Medicinal Chemistry Reviews - Online最新文献

{"title":"The Benzodiazepine Recognition Site on GABAA Receptors","authors":"E. Sigel","doi":"10.2174/1567203054065673","DOIUrl":"https://doi.org/10.2174/1567203054065673","url":null,"abstract":"","PeriodicalId":438191,"journal":{"name":"Medicinal Chemistry Reviews - Online","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121097173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review of the most important classes of serine protease inhibitors in insects and leeches","authors":"E. Clynen, L. Schoofs, M. Salzet","doi":"10.2174/1567203054065682","DOIUrl":"https://doi.org/10.2174/1567203054065682","url":null,"abstract":"The constant increase of life expectancy is associated with major aging of developed populations. This indicates that the new century will have one of most epidemic progressions of cardiovascular, cancer and inflammatory diseases. The high challenge for medical research is to compress such morbidity. Invertebrates have demonstrated to be truly useful models in drug discovery for such aging diseases. The last decade, drug discovery in leeches has opened the gate for new molecules to treat emphysema, coagulation, inflammation, dermatitis and cancer. Also other invertebrates, such as insects, harvest potential interesting molecules, such as serine protease inhibitors that can be exploited by the medical industry. In this review we discuss the most important classes of serine protease inhibitors in insects and leeches","PeriodicalId":438191,"journal":{"name":"Medicinal Chemistry Reviews - Online","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126370159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of Tumor Targeting Agents by Phage Display","authors":"V. Romanov","doi":"10.2174/1567203054065655","DOIUrl":"https://doi.org/10.2174/1567203054065655","url":null,"abstract":"","PeriodicalId":438191,"journal":{"name":"Medicinal Chemistry Reviews - Online","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133673223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Review of Current Drug Targets and Pharmacology of Antipsychotic Treatment","authors":"R. Conley, D. Kelly","doi":"10.2174/1567203054065709","DOIUrl":"https://doi.org/10.2174/1567203054065709","url":null,"abstract":"","PeriodicalId":438191,"journal":{"name":"Medicinal Chemistry Reviews - Online","volume":"169 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133152167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leishmania-Host Interplay: The Everlasting Rivalry","authors":"A. Martiny, M. Vannier-Santos","doi":"10.2174/1567203054065718","DOIUrl":"https://doi.org/10.2174/1567203054065718","url":null,"abstract":"Fundacao de Amparo a Pesquisa do Estado da \u0000Bahia (FAPESB), Conselho Nacional de Desenvolvimento \u0000Cientifico e Tecnologico (CNPq), Coordenacao de \u0000Aperfeicoamento de Pessoal de Nivel Superior (CAPES - \u0000PROCAD) and Fundacao Oswaldo Cruz (FIOCRUZ).","PeriodicalId":438191,"journal":{"name":"Medicinal Chemistry Reviews - Online","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115901759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evolving Phage Vectors for Cell Targeted Gene Delivery - An Update","authors":"D. Larocca, M. Burg, A. Baird","doi":"10.2174/1567203053587026","DOIUrl":"https://doi.org/10.2174/1567203053587026","url":null,"abstract":"","PeriodicalId":438191,"journal":{"name":"Medicinal Chemistry Reviews - Online","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127642268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Studies on Target Genes of General Anesthetics-Version 2","authors":"S. Gamo","doi":"10.2174/1567203053586982","DOIUrl":"https://doi.org/10.2174/1567203053586982","url":null,"abstract":"","PeriodicalId":438191,"journal":{"name":"Medicinal Chemistry Reviews - Online","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129466766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic implications of gene deletion of ligands and receptors of members of TNF superfamily","authors":"S. Shishodia, Y. Takada, B. Aggarwal","doi":"10.2174/1567203053587008","DOIUrl":"https://doi.org/10.2174/1567203053587008","url":null,"abstract":"","PeriodicalId":438191,"journal":{"name":"Medicinal Chemistry Reviews - Online","volume":"103 Suppl 1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133447218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent developments in the understanding and treatment of neurodegenerative disorders involving protein conformational misfolding and amyloid formation","authors":"A. Thompson, C. Barrow","doi":"10.2174/1567203053587035","DOIUrl":"https://doi.org/10.2174/1567203053587035","url":null,"abstract":"Conformational disease represents an intriguing but devastating class of neurodegenerative disorders that includes prion disease, Alzheimer’s disease, Parkinson’s disease and Huntington’s disease. Although symptoms, on-set times and prognosis among the diseases can vary markedly, the deposition of neurotoxic protein aggregates is a significant commonality, and as such is an attractive therapeutic target. Understanding the mechanisms of protein misfolding and deposition in these conditions is critical to developing effective diagnostic and therapeutic agents. This review serves as an update for the sister publication “Protein Conformational Misfolding and Amyloid Formation: Characteristics of a New Class of Disorders that Include Alzheimer’s and Prion Diseases” in Curr. Med. Chem. 2002, 9, 1751-62, and focuses primarily on recent developments in understanding prion disease and Alzheimer’s disease in context with other conformational disease. New research in amyloid-related therapeutic strategies is also discussed. INTRODUCTION Protein misfolding and amyloid formation occurs in a number of neurodegenerative disorders including but not limited to Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD) and prion diseases. Although the identity and nature of the aggregating protein and the mechanisms of aggregation and toxicity vary widely between the diseases, protein conformational change and subsequent aggregation are central to their pathology. This shared characteristic has led to the categorization of these diseases under the umbrella terms ‘conformational disease’ and ‘cerebral proteopathies’ [1]. These diseases have been more comprehensively reviewed previously [2]. This review serves as an update on recent advances in the field which have focused predominantly on Prion diseases and AD. Recent advances in amyloid-related therapeutic strategies are also presented, which can target specific diseases but may also have the potential for broader application in treating conformational diseases in general. RECENT ADVANCES IN UNDERSTANDING PRION DISEASES Numerous advances in the understanding of prion diseases have occurred over the last few years. Further understanding of the mechanism of conversion of PrP to PrP and the means of neurotoxicity and infectivity of PrP, has led to the development of first generation diagnostic tests for prions and new therapeutic strategies. Improved mechanistic models and therapeutic strategies for other amyloidgenic disorders such as Alzheimer’s disease have also increased the rate of progress in prion disease research. Most proteins and peptides can be made to form amyloid under appropriate environmental conditions. Proteins that form amyloid in the brain and cause neuronal damage include the amyloid-β (Aβ) peptide in AD, α-synuclein in Parkinson’s disease, the Huntingtin protein in Huntington’s disease, and PrP in prion diseases such as Creutzfeldt-Jakob’s disease (CJD) [2]. In these diseases a","PeriodicalId":438191,"journal":{"name":"Medicinal Chemistry Reviews - Online","volume":"118 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123244674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Vivo Methods to Estimate Drug Transport to the Brain Across the Blood-Brain Barrier","authors":"A. Boer, P. Gaillard","doi":"10.2174/1567203053586973","DOIUrl":"https://doi.org/10.2174/1567203053586973","url":null,"abstract":"","PeriodicalId":438191,"journal":{"name":"Medicinal Chemistry Reviews - Online","volume":"55 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132507346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}