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Unnatural Protein Engineering: Producing Proteins with Unnatural Amino Acids 非天然蛋白质工程:用非天然氨基酸生产蛋白质
Medicinal Chemistry Reviews - Online Pub Date : 2005-08-01 DOI: 10.2174/1567203054637542
T. Magliery
{"title":"Unnatural Protein Engineering: Producing Proteins with Unnatural Amino Acids","authors":"T. Magliery","doi":"10.2174/1567203054637542","DOIUrl":"https://doi.org/10.2174/1567203054637542","url":null,"abstract":"Less than a decade ago, the ability to generate proteins with unnatural modifications was a Herculean task available only to specialty labs. Recent advances make it possible to generate reasonable quantities of protein with un- natural amino acids both in vitro and in vivo . The combination of solid-phase peptide synthesis and enzymatic or che- moselective ligation now permits construction of entirely-synthetic proteins as large as 25 kD. Incorporation of recombi- nant fragments (expressed protein ligation) allows unnatural modifications near protein termini in proteins of virtually any size. Site-specific modification of small quantities of protein at any position can be achieved using chemically-acylated tRNA. Microelectroporation now extends this method to cells like mammalian neurons, and combination with RNA- display makes unnatural proteins compatible with combinatorial methods. Widespread or residue-speci fic methods of amino acid replacement are especially suitable for the production of biomaterials, and bacteria have been engineered to expand the repertoire of amino acids available for this technique. Excitingly, the wholesale addition of engineered tRNAs and synthetases to bacteria and yeast now makes site-specific incorporation of unnatural amino acids possible in living cells with no chemical intervention. Methods of expanding the genetic code at the nucleic acid level, including 4-base codons and unnatural base pairs, are becoming useful for the addition of multiple amino acids to the genetic code. These recent advances in unnatural protein engineering are reviewed with an eye toward future challenges, including methods of creating nonpeptidic molecules using templated synthesis.","PeriodicalId":438191,"journal":{"name":"Medicinal Chemistry Reviews - Online","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134005732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 19
Proteoglycan Involvement in Inflammatory Diseases. New Developments in GAG-Based Therapies 蛋白多糖与炎性疾病的关系。基于gag疗法的新进展
Medicinal Chemistry Reviews - Online Pub Date : 2005-07-31 DOI: 10.2174/1567203054637560
M. Delehedde, H. Lortat‐Jacob, J. Gallagher, D. Bonnaffé, E. Adam, O. Querolle, S. Lequien, Stéphane Degove, P. Lassalle, D. Béchard
{"title":"Proteoglycan Involvement in Inflammatory Diseases. New Developments in GAG-Based Therapies","authors":"M. Delehedde, H. Lortat‐Jacob, J. Gallagher, D. Bonnaffé, E. Adam, O. Querolle, S. Lequien, Stéphane Degove, P. Lassalle, D. Béchard","doi":"10.2174/1567203054637560","DOIUrl":"https://doi.org/10.2174/1567203054637560","url":null,"abstract":"","PeriodicalId":438191,"journal":{"name":"Medicinal Chemistry Reviews - Online","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125026120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Bifunctional Penicillin-Binding Proteins as an Antibacterial Target: Update on Enzymatic Properties and Cellular Functions 双功能青霉素结合蛋白作为抗菌靶点:酶特性和细胞功能的最新进展
Medicinal Chemistry Reviews - Online Pub Date : 2005-07-31 DOI: 10.2174/1567203054637597
A. D. Guilmi
{"title":"Bifunctional Penicillin-Binding Proteins as an Antibacterial Target: Update on Enzymatic Properties and Cellular Functions","authors":"A. D. Guilmi","doi":"10.2174/1567203054637597","DOIUrl":"https://doi.org/10.2174/1567203054637597","url":null,"abstract":"","PeriodicalId":438191,"journal":{"name":"Medicinal Chemistry Reviews - Online","volume":"90 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133954138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pandemic of Atopic Diseases - A Lack of Microbial Exposure in Early Infancy? 特应性疾病大流行-婴儿早期缺乏微生物暴露?
