Journal of Reproductive Healthcare and Medicine最新文献_第3页

The genetically engineered vaccine against human chorionic gonadotropin enters Phase I/II clinical trials faces a problem, its possible resolution 人绒毛膜促性腺激素基因工程疫苗进入I/II期临床试验面临的问题及其可能的解决方案

Journal of Reproductive Healthcare and Medicine Pub Date : 2022-02-07 DOI: 10.25259/jrhm_31_2021

G. P. Talwar, R. Sehgal, M. Shrivastava, R. S. Sharma, J. C. Gupta, Satish K Gupta, K. Buckshee, Priyanka Pal, Kirti Nain, Sunesh Kumar

引用次数: 0

Intrauterine device translocation: Case series and management algorithm 宫内节育器移位:病例序列及管理算法

Journal of Reproductive Healthcare and Medicine Pub Date : 2022-02-07 DOI: 10.25259/jrhm_29_2021

H. Situmorang, Gabriella Argy, A. Putri, E. R. Gunardi

{"title":"Intrauterine device translocation: Case series and management algorithm","authors":"H. Situmorang, Gabriella Argy, A. Putri, E. R. Gunardi","doi":"10.25259/jrhm_29_2021","DOIUrl":"https://doi.org/10.25259/jrhm_29_2021","url":null,"abstract":"Intrauterine devices (IUDs) are the most commonly used long-term contraception due to their 98–99% effectiveness in preventing pregnancy. There are two types of IUD available in Indonesia, a copper-containing IUD and levonorgestrel-releasing IUD. IUD causes chronic inflammatory changes in the endometrium and fallopian tubes that inhibit fertilization and make a hostile environment for implantation. The increased number of endometrial leukocytes is fatal for sperm. In addition, levonorgestrel will inhibit ovulation. The use of an IUD is associated with side effects and complications. The most commonly met complications are IUD expulsion, displacement, translocation, and pregnancy. The average IUD translocation prevalence is 1.3/1000 which mainly occurs during insertion. Translocated IUD may further cause perforation of the bladder or intestines, intestinal obstruction, fistula formation, abscess, adhesion, undesired pregnancy, and chronic pelvic pain. Regardless of the type and location, the WHO recommends removal of the translocated IUD due to its potentially severe complications. Here, we present four cases of IUD translocation at Cipto Mangunkusumo National Hospital from 2020 to 2021, focusing on how to diagnose and the management to remove it.","PeriodicalId":434467,"journal":{"name":"Journal of Reproductive Healthcare and Medicine","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115243047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Pregnancy management in coronavirus disease – Challenges in developing countries 冠状病毒疾病中的妊娠管理——发展中国家面临的挑战

Journal of Reproductive Healthcare and Medicine Pub Date : 2021-07-19 DOI: 10.25259/JRHM_58_2020

N. Malhotra, R. Garg, S. Singh, P. Agrawal, J. Malhotra, N. Malhotra

引用次数: 0

Gender-based differences in coronavirus disease 2019: Hormonal influencers of severe acute respiratory syndrome coronavirus receptors and immune responses 2019冠状病毒病的性别差异:严重急性呼吸综合征冠状病毒受体和免疫反应的激素影响

Journal of Reproductive Healthcare and Medicine Pub Date : 2021-06-18 DOI: 10.25259/jrhm_10_2021

Rita Singh, Divya Mehul, Gordhan Singh, Rohit Kumar, Smita Bhatia

{"title":"Gender-based differences in coronavirus disease 2019: Hormonal influencers of severe acute respiratory syndrome coronavirus receptors and immune responses","authors":"Rita Singh, Divya Mehul, Gordhan Singh, Rohit Kumar, Smita Bhatia","doi":"10.25259/jrhm_10_2021","DOIUrl":"https://doi.org/10.25259/jrhm_10_2021","url":null,"abstract":"Coronavirus disease 2019 (COVID-19) became a pandemic due to a high rate of infection by the novel severe acute respiratory syndrome coronavirus (SARS-CoV-2). People with comorbidities such as cardiovascular diseases, Type II diabetes, and COPD have been having acute symptoms and higher rate of mortality. Further, increased severity and lethality of SARS-CoV-2 infection has been observed among men than in women. SARSCoV-2 infects human cells by binding to angiotensin-converting enzyme 2 (ACE2) through its spike protein (S-Protein). ACE2 is a critical transmembrane protein of the renin-angiotensin-aldosterone system which modulates the cardiovascular system and fluid homeostasis. This article reviews the current knowledge about the mechanisms of sex-based differences that may cause variations in COVID-19 susceptibility and outcomes among males and females. Males have been shown to have a delayed viral clearance due to increased retention of coronavirus as compared to females. Recent studies indicate that a severe infection with SARS-CoV-2 impairs spermatogenesis in males, however, the mechanisms by which SARS-CoV-2 damages testicular cells need more studies. We discuss here the distinctive features such as sex hormone milieu, receptor biology, and immunology that may be responsible for the gender-based differences in the outcome of COVID-19.","PeriodicalId":434467,"journal":{"name":"Journal of Reproductive Healthcare and Medicine","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129664943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Renin-angiotensin system: A possible clue for gender bias in coronavirus disease 2019 infection 肾素-血管紧张素系统:2019冠状病毒感染中性别偏见的可能线索

