Medicinal Chemistry Reviews - Online最新文献

{"title":"An Overview of Immunotherapy for Allergic Disease: New Developments and Future Strategies","authors":"Susan Thornton","doi":"10.2174/1567203043480368","DOIUrl":"https://doi.org/10.2174/1567203043480368","url":null,"abstract":"","PeriodicalId":438191,"journal":{"name":"Medicinal Chemistry Reviews - Online","volume":"106 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121230917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Focus on Immunology of Trichinellosis","authors":"F. Bruschi","doi":"10.2174/1567203043480313","DOIUrl":"https://doi.org/10.2174/1567203043480313","url":null,"abstract":"","PeriodicalId":438191,"journal":{"name":"Medicinal Chemistry Reviews - Online","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115601377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel Concepts in the Development of Platinum Antitumour Drugs: An Update","authors":"M. Fuertes, J. Castilla, P. Nguewa, C. Alonso, J. Pérez","doi":"10.2174/1567203043480278","DOIUrl":"https://doi.org/10.2174/1567203043480278","url":null,"abstract":"","PeriodicalId":438191,"journal":{"name":"Medicinal Chemistry Reviews - Online","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126702663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Update on Management of Acute and Chronic Open Wounds: The Importance of Moist Environment in Optimal Wound Healing","authors":"Bishara S. Atiyeh and Shady N. Hayek","doi":"10.2174/1567203043480304","DOIUrl":"https://doi.org/10.2174/1567203043480304","url":null,"abstract":"","PeriodicalId":438191,"journal":{"name":"Medicinal Chemistry Reviews - Online","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131109956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-Infective Agents Produced by the Hyphomycetes Genera Trichoderma and Gliocladium","authors":"E. Ghisalberti","doi":"10.2174/1567203043401257","DOIUrl":"https://doi.org/10.2174/1567203043401257","url":null,"abstract":"","PeriodicalId":438191,"journal":{"name":"Medicinal Chemistry Reviews - Online","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2002-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121494351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scintigraphic Imaging of Inflammatory Processes","authors":"H. Rennen, O. Boerman, W. Oyen, F. Corstens","doi":"10.2174/1567203043480449","DOIUrl":"https://doi.org/10.2174/1567203043480449","url":null,"abstract":"Nuclear medicine offers ideal techniques to visualize inflammatory processes using noninvasive methods of whole-body scanning, enabling the determination of both the localization and the number of inflammatory foci. In nuclear medicine, a radiolabeled compound is injected (mostly) intravenously and accumulates in the inflammatory lesion due to the locally changed physiological condition. These changes are enhanced blood flow, enhanced vascular permeability and enhanced influx of leukocytes. Radiopharmaceuticals can be primarily divided into two classes: those accumulating in the inflammatory lesion based on non-specific processes and those accumulating in connection to leukocytes. Nonspecific tracers like Ga-citrate, radiolabeled non-specific immunoglobulins and radiolabeled liposomes are discussed in detail. Studies using specific tracers mainly focus on radiolabeling leukocytes, either directly or indirectly. Direct labeling of isolated leukocytes and reinjecting them is considered the “gold standard” nuclear medicine technique for imaging inflammation. Labeling leukocytes in vivo (the indirect approach) can be achieved by the use of radiolabeled antibodies or by compounds binding to leukocyte receptors with high affinity. At least three anti-granulocyte antibodies have been tested for infection imaging: anti-NCA-95 IgG (BW250/183), anti-NCA-90 Fab' (Immu-MN3, leukoscan®: anti-CD66), and anti-SSEA-1 IgM (LeuTech: anti-CD15). In addition, a w ide var iety of pe ptide s binding to le ukocyte re ceptors ha s be en inve stiga ted, e.g. chemota ctic pe ptide formylMe t-L eu-Phe, cytokines such as inte rleukin-1, inte rleukin-2, inte rleukin-8 and pla te let f actor 4 (deriva tives) a nd complement f ac tor s suc h as C5a. Furthermore, positron emission tomography with Ffluorodeoxyglucose takes advantage of the enhanced glucose requirements of leukocytes and macrophages in inflammatory foci. A totally different approach is to target directly micro-organisms, without intervention of leukocytes. This strategy is adopted in radiopharmaceuticals such as Infecton and antimicrobial peptides. The discussed radiopharmaceuticals enable accurate diagnosis of the inflammatory condition and with these agents the effectiveness of anti-inflammatory therapies can be monitored.","PeriodicalId":438191,"journal":{"name":"Medicinal Chemistry Reviews - Online","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2002-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129824705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxidative Stress Mechanisms and Potential Therapeutic Modalities in Alzheimer Disease","authors":"A. D. Cash, Mark A. Smith, George Perry","doi":"10.2174/1567203043480386","DOIUrl":"https://doi.org/10.2174/1567203043480386","url":null,"abstract":"","PeriodicalId":438191,"journal":{"name":"Medicinal Chemistry Reviews - Online","volume":"101 4 Pt 2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130316340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Update to Medicinal Chemistry of Nicotinamide in the Treatment of Ischemia and Reperfusion","authors":"J. Yang, K. Klaidman, J. Adams","doi":"10.2174/1567203043480403","DOIUrl":"https://doi.org/10.2174/1567203043480403","url":null,"abstract":"Nicotinamide and its analogs are currently being used or investigated for the treatment of ischemia reperfusion conditions. Nicorandil has been investigated for use in cardiac ischemia and reperfusion and is approved for use in Europe and Japan in angina. Nicotinamide has been extensively investigated in animal models of stroke, including middle cerebral artery occlusion and spontaneously hypertensive rats. Dose response curves and time response curves have been produced for nicotinamide in these models. Nicotinamide spares ATP by increasing NAD levels and protecting DNA from fragmentation. Inhibitors of poly(ADP-ribo se) polymerase, including nicotinamide, have been investigated in ischemia reperfusion conditions in other organs such as the testicles and liver. New evidence suggests that nicotinamide may have other mechanisms of action involving the regulation of cellular processes. allergic encephalomyelitis (4). PARP has also been shown to associate with and regulate the function of several transcription factors. Of special interest is the enhancement by PARP of nuclear factor kappa B-mediated transcription, which plays a central role in the expression of inflammatory cytokines, chemokines, adhesion molecules, and inflammatory mediators. Therefore, PARP inhibitors, such as nicotinamide may prove useful for the therapy of these diseases. Most of its effects have been shown in preclinical animal disease models.","PeriodicalId":438191,"journal":{"name":"Medicinal Chemistry Reviews - Online","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131322649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel Therapeutic Targets for Acute Pancreatitis and Associated Multiple Organ Dysfunction Syndrome: An Update","authors":"M. Bhatia","doi":"10.2174/1567203043480395","DOIUrl":"https://doi.org/10.2174/1567203043480395","url":null,"abstract":"","PeriodicalId":438191,"journal":{"name":"Medicinal Chemistry Reviews - Online","volume":"362 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133781300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Use of Auxiliary Agents to Improve the Mucosal Uptake of Peptides","authors":"A. Bernkop‐Schnürch, A. Clausen, D. Guggi","doi":"10.2174/1567203043480467","DOIUrl":"https://doi.org/10.2174/1567203043480467","url":null,"abstract":"","PeriodicalId":438191,"journal":{"name":"Medicinal Chemistry Reviews - Online","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126483411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}