M. Stedman, Saydah Eltom, E. Solomon, R. Rea, K. Grady, Nadia Chaudhury, S. Brown, A. Paisley, R. Gadsby, A. Heald
{"title":"Living with diabetes and its impact on mental health: results of an online survey","authors":"M. Stedman, Saydah Eltom, E. Solomon, R. Rea, K. Grady, Nadia Chaudhury, S. Brown, A. Paisley, R. Gadsby, A. Heald","doi":"10.1097/XCE.0000000000000262","DOIUrl":"https://doi.org/10.1097/XCE.0000000000000262","url":null,"abstract":"Mike Stedman, Saydah Eltom, Emma Solomon, Rustam Rea, Katherine Grady, Nadia Chaudhury, Stephen Brown, Angela Paisley, Roger Gadsby and Adrian H. Heald, Medical Research, Res Consortium, Andover, Departments of Diabetes and Endocrinology and Clinical Psychology, Salford Royal Hospital, Salford, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, Research for the Future, Northern Care Alliance National Health Service Group, Salford, University Hospitals Coventry and Warwickshire, Coventry, The School of Medicine and Manchester Academic Health Sciences Centre, University of Manchester, Manchester and University of Warwick Medical School, Coventry, UK","PeriodicalId":43231,"journal":{"name":"Cardiovascular Endocrinology & Metabolism","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2022-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41329449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kamran Qureshy, Andreas Ross Kirk, Michael Lyng Wolden, Amir Abbas Mohseni Zonoozi, Aiden Liu
{"title":"A survey of physician experience and treatment satisfaction prescribing once-weekly semaglutide injections for patients with type 2 diabetes in Canada.","authors":"Kamran Qureshy, Andreas Ross Kirk, Michael Lyng Wolden, Amir Abbas Mohseni Zonoozi, Aiden Liu","doi":"10.1097/XCE.0000000000000260","DOIUrl":"10.1097/XCE.0000000000000260","url":null,"abstract":"<p><p>We assessed physicians' experiences of prescribing once-weekly (OW) semaglutide to patients with type 2 diabetes (T2D) in Canada. Physicians who had prescribed OW semaglutide to ≥2 patients with T2D in the past 12 months and had been doing so for ≥3 months were surveyed during 1-17 October 2018. Prescribing reasons, treatment satisfaction and reasons for discontinuation were assessed. Of the 50 participants, 72% and 54% were prescribed OW semaglutide due to its superior glycemic control and effect on weight, respectively. Most physicians were more satisfied with injection frequency (62%), effect on weight (60%), achieving HbA1c target (54%) and therapy simplicity (50%) with OW semaglutide versus other glucagon-like peptide-1 receptor agonists. Treatment discontinuations in 13% of OW semaglutide-treated patients were reported by physicians, primarily due to gastrointestinal symptoms (70%). The survey suggests that physicians are satisfied with the OW semaglutide clinical effects. Video Abstract: http://links.lww.com/CAEN/A34.</p>","PeriodicalId":43231,"journal":{"name":"Cardiovascular Endocrinology & Metabolism","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2022-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8955057/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41257506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Heald, Elisabeth Malm, Ghassan Darwiche, Adintya Putri, D. Zdravković
{"title":"Actiste diabetes management as a service innovation – impact on everyday life – Swedish patients experience assessed by validated MedTech20 questionnaire","authors":"A. Heald, Elisabeth Malm, Ghassan Darwiche, Adintya Putri, D. Zdravković","doi":"10.1097/xce.0000000000000259","DOIUrl":"https://doi.org/10.1097/xce.0000000000000259","url":null,"abstract":"","PeriodicalId":43231,"journal":{"name":"Cardiovascular Endocrinology & Metabolism","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2022-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44492659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Adrian H Heald, David A Jenkins, Nadia Chaudhury, Richard Williams, Matthew Sperrin, Niels Peek, William Ollier, Kelly Bowden-Davies, Gayathri Delanerolle, Simon G Anderson, John Martin Gibson
{"title":"SARS-CoV-2, diabetes and mortality: month by month variation in mortality rate from June 2020 to June 2021.","authors":"Adrian H Heald, David A Jenkins, Nadia Chaudhury, Richard Williams, Matthew Sperrin, Niels Peek, William Ollier, Kelly Bowden-Davies, Gayathri Delanerolle, Simon G Anderson, John Martin Gibson","doi":"10.1097/XCE.0000000000000258","DOIUrl":"https://doi.org/10.1097/XCE.0000000000000258","url":null,"abstract":"Adrian H. Heald, David A. Jenkins, Nadia Chaudhury, Richard Williams, Matthew Sperrin, Niels Peek, William Ollier, Kelly Bowden-Davies, Gayathri Delanerolle, Simon G. Anderson and John Martin Gibson, The School of Medicine and Manchester Academic Health Sciences Centre, The University of Manchester, Manchester, Department of Diabetes and Endocrinology, Salford Royal NHS Foundation Trust, Salford, Division of Informatics, Imaging and Data Science, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, NIHR