Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy最新文献

{"title":"Investigation of spatial distributions of components within a pyrite concretion through Raman imaging coupled with classical least squares method","authors":"Yaxuan Han ,&nbsp;Kazuya Shimooka ,&nbsp;Jiacheng Gao ,&nbsp;Meng-Wan Yeh ,&nbsp;Harumi Sato ,&nbsp;Yukihiro Ozaki ,&nbsp;Motohiro Tsuboi","doi":"10.1016/j.saa.2026.127512","DOIUrl":"10.1016/j.saa.2026.127512","url":null,"abstract":"<div><div>Raman imaging offers powerful capabilities for geoscience research; however, its quantitative application to mineral–organic interactions remains underdeveloped. Building upon the work of Kitanaka et al. (2024), who combined Raman imaging with chemometric analysis for concretion studies, this research advances the approach by coupling Raman imaging with the classical least squares (CLS) method to visualize the compositional distributions within a pyrite concretion from Taiwan. Standard Raman spectroscopic analysis identified quartz, anatase, pyrite, and well-preserved organic matter as the principal constituents. By applying the CLS algorithm to hyperspectral Raman datasets, the method enables semi-quantitative determination and spatial mapping of both mineral and organic components with high precision. The resulting CLS-based Raman images reveal distinct co-localization of pyrite and kerogen within microstructures resembling biogenetic textures. These spatial patterns provide direct visual evidence that supports bacterial sulfate reduction (BSR) as a key microbial process mediating concretion growth. This study demonstrates that integrating Raman imaging with CLS modeling not only enhances quantitative interpretation of complex mineral–organic assemblages but also provides new insights into the microbially influenced mineralization processes in sedimentary environments. The proposed approach establishes a robust framework for non-destructive, semi-quantitative, and spatially resolved characterization of geobiological materials.</div></div>","PeriodicalId":433,"journal":{"name":"Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy","volume":"352 ","pages":"Article 127512"},"PeriodicalIF":4.6,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146076351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction of a multidimensional quality evaluation system for Scutellariae Radix: Integrated research on chemical components, biological potency, near-infrared spectroscopy technology, and intelligent algorithms","authors":"Guiling Peng ,&nbsp;Qianqian Xue ,&nbsp;Huixin Liu ,&nbsp;Danni Chen ,&nbsp;Qiao Liu ,&nbsp;Siyao Zhang ,&nbsp;Tulin Lu ,&nbsp;Yuejun Wu ,&nbsp;Xian Zhang ,&nbsp;Fangzhou Yin","doi":"10.1016/j.saa.2026.127514","DOIUrl":"10.1016/j.saa.2026.127514","url":null,"abstract":"<div><div>Scutellariae Radix (SR), a traditional herbal medicine with significant medicinal value, is widely used worldwide. To address the quality differences caused by its various commercial specifications, processing methods, and provenances, a multi-dimensional quality evaluation system was established based on content, biological potency, and spectroscopy, compensating for the inadequacy of using baicalin as sole indicator for assessing SR quality. UHPLC-Q-TOF-MS/MS technology was employed to systematically identify the chemical profiles of SR and confirm differential components among multi-source samples. The varying distribution of flavone glycosides and their aglycones in the samples was identified as the primary reason for differences in commercial specifications and processing methods. Based on this, ten marker compounds with high content and significant bioactivity were selected for quantitative analysis using UHPLC-QqQ-MS/MS. Six components are proposed as the content markers for each sample category, with corresponding limits established. Additionally, the anti-inflammatory activity of the samples was evaluated through biological potency assays, and the potency significantly increased after SR processing. To achieve real-time and efficient detection, an innovative technology combined near-infrared spectroscopy (NIR) with intelligent algorithm was developed. After preprocessing with SG+ SNV + MSC, and selecting characteristic wavelengths by SPA, the GWO-SVM model achieved 100% accuracy in sample classification. Meanwhile, after sequential optimization, the PLSR model reliably predicting the concentration of active constituents and anti-inflammatory potency. This study has accomplished a shift in quality control of SR, moving from single-component quantitative analysis to comprehensive evaluation combining active ingredient detection and bioactivity assessment, while also advancing from precise measurement to rapid predictive methods.