Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy最新文献_第2页

Sensitive detection of cyanazine residues using N, P-co-doped carbon dots/gold nanoparticles (N, P-CDs/AuNPs) fluorescent probe N， p共掺杂碳点/金纳米粒子（N, P-CDs/AuNPs）荧光探针对氰嗪残留的灵敏检测

IF 4.3 2区化学

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy Pub Date : 2025-07-21 DOI: 10.1016/j.saa.2025.126709

Wenbo Li , Maoxia Ran , Haiyan Qi , Tao Jing , Jun Li

{"title":"Sensitive detection of cyanazine residues using N, P-co-doped carbon dots/gold nanoparticles (N, P-CDs/AuNPs) fluorescent probe","authors":"Wenbo Li , Maoxia Ran , Haiyan Qi , Tao Jing , Jun Li","doi":"10.1016/j.saa.2025.126709","DOIUrl":"10.1016/j.saa.2025.126709","url":null,"abstract":"<div><div>A novel fluorescent probe based on nitrogen and phosphorus co-doped carbon dots (N, P-CDs) and gold nanoparticles (AuNPs) was developed for the sensitive and selective detection of cyanazine pesticide residues. N, P-CDs exhibited dual excitation wavelengths (460 nm and 490 nm) and a single emission peak at 515 nm. Upon conjugation with AuNPs, the prepared N, P-CDs/AuNPs fluorescent probe demonstrated fluorescence quenching via inner filter effect (IFE) and a remarkable restoration of fluorescence in the presence of cyanazine, attributed to the interaction between cyanide groups and gold nanoparticles. The probe exhibited high sensitivity with a detection limit of 0.14 μmol/L for cyanazine. Selectivity studies showed that the probe was minimally affected by common interfering substances, and recovery experiments in food samples demonstrated good accuracy with spiked recoveries ranging from 93.91 % to 114.30 %. This study provides a promising approach for detecting cyanazine in food samples with high specificity and reliability.</div></div>","PeriodicalId":433,"journal":{"name":"Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy","volume":"344 ","pages":"Article 126709"},"PeriodicalIF":4.3,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144695448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bifunctional phenothiazine-Coumarin probe Tz.3: Visual detection of Ag+/ ClO− in aqueous media and selective imaging of hypochlorite in living cells 双功能吩噻嗪-香豆素探针Tz.3：水介质中Ag+/ ClO−的视觉检测和活细胞中次氯酸盐的选择性成像

IF 4.3 2区化学

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy Pub Date : 2025-07-21 DOI: 10.1016/j.saa.2025.126730

Huaxin Xu , Yi Han , Yuying Zhu , Lingxin Chen , Jianye Xu , Zhihao Shan , Hong Chen , Yueheng Qi , Zhiyong Guo

{"title":"Bifunctional phenothiazine-Coumarin probe Tz.3: Visual detection of Ag+/ ClO− in aqueous media and selective imaging of hypochlorite in living cells","authors":"Huaxin Xu , Yi Han , Yuying Zhu , Lingxin Chen , Jianye Xu , Zhihao Shan , Hong Chen , Yueheng Qi , Zhiyong Guo","doi":"10.1016/j.saa.2025.126730","DOIUrl":"10.1016/j.saa.2025.126730","url":null,"abstract":"<div><div>Excessive exposure of hypochlorite ions (ClO<sup>−</sup>) and silver ions (Ag<sup>+</sup>) lead to significant environmental safety and human health risks. How to quick and accurate detecting of Ag<sup>+</sup> and ClO<sup>−</sup> in aquatic environment seems urgent. Continuation of preliminary work, a novel bifunctional fluorescent probe molecule of <strong>Tz.3</strong> was designed basing on an electron donor phenothiazine core structure with intramolecular charge transfer (ICT) effect. Experimental results showed that fluorescent probe molecule of <strong>Tz.3</strong> can rapidly detect ClO<sup>−</sup> with LOD = 2.478 nM in less 30 s and no response to Ag<sup>+</sup> in MeOH/PBS solution. However, under UV lamp irradiation, <strong>Tz.3</strong> can respond to Ag<sup>+</sup> with LOD = 8.628 nM. Furthermore, the sensing mechanism of <strong>Tz.3</strong> to ClO<sup>−</sup> and Ag<sup>+</sup> ions were elucidated by characterization of the reaction products with UV–vis absorption, fluorescence emission spectroscopy, mass spectrometry, and DFT calculations. Finally, the colorimetric-fluorescent dual-response fluorescent probe molecule of Tz.3 was applied to detect Ag<sup>+</sup> and ClO<sup>−</sup> ions in real water samples, and demonstrates significant potential for monitoring exogenous and endogenous ClO<sup>−</sup> in living cells.</div></div>","PeriodicalId":433,"journal":{"name":"Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy","volume":"344 ","pages":"Article 126730"},"PeriodicalIF":4.3,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144686219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design and synthesis of a carbonyl–nitrogen multi-resonance thermally activated delayed fluorophore with enhanced charge transfer for electroluminescence application 电致发光用羰基-氮多共振热激活延迟荧光团的设计与合成

