Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy最新文献

{"title":"Stochastic resonance-based Raman spectroscopy denoising","authors":"Junqiang Liu,&nbsp;Jijun Tong","doi":"10.1016/j.saa.2025.126094","DOIUrl":"10.1016/j.saa.2025.126094","url":null,"abstract":"<div><div>Raman spectroscopy is a non-destructive technique that analyzes the vibrational modes and other properties of molecular systems by measuring scattered light from a laser. However, due to the short exposure time and low power of the excitation laser, Raman signals are often very weak, sometimes even weaker than the noise, making them prone to being overwhelmed by noise. This reduces sensitivity and classification accuracy, affecting practical applications.</div><div>Currently, traditional denoising methods face several challenges, primarily because their effectiveness heavily depends on manual parameter tuning, which is not beginner-friendly and adds complexity to using these methods. This study proposes an Adaptive Bistable Stochastic Resonance (ABSR) system, which enhances signals by utilizing noise energy and adjusts system parameters through a Particle Swarm Optimization (PSO) algorithm, eliminating the need for manual parameter tuning to achieve optimal signal enhancement.</div><div>In the experimental section, the denoising performance of the ABSR algorithm was systematically validated using simulated Raman spectra. The experimental results demonstrate that, compared to traditional methods such as Savitzky–Golay (SG) filtering, Gaussian filtering, Soft and Hard Threshold Wavelet Transform (SHTWT), Adaptive Savitzky–Golay (ASG), and Stein’s Unbiased Risk Estimate Wavelet Transform (SUREWT), the ABSR algorithm exhibits significant advantages in denoising effectiveness. Specifically, ABSR is more effective in preserving the detailed features of spectral signals while demonstrating superior performance in noise suppression. Besides, using Raman spectra from diabetic patients, ABSR showed significant improvements in SNR and RMSE, and performed better in classification algorithms like SVM, Random Forest, and Decision Trees. The ABSR method effectively enhances Raman spectral resolution, reduces laser exposure, and is simple to use, making it valuable for beginners in Raman spectroscopy research.</div></div>","PeriodicalId":433,"journal":{"name":"Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy","volume":"338 ","pages":"Article 126094"},"PeriodicalIF":4.3,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143784987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An acylaminoacyl-peptide hydrolase-activated fluorescent probe for ultrasensitive detection of pesticide residue","authors":"Le-Yu Huang ,&nbsp;Huiling Wang ,&nbsp;Yue-Yang Zhang ,&nbsp;Shi-Yu Liu","doi":"10.1016/j.saa.2025.126152","DOIUrl":"10.1016/j.saa.2025.126152","url":null,"abstract":"<div><div>Due to increasing threats to global public health and widespread environmental pollution issues caused by improper and excessive application of pesticides, the detection of pesticide residues is important in securing food safety and responding to public health. However, conventional methods for pesticide residues detection were usually labor- and time-consuming, making the acquisition of efficient tools for rapid and sensitive detection of pesticide residues an urgent need. Enzyme-targeted organic fluorescent probes, which displayed high simplicity and sensitivity, have shown great potential in enzyme inhibition-based pesticide residues detection and related bioimaging. Among these, fluorescent probes-based biosensors for pesticide targeted serine hydrolyses such as carboxylesterases and cholinesterases have been widely developed.</div><div>Acylaminoacyl-peptidase hydrolase (APEH), a serine hydrolase with typical α/β fold structure, is a promising protein target for pesticides such as organophosphorus (OPs) and carbamate. However, no fluorescent probe targeting APEH has been reported for pesticide detection or related research. To address this, an enzyme-activated fluorescent probe (named as <strong>RH-AcA</strong>) with high sensitivity (limit of detection = 3.7 mU/mL), binding affinity (<em>K</em>_m = 6.49 ± 0.29 μM) and high specificity toward APEH was constructed whilst inhibitory efficacy of different pesticides toward APEH in living cells and zebrafish was first visualized. Most importantly, APEH-inhibition-based pesticide residues detection was first achieved using <strong>RH-AcA</strong>, revealing significantly higher detection sensitivity toward OPs compared to esterase-based fluorescent probes This demonstrated APEH is a promising non-esterase target for enzyme-inhibition-based pesticide residues detection, and <strong>RH-AcA</strong> could serve as an ultrasensitive and practical tool for pesticides detection and related bioimaging.