</div></div>","PeriodicalId":433,"journal":{"name":"Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy","volume":"352 ","pages":"Article 127514"},"PeriodicalIF":4.6,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146076493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Undoped zinc gallogermanate nanoparticles based persistent luminescence aptasensor for the determination of bisphenol A in aquatic products","authors":"Li-Wen Zhang ,&nbsp;Zhu-Ying Yan ,&nbsp;Xu Zhao ,&nbsp;Li-Xia Yan ,&nbsp;Li-Jian Chen ,&nbsp;Xiu-Ping Yan","doi":"10.1016/j.saa.2026.127553","DOIUrl":"10.1016/j.saa.2026.127553","url":null,"abstract":"<div><div>Bisphenol A (BPA) poses significant health risks, so its selective and sensitive determination in food is crucial. Here, we report a “turn-on” persistent luminescence aptasensor using undoped zinc gallogermanate nanoparticles (ZGGO) for selective and sensitive BPA determination in aquatic products. The sensor consists of a BPA-specific aptamer-grafted ZGGO (donor) hybridized with Cy3-labeled complementary DNA (cDNA-Cy3, acceptor). The persistent luminescence of the aptasensor is quenched via resonance energy transfer to the acceptor in the absence of BPA, and recovered in the presence of BPA due to the competitive binding of BPA with the aptamer to release cDNA-Cy3. This design effectively eliminates autofluorescence and background interference, enhancing sensitivity and selectivity. The aptasensor gives a wide linear range (1–1000 ng L⁻¹), low detection limit (0.27 ng L⁻¹), high selectivity, and good precision. Spike-recovery tests in fish samples yield the recovery of 85.2%–101.6%, proving its potential for monitoring BPA in complex food matrices.</div></div>","PeriodicalId":433,"journal":{"name":"Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy","volume":"352 ","pages":"Article 127553"},"PeriodicalIF":4.6,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146183858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Next-generation advanced surface plasmon resonance biosensor for dopamine detection with ZnO-ag multilayer design: Machine learning optimization for high sensitivity","authors":"Trupti Kamani ,&nbsp;Shobhit K. Patel ,&nbsp;Yogesh Sharma ,&nbsp;Fahad Ahmed Alzahrani","doi":"10.1016/j.saa.2026.127543","DOIUrl":"10.1016/j.saa.2026.127543","url":null,"abstract":"<div><div>The individual's physiological system needs to function effectively for a person to maintain life in good health. Deficiency of vitamins and minerals and a structured approach to life tend to trigger variations in the quantity of biological substances, which include hormonal substances, proteins, and neurotransmitters, and threaten the well-being of humans. The most common and the most fundamental catecholamine neurotransmitter present throughout the brain and nervous system is dopamine. The primary nervous system, kidneys, the hormone-sensitive, cardiac, and metabolic functions of humans have each been controlled by how much it is in the body's tissues. Consequently, it would be desirable to come up with an exceptionally sensitive, precise and productive approach that allows for a quick determination of Dopamine levels. Here, we have defined a novel design of Radial Petal-Loop Pattern Refractive Index Biosensor (RPLPRIB) for measurements of dopamine components like Dn1, Dn2, Dn3, Dn4, and Dn5, with refractive index values of 1.256, 1.267, 1.289, 1.291, and 1.309. This structure's petal rings possess a greater efficient area of surface for substrate binding, which enabled greater numbers of dopamine receptors for interaction at the same time, therefore reducing the limit of detection. The outcomes of the RPLPRIB show substantial sensitivity of 1666.66 nm/RIU, and substantial limits of detection 0.000190 RIU, for the concentrations of Dn5 and Dn3, respectively. The substantial quality factor values of 2077.66 and the sensor range value of 2108.78 RIU have been achieved for the concentration of Dn4. The machine learning approach also shows a substantial R-square value of 0.991156 with a low mean-square error. The defined idea represents suitable results that can perfectly help to determine dopamine.</div></div>","PeriodicalId":433,"journal":{"name":"Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy","volume":"352 ","pages":"Article 127543"},"PeriodicalIF":4.6,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146159650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A concentration detection model combining frequency-domain physical priors and deep learning: For SO2 and NO mixed gas under NH3 interference","authors":"Bo Peng ,&nbsp;Haiwang Liu ,&nbsp;Shuai Li ,&nbsp;Yong Zhou ,&nbsp;Mi Zhu ,&nbsp;Bingsheng Du ,&nbsp;Ningsheng Liao","doi":"10.1016/j.saa.2026.127513","DOIUrl":"10.1016/j.saa.2026.127513","url":null,"abstract":"<div><div>In the 200–230 nm ultraviolet wavelength range, there is a significant overlap in the absorption spectra of sulfur dioxide (SO₂), nitric oxide (NO), and ammonia (NH₃). This overlap significantly complicates the detection of SO₂ and NO concentrations. This study proposes a hybrid concentration detection model that combines frequency-domain physical priors with deep learning. Firstly, by utilizing characteristic differences among the three gases in the frequency domain, a band-pass filtering layer separates the frequency band of each target gas from the mixed spectrum. Secondly, we design a parallel dual-output network structure incorporating an efficient channel attention mechanism. Multi-branch feature extraction and an attention-weighting mechanism enhance the model's ability to extract key features. Latin hypercube sampling is employed to generate diverse concentration combinations, and fine-tuning strategies effectively bridge the distribution gap between synthesized and real data. Under the interference of NH₃, the detection limits of SO₂ and NO are 0.25 ppm and 0.26 ppm, respectively, with corresponding uncertainties of 1.25% and 1.30%. This study provides a novel and effective technical path for solving the problem of spectral interference in multi-component gas analysis.