Ali S. Al-Ghamdi, Noah Alghanemy, Hanan Joharji, Dhafer Al-Qahtani, Hasan Alghamdi
{"title":"肉毒杆菌毒素:非化妆品和标签外的皮肤病学用途","authors":"Ali S. Al-Ghamdi, Noah Alghanemy, Hanan Joharji, Dhafer Al-Qahtani, Hasan Alghamdi","doi":"10.1016/j.jdds.2014.06.002","DOIUrl":null,"url":null,"abstract":"<div><p>Botulinum toxin (BT-A) is a neurotoxin which is produced by the Gram-positive anaerobic bacterium <em>Clostridium botulinum</em>. The efficacy of Botulinum toxin in treating hyperhidrosis and the glabellar lines is well known and FDA approved.</p><p>Because BT-A inhibits the release of acetylcholine and many other neurotransmitters such as norepinephrine and substance P at the level of nerve ending, this toxin has been used to treat a lot of dermatological disorders which are thought to be triggered by these neurotransmitters.</p><p>In this article we are discussing the medical off-label uses of BT-A in dermatology.</p></div>","PeriodicalId":43409,"journal":{"name":"Journal of Dermatology & Dermatologic Surgery-JDDS","volume":"19 1","pages":"Pages 1-8"},"PeriodicalIF":0.2000,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jdds.2014.06.002","citationCount":"11","resultStr":"{\"title\":\"Botulinum toxin: Non cosmetic and off-label dermatological uses\",\"authors\":\"Ali S. Al-Ghamdi, Noah Alghanemy, Hanan Joharji, Dhafer Al-Qahtani, Hasan Alghamdi\",\"doi\":\"10.1016/j.jdds.2014.06.002\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Botulinum toxin (BT-A) is a neurotoxin which is produced by the Gram-positive anaerobic bacterium <em>Clostridium botulinum</em>. The efficacy of Botulinum toxin in treating hyperhidrosis and the glabellar lines is well known and FDA approved.</p><p>Because BT-A inhibits the release of acetylcholine and many other neurotransmitters such as norepinephrine and substance P at the level of nerve ending, this toxin has been used to treat a lot of dermatological disorders which are thought to be triggered by these neurotransmitters.</p><p>In this article we are discussing the medical off-label uses of BT-A in dermatology.</p></div>\",\"PeriodicalId\":43409,\"journal\":{\"name\":\"Journal of Dermatology & Dermatologic Surgery-JDDS\",\"volume\":\"19 1\",\"pages\":\"Pages 1-8\"},\"PeriodicalIF\":0.2000,\"publicationDate\":\"2015-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.jdds.2014.06.002\",\"citationCount\":\"11\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Dermatology & Dermatologic Surgery-JDDS\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2352241014000140\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"DERMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Dermatology & Dermatologic Surgery-JDDS","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2352241014000140","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"DERMATOLOGY","Score":null,"Total":0}
Botulinum toxin: Non cosmetic and off-label dermatological uses
Botulinum toxin (BT-A) is a neurotoxin which is produced by the Gram-positive anaerobic bacterium Clostridium botulinum. The efficacy of Botulinum toxin in treating hyperhidrosis and the glabellar lines is well known and FDA approved.
Because BT-A inhibits the release of acetylcholine and many other neurotransmitters such as norepinephrine and substance P at the level of nerve ending, this toxin has been used to treat a lot of dermatological disorders which are thought to be triggered by these neurotransmitters.
In this article we are discussing the medical off-label uses of BT-A in dermatology.
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