</div></div>","PeriodicalId":433,"journal":{"name":"Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy","volume":"338 ","pages":"Article 126152"},"PeriodicalIF":4.3,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143783160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual-functional carboxymethyl chitosan-coated silver nanoparticles for bacterial detection integrated with spectral processing and sterilization","authors":"Qingyi Wei ,&nbsp;Jingjun Chen ,&nbsp;Jingxiao Yu ,&nbsp;Hongbin Pu","doi":"10.1016/j.saa.2025.126171","DOIUrl":"10.1016/j.saa.2025.126171","url":null,"abstract":"<div><div>The development of a dual-functional nanomaterial integrating microbial detection and sterilization capabilities are of great significance for advancing food safety applications. In this work, we synthesized carboxymethyl chitosan coated with spherical silver nanoparticles (CMCS@Ag NPs). CMCS@Ag NPs exhibited improved stability of surface-enhanced Raman scattering (SERS) signals compared to single silver nanoparticles in the detection of three strains including <em>E. coli</em>, <em>S. aureus</em> and <em>S. putrefaciens</em>. Through deuterium isotope labelling, metabolically active bacterial cells produced characteristic carbon-deuterium (C–D) vibrational signatures detectable by Raman spectroscopy. The spectral overlap between C-D and C–H stretching modes showed concentration-dependent linear responses, achieving a detection sensitivity of 0.64 CFU/mL for <em>E. coli</em>. Meanwhile, different combinations of algorithm were used to pretreatment with the raw Raman spectra, among that adaptive iterative reweighting punishment least square method and moving average smoothing (air-PLS + MAS) sensitively obtain better preprocessing accuracy of the three strains. Principal component analysis (PCA) was used to extract characteristic peaks from pretreatment spectra to successfully discriminate the three microorganisms. Furthermore, CMCS@Ag NPs incubated with phosphate-buffered saline (pH ∼ 5.8) exhibited potent antibacterial activity, achieving 99 % reduction in viability for <em>E. coli</em>, <em>S. aureus</em> and <em>S. putrefaciens</em> at a concentration of <span><math><mrow><mn>5</mn><mo>×</mo><msup><mrow><mn>10</mn></mrow><mn>7</mn></msup></mrow></math></span> CFU/mL within 45 min. This work presents a versatile nanomaterial-based strategy for simultaneous pathogen detection and inhibition.</div></div>","PeriodicalId":433,"journal":{"name":"Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy","volume":"338 ","pages":"Article 126171"},"PeriodicalIF":4.3,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143785159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Imidazo-phenanthroline based ratiometric optical sensing platform for cyanide and fluoride ions","authors":"Nidhi Goswami ,&nbsp;Sudhanshu Naithani ,&nbsp;Jimmy Mangalam ,&nbsp;Vikas Yadav ,&nbsp;Saakshi Saini ,&nbsp;Partha Roy ,&nbsp;Tapas Goswami ,&nbsp;Sushil Kumar","doi":"10.1016/j.saa.2025.126123","DOIUrl":"10.1016/j.saa.2025.126123","url":null,"abstract":"<div><div>The severe toxicity and widespread distribution of fluoride (F⁻) and cyanide (CN⁻) ions in various environmental matrices highlight the urgent need for their efficient and reliable detection methods. In this study, we present a fluorogenic imidazo-phenanthroline based probe (<strong>L</strong>) for selective detection of F⁻ and CN⁻ in semi-aqueous medium. Probe <strong>L</strong> exhibits a pronounced ratiometric fluorescence response upon interaction with these anions, driven by hydrogen bonding interaction involving the N–H group of the imidazole moiety. Notably, <strong>L</strong> enables clear discrimination of CN⁻ from other anions