Tetrahedron Letters最新文献_第9页

Regio- and Stereoselective [3 + 2] cycloaddition of Isatogens with functionalized alkenes and its application to the synthesis of Halichrome A 功能化烯烃与异源物的区域和立体选择性[3 + 2]环加成及其在盐色胺A合成中的应用

IF 1.5 4区化学

Tetrahedron Letters Pub Date : 2025-04-26 DOI: 10.1016/j.tetlet.2025.155626

Nanaka Ishihara , Ryu Fukuoka , Shinji Harada , Kenzo Yamatsugu , Shigeru Arai

引用次数: 0

Design, synthesis and Aphicidal activity of novel Pentafluorophenyl erivatives against Brevicoryne brassicae 新型五氟苯衍生物的设计、合成及杀蚜活性研究

IF 1.5 4区化学

Tetrahedron Letters Pub Date : 2025-04-26 DOI: 10.1016/j.tetlet.2025.155605

Jiting Li , Feng Hao , Wenxuan Wu , Xiaoyan Zhou , Liyun Jiang , Huawen Wang , Kaida Li , Liang Deng , Le Cai

{"title":"Design, synthesis and Aphicidal activity of novel Pentafluorophenyl erivatives against Brevicoryne brassicae","authors":"Jiting Li , Feng Hao , Wenxuan Wu , Xiaoyan Zhou , Liyun Jiang , Huawen Wang , Kaida Li , Liang Deng , Le Cai","doi":"10.1016/j.tetlet.2025.155605","DOIUrl":"10.1016/j.tetlet.2025.155605","url":null,"abstract":"<div><div>As the global population increases, food security becomes an urgent concern, with pest infestations posing a major threat to agricultural productivity. <em>Brevicoryne brassicae</em>, a harmful pest to cruciferous crops, not only damages plants directly but also acts as a vector for plant viruses. Over-reliance on pesticides has led to the development of pest resistance, prompting the need for novel insecticides. This study explores the incorporation of the pentafluorobenzene fragment, known for its electron-withdrawing properties and stability, into agricultural chemical molecules to enhance their insecticidal efficacy and combat resistance. A new class of compounds, combining pentafluorobenzene with pyrrole, was synthesized and evaluated for aphicidal activity against cabbage aphids. The results show that <strong>SO</strong>-type compounds exhibit potent insecticidal activity, with compound <strong>SO-3</strong> outperforming imidacloprid in terms of aphid mortality and binding affinity to AChBP. Molecular docking analysis revealed that <strong>SO-3</strong> forms six hydrogen bonds with AChBP, which may contribute to its superior efficacy. Additionally, pharmacokinetic modeling of <strong>SO-3</strong> predicted favorable lipophilicity and promising oral bioavailability. These findings suggest that the pentafluorobenzene-containing compounds could provide a promising avenue for the development of more effective agrochemicals to address pest resistance and improve crop protection strategies.</div></div>","PeriodicalId":438,"journal":{"name":"Tetrahedron Letters","volume":"164 ","pages":"Article 155605"},"PeriodicalIF":1.5,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143942037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis of Oxazoline-spirocyclohexadienone via Electrochemical Dearomatization of Phenol Derivatives 苯酚衍生物电化学脱芳合成恶唑-螺环己二酮

IF 1.5 4区化学

Tetrahedron Letters Pub Date : 2025-04-25 DOI: 10.1016/j.tetlet.2025.155622

Long-Hao Zhu , Yuan-Zheng Cheng , Shu-Li You

引用次数: 0

Silver-catalyzed direct decarboxylative CH functionalization of azauracils with aliphatic carboxylic acids 银催化的杜鹃酸与脂肪羧酸直接脱羧甲基化反应

IF 1.5 4区化学

Tetrahedron Letters Pub Date : 2025-04-23 DOI: 10.1016/j.tetlet.2025.155619

Jie Zeng , Houwen Zhou , Shenghao Wang , Fenghua Zhang , Fei Li , Jingjing Wang , Lin Li , Tianbao Dong , Mingyue Cui , Feng Li

引用次数: 0

Erratum to ‘Mechanosynthesis of polysubstituted pyridines via FeBr3-catalyzed cascade reaction of arylidene isoxazolones with β-carbonyl esters’ [Tetrahedron Lett. 161 (2025) 155569] “二甲苯催化芳基异恶唑酮与β-羰基酯级联反应的机械合成多取代吡啶”[j] .四面体学报，161(2025):155569。

