Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy最新文献

{"title":"A Multimode fluorescent sensor for sequential detection of Cu2+ and cysteine as well as pH sensor with real sample Applications: Extensive experimental and DFT studies","authors":"Alam Shabbir ,&nbsp;Sohail Anjum Shahzad ,&nbsp;Abdullah Yahya Abdullah Alzahrani ,&nbsp;Zulfiqar Ali Khan ,&nbsp;Muhammad Yar ,&nbsp;Waqar Rauf","doi":"10.1016/j.saa.2024.125414","DOIUrl":"10.1016/j.saa.2024.125414","url":null,"abstract":"<div><div>Highly responsive and optically selective (<em>E</em>)-1-((4-phenoxyphenyl) diazenyl)naphthalen-2-ol) sensor <strong>PDN</strong> with aggregation induced emission enhancement (AIEE) properties has been developed for the sequential detection of Cu²⁺ and L- Cysteine through fluorescence On-Off-On strategy. The selectivity of sensor depends on the presence of a diazo functional group and its appropriate cavity location in sensor molecule. Azo dye-based (<em>E</em>)-1-((4-phenoxyphenyl) diazenyl)naphthalen-2-ol) sensor <strong>PDN</strong> has been synthesized by utilizing a simple diazotization synthetic methodology that showed extraordinary AIEE behavior with bathochromic shift owing to the formation of J-aggregates. The morphology and size of aggregates were analyzed by SEM and DLS analysis, respectively. The calculated LOD of sensor <strong>PDN</strong> for Cu²⁺, and L-cysteine is 0.113 nM, and 84 nM, respectively. Fluorescence, UV–visible, LC-MS, ¹H and ¹³C NMR titration were carried out to understand the interaction of sensor with Cu²⁺. The sensor was practically utilized in the sequential sensing of Cu²⁺ and Cys in real samples. Interestingly, sensor <strong>PDN</strong> was successfully employed for the sensing of a strong acid and base as well as the detection of Cu²⁺ ions in the solid state. Moreover, these experimental results were supported through DFT calculations.</div></div>","PeriodicalId":433,"journal":{"name":"Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy","volume":"327 ","pages":"Article 125414"},"PeriodicalIF":4.3,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142650042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nd3+-doped B2O3-SiO2-AlF3-NaF-CaF2 glass ceramics for 1.06 μm emission","authors":"Bungala Chinna Jamalaiah","doi":"10.1016/j.saa.2024.125405","DOIUrl":"10.1016/j.saa.2024.125405","url":null,"abstract":"<div><div>Trivalent neodymium (Nd³⁺) doped transparent oxyfluoroborosilicate glass and glass ceramics (GCs) comprising CaF₂ nanoparticles (NPs) were fabricated via melt quench route followed by two step heat treatment process. The X-ray diffraction and scanning electron microscopic studies confirm the presence of CaF₂ NPs. The GC environment for efficient luminescence was obtained at a heat treatment of 450 °C/1 h. The wavelength of pumping laser source was optimized as 808 nm by studying the luminescence properties at different excitations. The Nd³⁺ ions exhibit their characteristic emission transitions with peak maxima at around 0.89 μm (⁴F_3/2 → ⁴I_9/2), 1.06 μm (⁴F_3/2 → ⁴I_11/2) and 1.32 μm (⁴F_3/2 → ⁴I_13/2). The Nd³⁺ concentration was also optimized as 1.0 mol% for strong emission up on 808 nm pumping. Various spectroscopic, radiative and laser characteristic parameters were determined using Judd–Ofelt theory. The luminescence decay of ⁴F_3/2 state was studied controlling the excitation and emission wavelengths at 808 and 1060 nm, respectively. The reasons for quenching in luminescence were discussed with suitable illustrations. The experimentally observed results confirm that the GC sample obtained at 450 °C/1 h heat treatment was highly appropriate to design 1.06 μm fiber lasers and optical amplifiers.