through a distinct color change, with an impressive detection limit in the nanomolar (nM) range. To enhance its practical applicability, paper-based sensing strips embedded with <strong>L</strong> were developed, effectively detecting CN⁻ and F⁻ under UV light illumination. The probe’s exceptional sensitivity and selectivity could be attributed to the strong acidity of the N–H proton, facilitating efficient hydrogen bonding interactions followed by deprotonation. The binding mechanism was thoroughly investigated using Job’s plot, NMR, and DFT analyses. Additionally, <strong>L</strong> demonstrated versatility in environmental and biological applications, successfully detecting cyanide and fluoride ions in soil samples and identifying F⁻ in live MCF-7 cell lines <em>via</em> blue fluorescence channel imaging.</div></div>","PeriodicalId":433,"journal":{"name":"Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy","volume":"338 ","pages":"Article 126123"},"PeriodicalIF":4.3,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143784985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection of green pepper impurities based on hyperspectral imaging technology","authors":"Jian Zhang ,&nbsp;Lingkai Ma ,&nbsp;Yujiang Gou ,&nbsp;Weihai Xia ,&nbsp;Xiangyu Chang ,&nbsp;Haijun Liu ,&nbsp;Ting An","doi":"10.1016/j.saa.2025.126170","DOIUrl":"10.1016/j.saa.2025.126170","url":null,"abstract":"<div><div>To date, the intelligent assessment of green pepper quality remains an open question, particularly in aspects of color, as impurities closely resemble green peppers. Here, the hyperspectral imaging technology was employed to acquire the original spectral and image information of green and impurities. Subsequently, the original information was processed, and then trained using the super vector machine (SVM), to construct the green pepper impurity detection model. After training, the constructed model achieved 100% accuracy in the training set and 89.7% accuracy in the testing set, which generally met the application requirements. Visualization images of the constructed model in the application of identification green pepper impurity were prepared and optimized, which significantly achieved relatively satisfactory outcomes. Findings of this case study revealed that the presented strategy would provide a theoretical basis for the intelligent processing of green pepper, especially accelerate the development of impurity detection technology.</div></div>","PeriodicalId":433,"journal":{"name":"Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy","volume":"338 ","pages":"Article 126170"},"PeriodicalIF":4.3,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143768211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A dual emission ratiometric nanothermometer for evaluating cell temperature during energy metabolism","authors":"Nana Yin,&nbsp;Xiaojuan Wang,&nbsp;Yang Shu,&nbsp;Jianhua Wang","doi":"10.1016/j.saa.2025.126163","DOIUrl":"10.1016/j.saa.2025.126163","url":null,"abstract":"<div><div>ATP synthesis and thermogenesis are two key outputs of intracellular oxidative phosphorylation (OXPHOS), and simultaneous monitoring of changes in ATP and temperature will facilitate understanding of the energy metabolism mechanisms. Herein, a ratiometric probe was developed to measure temperature variations during ATP synthesis/hydrolysis. Firstly, poly(methyl methacrylate) (PMMA) copolymers with different types of charged groups (carboxylate, sulfonate and trimethylammonium) were prepared to obtain size-controllable nanoparticles by nanoprecipitation. The back energy transfer between excited state of Eu³⁺ and the ligand triplet state was sensitive to heat, so Eu³⁺ exhibited temperature-dependent emission behavior. Eu-complex-loaded polymer PMMA-trimethylammonium (PMMA-NMe₃) nanoparticles (Eu@PMMA-NMe₃ NPs) showed the strongest fluorescence and the smallest particle size, making them suitable as labels for cell imaging. Eu@PMMA-NMe₃ NPs were subsequently doped with temperature-insensitive rhodamine dye to construct ratiometric temperature probes. The maximum relative thermal sensitivity of the temperature probe was 2.7 % °C⁻¹ with a temperature resolution of 0.1–0.3 °C in the range of cell temperatures from 30.9 to 40.1 °C. Combining the temperature probe with an ATP indicator successfully monitored changes in temperature and ATP during OXPHOS and Ca²⁺ burst. When OXPHOS was inhibited, cell temperature increased by about 2.5 °C and ATP levels decreased by about 13 % within 360 s. The Ca²⁺ burst also induced a decrease in ATP levels and an increase in temperature attributed to the process of Ca²⁺ transport from the cytoplasm to the endoplasmic reticulum, which promoted ATP hydrolysis. These results have important implications for understanding energy conversion and metabolic pathways.