Journal of Dermatology & Dermatologic Surgery-JDDS最新文献

{"title":"Botulinum toxin: Non cosmetic and off-label dermatological uses","authors":"Ali S. Al-Ghamdi,&nbsp;Noah Alghanemy,&nbsp;Hanan Joharji,&nbsp;Dhafer Al-Qahtani,&nbsp;Hasan Alghamdi","doi":"10.1016/j.jdds.2014.06.002","DOIUrl":"10.1016/j.jdds.2014.06.002","url":null,"abstract":"<div><p>Botulinum toxin (BT-A) is a neurotoxin which is produced by the Gram-positive anaerobic bacterium <em>Clostridium botulinum</em>. The efficacy of Botulinum toxin in treating hyperhidrosis and the glabellar lines is well known and FDA approved.</p><p>Because BT-A inhibits the release of acetylcholine and many other neurotransmitters such as norepinephrine and substance P at the level of nerve ending, this toxin has been used to treat a lot of dermatological disorders which are thought to be triggered by these neurotransmitters.</p><p>In this article we are discussing the medical off-label uses of BT-A in dermatology.</p></div>","PeriodicalId":43409,"journal":{"name":"Journal of Dermatology & Dermatologic Surgery-JDDS","volume":"19 1","pages":"Pages 1-8"},"PeriodicalIF":0.4,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jdds.2014.06.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74323014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shaving area of unwanted hair before laser operation is useful in cosmetic procedure: A simulation study","authors":"Farhad H. Mustafa ,&nbsp;Mohamad S. Jaafar","doi":"10.1016/j.jssdds.2013.10.001","DOIUrl":"10.1016/j.jssdds.2013.10.001","url":null,"abstract":"<div><p>In laser dermatology applications, the process of photon absorption, the reflectance and the thermal energy diffusion in the target tissue and its surrounding tissue during laser irradiation is crucial. The aim of the study is to compare the changes of the optical power absorption per unit volume between shaving and non shaving hair on the skin surface and to demonstrate the effect of shaving of the skin surface on power absorption by Advanced System Analysis Program (ASAP) techniques. The method is performed to create hair on the skin surface and also by laser sources. Comparisons of optical power absorption have been performed between the samples of skin before and after shaving hair using the deviation and ratio of absorption power in each layer. Furthermore, the shape of Gaussian-profile in stratum corneum and epidermal layer has been compared, respectively. A power absorption of a laser increase in transmittance and decrease in diffuse reflectance occurred within a stratum corneum on the skin surface after applying shaved hair of skin. This indicates that the shaving of hair on the skin surface will have an effect on the efficacy of laser transmission as well as on the shape of the laser beam.</p></div>","PeriodicalId":43409,"journal":{"name":"Journal of Dermatology & Dermatologic Surgery-JDDS","volume":"19 1","pages":"Pages 36-42"},"PeriodicalIF":0.4,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jssdds.2013.10.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80782790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erythema Induratum of Bazin – Tuberculosis in disguise","authors":"Anuradha Kakkanatt Babu ,&nbsp;Prasad Krishnan ,&nbsp;Andezuth Divakaran Dharmaratnam","doi":"10.1016/j.jdds.2014.03.001","DOIUrl":"10.1016/j.jdds.2014.03.001","url":null,"abstract":"<div><p>Erythema Induratum of Bazin (EIB) is a tuberculid showing lobular panniculitis. EIB is classified under cutaneous tuberculosis. A diagnosis of EIB is based on cutaneous characteristics, a positive mantoux test, evidence of tuberculosis and histopathological findings. We present a case of a 43-year-old lady with recurrent crops of nodules on legs. Mantoux test was positive. Histopathology revealed lobular panniculitis, epithelioid cells, lymphocytes and giant cells surrounding foci of caseous necrosis which was suggestive of erythema induratum. Her lesions responded to antitubercular therapy (ATT).