVH) and the statistical analyses were performed for the two plans of all patients. Results: The DVH for the planning target volume (PTV) of the two techniques was estimated. Optimized plans were carried out to ensure that 95 % of the target volume takes 95 % of the dose. Based on the statistical analysis, the best coverage of dose had no relationship with the number of beams because the P-value of V105 %, V95 %,V110 %, D mean, D max, CI, HI, and D5% were 0.9537, 0.9152, 0.3446, 0.8156, 0.9516, 0.7888, 0.2127, and 0.7282, respectively. The Mean ±SEM for all PTV parameters was nearly the same. Also, the organ at risk had no significant difference after changing the number of beams, which means that the complication to normal tissue was nearly the same for both plans. Conclusion: The number of beams has no effect on PTV and normal tissue. Therefore, it is important for medical physicists to conduct the optimized plan without exceeding the number of beams to reduce the scattered radiation.","PeriodicalId":44005,"journal":{"name":"Middle East Journal of Cancer","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2021-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44348873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}