</div></div>","PeriodicalId":433,"journal":{"name":"Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy","volume":"327 ","pages":"Article 125405"},"PeriodicalIF":4.3,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142640521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elucidating the isotope effect in the Morse approximation of the ground state electronic term of hydrogen molecules nH2, n = 1 ÷ 7. Showcasing the Herzberg anomaly and anharmonicity","authors":"Gleb S. Denisov ,&nbsp;Edem R. Chakalov ,&nbsp;Peter M. Tolstoy","doi":"10.1016/j.saa.2024.125410","DOIUrl":"10.1016/j.saa.2024.125410","url":null,"abstract":"<div><div>The Morse function is the simplest anharmonic approximation of the potential of a diatomic molecule, for which the vibrational Schrödinger equation could be solved almost precisely. Despite its crudeness, the Morse function has been widely used in solving various problems in molecular spectroscopy. In recent years, special attention was paid to the existence of two Morse approximations for the electronic terms U(<em>r</em>) of diatomic molecules, M1(<em>r</em>) and M2(<em>r</em>), which differ by the selection of primary fitting parameters and satisfactorily reproduce different parts of U(<em>r</em>). Some fine features of simple terms U(<em>r</em>), whose form does not differ much from the Morse function, could be highlighted by considering difference functions U(<em>r</em>) − M(<em>r</em>). The set of vibrational levels G(υ), predicted by Morse approximation, can be conveniently characterized by the difference functions Δ₁G(υ) and Δ₂G(υ), which are, respectively, the energies of vibrational quanta and the rates of their change. The function Δ₂G(υ) can be considered as a generalization of the anharmonicity constant, determined experimentally by the position of levels υ = 0,1,2. Finally, analysing the anharmonicity, it is useful to compare the results obtained for various isotopologues, for which U(<em>r</em>) is the same, but the density of vibrational levels is different. The maximal range of isotope effects is expected for hydrogen, which has seven known isotopes, including extremely short-lived ones. In this work, the influence of the reduced mass on the results of the approximation of the ground state electronic potential U(<em>r</em>) by the Morse function is studied for seven isotopologues of hydrogen molecule <em>ⁿ</em>H₂ (<em>n</em> = 1–7). For each isotopologue, alternative approximations M1(<em>r</em>) and M2(<em>r</em>) are considered. The systematic deviation of M1(<em>r</em>) from U(<em>r</em>) increases with <em>r</em>, reaching 1700–2770 cm⁻¹ (for ⁷H₂–¹H₂) in the region of the asymptote. The systematic deviation of M2(<em>r</em>) from U(<em>r</em>) decreases at larger distances: it is dome-shaped with a maximum of ca. 1500 cm⁻¹ at <em>r</em> ∼ 2 Å, after which it falls to zero. The M2(<em>r</em>) curves for different isotopologues diverge by less than 20 cm⁻¹. The U(<em>r</em>) − M(<em>r</em>) functions are used to analyse the so-called “Herzberg anomaly” in the region where M1(<em>r</em>) and M2(<em>r</em>) intersect U(<em>r</em>). For example, at around <em>r</em> = 1.08 Å the U(<em>r</em>) − M2(<em>r</em>) function shows anomalous negative values ranging from −125 cm⁻¹ (for ¹H₂) to −142 cm⁻¹ (for ⁷H₂).</div></div>","PeriodicalId":433,"journal":{"name":"Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy","volume":"327 ","pages":"Article 125410"},"PeriodicalIF":4.3,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142640515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implantation of impressive chromatographic and built-in UV spectrophotometry approaches for sustainable Estimation of olopatadine and mometasone in pharmaceuticals; eco-scale and BAGI applications","authors":"Amal A. El-Masry ,&nbsp;Samah A. Elsabour ,&nbsp;Ahmed Emad F. Abbas ,&nbsp;Yomna A. Salem","doi":"10.1016/j.saa.2024.125409","DOIUrl":"10.1016/j.saa.2024.125409","url":null,"abstract":"<div><div>The development of analytical methods that adhere to the principles of sustainable green chemistry is essential in the modern scientific arena. This research presents two novel methods for the concurrent quantification of olopatadine (OLO) and mometasone (MOM), targeting sustainable green chemistry principles in their raw materials, dosage forms and combined nasal spray formulations. The first method is a rapid isocratic high-performance liquid chromatography (HPLC) that achieves excellent resolution within 4 min, with retention times of 2.37 ± 0.1 min for OLO and 4.05 ± 0.1 min for MOM. It features optimal sensitivity, with detection limits of 0.13 µg/mL for OLO and 0.03 µg/mL