Medicinal Chemistry Reviews - Online Pub Date : 2005-07-31 DOI: 10.2174/1567203054637588
M. Kalliomaki
{"title":"Pandemic of Atopic Diseases - A Lack of Microbial Exposure in Early Infancy?","authors":"M. Kalliomaki","doi":"10.2174/1567203054637588","DOIUrl":"https://doi.org/10.2174/1567203054637588","url":null,"abstract":"","PeriodicalId":438191,"journal":{"name":"Medicinal Chemistry Reviews - Online","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129293581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
New insights about the potential application of the association of vitamins C (sodium ascorbate) and K3 (menadione) as auxiliary therapy in cancer treatment 关于维生素C(抗坏血酸钠)和K3(美萘醌)联合作为癌症辅助疗法潜在应用的新见解
Medicinal Chemistry Reviews - Online Pub Date : 2005-07-31 DOI: 10.2174/1567203054637551
J. Verrax, S. Bollen, M. Delvaux, H. Taper, P. Calderon
{"title":"New insights about the potential application of the association of vitamins C (sodium ascorbate) and K3 (menadione) as auxiliary therapy in cancer treatment","authors":"J. Verrax, S. Bollen, M. Delvaux, H. Taper, P. Calderon","doi":"10.2174/1567203054637551","DOIUrl":"https://doi.org/10.2174/1567203054637551","url":null,"abstract":"Cancer is characterized by cell cycle deregulation, progressive loss of cell differentiation and uncontrolled growth. Since cancer cells are particulary sensitive to oxidative stress, we took advantage of this poor antioxidant status to develop an experimental approach to selectively expose cancer cells to an oxidant insult induced by the association of vitamins C and K3 (CK3). The results we obtained reinforce the major role of oxidative stress as the main mechanism involved in cell killing by CK3, either under in vivo or in vitro conditions. such an antitumor activity has been attributed to redox cycling of the vitamins and the possible generation of peroxides and other reactive oxygen species. We report herein, on the ability of the association of ascorbate with several quinone derivatives (having differentredox potentials) to cause cell death. Finally, we determined that cell death by CK3 is not related to the activation of MAP kinases pathways.","PeriodicalId":438191,"journal":{"name":"Medicinal Chemistry Reviews - Online","volume":"216 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134241695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Regulating Cysteine Protease Activity: Essential Role of Protease Inhibitors as Guardians and Regulators 调节半胱氨酸蛋白酶活性:蛋白酶抑制剂作为监护人和调节剂的重要作用
Medicinal Chemistry Reviews - Online Pub Date : 2005-07-31 DOI: 10.2174/1567203054637524
B. Turk, D. Turk, G. Salvesen
{"title":"Regulating Cysteine Protease Activity: Essential Role of Protease Inhibitors as Guardians and Regulators","authors":"B. Turk, D. Turk, G. Salvesen","doi":"10.2174/1567203054637524","DOIUrl":"https://doi.org/10.2174/1567203054637524","url":null,"abstract":"","PeriodicalId":438191,"journal":{"name":"Medicinal Chemistry Reviews - Online","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125575990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 28
Conformational Changes Preceding Amyloid-Fibril Formation of Amyloid- Beta, Prion Protein and Stefin B; Parallels in pH Dependence 淀粉样蛋白- β、朊蛋白和stein B在淀粉样纤维形成前的构象变化pH依赖性的相似点
Medicinal Chemistry Reviews - Online Pub Date : 2005-07-31 DOI: 10.2174/1567203054637533
Y. Matsunaga, E. Žerovnik, Tatsuo Yamada, V. Turk
{"title":"Conformational Changes Preceding Amyloid-Fibril Formation of Amyloid- Beta, Prion Protein and Stefin B; Parallels in pH Dependence","authors":"Y. Matsunaga, E. Žerovnik, Tatsuo Yamada, V. Turk","doi":"10.2174/1567203054637533","DOIUrl":"https://doi.org/10.2174/1567203054637533","url":null,"abstract":"","PeriodicalId":438191,"journal":{"name":"Medicinal Chemistry Reviews - Online","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125849645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Acquired Carbapenem-Hydrolyzing β-Lactamases and their Genetic Support - An Update 获得性碳青霉烯水解β-内酰胺酶及其遗传支持-最新进展