IF 1.5 4区化学

Tetrahedron Letters Pub Date : 2025-04-23 DOI: 10.1016/j.tetlet.2025.155607

Lei Wang, Ming-Jun Li, Qing-Hai Li, Peng Xu, Si-Qi Chen, Hui Xu, Ze Zhang

引用次数: 0

Innovative advancements in transition metal-catalyzed C(sp2)-H bond activation of phthalazinone: Unlocking the gateway to diverse hybrid polyheterocyclic architectures 过渡金属催化邻苯二嗪酮C(sp2)-H键活化的创新进展：打开多种杂化多杂环结构的大门

IF 1.5 4区化学

Tetrahedron Letters Pub Date : 2025-04-23 DOI: 10.1016/j.tetlet.2025.155618

Swarnali Ghosh , Anindita Sarkar , Rahul Dev Mandal , Asish R. Das

{"title":"Innovative advancements in transition metal-catalyzed C(sp2)-H bond activation of phthalazinone: Unlocking the gateway to diverse hybrid polyheterocyclic architectures","authors":"Swarnali Ghosh , Anindita Sarkar , Rahul Dev Mandal , Asish R. Das","doi":"10.1016/j.tetlet.2025.155618","DOIUrl":"10.1016/j.tetlet.2025.155618","url":null,"abstract":"<div><div>Phthalazinones, a fused diaza heterocycles have been recognized as remarkable structural leads in medicinal chemistry owing to its wider application in pharmaceutical and agrochemical industries. Moreover, having unique structural feature and potent biological activities, this scaffold allures the attention of synthetic chemists toward selective activation and functionalization of C<img>H bonds to synthesize its fused polycyclic frameworks. To attain this goal, transition-metal-catalyzed directing group-assisted inert Csp<sup>2</sup>-H functionalization has pooled up powerful strategies into modern chemistry toolbox in the last decade. The regioselective activation and annulation of C<img>H bonds are improving the synthetic approach and revolutionizing conventional cross-coupling techniques in current research. In this domain, the selective functionalization of C<img>H bonds in heteroarenes is primarily accomplished by Ru, Rh, Ir, and Pd metal complexes and their salts. This review primarily focuses on recent developments in the selective activation and functionalization of C<img>H bonds and the annulation of phthalazinones to synthesize their fused polycyclic frameworks. It explores their interactions with metal catalysts, along with various coupling partners such as amides, imides, ynones, vinylene carbonates, propargyl alcohols, alkenes, and alkynes which in turn led to the formation of different types of C<img>C and C<img>N bonds through selective C<img>H bond activation and subsequent annulation leading to pi-extended heterocycles.</div></div>","PeriodicalId":438,"journal":{"name":"Tetrahedron Letters","volume":"163 ","pages":"Article 155618"},"PeriodicalIF":1.5,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143917579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electrochemical synthesis of 2,5-disubstituted-1,3,4-thiadiazoles via oxidative cyclization of benzothiohydrazides and aldehydes catalyzed by tetra-n-butylammonium iodide 四正丁基碘化铵催化苯并噻唑和醛的氧化环化电化学合成2,5-二取代-1,3,4-噻二唑

IF 1.5 4区化学

Tetrahedron Letters Pub Date : 2025-04-21 DOI: 10.1016/j.tetlet.2025.155606

Kemparajegowda , Rajaghatta N. Suresh , Toreshettahally R. Swaroop , Muddegowda Umashankara , Kempegowda Mantelingu , Kanchugarakoppal S. Rangappa

引用次数: 0

Tamaru reaction-based approach towards the synthesis of muscone and analogues using renewable sources 基于Tamaru反应的可再生资源合成麝香酮及其类似物的方法

IF 1.5 4区化学

Tetrahedron Letters Pub Date : 2025-04-18 DOI: 10.1016/j.tetlet.2025.155593

Santosh J. Gharpure, Saidurga Prasad Kommyreddy

引用次数: 0

Stereoselective access to bioactive cyclopropanes (+)-PPCC and (1R,2S)-2-aminomethyl-1-arylcyclopropane-1-carboxamides from (−)-levoglucosenone 立体选择性地从（−）左旋葡萄糖酮中获得生物活性环丙烷(+)-PPCC和(1R,2S)-2-氨基甲基-1-芳基环丙烷-1-羧酰胺