for MOM. It utilizes a cyano column with an isocratic mobile phase of acetonitrile and 0.1 M OPA (50: 50, v/v), making it accessible to standard laboratory equipment. The second method is UV–visible spectrophotometry, which includes first-order derivative measurement (D1) and ratio derivative spectra (RDS) methods. These spectroscopic approaches provide linear response range of 0.2–20.0 µg/mL for OLO and 4.0–40.0 µg/mL for MOM, respectively serving as cost-effective alternatives for labs with limited resources. Validation results show high accuracy (98–102 %) and precision (RSD &lt; 2 %). Green assessments using Eco-Scale indicate scores of 86 for HPLC and 100 for spectrophotometry, while the “blueness” concept via BAGI demonstrates strong sustainability with scores of 87.5 and 90. These methods effectively quantify OLO and MOM in their raw materials, different formulations and combined nasal spray, providing a sustainable and reliable approach for pharmaceutical analysis. This work is the first green assessment for the determination of OLO and MOM in pure drug and in the pharmaceutical formulations using less hazard solvent and simple technique.</div></div>","PeriodicalId":433,"journal":{"name":"Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy","volume":"327 ","pages":"Article 125409"},"PeriodicalIF":4.3,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142640518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel self-assembled spirochiral nanofluorescent probe for fipronil detection efficiently by PET mechanism","authors":"Li Xue Yang ,&nbsp;Kaiyue Song ,&nbsp;Rong Wang ,&nbsp;Yue Sun ,&nbsp;Xiaoxia Sun ,&nbsp;Yu Hu ,&nbsp;Beibei Yu","doi":"10.1016/j.saa.2024.125407","DOIUrl":"10.1016/j.saa.2024.125407","url":null,"abstract":"<div><div>A novel spirochiral compound <em>S</em>-SPINOL-Y1 (<em>S</em>-6,6′-bis (thiophen-2-yl)-2,2′, 3,3′-tetrahydro-1,1′-spirobis[indinee]-7,7′-diol) was synthesized via a Suzuki reaction and self-assembled into nanospheres in ethanol solution. Nano or micron vesicles could be formed by changing the concentration of ethanol solvent. The resulting nanoprobe demonstrated rapid and effective recognition of fipronil (FIP) through the photoinduced electron transfer effect (PET mechanism), as evidenced by complete fluorescence quenching. Concurrently, the spiral chiral <em>S</em>-SPINOL-Y1 and FIP co-assembled into vein-like nanotubes within the ethanol solution by covalent bonding and intermolecular hydrogen bonding.</div></div>","PeriodicalId":433,"journal":{"name":"Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy","volume":"327 ","pages":"Article 125407"},"PeriodicalIF":4.3,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142635462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparation of amorphous Nd/Dy-based metal organic framework@MXene for solar driven selective photocatalytic and serving as sensor for fluorescence quenching detection, and biological activity","authors":"Rustem R. Zairov ,&nbsp;Asad Syed ,&nbsp;Maha Mohammed Tawfiq ,&nbsp;Ali Fawzi Al-Hussainy ,&nbsp;Aseel Salah Mansoor ,&nbsp;Usama Kadem Radi ,&nbsp;Ameer Hassan Idan ,&nbsp;Hala Bahair ,&nbsp;Hind A. AL-Shwaiman ,&nbsp;Manjula Subramaniam ,&nbsp;Ling Shing Wong ,&nbsp;Baadal Jushi Janani ,&nbsp;Oleg G. Sinyashin","doi":"10.1016/j.saa.2024.125406","DOIUrl":"10.1016/j.saa.2024.125406","url":null,"abstract":"<div><div>The development of a new Neodymium/Dysprosium metal–organic framework, referred to as Nd/Dy-BTC MOF, based on benzene-1,2,4-tricarboxylic acid, has been achieved through an in situ growth process on 2D transition metal carbides (MXene) surfaces. This synthesis was conducted via a solvothermal method utilizing a solvent mixture of water, ethanol, and dimethylformamide. The primary objective of this research is to investigate the framework’s efficacy as a photocatalyst for the degradation of anionic dye, as well as its potential for sensing certain explosives. The Nd/Dy-MOF@MXene has been characterized by various analysis techniques. The prepared Nd/Dy-MOF@MXene was utilized as catalyst in selective degradation of methyl orange dye. The study examined the influence of pH and catalyst