Journal of Reproductive Healthcare and Medicine Pub Date : 2021-02-22 DOI: 10.25259/JRHM_28_2020

Renjini A. Padmanabhan, M. Laloraya

{"title":"Renin-angiotensin system: A possible clue for gender bias in coronavirus disease 2019 infection","authors":"Renjini A. Padmanabhan, M. Laloraya","doi":"10.25259/JRHM_28_2020","DOIUrl":"https://doi.org/10.25259/JRHM_28_2020","url":null,"abstract":"The novel coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2), has been declared as a pandemic by WHO on March 11, 2020. Previous history of viral infections such as Middle East respiratory syndrome coronavirus (MERS-CoV) and SARS-CoV had shown high risk for maternal and neonates, with vertical transmission (VT) and perinatal as well as maternal mortality; hence, the possibility of the same cannot be ruled out in case of COVID-19. Authors’ literature survey on Scopus/Embase/ PubMed/Google using the terms “COVID-19* and pregnancy, VT, and gender difference in COVID-19 infection. All the relevant literatures were included in this review. Like other respiratory infections made by coronavirusesMERS-CoV and severe acute respiratory syndrome coronavirus 2 (SARS-CoV), the Viral spike of SARS-Cov-2 catches angiotensin converting enzyme 2 (ACE2) (a part of renin angiotensin system [RAS]) to enter the body. For those with risk factors, namely, cardiovascular complications, diabetes, and respiratory disorders, this entry is fatal We suggest that pregnancy is a well-orchestrated event capable of tackling COVID-19 infection by virtue of its hormone dependency which is capable of curbing the cytokine storm despite increased ACE2 expression. This review summarizes the gender bias of RAS; importance of RAS in pregnancy and sex hormonal influence on COVID-19 infection.","PeriodicalId":434467,"journal":{"name":"Journal of Reproductive Healthcare and Medicine","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117132513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sperm a cell in distress: Yoga to the rescue 精子细胞陷入困境:瑜伽拯救

Journal of Reproductive Healthcare and Medicine Pub Date : 2021-01-21 DOI: 10.25259/JRHM_8_2020

V. Dhawan, Rajeev Kumar, N. Malhotra, V. Dadhwal, D. Borthakur, R. Dada

{"title":"Sperm a cell in distress: Yoga to the rescue","authors":"V. Dhawan, Rajeev Kumar, N. Malhotra, V. Dadhwal, D. Borthakur, R. Dada","doi":"10.25259/JRHM_8_2020","DOIUrl":"https://doi.org/10.25259/JRHM_8_2020","url":null,"abstract":"Sperm, one of the complex cells of biological inheritance, are not only considered as mere vectors of transmission of paternal genome at the time of fertilization but also to events post-fertilization. The contribution of sperm molecular factors as a critical determinant of optimal embryonic development and pregnancy outcomes has been brought to surface. Spermatozoa with derangements in redox status, nuclear and mitochondrial genomic integrity, and dysregulated gene expression may affect the fertility status of the male and may result in impaired embryonic development and increase risk of genetic and epigenetic diseases in offspring. The integration of yoga-based lifestyle (YBL) as a part of the modern lifestyle has been found to be beneficial in the management of the derangements in the male reproductive functions in the distressing issue of infertility and early pregnancy loss (EPL) patients. As infertility and EPL are issues with a strong psychosomatic component, yoga a mind body intervention may be a useful adjunctive therapy in the management of these cases and may not only improve the sperm quality but also positively impact the reproductive potential, embryogenesis, and the health of the progeny. This short communication intends to highlight the importance of paternal factors as a causal factor for infertility, EPL, and also the promising role of integration of YBL in the management of such disorders.","PeriodicalId":434467,"journal":{"name":"Journal of Reproductive Healthcare and Medicine","volume":"55 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114855777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0