IF 4.3 2区化学

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy Pub Date : 2025-07-21 DOI: 10.1016/j.saa.2025.126728

Chengxiang Shi , Ya-Rong Gong , Jia-Ming Jin , Yu-Kang Li , Yan Li , Lin-Na Qi , Ji-Hua Tan , Yuan Liu , Yanping Huo , Wen-Cheng Chen

{"title":"Design and synthesis of a carbonyl–nitrogen multi-resonance thermally activated delayed fluorophore with enhanced charge transfer for electroluminescence application","authors":"Chengxiang Shi , Ya-Rong Gong , Jia-Ming Jin , Yu-Kang Li , Yan Li , Lin-Na Qi , Ji-Hua Tan , Yuan Liu , Yanping Huo , Wen-Cheng Chen","doi":"10.1016/j.saa.2025.126728","DOIUrl":"10.1016/j.saa.2025.126728","url":null,"abstract":"<div><div>By employing an “intramolecular lock” strategy, a novel multi-resonance thermally activated delayed fluorescence (MR-TADF) emitter, QAO-PhIDA, has been designed through modulating the excited-state properties of the QAO acceptor using a steric hindrance donor PhIDA. The appropriate electron donor facilitates effective intramolecular charge transfer (ICT), while retaining the MR-TADF characteristics. Additionally, the presence of the bulky donor effectively suppresses the aggregation-caused quenching (ACQ) behavior caused by long-range π-π stacking of the QAO chromophore, which is beneficial for achieving efficient luminescence under solid-state conditions. The QAO-PhIDA emitter exhibits an emission wavelength (<em>λ</em><sub>PL</sub>) of 489 nm with a narrow FWHM of 33 nm. The organic light-emitting diodes (OLEDs) device based on QAO-PhIDA achieves a maximum external quantum efficiency (EQE<sub>max</sub>) of 18.0 %, which is a pre-eminently promising candidate for applications in OLEDs.</div></div>","PeriodicalId":433,"journal":{"name":"Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy","volume":"344 ","pages":"Article 126728"},"PeriodicalIF":4.3,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144695457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A thiourea-bridged quinoline–naphthalene fluorescent chemosensor for selective Cu2+ detection: Application in real samples, strip and swab portable assays 用于选择性Cu2+检测的硫脲桥接喹啉-萘荧光化学传感器：在实际样品，试纸和拭子便携式分析中的应用

IF 4.3 2区化学

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy Pub Date : 2025-07-20 DOI: 10.1016/j.saa.2025.126721

T. Johny Dathees , G. Narmatha , J. Prabhu , S. Abisha Nancy , A. Abiram , Abdulrahman I. Almansour , Raju Suresh Kumar , R. Nandhakumar

