发布求助
文献互助 智能选刊 最新文献

Medicinal Chemistry Reviews - Online最新文献

筛选
英文 中文
Neuronal Nicotinic Receptors and Neuroprotection: Newer Ligands May Help us Understand their Role in Neurodegeneration 神经元尼古丁受体和神经保护:新的配体可能帮助我们理解它们在神经变性中的作用
Medicinal Chemistry Reviews - Online Pub Date : 2005-12-01 DOI: 10.2174/156720305775009616
M. O'Neill, P. Astles, C. Dell, M. Keenan, T. Murray, V. Lakics, N. Visanji, S. Duty
{"title":"Neuronal Nicotinic Receptors and Neuroprotection: Newer Ligands May Help us Understand their Role in Neurodegeneration","authors":"M. O'Neill, P. Astles, C. Dell, M. Keenan, T. Murray, V. Lakics, N. Visanji, S. Duty","doi":"10.2174/156720305775009616","DOIUrl":"https://doi.org/10.2174/156720305775009616","url":null,"abstract":"","PeriodicalId":438191,"journal":{"name":"Medicinal Chemistry Reviews - Online","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131258873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Proteinases of Trypanosoma cruzi: Potential Targets for the Chemotherapy of Chagas Disease 克氏锥虫的蛋白酶:恰加斯病化疗的潜在靶点
Medicinal Chemistry Reviews - Online Pub Date : 2005-11-30 DOI: 10.2174/156720305775009625
J. Cazzulo
{"title":"Proteinases of Trypanosoma cruzi: Potential Targets for the Chemotherapy of Chagas Disease","authors":"J. Cazzulo","doi":"10.2174/156720305775009625","DOIUrl":"https://doi.org/10.2174/156720305775009625","url":null,"abstract":"Trypanosoma cruzi, the agent of the American Trypanosomiasis, Chagas Disease, contains cysteine, serine, threonine and metallo proteinases. Aspartic proteinases have not been found so far. The most abundant among these enzymes is cruzipain, a cysteine proteinase expressed as a complex mixture of isoforms by the major developmental stages of the parasite, including some membrane-bound isoforms. The enzyme is an immunodominant antigen in human chronic Chagas disease and seems to be important in the host/parasite relationship. Inhibitors of cruzipain kill the parasite and cure infected mice, thus making the enzyme a very promising target for the development of new drugs against Chagas disease. In addition 30 kDa cathepsin B-like enzymes have been described. Serine peptidases described in the parasite include oligopeptidase B, a member of the prolyl oligopeptidase family involved in Ca(2+)-signalling during mammalian cell invasion; a prolyl endopeptidase (Tc80), against which inhibitors are being developed, and a serine carboxypeptidase belonging to the S10 family. Metalloproteinases homologous to the gp63 of Leishmania spp. are also present. The proteasome has properties similar to those of other eukaryotes, and its inhibition by lactacystin blocks some differentiation steps in the life cycle of the parasite.","PeriodicalId":438191,"journal":{"name":"Medicinal Chemistry Reviews - Online","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115266382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 37
Cognition-Enhancing Drugs in Mild Cognitive Impairment (MCI) and Alzheimers Disease (AD): An Update [1] 轻度认知障碍(MCI)和阿尔茨海默病(AD)的认知增强药物:最新进展[1]
Medicinal Chemistry Reviews - Online Pub Date : 2005-11-30 DOI: 10.2174/156720305775009643
F. Gualtieri, L. Guandalini, D. Manetti, E. Martini, M. Romanelli
{"title":"Cognition-Enhancing Drugs in Mild Cognitive Impairment (MCI) and Alzheimers Disease (AD): An Update [1]","authors":"F. Gualtieri, L. Guandalini, D. Manetti, E. Martini, M. Romanelli","doi":"10.2174/156720305775009643","DOIUrl":"https://doi.org/10.2174/156720305775009643","url":null,"abstract":"","PeriodicalId":438191,"journal":{"name":"Medicinal Chemistry Reviews - Online","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130361939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Macrolide Resistance in Mycobacteria 分枝杆菌对大环内酯类药物的耐药性
Medicinal Chemistry Reviews - Online Pub Date : 2005-11-30 DOI: 10.2174/156720305775009634
F. Doucet-Populaire, K. Buriánková, J. Weiser, J. Pernodet
{"title":"Macrolide Resistance in Mycobacteria","authors":"F. Doucet-Populaire, K. Buriánková, J. Weiser, J. Pernodet","doi":"10.2174/156720305775009634","DOIUrl":"https://doi.org/10.2174/156720305775009634","url":null,"abstract":"","PeriodicalId":438191,"journal":{"name":"Medicinal Chemistry Reviews - Online","volume":"93 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126700270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Novel Agents in Anticancer Drug Therapy I (Antiangiogenic Agents, Egfr Inhibitors) 抗癌药物治疗中的新药物I(抗血管生成药物，Egfr抑制剂)
