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Cells of the Macrophage Lineage and their Role in the Pathogenesis of HIV-1 Infection: An Update 巨噬细胞谱系及其在HIV-1感染发病机制中的作用:最新进展
Medicinal Chemistry Reviews - Online Pub Date : 2004-06-30 DOI: 10.2174/1567203043401752
K. Kedzierska, Clare L V Maslin, S. Crowe
{"title":"Cells of the Macrophage Lineage and their Role in the Pathogenesis of HIV-1 Infection: An Update","authors":"K. Kedzierska, Clare L V Maslin, S. Crowe","doi":"10.2174/1567203043401752","DOIUrl":"https://doi.org/10.2174/1567203043401752","url":null,"abstract":"","PeriodicalId":438191,"journal":{"name":"Medicinal Chemistry Reviews - Online","volume":"74 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128377011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Tumor Necrosis Factor-a Blockade in Rheumatoid Arthritis: Responders Vs Non Responders 类风湿关节炎的肿瘤坏死因子-a阻断:有应答者Vs无应答者
Medicinal Chemistry Reviews - Online Pub Date : 2004-06-30 DOI: 10.2174/1567203043401770
Y. el-Miedany
{"title":"Tumor Necrosis Factor-a Blockade in Rheumatoid Arthritis: Responders Vs Non Responders","authors":"Y. el-Miedany","doi":"10.2174/1567203043401770","DOIUrl":"https://doi.org/10.2174/1567203043401770","url":null,"abstract":"","PeriodicalId":438191,"journal":{"name":"Medicinal Chemistry Reviews - Online","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128892820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Annexins in the Central Nervous System: Are they Neuroprotective or Proapoptotic Agents? 中枢神经系统中的膜联蛋白:它们是神经保护剂还是促凋亡剂?
Medicinal Chemistry Reviews - Online Pub Date : 2004-06-30 DOI: 10.2174/1567203043401798
J. Bandorowicz-Pikula
{"title":"Annexins in the Central Nervous System: Are they Neuroprotective or Proapoptotic Agents?","authors":"J. Bandorowicz-Pikula","doi":"10.2174/1567203043401798","DOIUrl":"https://doi.org/10.2174/1567203043401798","url":null,"abstract":"","PeriodicalId":438191,"journal":{"name":"Medicinal Chemistry Reviews - Online","volume":"72 1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129680042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Intriguing Classes of Acridine Derivatives as DNA-binding Antitumour Agents: From Pyrimido[5,6,1-de]acridines to Bis(acridine-4-carboxamides) 令人感兴趣的吖啶衍生物dna结合抗肿瘤药物:从嘧啶[5,6,1-de]吖啶到二(吖啶-4-羧酰胺)
Medicinal Chemistry Reviews - Online Pub Date : 2004-06-30 DOI: 10.2174/1567203043401851
I. Antonini
{"title":"Intriguing Classes of Acridine Derivatives as DNA-binding Antitumour Agents: From Pyrimido[5,6,1-de]acridines to Bis(acridine-4-carboxamides)","authors":"I. Antonini","doi":"10.2174/1567203043401851","DOIUrl":"https://doi.org/10.2174/1567203043401851","url":null,"abstract":"","PeriodicalId":438191,"journal":{"name":"Medicinal Chemistry Reviews - Online","volume":"96 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114972160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Differential Developmental Origin of Arteries: Impact on Angiogenesis and Arteriogenesis 动脉的不同发育起源:对血管生成和动脉生成的影响
Medicinal Chemistry Reviews - Online Pub Date : 2004-06-30 DOI: 10.2174/1567203043401725
J. Pelisek, M. Shimizu, S. Nikol
{"title":"Differential Developmental Origin of Arteries: Impact on Angiogenesis and Arteriogenesis","authors":"J. Pelisek, M. Shimizu, S. Nikol","doi":"10.2174/1567203043401725","DOIUrl":"https://doi.org/10.2174/1567203043401725","url":null,"abstract":"","PeriodicalId":438191,"journal":{"name":"Medicinal Chemistry Reviews - Online","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122280769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Temozolomide: An Update on Pharmacological Strategies to Increase its Antitumour Activity 替莫唑胺:增加其抗肿瘤活性的药理学策略的最新进展
Medicinal Chemistry Reviews - Online Pub Date : 2004-04-01 DOI: 10.2174/1567203043480287
L. Tentori, G. Graziani