</div></div>","PeriodicalId":433,"journal":{"name":"Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy","volume":"352 ","pages":"Article 127513"},"PeriodicalIF":4.6,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146045223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spectroscopy of carotenoid oxidation and flavone derivatives in carrot raw material","authors":"S.H. Astanov ,&nbsp;S.U. Tursunov ,&nbsp;G.K. Kasimova ,&nbsp;A.B. Mukhamadova ,&nbsp;N. Razzokov ,&nbsp;A. Jumabaev","doi":"10.1016/j.saa.2026.127929","DOIUrl":"10.1016/j.saa.2026.127929","url":null,"abstract":"<div><div>The processes of complex formation between carotenoids (β-carotene and lutein) and molecular oxygen present in carrot raw materials, followed by the formation of [unclear text] were studied using spectral-quantum-chemical calculations. Complex formation was recorded using IR and Raman spectroscopy, as well as by analyzing the adsorption properties of the semi-finished carrot product. It was shown that the formation of a complex in the juice volume contributes to a change in its color from yellow to yellow-brown, which is due to the destruction of carotenoids. In order to preserve the color of the carrot juice volume, the authors proposed a number of methods for neutralizing the molecular oxygen present in the raw material. To preserve the original color and quality of carrot juice, methods for removing or limiting the access of molecular oxygen in the juice volume were proposed: juice crystallization followed by the removal of dissolved molecular oxygen. From the resulting products. In this case, it is possible to crystallize the juice followed by the removal of dissolved molecular oxygen from the juice volume. Sparging the juice with molecular nitrogen, which then displaces O₂ from the color pigments of the carrot product. This process prevents the oxidation of the color pigments.</div></div>","PeriodicalId":433,"journal":{"name":"Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy","volume":"360 ","pages":"Article 127929"},"PeriodicalIF":4.6,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147853165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis of a new acetylcholinesterase-activated curcumin-derived fluores cent probe for highly sensitive and sensitive detection of diazinon pesticide and its application in foodstuffs and biological systems","authors":"Xiaoya Yue,&nbsp;Xin Zhou,&nbsp;Zhiyuan Meng,&nbsp;Yueyin Liang,&nbsp;Yan Zhang,&nbsp;Xu Xu,&nbsp;Shifa Wang,&nbsp;Zhonglong Wang","doi":"10.1016/j.saa.2026.127499","DOIUrl":"10.1016/j.saa.2026.127499","url":null,"abstract":"<div><div>The extensive usage of diazinon in agriculture production has constituted a serious risk to food safety and public health. In this context, a new boron difluoride complex of curcumin was constructed as an effective enzyme-activatable fluorescent probe <strong>YPC</strong>. Acetylcholinesterase (AChE) is able to respond and break the unilateral ester bond on the dimethylcarbamate group of the probe <strong>YPC</strong>, which resulted in a significant enhancement effect orange fluorescence signal at 611 nm. Because diazinon has an obvious inhibitory effect on AChE activity, the fluorescence emission of probe <strong>YPC</strong> was quenched in the presence of diazinon, enabling it to be used as an excellent fluorescent platform for diazinon detection. More critically, the probe <strong>YPC</strong> has been successfully applied to the quantitative determination of trace residues of diazinon in agricultural product, and the determination results have high accuracy. Furthermore, the probe <strong>YPC</strong> could realize the detection of diazinon in living cells. Through this study, a novel detection technique will be established that can determine OPs residues in food and biological samples with high sensitivity and accuracy.</div></div>","PeriodicalId":433,"journal":{"name":"Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy","volume":"351 ","pages":"Article 127499"},"PeriodicalIF":4.6,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146069269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A “turn-off” fluorescent probe based on terbium doped Zn-MOF for sensitive detection of the food additives","authors":"Qinyi Zhang,&nbsp;Junyi Zhang,&nbsp;Jiaqi Liang,&nbsp;Changyan Sun","doi":"10.1016/j.saa.2026.127478","DOIUrl":"10.1016/j.saa.2026.127478","url":null,"abstract":"<div><div>The overconsumption of food additives butylated hydroxyanisole (BHA) and acesulfame K (AK) may cause health hazards. Therefore, it is urgent to develop sensitive detection methods for them in food safety surveillance. This study reports the synthesis of terbium doped metal-organic framework material (Tb³⁺@Zn-MOF), which serves as the first MOF-based fluorescent probe for detecting BHA and AK, with detection limits as low as 0.42 μM (BHA) and 78 nM (AK). The detection mechanism is attributed to synergistic effect of competitive absorption (BHA) and photo induced electron transfer(AK). Furthermore, the spiked recovery experiments in actual food matrices showed that the recovery range was from 99.4% to 100.5% (BHA) and 95.56% to 101.6% (AK)，indicating good accuracy and precision. Moreover, a reliable and portable platform for rapid on-site detection of BHA was fabricated by physically incorporating Tb³⁺@Zn-MOF into polyvinyl alcohol (PVA) matrix.