</p></div>","PeriodicalId":43409,"journal":{"name":"Journal of Dermatology & Dermatologic Surgery-JDDS","volume":"19 1","pages":"Pages 66-68"},"PeriodicalIF":0.4,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jdds.2014.03.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91387565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depression Over Psoriasis: Assessment of associated Relief by addition of ADalimumab for the treatment of Psoriasis: Observational study (DORADO - Ps)","authors":"Ayman Elgendi ,&nbsp;Hanan Nada ,&nbsp;Al Sadat Mosbeh ,&nbsp;Mona Maatouk ,&nbsp;Majdy Abulghany ,&nbsp;Wayne Gulliver","doi":"10.1016/j.jdds.2014.03.005","DOIUrl":"10.1016/j.jdds.2014.03.005","url":null,"abstract":"<div><h3>Background</h3><p>Psoriasis is associated with a variety of psychological difficulties, including poor self-esteem, sexual dysfunction, anxiety, depression, and suicidal ideation.</p></div><div><h3>Objectives</h3><p>The aim of this study was to obtain further data on the extent of depression among psoriatic patients, the effectiveness of adalimumab treatment on the depression symptoms associated with psoriasis and to explore the association between improvement in depression symptoms and improvement in Psoriasis Area and Severity Index.</p></div><div><h3>Methods</h3><p>The effects of adalimumab (40<!--> <!-->mg every other week) on ZDS score and PASI at week 24 were assessed. Relationships between ZDS and PASI were assessed. Changes in ZDS score were compared for patients with and without a 75% or greater reduction in baseline PASI score. An improvement of 6 points or more in the Zung depression scale was considered a clinically meaningful improvement.</p></div><div><h3>Results</h3><p>Forty five Patients with moderate to severe psoriasis were assessed for depression symptoms at baseline and week 24 using the Zung Self-rating Depression Scale (ZDS). At month 6 after starting adalimumab, 80% of enrolled patients achieved 75% improvement in their PASI score (PASI75) at month 6 of adalimumab therapy and 97.8% achieved a meaningful improvement of Zung depression score (more than 6 points decline in the Zung depression score). Age at time of assessment significantly predicted depression (<em>p</em> <!-->=<!--> <!-->0∗030), with the younger age predicting a higher depression score (standard co-efficient -.451). Achieving PASI 75 could significantly predict improvement in depression (<em>p</em> <!-->=<!--> <!-->0.002, standard coefficient-.746).</p></div><div><h3>Conclusion</h3><p>Adalimumab may be associated with relief symptoms of depression in patients with moderate to severe psoriasis. Reductions in depression symptoms were significantly correlated with reductions in psoriasis severity.</p></div>","PeriodicalId":43409,"journal":{"name":"Journal of Dermatology & Dermatologic Surgery-JDDS","volume":"19 1","pages":"Pages 15-20"},"PeriodicalIF":0.4,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jdds.2014.03.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82111833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Giant congenital melanocytic nevus with neurofibroma-like lesions and onset of vitiligo","authors":"Iman Hadj ,&nbsp;Mariam Meziane ,&nbsp;Taoufik Harmouch ,&nbsp;Fatima Zahra Mernissi","doi":"10.1016/j.jdds.2014.08.002","DOIUrl":"10.1016/j.jdds.2014.08.002","url":null,"abstract":"<div><p>Giant congenital pigmented nevus and neurofibromatosis type 1 may rarely occur together. We reported here an unusual case where giant congenital melanocytic nevus was associated with neurofibroma-like lesions and vitiligo, emphasizing the clinical and histological diagnostic difficulties posed by this presentation, the signification of vitiligo which can testify of a possible malignant transformation of the giant nevus to a melanoma, and highlights the importance of an accurate diagnosis and a close follow-up of such patients.</p></div>","PeriodicalId":43409,"journal":{"name":"Journal of Dermatology & Dermatologic Surgery-JDDS","volume":"19 1","pages":"Pages 58-61"},"PeriodicalIF":0.4,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jdds.2014.08.