concentration, revealing that the catalyst achieves peak efficiency of 93.55% when exposed to sunlight in an acidic medium. The reusability of the catalyst shows the highest efficient photocatalyst after four cycles of reusability. The detection of explosives, specifically 2,4,6-trinitrophenol, through photoluminescence techniques has been conducted, utilizing the Stern-Volmer equation to evaluate the quenching efficiency. The findings indicated remarkable efficiency and selectivity of Nd/Dy-MOF@MXene for 2,4,6-trinitrophenol, achieving a quenching efficiency of 91%. Furthermore, the reusability tests demonstrated that Nd/Dy-MOF@MXene exhibits outstanding recyclability, maintaining performance over five cycles. The antibacterial activity of Nd/Dy-MOF@MXene was investigated against Gram-positive and Gram-negative strains due to indication of medicine properties of Nd/Dy-MOF@MXene. These results paves a way for manufacturing innnovation in near future.</div></div>","PeriodicalId":433,"journal":{"name":"Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy","volume":"327 ","pages":"Article 125406"},"PeriodicalIF":4.3,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142640522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emissive glutathione modified sulphur quantum dots for the sensing of lemon yellow and luminescent hydrogels/films","authors":"Yining Chang ,&nbsp;XiaoMeng Zhong ,&nbsp;Yanli Wei ,&nbsp;Li Wang","doi":"10.1016/j.saa.2024.125401","DOIUrl":"10.1016/j.saa.2024.125401","url":null,"abstract":"<div><div>Lemon yellow (LY) is an azo dye which is widely used as food colorant. The continuous consumption can result in the safety concerns for both human and environmental health. This study describes a new sulphur quantum dot (SQD) based fluorescent sensor, which was facilely prepared with oxidized-glutathione (GSSG) as passivator at mild condition of 75 °C. The obtained sulphur quantum dots (GSSG-SQDs) have a relative quantum yield of 0.25, which is 2–5 times that of most SQDs. GSSG-SQDs were used as a sensor for lemon yellow in the concentration range of 0.10–70 μM and the limit of detection of 60 nM. The application was verified with the real sensing of lemon yellow in the soft drinking and tap water, having the standard recovery from 92.5 % to 105 %. Given the great luminescence and photostability, GSSG-SQDs were used as a filler for the preparation of luminescent films and hydrogels as a promising material for a wide range of applications such as information encryption and bioengineering.</div></div>","PeriodicalId":433,"journal":{"name":"Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy","volume":"327 ","pages":"Article 125401"},"PeriodicalIF":4.3,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142607853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High acid-base tolerance and long storage time lanthanum cerium co-doped carbon quantum dots for Fe3+ detection","authors":"Bangxing Li ,&nbsp;Fei Wu ,&nbsp;Zhenjun Xie ,&nbsp;Xing Kang ,&nbsp;Yanghua Wang ,&nbsp;Wei Li ,&nbsp;Xiaolin Hu","doi":"10.1016/j.saa.2024.125403","DOIUrl":"10.1016/j.saa.2024.125403","url":null,"abstract":"<div><div>In this paper, lanthanum and cerium co-doped carbon quantum dots (LaCe-CQDs) was firstly synthesized by one step hydrothermal method. The obtained LaCe-CQDs shown sable fluorescence properties with pH values from 3 to 9 and after 4 weeks of storage. The average particle size of LaCe-CQDs, with excitation and emission wavelengths of 350 nm and 446 nm, is 3.27 ± 0.12 nm. Selective analysis of various metal ions revealed the sensitivity of LaCe-CQDs towards Fe³⁺ ions. Within the 0–60 μM, the fluorescence intensity exhibits a strong linear correlation with the concentration of Fe³⁺. The limit of detection (LOD) was determined to be 0.753 μM. Additionally, the accuracy of LaCe-CQDs were demonstrated in natural water samples. Therefore, LaCe-CQDs are a promising sensor for Fe³⁺ detection.