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Recent Advances in Multidrug Resistance Modulators 多药耐药调节剂的最新进展
Medicinal Chemistry Reviews - Online Pub Date : 2004-09-30 DOI: 10.2174/1567203043401608
C. Avendaño, J. Menéndez
{"title":"Recent Advances in Multidrug Resistance Modulators","authors":"C. Avendaño, J. Menéndez","doi":"10.2174/1567203043401608","DOIUrl":"https://doi.org/10.2174/1567203043401608","url":null,"abstract":"Multidrug resistance (MDR) is a type of resistance to structurally unrelated chemotherapeutic drugs, and is one of the main obstacles in the chemotherapy of cancer, malaria and other diseases. In the case of cancer, its inhibition by combination of chemosensitizers with antitumor compounds continues to be a very active field of research, since the availability of safe and potent reversal agents would be very beneficial for clinical use. The discovery of new structures with MDR modulating properties is taking place at a fast pace, together with the clinical evaluation of the most promising of the previously known compounds. Most modulators act by binding to membrane transport proteins (specially P-gp and MRP) and inhibiting their drug-effluxing activity, but some of them act by indirect mechanisms, including inhibition of the expression of the mdr1 gene. General structure- activity studies of this therapeutic group are hampered by the very heterogeneous chemical structure of the compounds, although some conclusions regarding the location of binding domains of P-gp and the structural requirements for MDR reversal have been drawn recently.","PeriodicalId":438191,"journal":{"name":"Medicinal Chemistry Reviews - Online","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116507664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 28
Management of Osteoporosis: Seeing the Future 骨质疏松症的管理:展望未来
Medicinal Chemistry Reviews - Online Pub Date : 2004-09-30 DOI: 10.2174/1567203043401374
Y. Miedany
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引用次数: 0
Hydroxamic Acids as Pharmacological Agents: An Update 羟肟酸作为药物:最新进展
Medicinal Chemistry Reviews - Online Pub Date : 2004-09-30 DOI: 10.2174/1567203043401572
E. Muri, Marcelo J. Nieto, J. Williamson
{"title":"Hydroxamic Acids as Pharmacological Agents: An Update","authors":"E. Muri, Marcelo J. Nieto, J. Williamson","doi":"10.2174/1567203043401572","DOIUrl":"https://doi.org/10.2174/1567203043401572","url":null,"abstract":"","PeriodicalId":438191,"journal":{"name":"Medicinal Chemistry Reviews - Online","volume":"71 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121764001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Targeting Human Telomerase by Antisense Oligonucleotides and Ribozymes: An Update 利用反义寡核苷酸和核酶靶向人类端粒酶:最新进展
Medicinal Chemistry Reviews - Online Pub Date : 2004-09-30 DOI: 10.2174/1567203043401518
M. Folini, M. Pennati, N. Zaffaroni
{"title":"Targeting Human Telomerase by Antisense Oligonucleotides and Ribozymes: An Update","authors":"M. Folini, M. Pennati, N. Zaffaroni","doi":"10.2174/1567203043401518","DOIUrl":"https://doi.org/10.2174/1567203043401518","url":null,"abstract":"","PeriodicalId":438191,"journal":{"name":"Medicinal Chemistry Reviews - Online","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130682043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quantitative Structure-Activity Relationship Studies on Cholecystokin Antagonists 胆囊收缩素拮抗剂的定量构效关系研究
Medicinal Chemistry Reviews - Online Pub Date : 2004-07-01 DOI: 10.2174/1567203043401680
Satya P. Gupta, A. Nagappa
{"title":"Quantitative Structure-Activity Relationship Studies on Cholecystokin Antagonists","authors":"Satya P. Gupta, A. Nagappa","doi":"10.2174/1567203043401680","DOIUrl":"https://doi.org/10.2174/1567203043401680","url":null,"abstract":"","PeriodicalId":438191,"journal":{"name":"Medicinal Chemistry Reviews - Online","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117002174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Novel Molecular Targets for Systemic Lupus Erythematosus and Other Immune-Complex and T-Cell Mediated Autoimmune Diseases - Update 系统性红斑狼疮和其他免疫复合物和t细胞介导的自身免疫性疾病的新分子靶点-最新进展
Medicinal Chemistry Reviews - Online Pub Date : 2004-06-30 DOI: 10.2174/1567203043401707
M. Marino, G. Fassina
{"title":"Novel Molecular Targets for Systemic Lupus Erythematosus and Other Immune-Complex and T-Cell Mediated Autoimmune Diseases - Update","authors":"M. Marino, G. Fassina","doi":"10.2174/1567203043401707","DOIUrl":"https://doi.org/10.2174/1567203043401707","url":null,"abstract":"","PeriodicalId":438191,"journal":{"name":"Medicinal Chemistry Reviews - Online","volume":"155 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122774918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in Therapeutic Drug Monitoring of Atypical Antipsychotic Drugs 非典型抗精神病药物治疗药物监测研究进展
Medicinal Chemistry Reviews - Online Pub Date : 2004-06-30 DOI: 10.2174/1567203043401761
M. A. Raggi, R. Mandrioli, V. Pucci, C. Sabbioni
{"title":"Advances in Therapeutic Drug Monitoring of Atypical Antipsychotic Drugs","authors":"M. A. Raggi, R. Mandrioli, V. Pucci, C. Sabbioni","doi":"10.2174/1567203043401761","DOIUrl":"https://doi.org/10.2174/1567203043401761","url":null,"abstract":"","PeriodicalId":438191,"journal":{"name":"Medicinal Chemistry Reviews - Online","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132108728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
Chemotherapeutic Effects of Acridine Derivatives 吖啶衍生物的化疗作用
Medicinal Chemistry Reviews - Online Pub Date : 2004-06-30 DOI: 10.2174/1567203043401923
W. Denny
{"title":"Chemotherapeutic Effects of Acridine Derivatives","authors":"W. Denny","doi":"10.2174/1567203043401923","DOIUrl":"https://doi.org/10.2174/1567203043401923","url":null,"abstract":"","PeriodicalId":438191,"journal":{"name":"Medicinal Chemistry Reviews - Online","volume":"82 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122088292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 31
Induction of Tumour Cell Senescence: A New Strategy in Anticancer Treatment 诱导肿瘤细胞衰老:抗癌治疗的新策略
Medicinal Chemistry Reviews - Online Pub Date : 2004-06-30 DOI: 10.2174/1567203043401833
Xianghong Wang, Y. Wong
{"title":"Induction of Tumour Cell Senescence: A New Strategy in Anticancer Treatment","authors":"Xianghong Wang, Y. Wong","doi":"10.2174/1567203043401833","DOIUrl":"https://doi.org/10.2174/1567203043401833","url":null,"abstract":"","PeriodicalId":438191,"journal":{"name":"Medicinal Chemistry Reviews - Online","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127012033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Peroxisome Proliferator-Activated Receptors and the Control of Inflammation Update 过氧化物酶体增殖物激活受体与炎症控制最新进展
Medicinal Chemistry Reviews - Online Pub Date : 2004-06-30 DOI: 10.2174/1567203043401815
M. Carrera
{"title":"Peroxisome Proliferator-Activated Receptors and the Control of Inflammation Update","authors":"M. Carrera","doi":"10.2174/1567203043401815","DOIUrl":"https://doi.org/10.2174/1567203043401815","url":null,"abstract":"","PeriodicalId":438191,"journal":{"name":"Medicinal Chemistry Reviews - Online","volume":"175 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124479588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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