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85556902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and factors associated with telogen effluvium in adult females at Makkah region, Saudi Arabia: A retrospective study","authors":"M.I. Fatani ,&nbsp;A.M. Bin mahfoz ,&nbsp;A.H. Mahdi ,&nbsp;K.A. Alafif ,&nbsp;W.A. Hussain ,&nbsp;A.S. Khan ,&nbsp;A.A. Banjar","doi":"10.1016/j.jdds.2014.04.002","DOIUrl":"10.1016/j.jdds.2014.04.002","url":null,"abstract":"<div><h3>Background</h3><p>Data on the epidemiology of telogen effluvium (TE) are limited, and its true incidence is largely unknown. Our aim is to calculate the prevalence of TE and evaluate its comorbidities and its relation to iron-deficiency anemia.</p></div><div><h3>Methods</h3><p>We performed a retrospective review of 279 medical records of the patients with TE seen at Hera Hospital, Makkah, Saudi Arabia, between 2011 and 2013.</p></div><div><h3>Results</h3><p>Of 279 female patients (mean age: 29.82<!--> <!-->years), 58.5% of the patients were between the age of 21 and 40. Hypothyroidism was reported in 21.1% of the patients, dermatitis in 11.8%, diabetes mellitus in 5.7%, and bronchial asthma in 3.6%. Low hemoglobin was observed in 94.9% of the patients, low MCH in 99.6%, and low hematocrit in 90.21%. Serum ferritin was at ⩽30<!--> <!-->ng/mL in 64% of the patients and ⩽70<!--> <!-->ng/mL in 89.1%. The systemic treatment included the following: iron supplementation in 58.8%, folic acid in 51.3%, and zinc in 25.1%. Topical treatments included steroid in 63.1%, minoxidil in 34.8%, hair tonic in 68.8%, and antidandruff in 19.4%.</p></div><div><h3>Conclusions</h3><p>All patients were females, with most of their ages of onset between 21 and 40. It was commonly associated with iron-deficiency anemia and hypothyroidism.</p></div>","PeriodicalId":43409,"journal":{"name":"Journal of Dermatology & Dermatologic Surgery-JDDS","volume":"19 1","pages":"Pages 27-30"},"PeriodicalIF":0.4,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jdds.2014.04.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84981083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Slow growing Squamous cell carcinoma over the back masquerading a pigmented naevus clinically – A rare case report","authors":"Anil Sunkara,&nbsp;R. Venkatesh,&nbsp;V. Srinivasan","doi":"10.1016/j.jdds.2014.03.007","DOIUrl":"10.1016/j.jdds.2014.03.007","url":null,"abstract":"<div><h3>Introduction</h3><p>Slow growing pigmented squamous cell carcinoma is a rare entity. We present a 55<!--> <!-->year old female who presented with a pigmented naevus of long duration which was excised and proven a squamous cell carcinoma and followed up with no recurrence.</p></div><div><h3>Conclusion</h3><p>We would like to consider our case report to be alarming as the presentation was masquerading a benign lesion, and if overlooked may turn fatal both for the surgeon and the patient.</p></div>","PeriodicalId":43409,"journal":{"name":"Journal of Dermatology & Dermatologic Surgery-JDDS","volume":"19 1","pages":"Pages 43-44"},"PeriodicalIF":0.4,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jdds.2014.03.007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81598138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aquagenic Wrinkling of the Palms, two new cases from Saudi Arabia","authors":"Mohammed G. Turkmani ,&nbsp;Abdulaziz H. Al-Hussain","doi":"10.1016/j.jdds.2014.06.004","DOIUrl":"10.1016/j.jdds.2014.06.004","url":null,"abstract":"<div><p>Aquagenic Wrinkling of the Palms (AWP) is a rare dermatologic disease. It was first described four decades ago as a potential test for Cystic Fibrosis (CF) by detecting “skin wrinkling” in response to water immersion. We are reporting two cases of AWP diagnosed at Derma Clinic, Riyadh, Saudi Arabia. The first case was a 9-year old girl and the second case was a 17-year adolescent male. The second case was associated with palmer hyperhidrosis. Both patients denied any medication use. Additionally, signs and symptoms suggesting CF were lacking. Local dermatologists should be aware of rare conditions such as AWP and lack of previous reports from the region may indicate under-reporting rather than lack of cases.