Medicinal Chemistry Reviews - Online Pub Date : 2005-11-30 DOI: 10.2174/156720305775009599
S. Eckhardt
{"title":"Novel Agents in Anticancer Drug Therapy I (Antiangiogenic Agents, Egfr Inhibitors)","authors":"S. Eckhardt","doi":"10.2174/156720305775009599","DOIUrl":"https://doi.org/10.2174/156720305775009599","url":null,"abstract":"","PeriodicalId":438191,"journal":{"name":"Medicinal Chemistry Reviews - Online","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131540287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Conformational Engineering of Lipases via Directed Immobilisation: Improving the Resolution of Chiral Drugs 定向固定化脂肪酶的构象工程:提高手性药物的分辨率
Medicinal Chemistry Reviews - Online Pub Date : 2005-10-01 DOI: 10.2174/156720305774330494
J. Palomo, G. Fernandez-Lorente, C. Ortiz, R. L. Segura, C. Mateo, M. Fuentes, J. Hermoso, R. F. Lafuente, J. Guisán
{"title":"Conformational Engineering of Lipases via Directed Immobilisation: Improving the Resolution of Chiral Drugs","authors":"J. Palomo, G. Fernandez-Lorente, C. Ortiz, R. L. Segura, C. Mateo, M. Fuentes, J. Hermoso, R. F. Lafuente, J. Guisán","doi":"10.2174/156720305774330494","DOIUrl":"https://doi.org/10.2174/156720305774330494","url":null,"abstract":"","PeriodicalId":438191,"journal":{"name":"Medicinal Chemistry Reviews - Online","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127875509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
The Molecular Targets of Anti-HIV-1 Triterpenes, An Update 抗hiv -1三萜分子靶点的研究进展
Medicinal Chemistry Reviews - Online Pub Date : 2005-09-30 DOI: 10.2174/156720305774330449
Li R. Huang, Chin-Ho Chen
{"title":"The Molecular Targets of Anti-HIV-1 Triterpenes, An Update","authors":"Li R. Huang, Chin-Ho Chen","doi":"10.2174/156720305774330449","DOIUrl":"https://doi.org/10.2174/156720305774330449","url":null,"abstract":"","PeriodicalId":438191,"journal":{"name":"Medicinal Chemistry Reviews - Online","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131656651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Trans-Platinum Complexes with Promising Antitumor Properties 具有良好抗肿瘤特性的反式铂配合物
Medicinal Chemistry Reviews - Online Pub Date : 2005-09-30 DOI: 10.2174/156720305774330476
S. Arandjelovic, Ž. Tešić, S. Radulović
{"title":"Trans-Platinum Complexes with Promising Antitumor Properties","authors":"S. Arandjelovic, Ž. Tešić, S. Radulović","doi":"10.2174/156720305774330476","DOIUrl":"https://doi.org/10.2174/156720305774330476","url":null,"abstract":"","PeriodicalId":438191,"journal":{"name":"Medicinal Chemistry Reviews - Online","volume":"70 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125243052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
New Immunosuppressants: Immunosuppression and Immunomodulation 新的免疫抑制剂:免疫抑制和免疫调节
Medicinal Chemistry Reviews - Online Pub Date : 2005-09-30 DOI: 10.2174/156720305774330467
A. Ma, J. Ouyang, Huifang Chen
{"title":"New Immunosuppressants: Immunosuppression and Immunomodulation","authors":"A. Ma, J. Ouyang, Huifang Chen","doi":"10.2174/156720305774330467","DOIUrl":"https://doi.org/10.2174/156720305774330467","url":null,"abstract":"","PeriodicalId":438191,"journal":{"name":"Medicinal Chemistry Reviews - Online","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133416424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Inhibition of Brain Phospholipase A2 by Antimalarial Drugs: Implications for Neuroprotection in Neurological Disorders 抗疟药物抑制脑磷脂酶A2:对神经系统疾病的神经保护意义
Medicinal Chemistry Reviews - Online Pub Date : 2005-09-30 DOI: 10.2174/156720305774330485
A. A. Farooqui, W. Ong, M. Go, L. Horrocks
{"title":"Inhibition of Brain Phospholipase A2 by Antimalarial Drugs: Implications for Neuroprotection in Neurological Disorders","authors":"A. A. Farooqui, W. Ong, M. Go, L. Horrocks","doi":"10.2174/156720305774330485","DOIUrl":"https://doi.org/10.2174/156720305774330485","url":null,"abstract":"","PeriodicalId":438191,"journal":{"name":"Medicinal Chemistry Reviews - Online","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132785745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：604180095
Book学术官方微信