</div></div>","PeriodicalId":433,"journal":{"name":"Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy","volume":"337 ","pages":"Article 126163"},"PeriodicalIF":4.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143777578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of fluorescent probe for specific recognition of chiral alanine","authors":"Zhuxiong Han ,&nbsp;Shijun Chen ,&nbsp;Yuwei Wu ,&nbsp;Cailing Fan ,&nbsp;Qiye Liu ,&nbsp;Xianzhe Yu ,&nbsp;Wei Shu ,&nbsp;Weijie Chi ,&nbsp;Qinxi Dong ,&nbsp;Chaoyuan Zeng","doi":"10.1016/j.saa.2025.126155","DOIUrl":"10.1016/j.saa.2025.126155","url":null,"abstract":"<div><div>Amino acids, the building blocks of life, exhibit significant chirality, whereas L-amino acids predominate in living organisms and play essential roles in protein synthesis and other biochemical processes. Although less abundant, D-amino acids play critical roles in forming bioactive compounds such as peptidoglycans in bacterial cell walls and find applications in the pharmaceutical industry and materials science. This study uses optical detection techniques to develop a chiral fluorescence sensor based on binaphthol (BINOL). We present the design and synthesis of the (<em>R</em>)-<strong>5</strong> probe, which exhibits exclusive selectivity for D-alanine (Ala) among the 20 chiral amino acids, with a detection limit of 10.7 nM. The enantioselectivity of the probe was confirmed through fluorescence spectroscopy and visual inspection, demonstrating its potential for detecting and quantifying D-alanine (D-Ala) in biological samples. This work lays the foundation for developing sensitive diagnostic tools that rely on D-amino acid levels.</div></div>","PeriodicalId":433,"journal":{"name":"Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy","volume":"338 ","pages":"Article 126155"},"PeriodicalIF":4.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143783114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis and characterization of Au@Ag nanoparticles for multiwavelength SERS biosensing","authors":"Gytaute Sirgedaite ,&nbsp;Martynas Talaikis ,&nbsp;Audrius Drabavicius ,&nbsp;Gediminas Niaura ,&nbsp;Lina Mikoliunaite","doi":"10.1016/j.saa.2025.126160","DOIUrl":"10.1016/j.saa.2025.126160","url":null,"abstract":"<div><div>Gold-core silver-shell (Au@Ag) nanoparticles are promising substrates for surface-enhanced Raman spectroscopy (SERS) due to their tunable plasmonic properties and enhanced stability. In this study, we synthesized Au@Ag nanoparticles with varying core sizes (13 nm and 23 nm) and silver shell thicknesses, controlled via silver nitrate concentration during a seed-mediated growth process. The nanoparticles were characterized using TEM, UV–vis, DLS, and zeta potential measurements. A significant shift from 528 nm to 405 nm in surface plasmon resonance maxima is observed in forming the Ag shell layer on the Au core. The SERS performance of the nanoparticles was systematically evaluated using 4-mercaptobenzoic acid (4-MBA) across multiple excitation wavelengths (442–830 nm). The results demonstrated that thicker silver shells significantly enhanced SERS signals, achieving an enhancement factor up to 9.4 × 10⁸ at 633 nm excitation. Additionally, biologically relevant ergothioneine was detected in fetal bovine serum with a limit of detection of 0.5 µM, corresponding to physiological concentrations. Spectral shifts observed at varying ergothioneine concentrations suggested adsorption-dependent molecular orientation changes. Stability tests confirmed that thin silver shells provided improved resistance to oxidation and aggregation, while thicker shells offered enhanced SERS activity at the expense of long-term colloidal stability. Overall, these systematically optimized Au@Ag core–shell nanoparticles show substantial potential for sensitive, stable, and versatile SERS-based biosensing and diagnostic applications.