{"title":"A thiourea-bridged quinoline–naphthalene fluorescent chemosensor for selective Cu2+ detection: Application in real samples, strip and swab portable assays","authors":"T. Johny Dathees , G. Narmatha , J. Prabhu , S. Abisha Nancy , A. Abiram , Abdulrahman I. Almansour , Raju Suresh Kumar , R. Nandhakumar","doi":"10.1016/j.saa.2025.126721","DOIUrl":"10.1016/j.saa.2025.126721","url":null,"abstract":"<div><div>A urea-based fluorescent chemosensor, <strong>ITCQ</strong>, was developed for the selective detection of Cu<sup>2+</sup> ions in a DMSO/H₂O (1:1, <em>v</em>/v) medium buffered with 50 mM HEPES at pH 7.4. Upon excitation at 350 nm, Cu<sup>2+</sup> induced a marked fluorescence quenching via an intramolecular charge transfer (ICT) mechanism. Probe <strong>ITCQ</strong> demonstrated high selectivity for Cu<sup>2+</sup> over other metal ions, as confirmed by competitive binding studies. Stern–Volmer analysis yielded a quenching constant of 3 × 10<sup>4</sup> M<sup>−1</sup>, with a low detection limit of 2.23 nM and a quantification limit of 7.45 nM. Job's plot, along with HRMS, IR, and <sup>1</sup>H NMR titration, confirmed a 1:1 binding stoichiometry. The sensor exhibited excellent reversibility and reusability, supporting its practical utility. Real sample analyses, including water and food matrices, validated its effectiveness. Additionally, swab and paper strip assays demonstrated strong potential for portable, on-site Cu<sup>2+</sup> monitoring. With a good sensitivity, selectivity, and field applicability, probe <strong>ITCQ</strong> marks a meaningful advancement in metal ion sensing.</div></div>","PeriodicalId":433,"journal":{"name":"Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy","volume":"344 ","pages":"Article 126721"},"PeriodicalIF":4.3,"publicationDate":"2025-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144704095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Graphitic nanozyme for visual ascorbic acid sensing in commercial beverages 用于商业饮料中抗坏血酸视觉检测的石墨纳米酶

IF 4.3 2区化学

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy Pub Date : 2025-07-20 DOI: 10.1016/j.saa.2025.126724

Xiaoyuan Sun , Shen Wang , Guofeng Gui , Shengkai Li

{"title":"Graphitic nanozyme for visual ascorbic acid sensing in commercial beverages","authors":"Xiaoyuan Sun , Shen Wang , Guofeng Gui , Shengkai Li","doi":"10.1016/j.saa.2025.126724","DOIUrl":"10.1016/j.saa.2025.126724","url":null,"abstract":"<div><div>Ascorbic acid (AA), an essential micronutrient that cannot be endogenously synthesized in humans, plays vital roles in various physiological processes and must be obtained through dietary intake. However, AA is prone to oxidative degradation during food processing, storage, and transportation, leading to significant loss of its bioactivity. These factors underscore the critical need for developing simple, rapid, and accurate methods for AA quantification in food products. Recently, nanozyme–mediated colorimetric sensing has emerged as a promising approach for AA detection, combining the advantages of nanozymes (including cost–effectiveness, high catalytic activity, excellent stability, and scalable production) with the simplicity of colorimetric analysis that enables equipment–free visual detection. Most nanozymes demonstrate optimal catalytic activity exclusively under acidic conditions, while simultaneously exhibiting poor stability in such environments. To address this limitation, we developed an ultra–stable peroxidase (POD)–like CoPt graphitic nanozyme (CoPt@G) through a one–pot chemical vapor deposition (CVD) method and constructed a robust colorimetric AA detection platform. The proposed biosensor exhibits a linear range of 5–60 μM and the detection limit (S/N = 3) of 1.4 μM, with results comparable to most of the related works. Additionally, the proposed sensor demonstrates good selectivity and promising practical application potential for AA detection in commercial beverages. This study develops a simple, rapid visual AA detection method, offering valuable guidance for scientifically informed dietary decisions.</div></div>","PeriodicalId":433,"journal":{"name":"Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy","volume":"344 ","pages":"Article 126724"},"PeriodicalIF":4.3,"publicationDate":"2025-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144695445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficient wheat variety identification using Raman hyperspectral imaging in combination with deep learning 结合深度学习的拉曼高光谱成像高效小麦品种识别

IF 4.3 2区化学

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy Pub Date : 2025-07-20 DOI: 10.1016/j.saa.2025.126722

Yaoyao Fan , Zheli Wang , Xueying Yao , Wenqian Huang , Qingyan Wang , Xi Tian , Liping Chen , Yuan Long