</div></div>","PeriodicalId":433,"journal":{"name":"Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy","volume":"351 ","pages":"Article 127478"},"PeriodicalIF":4.6,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146004682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An hMAO-B-activatable mitochondrial binding fluorescent probe in live-cell via enzyme-anchored and charge-driven dual targeting","authors":"Siqi Li ,&nbsp;Lin Ma ,&nbsp;Rong Lin ,&nbsp;Xiongwang Li ,&nbsp;Xinyi Yao ,&nbsp;Yufei Hu ,&nbsp;Jia-Jia Lang ,&nbsp;Zhonghua Yuan ,&nbsp;Pengbing Mi","doi":"10.1016/j.saa.2026.127464","DOIUrl":"10.1016/j.saa.2026.127464","url":null,"abstract":"<div><div>Enzyme-responsive (ER) probes trageting human monoamine oxidase B (<em>h</em>MAO-B) represent pivotal tools for investigating a variety of diseases, including neurodegenerative pathologies, liver diseases, heart failure, metabolic disorders and cancers. Herein, we report <strong>THT-MTP</strong>—a thiochromone-based fluorescent probe exhibiting highly sensitivity and specificity for <em>h</em>MAO-B that undergoes <em>h</em>MAO-B-catalyzed oxidative conversion of its <strong>MTP</strong> moiety to <strong>MPy</strong>^{<strong>+</strong>}, along with &gt;100-fold fluorescence enhancement. Its activation mechanism was validated through safinamide-inhibition assays in both enzyme and cellular models. The <em>h</em>MAO-B-activatable imaging capability demonstrates intensity proportionality to enzyme levels across cell lines with differential MAO-B expression (HepG2 &gt; SH-SY5Y ≫ NIH-3T3). <strong>THT-MTP</strong> exhibited excellent mitochondrial accumulation via enzyme-anchored and charge-driven dual targeting. This work establishes a design paradigm for <em>h</em>MAO-B-selectvie probes combining high-precision subcellular targeting, activatable imaging capability and wash-free operation, offering a robust molecular tool for investigating <em>h</em>MAO-B-associated diseases.</div></div>","PeriodicalId":433,"journal":{"name":"Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy","volume":"351 ","pages":"Article 127464"},"PeriodicalIF":4.6,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145976116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progress of stimuli-responsive fluorescent materials with time-dependent optical properties for information anti-counterfeiting and encryption","authors":"Qi Zhang ,&nbsp;Guoxin Liu","doi":"10.1016/j.saa.2026.127476","DOIUrl":"10.1016/j.saa.2026.127476","url":null,"abstract":"<div><div>Information security and anti-counterfeiting technologies are facing increasingly severe challenges worldwide. Traditional static anti-counterfeiting methods, being relatively easy to replicate, are gradually becoming inadequate to meet high-end security demands. In recent years, time-dependent stimuli-responsive optical materials have emerged as a focus of research for next-generation anti-counterfeiting and encryption systems, owing to their dynamic and tunable optical behaviors as well as their capacity for encoding information in the time domain. These materials exhibit time-evolving optical properties—such as luminescence color, intensity, lifetime, or polarization state—in response to external stimuli like light, pH, or chemical environments, often demonstrating reversible relaxation or specific kinetic behaviors. Based on these materials, information anti-counterfeiting and encryption systems can only reveal authentic data within specific time windows and enable self-destruction of information, which significantly enhance anti-counterfeiting complexity and security. This review systematically summarizes recent advances in the design strategies, response mechanisms, and applications of such materials, covering systems including metal–organic frameworks (MOFs), perovskite nanocrystals, organic small molecules, carbon nanodots (CDs), and smart hydrogels. It highlights their application potential in multilevel encryption, dynamic information storage and self-erasing labels. The article also identifies current challenges, such as strong reliance on UV light, insufficient dynamic control precision, and biocompatibility issues. Finally, it outlines future research directions, including multimodal stimulus responses, AI-assisted design, organic–inorganic hybrid systems, and environmentally friendly materials, to promote the practical application of these technologies in high-security anti-counterfeiting and encryption systems.</div></div>","PeriodicalId":433,"journal":{"name":"Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy","volume":"351 ","pages":"Article 127476"},"PeriodicalIF":4.6,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146036110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}