</div></div>","PeriodicalId":433,"journal":{"name":"Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy","volume":"338 ","pages":"Article 126160"},"PeriodicalIF":4.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143783113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ratiometric fluorescent probe for triphosgene detection and its application in electrospun fluorescent fibers","authors":"Mengyu Chen ,&nbsp;Cuibing Bai ,&nbsp;Wenhui Xue,&nbsp;Xin Wang,&nbsp;Shizhen Wang,&nbsp;Qixiang Song,&nbsp;Xinyu Wang,&nbsp;Chenxu Liu,&nbsp;Lin Zhang,&nbsp;Biao Wei,&nbsp;Hui Miao,&nbsp;Rui Qiao","doi":"10.1016/j.saa.2025.126149","DOIUrl":"10.1016/j.saa.2025.126149","url":null,"abstract":"<div><div>Triphosgene poses a potentially great threat to human health and safety. Therefore, it is of great significance to develop an effective method to realize the inexpensive, on-site, convenient, and rapid detection of triphosgene. Herein, based on the excited-state intramolecular proton transfer mechanism, a new fluorescent probe <strong>DPIM</strong> was designed and synthesized, which realized the rapid ratiometric identification and detection of triphosgene for the first time. Its limit of detection for triphosgene was 3.54 × 10⁻⁸ M, and it had a large Stokes shift of 198 nm. Its recognition mechanism was comprehensively analyzed. A smartphone detection platform and probe-loaded test paper were prepared to realize the inexpensive, on-site, and convenient detection of triphosgene. <strong>DPIM</strong> effectively enabled the ratiometric fluorescence “turn-on” for detecting residual triphosgene in the sand, showing its application practicality. Most importantly, the probe was incorporated into nanofibers and successfully used to monitor gaseous triphosgene with high specificity, showing its excellent application potential. This study provides a promising analytical tool for the rapid quantitative detection of triphosgene in solution and gaseous phases.</div></div>","PeriodicalId":433,"journal":{"name":"Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy","volume":"337 ","pages":"Article 126149"},"PeriodicalIF":4.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143760506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Templating assisted fabrication of flexible, highly stable and uniform plasmonic platform for ultrahigh enhancement of Raman and fluorescence signals: Model sensing of rhodamine-6G","authors":"Riya Choudhary ,&nbsp;Sachin Kumar Srivastava","doi":"10.1016/j.saa.2025.126125","DOIUrl":"10.1016/j.saa.2025.126125","url":null,"abstract":"<div><div>Raman-fluorescence dual enhancement offers transformative potential in fields like biosensing and bioimaging, combining exceptional sensitivity with rapid response. In this study, a novel flexible plasmonic platform, composed of silver nanocolumns (Ag-NCOLs) embedded in polydimethylsiloxane (PDMS), was investigated using 4-aminothiophenol (4-ATP) for Raman and rhodamine-6G (R6G) for fluorescence studies. This platform demonstrated remarkable enhancement factors (EFs) of ∼10¹⁴ for Raman and ∼273 for fluorescence, surpassing Ag-NCOLs on silicon (Si) by factors of 10 and 24.8, respectively. A number of control experiments confirmed the platform’s uniformity, long-term stability, and flexibility (bending and stretching). The system’s efficacy was validated through R6G detection, achieving detection limits of 0.54 nM for Raman and 0.26 nM for fluorescence. These findings establish the platform as a promising tool for diverse applications, including label-free and labeled biosensing, pathogen detection, bioimaging, in vitro diagnostics, wearable sensors, material characterization, and environmental monitoring. This work underscores the immense potential of flexible plasmonic platforms for advancing next-generation sensing and imaging technologies.</div></div>","PeriodicalId":433,"journal":{"name":"Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy","volume":"338 ","pages":"Article 126125"},"PeriodicalIF":4.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143784986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}