Medicinal Chemistry Reviews - Online Pub Date : 2005-05-31 DOI: 10.2174/1567203054065664
L. Poirel, P. Nordmann
{"title":"Acquired Carbapenem-Hydrolyzing β-Lactamases and their Genetic Support - An Update","authors":"L. Poirel, P. Nordmann","doi":"10.2174/1567203054065664","DOIUrl":"https://doi.org/10.2174/1567203054065664","url":null,"abstract":"","PeriodicalId":438191,"journal":{"name":"Medicinal Chemistry Reviews - Online","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133670258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 31
Targeting DNA Associated Processes for Cancer Therapy by the Use of SELEX and Anti-gene Approaches - When Selection Meets Rational Design 利用SELEX和抗基因方法靶向癌症治疗的DNA相关过程-当选择符合理性设计时
Medicinal Chemistry Reviews - Online Pub Date : 2005-05-31 DOI: 10.2174/1567203054065646
P. Majumder, M. Faria, H. Ulrich
{"title":"Targeting DNA Associated Processes for Cancer Therapy by the Use of SELEX and Anti-gene Approaches - When Selection Meets Rational Design","authors":"P. Majumder, M. Faria, H. Ulrich","doi":"10.2174/1567203054065646","DOIUrl":"https://doi.org/10.2174/1567203054065646","url":null,"abstract":"In the multi-cause and multi-step diseases we globally refer to as cancer, often the same or redundant bio- chemical circuits are disrupted or uncoupled by the cumulative action of diverse mutation events. Anticancer agents have been extensively designed and selected by their ability to specifically interact with malignant cells by the targeting of proteins, mRNAs or DNA sequences involved in the production of a transformed phenotype. In the post-genomic age, the amount of available information concerning DNA increases the interest of the genome and associated proteins as drug tar- gets. The SELEX (Systematic Evolution of L igands by EX ponential enrichment) technique and Anti-gene strategy are both based on the production of high affinity ligands targeted to protein or nucleic acid counterparts, respectively. The dif- ferent rational backgrounds of SELEX and Anti-gene approaches might be the basis for a complementary action in anti- cancer therapy. Keyword: Aptamer, SELEX, anti-gene, triplex-forming molecules, cancer, epigenome targeting.","PeriodicalId":438191,"journal":{"name":"Medicinal Chemistry Reviews - Online","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115639529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Recent Advances in the Industrial Enzymatic Synthesis of Semi-Synthetic βLactam Antibiotics 半合成β内酰胺类抗生素的工业酶法合成研究进展
Medicinal Chemistry Reviews - Online Pub Date : 2005-05-31 DOI: 10.2174/1567203054065691
C. Mateo, O. Abián, V. Grazú, G. Fernandez-Lorente, J. Palomo, M. Fuentes, R. L. Segura, T. Montes, F. López‐Gallego, L. Wilson, R. Torres, J. Guisán, R. Fernández-Lafuente
{"title":"Recent Advances in the Industrial Enzymatic Synthesis of Semi-Synthetic βLactam Antibiotics","authors":"C. Mateo, O. Abián, V. Grazú, G. Fernandez-Lorente, J. Palomo, M. Fuentes, R. L. Segura, T. Montes, F. López‐Gallego, L. Wilson, R. Torres, J. Guisán, R. Fernández-Lafuente","doi":"10.2174/1567203054065691","DOIUrl":"https://doi.org/10.2174/1567203054065691","url":null,"abstract":"","PeriodicalId":438191,"journal":{"name":"Medicinal Chemistry Reviews - Online","volume":"96 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133241785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
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