{"title":"Efficient wheat variety identification using Raman hyperspectral imaging in combination with deep learning","authors":"Yaoyao Fan , Zheli Wang , Xueying Yao , Wenqian Huang , Qingyan Wang , Xi Tian , Liping Chen , Yuan Long","doi":"10.1016/j.saa.2025.126722","DOIUrl":"10.1016/j.saa.2025.126722","url":null,"abstract":"<div><div>Wheat (<em>Triticum aestivum</em> L.) is recognized as a globally important staple crop, with its varietal differences influencing food processing, nutritional value, and agricultural productivity. Traditional identification methods are often considered inefficient and subjective, while existing spectral techniques are hindered by complex preprocessing procedures and limited model interpretability. To address these limitations, an efficient and interpretable approach was developed by integrating Raman hyperspectral imaging with deep learning techniques. First, a segmentation framework, One-Target Hyperspectral Image Segmentation and Extraction based on the Segment Anything Model, was developed to efficiently and reliably extract regions of interest from wheat grains in Raman hyperspectral images. Subsequently, Raman characteristic peaks were selected using chemical prior knowledge, rather than traditional data-driven methods that rely on statistical features, to enhance the chemical interpretability of the features. Finally, a Raman Spectral Attention Network was designed by incorporating multiscale feature extraction and a Transformer module to improve the modeling performance on the selected Raman characteristic peaks. Experimental results demonstrated that the segmentation framework significantly improved preprocessing efficiency, while Raman Spectral Attention Network achieved an accuracy of up to 99 % in classifying eight wheat varieties. Overall, this study provides a reliable, interpretable, and efficient solution for wheat variety identification, with promising applications in food quality assessment, precision agriculture, and food safety monitoring.</div></div>","PeriodicalId":433,"journal":{"name":"Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy","volume":"344 ","pages":"Article 126722"},"PeriodicalIF":4.3,"publicationDate":"2025-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144678770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The chemical instability of the survivin inhibitor – sepantronium bromide (YM155) studied by stimulated Raman, NMR and UV–Vis spectroscopies 利用受激拉曼光谱、核磁共振光谱和紫外可见光谱研究了生存素抑制剂-溴化异丙胺（YM155）的化学不稳定性

IF 4.3 2区化学

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy Pub Date : 2025-07-19 DOI: 10.1016/j.saa.2025.126720

Samaneh Shahab , Jonathan Ramírez-Cárdenas , Jesús Angulo , Gonzalo Angulo , Marcin Pastorczak

{"title":"The chemical instability of the survivin inhibitor – sepantronium bromide (YM155) studied by stimulated Raman, NMR and UV–Vis spectroscopies","authors":"Samaneh Shahab , Jonathan Ramírez-Cárdenas , Jesús Angulo , Gonzalo Angulo , Marcin Pastorczak","doi":"10.1016/j.saa.2025.126720","DOIUrl":"10.1016/j.saa.2025.126720","url":null,"abstract":"<div><div>Sepantronium bromide, which shows a broad spectrum of anticancer action, is allegedly chemically unstable. This instability might significantly limit the final antineoplastic efficacy of the drug. Here, we report our studies on these chemical stability issues under different chemical environments using advanced spectroscopies. With UV–Vis spectroscopy, we observed a degradation product which absorbs around 450 nm. The degradation accelerated strongly at alkaline pH (>8.5) and in the presence of a buffer, particularly PBS. We performed NMR and stimulated Raman studies to identify the degradation product and analysed the degradation kinetics. With both methods, we observed H → D isotope exchange at the methyl group linked to the imidazole group of YM155, after dissolving YM155 in D<sub>2</sub>O. The exchange was similarly both alkaline- and buffer-catalysed. We were unable to identify the 450 nm-absorbing product of the degradation neither by NMR nor stimulated Raman, yet our studies pointed at imidazole-linked methyl as being associated with the YM155 degradation. The alkaline degradation of YM155 could be related to its mechanism of action – binding to DNA in mitochondria with pH values above 8.</div></div>","PeriodicalId":433,"journal":{"name":"Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy","volume":"344 ","pages":"Article 126720"},"PeriodicalIF":4.3,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144703999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A solid AIE sensor for visual monitoring of food freshness 用于视觉监测食物新鲜度的固体AIE传感器

IF 4.3 2区化学

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy Pub Date : 2025-07-19 DOI: 10.1016/j.saa.2025.126716

Na-Na Li , Xing-Yu Xu , Hai-Long Li , Qing-Lin Shi , Tian-Meng Shi , Li-Xue Wang , Hai-Xian Ren , Zi-Ao Zong , Jing Wang , Qin-ling Wei

引用次数: 0

Applications of benchtop and portable spectroscopy techniques for food quality monitoring 台式和便携式光谱技术在食品质量监测中的应用