</div></div>","PeriodicalId":433,"journal":{"name":"Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy","volume":"327 ","pages":"Article 125403"},"PeriodicalIF":4.3,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142607855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced visible-light-driven photocatalytic degradation via in-situ AIS/ZIS high-low junctions","authors":"Zhenhua Wang ,&nbsp;Jin Miao ,&nbsp;Tao Tan ,&nbsp;Lin Guo ,&nbsp;Rongli Gao ,&nbsp;Yue Chen ,&nbsp;Wei Cai ,&nbsp;Chunlin Fu ,&nbsp;Xiang Lei","doi":"10.1016/j.saa.2024.125392","DOIUrl":"10.1016/j.saa.2024.125392","url":null,"abstract":"<div><div>The I-III-VI QDs Ag-In-S (AIS) exhibits excellent properties in photocatalysis because of the adjustable band gap, wide light absorption range, and multiple active sites. Introducing homologous or heterogeneous ions not only derives the composition into quaternary/ quinary quantum dots but also generates new sulfide QDs to form composites, which is an effective strategy to promote photoactivity. In this work, we in-situ synthesized the AIS/ZIS (AgIn₅S₈/Zn₄In₂S₇) composite photocatalyst by introducing Zn²⁺ and changing the reaction temperature. We found that the composite photocatalyst could efficiently photodegrade larger concentrations of RhB than that of the previous reports. The superior photocatalytic activity was due to the formation of the type I high-low junction, which could effectively separate carriers. The photoelectrons on the CB of AIS reacted with dissolved oxygen to produce strongly oxidative <img>O₂^–, which degraded RhB into intermediates and eventually into CO₂ and H₂O. This work not only reports an excellent photocatalyst but also offers new ideas on the design and manufacture of highly efficient high-low junction photocatalysts.</div></div>","PeriodicalId":433,"journal":{"name":"Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy","volume":"327 ","pages":"Article 125392"},"PeriodicalIF":4.3,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142607854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design and green synthesis of carbon Dots/Gold nanoparticles Composites and their applications for neurotransmitters sensing based on emission Spectroscopy","authors":"Waleed A. El-Said,&nbsp;Abdullah Akhdhar,&nbsp;Abdullah S. Al-Bogami,&nbsp;Tamer S. Saleh","doi":"10.1016/j.saa.2024.125402","DOIUrl":"10.1016/j.saa.2024.125402","url":null,"abstract":"<div><div>Changes in the neurotransmitters are indications for several diseases. Several sensors were reported for monitoring dopamine (DA), but the simple and accurate DA detection in biological samples still faces many challenges. The research proposal aims to develop an optical sensor for detecting neurotransmitters based on luminescence emission spectra in different biological samples. Carbon dots (CDs) were fabricated based on a green synthesis route. Then the prepared CDs were decorated with varying concentrations of gold nanoparticles (Au NPs). The synthesis process was optimized, and the obtained CDs/Au NPs nanocomposites were applied as neurotransmitters’ optical nanosensors. The optical nanosensor approach provides easy and sensitive multiplex analysis. A wide range of neurotransmitters was monitored. The developed sensor’s sensitivity, selectivity, and reproducibility were investigated. Au NPs act as CDs’ stabilizers, enhancing the emission effect, and scaffolds for binding DA with CDs’ surface. DA moieties bind to CDs through the interaction between the DA-NH₂ groups and Au NPS. Due to electron transfer, the bonding of DA molecules leads to fluorescence quenching of AuNPs/CDs. The Au-CDs-based DA fluorescence showed high sensitivity with a<!--> <!-->detection limit, and limit quantification of 2.04 nM and 6.18 nM, respectively. Furthermore, the selectivity of the sensor was investigated in the presence of glucose, uric acid (UA), and ascorbic acid (AA), which showed no interference effect at 10 times higher concentrations. Moreover, the proposed sensor has been successfully utilized for DA detection in human serum samples with a high recovery efficiency between 98.83 % and 103.5 %.</div></div>","PeriodicalId":433,"journal":{"name":"Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy","volume":"327 ","pages":"Article 125402"},"PeriodicalIF":4.3,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142607852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}