</p></div>","PeriodicalId":43409,"journal":{"name":"Journal of Dermatology & Dermatologic Surgery-JDDS","volume":"19 1","pages":"Pages 69-71"},"PeriodicalIF":0.4,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jdds.2014.06.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76854139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A clinicopathological study of cutaneous lichen planus","authors":"Asmita Parihar ,&nbsp;Sonal Sharma ,&nbsp;Sambit Nath Bhattacharya ,&nbsp;Usha Rani Singh","doi":"10.1016/j.jssdds.2013.12.003","DOIUrl":"10.1016/j.jssdds.2013.12.003","url":null,"abstract":"<div><h3>Background</h3><p>Lichen planus is an idiopathic subacute or chronic inflammatory disease of the skin, mucous membranes and nails. We studied the clinicopathological profile of lichen planus in Indian population.</p></div><div><h3>Methods</h3><p>A total of 145 cases of histologically diagnosed lichen planus samples were included. Clinical features like age, sex, type of lichen planus, location were recorded in the case record form. Histological features of lichen planus were studied.</p></div><div><h3>Results</h3><p>Out of 145 cases, majority (61%) were of classical lichen planus. Majority of cases were in the age group of 20–40<!--> <!-->years and showed female preponderance. Most commonly, violaceous lesions occurred in lichen planus, pigmented in lichen planus pigmentosus, and both violaceous and pigmented in lichen planopilaris.</p></div><div><h3>Conclusions</h3><p>In Indian population, common age of occurrence of lichen planus is lower as compared to western literature, and a large number of cases (28%) are in the paediatric age group (&lt;18<!--> <!-->years).</p></div>","PeriodicalId":43409,"journal":{"name":"Journal of Dermatology & Dermatologic Surgery-JDDS","volume":"19 1","pages":"Pages 21-26"},"PeriodicalIF":0.4,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jssdds.2013.12.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84012760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of mean platelet volume levels with severity of chronic urticaria","authors":"Samia Aleem,&nbsp;Qazi Masood,&nbsp;Iffat Hassan","doi":"10.1016/j.jdds.2014.03.006","DOIUrl":"10.1016/j.jdds.2014.03.006","url":null,"abstract":"<div><h3>Background</h3><p>Chronic urticaria (CU) is a multifactorial disease, however, in a majority of patients, it is not possible to ascribe a specific aetiology, which is termed ‘idiopathic’. Although autoimmunity has been implicated as a principal cause in 30–50% of these idiopathic cases, activation of coagulatory and inflammatory cascades has gained attention in last few years.</p></div><div><h3>Aims</h3><p>To evaluate levels of mean platelet volume, an indicator of platelet activity, in patients with chronic urticaria and determine its correlation with its severity.</p></div><div><h3>Methods</h3><p>Mean platelet volume levels were assessed in 194 patients with chronic urticaria and were compared with equal number of age and sex matched controls. Its levels were also correlated with the severity of urticaria and results of autologous serum skin test.</p></div><div><h3>Result</h3><p>Mean platelet volume (MPV) levels were found to be higher in patients with ASST positive chronic urticaria compared to patients with ASST negative chronic urticaria and controls. MPV levels also showed a positive correlation with the severity of chronic urticaria.</p></div><div><h3>Conclusion</h3><p>As platelets secrete and express a number of crucial mediators of coagulation and inflammation, coagulation and inflammatory cascades may play a positive role in chronic urticaria, paving the way for better understanding of pathogenesis and introduction of newer drugs.</p></div>","PeriodicalId":43409,"journal":{"name":"Journal of Dermatology & Dermatologic Surgery-JDDS","volume":"19 1","pages":"Pages 9-14"},"PeriodicalIF":0.4,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jdds.2014.03.006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73037937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}