IF 4.3 2区化学

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy Pub Date : 2025-07-18 DOI: 10.1016/j.saa.2025.126713

Muhammad Zareef , Muhammad Arslan , Waqas Ahmad , Md Mehedi Hassan , Muhammad Shoaib , Qin Ouyang , Huanhuan Li , Malik Muhammad Hashim , Sadaf Javaria , Quansheng Chen

{"title":"Applications of benchtop and portable spectroscopy techniques for food quality monitoring","authors":"Muhammad Zareef , Muhammad Arslan , Waqas Ahmad , Md Mehedi Hassan , Muhammad Shoaib , Qin Ouyang , Huanhuan Li , Malik Muhammad Hashim , Sadaf Javaria , Quansheng Chen","doi":"10.1016/j.saa.2025.126713","DOIUrl":"10.1016/j.saa.2025.126713","url":null,"abstract":"<div><div>Food safety and quality have become major worldwide issues. Because of their quickness, effectiveness, and non-destructive nature, spectroscopy methods are essential for guaranteeing the safety and quality of food items. These techniques include Fourier transform infrared (FTIR), Infrared (IR), Raman spectroscopy, near-infrared (NIR), and Fluorescence spectroscopies, which can be used to evaluate food composition analysis, food adulteration, spoilage indicators, and various levels of contamination. Machine learning-based chemometrics becomes essential for data analysis as spectroscopy techniques generate complex spectral data. Various multivariate analysis approaches have been recently used for spectral data analysis, and they are mostly classified as pre-processing methods for removing unnecessary information, qualitative, and quantitative analysis that can be used for data identification, classification, and prediction. This review examines the integration of spectroscopic techniques and chemometric methods, emphasizing how their combined application improves product quality and ensures food safety.</div></div>","PeriodicalId":433,"journal":{"name":"Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy","volume":"344 ","pages":"Article 126713"},"PeriodicalIF":4.3,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144686184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of rare-earth upconversion luminescent nanoprobe for bisulfate sensing and imaging of drug-induced hepatotoxicity 稀土上转换发光纳米探针在亚硫酸氢盐检测和药物肝毒性成像中的应用

IF 4.3 2区化学

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy Pub Date : 2025-07-18 DOI: 10.1016/j.saa.2025.126714

Yuting Han, Shufen Pan, Xi Chen, Xiao Ma, Qinglin Chen, Yanyan Tang, Yongquan Wu, Xun Li

{"title":"Development of rare-earth upconversion luminescent nanoprobe for bisulfate sensing and imaging of drug-induced hepatotoxicity","authors":"Yuting Han, Shufen Pan, Xi Chen, Xiao Ma, Qinglin Chen, Yanyan Tang, Yongquan Wu, Xun Li","doi":"10.1016/j.saa.2025.126714","DOIUrl":"10.1016/j.saa.2025.126714","url":null,"abstract":"<div><div>Abnormal levels of bisulfite in living organisms may cause respiratory diseases, cardiovascular diseases and even cancer. Rare-earth upconversion luminescent nanomaterials have anti-Stokes luminescence characteristics, excellent photostability and high chemical stability, while organic fluorescent probe has the advantages of the specific recognition groups. Thus, the combination of luminescent nanomaterials and an organic fluorescent probe can offer a novel approach to detect the content of HSO<sub>3</sub><sup>−</sup>. A NIR-excited nanoprobe (UCNP@PEG@HAM) was developed by assembling HSO<sub>3</sub><sup>−</sup>-sensitive dye (HAM) on the surface of upconversion nanoparticles (UCNP) with the assistance of DSPE-PEG<sub>2000</sub>-NH<sub>2</sub>. Upon being excited by light at 980 nm, UCNP@PEG@HAM could achieve upconversion luminescence response to HSO<sub>3</sub><sup>−</sup> and has the advantages of short response time, high sensitivity (LOD = 0.652 μM) and good selectivity. It could be used not only <em>in vitro</em> applications, but also in fluorescence imaging in mouse liver injury and the remediation models. The nanoprobe can monitor liver injury in living animals using near-infrared excitation. Furthermore, the nanoprobe could be a simple strategy to quickly check whether synthetic drugs can cause liver damage.</div></div>","PeriodicalId":433,"journal":{"name":"Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy","volume":"344 ","pages":"Article 126714"},"PeriodicalIF":4.3,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144678771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0