{"title":"Temozolomide: An Update on Pharmacological Strategies to Increase its Antitumour Activity","authors":"L. Tentori, G. Graziani","doi":"10.2174/1567203043480287","DOIUrl":"https://doi.org/10.2174/1567203043480287","url":null,"abstract":"Temozolomide (TMZ) is a methylating agent with promising antitumour activity against primary or secondary \u0000brain tumours. Through the generation of a reactive intermediate, TMZ interacts with DNA at different base site positions, \u0000generating a wide spectrum of methyl adducts represented mainly by N-methylpurines (70%) while, at a lesser extent, by \u0000N3-methyladenine (9%) and O6-methylguanine (5%). The antitumour activity of TMZ has been primarily attributed to O6- \u0000methylguanine, since tumour cell sensitivity inversely correlates with the levels of O6-alkylguanine DNA alkyltransferase \u0000and requires an intact mismatch repair system. \u0000Even though the pharmacokinetics properties, favourable toxicity profile and antitumour activity against a broad range of \u0000tumour types render TMZ an attractive agent in oncology, resistance to the methylating agent occurs relatively often and \u0000strongly affects the rate and durability of clinical response in cancer patients. Thus, different strategies aimed at \u0000counteracting resistance and increasing the efficacy of TMZ have been designed and for many of them investigation is \u0000still underway. Herein, we provide an update on the latest findings of preclinical and clinical studies on TMZ in \u0000combination with resistance or biological modulators and anticancer drugs with different mechanisms of action.","PeriodicalId":438191,"journal":{"name":"Medicinal Chemistry Reviews - Online","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133802657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
β-Lactams as Inhibitors of Serine Enzymes: An Update β-内酰胺作为丝氨酸酶抑制剂的研究进展
Medicinal Chemistry Reviews - Online Pub Date : 2004-03-31 DOI: 10.2174/1567203043480322
M. Konaklieva
{"title":"β-Lactams as Inhibitors of Serine Enzymes: An Update","authors":"M. Konaklieva","doi":"10.2174/1567203043480322","DOIUrl":"https://doi.org/10.2174/1567203043480322","url":null,"abstract":"","PeriodicalId":438191,"journal":{"name":"Medicinal Chemistry Reviews - Online","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125088185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Metabolism of the Novel IMP Dehydrogenase Inhibitor Benzamide Riboside 新型IMP脱氢酶抑制剂苯甲酰胺核苷的代谢
Medicinal Chemistry Reviews - Online Pub Date : 2004-03-31 DOI: 10.2174/1567203043480269
W. Jäger, A. Salamon, T. Szekeres
{"title":"Metabolism of the Novel IMP Dehydrogenase Inhibitor Benzamide Riboside","authors":"W. Jäger, A. Salamon, T. Szekeres","doi":"10.2174/1567203043480269","DOIUrl":"https://doi.org/10.2174/1567203043480269","url":null,"abstract":"","PeriodicalId":438191,"journal":{"name":"Medicinal Chemistry Reviews - Online","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124899083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Macrolides as Immunomodulatory Agents: Review and Future Directions 大环内酯类免疫调节剂的研究进展及未来发展方向
Medicinal Chemistry Reviews - Online Pub Date : 2004-03-31 DOI: 10.2174/1567203043480296
P. Woo, S. Lau, K. Yuen
{"title":"Macrolides as Immunomodulatory Agents: Review and Future Directions","authors":"P. Woo, S. Lau, K. Yuen","doi":"10.2174/1567203043480296","DOIUrl":"https://doi.org/10.2174/1567203043480296","url":null,"abstract":"","PeriodicalId":438191,"journal":{"name":"Medicinal Chemistry Reviews - Online","volume":"141 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121620653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
5-Lipoxygenase: Regulation and Pharmacology 5-脂氧合酶:调控和药理学
Medicinal Chemistry Reviews - Online Pub Date : 2004-03-31 DOI: 10.2174/1567203043480331
O. Werz
{"title":"5-Lipoxygenase: Regulation and Pharmacology","authors":"O. Werz","doi":"10.2174/1567203043480331","DOIUrl":"https://doi.org/10.2174/1567203043480331","url":null,"abstract":"","PeriodicalId":438191,"journal":{"name":"Medicinal Chemistry Reviews - Online","volume":"95 6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129597070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
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