Visible and near infrared absorption and fluorescence studies of the adsorption and coverage of doxorubicin on single-walled carbon nanotubes

IF 4.6 2区化学 Q1 SPECTROSCOPY

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy Pub Date : 2025-10-03 DOI:10.1016/j.saa.2025.127013

Luc Chavignon , Christophe Blanc , Tiago Serodre , May C. Morris , Eric Anglaret

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Abstract

Single-walled carbon nanotubes have been identified as promising materials for drug delivery due to their large specific surface area, their ability to pass through the cell membrane without damaging it and their physicochemical properties, allowing their surface to be easily functionalised. Additionally, their optical properties permit investigation in biological media in the near infrared (the “biological window”). In this paper, adsorption of doxorubicin on single-walled carbon nanotubes dispersed with carboxymethylcellulose salt is monitored by absorption and fluorescence spectroscopy in the visible and near infrared. We confirm that Raman-fluorescence coupled spectroscopy in the near infrared is a useful tool for probing the adsorption of drugs on single-walled carbon nanotubes in a sub-monolayer regime. By combining spectroscopic studies of doxorubicin in the visible range, we propose a protocol for quantifying the amount of adsorbed drug over a broad range of concentrations.

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多柔比星在单壁碳纳米管上的吸附和覆盖的可见和近红外吸收和荧光研究。

单壁碳纳米管由于其大的比表面积、穿过细胞膜而不破坏细胞膜的能力以及其物理化学性质，使其表面易于功能化，已被确定为很有前途的药物递送材料。此外，它们的光学特性允许在近红外生物介质中进行研究（“生物窗口”）。研究了羧甲基纤维素盐分散的单壁碳纳米管在可见光和近红外光谱下对阿霉素的吸附。我们证实了近红外拉曼荧光耦合光谱是探测药物在亚单层单壁碳纳米管上吸附的有用工具。通过在可见范围内结合阿霉素的光谱研究，我们提出了一种在广泛浓度范围内定量吸附药物量的方案。

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来源期刊

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 物理-光谱学

CiteScore

8.40

自引率

11.40%

发文量

1364

审稿时长

40 days

期刊介绍： Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy (SAA) is an interdisciplinary journal which spans from basic to applied aspects of optical spectroscopy in chemistry, medicine, biology, and materials science. The journal publishes original scientific papers that feature high-quality spectroscopic data and analysis. From the broad range of optical spectroscopies, the emphasis is on electronic, vibrational or rotational spectra of molecules, rather than on spectroscopy based on magnetic moments. Criteria for publication in SAA are novelty, uniqueness, and outstanding quality. Routine applications of spectroscopic techniques and computational methods are not appropriate. Topics of particular interest of Spectrochimica Acta Part A include, but are not limited to: Spectroscopy and dynamics of bioanalytical, biomedical, environmental, and atmospheric sciences, Novel experimental techniques or instrumentation for molecular spectroscopy, Novel theoretical and computational methods, Novel applications in photochemistry and photobiology, Novel interpretational approaches as well as advances in data analysis based on electronic or vibrational spectroscopy.