Greater Manchester Patient Safety Translational Research Centre, The University of Manchester, Manchester, University Hospitals Coventry and Warwickshire, Coventry, Faculty of Science and Engineering, Manchester Metropolitan University, Manchester, Department of Sport and Exercise Sciences, Musculoskeletal Science and Sports Medicine Research Centre, Manchester Metropolitan University, Manchester, Nuffield Department of Primary Health Care Science, University of Oxford (Substantive), Oxford, Clinical Research Facility, Southern Health NHS Foundation Trust (Honorary), Southampton, UK, The George Alleyne Chronic Disease Research Centre, University of the West Indies, Cave Hill Campus, Bridgetown, Barbados and Division of Cardiovascular Sciences, Faculty of Biology Medicine and Health, University of Manchester, Manchester, UK","PeriodicalId":43231,"journal":{"name":"Cardiovascular Endocrinology & Metabolism","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2022-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8805796/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39895413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Adrian H Heald, David A Jenkins, Nadia Chaudhury, Richard Williams, Matthew Sperrin, Niels Peek, William Ollier, Kelly Bowden-Davies, Gayathri Delanerolle, Simon G Anderson, John Martin Gibson
{"title":"Application of a city wide digital population database for outcome analysis in diabetes: SARS-CoV-2, diabetes and hospital admission rate month by month in Greater Manchester, UK.","authors":"Adrian H Heald, David A Jenkins, Nadia Chaudhury, Richard Williams, Matthew Sperrin, Niels Peek, William Ollier, Kelly Bowden-Davies, Gayathri Delanerolle, Simon G Anderson, John Martin Gibson","doi":"10.1097/XCE.0000000000000257","DOIUrl":"https://doi.org/10.1097/XCE.0000000000000257","url":null,"abstract":"Adrian H. Heald, David A. Jenkins, Nadia Chaudhury, Richard Williams, Matthew Sperrin, Niels Peek, William Ollier, Kelly Bowden-Davies, Gayathri Delanerolle, Simon G. Anderson and John Martin Gibson, The School of Medicine and Manchester Academic Health Sciences Centre, The University of Manchester, Manchester, Department of Diabetes and Endocrinology, Salford Royal NHS Foundation Trust, Salford, Division of Informatics, Imaging and Data Science, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, NIHR Greater Manchester Patient Safety Translational Research Centre, The University of Manchester, Manchester, University Hospitals Coventry and Warwickshire, Coventry, Faculty of Science and Engineering, Manchester Metropolitan University, Manchester, Department of Sport and Exercise Sciences, Musculoskeletal Science and Sports Medicine Research Centre, Manchester Metropolitan University, Manchester, Nuffield Department of Primary Health Care Science, University of Oxford (Substantive), Oxford, Clinical Research Facility, Southern Health NHS Foundation Trust (Honorary), Southampton, UK, The George Alleyne Chronic Disease Research Centre, University of the West Indies, Cave Hill Campus, Bridgetown, Barbados and Division of Cardiovascular Sciences, Faculty of Biology Medicine and Health, University of Manchester, Manchester, UK","PeriodicalId":43231,"journal":{"name":"Cardiovascular Endocrinology & Metabolism","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2022-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8805797/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39895412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hayder A Giha, Dhuha M B AlDehaini, Faris E Joatar, Muhalab E Ali, Einas M Al-Harbi, Ali A Al Qarni
{"title":"Hormonal and metabolic profiles of obese and nonobese type 2 diabetes patients: implications of plasma insulin, ghrelin, and vitamin D levels.","authors":"Hayder A Giha, Dhuha M B AlDehaini, Faris E Joatar, Muhalab E Ali, Einas M Al-Harbi, Ali A Al Qarni","doi":"10.1097/XCE.0000000000000256","DOIUrl":"https://doi.org/10.1097/XCE.0000000000000256","url":null,"abstract":"<p><p>Type 2 diabetes (T2D) is associated with obesity whereas loss of weight is a feature of the disease; however, the two states are not mutually exclusive. Obesity is linked with changes in hormonal activity and overall body metabolism.</p><p><strong>Materials and methods: </strong>In this study, 408 T2D patients were recruited in three distinct studies conducted in Bahrain, Saudi Arabia, and Kuwait in three different intervals between 2001 and 2019. In addition to demographics, glycemic and lipid profiles were obtained in all studies, whereas plasma insulin and HOMA-IR, vitamin D, and ghrelin were analyzed in Saudi Arabia. Different techniques such as chemical auto-analyzer, ELISA, chemiluminescent immunoassay, radioimmunoassay were used.</p><p><strong>Results: </strong>The obese (BMI ≥ 30 kg/m<sup>2</sup>) compared with nonobese (BMI 18.5 to <30) patients with diabetes were more likely to be women (<i>P</i> < 0.001), smaller in age (<i>P</i> = 0.028), and with shorter disease duration (<i>P</i> = 0.018). Unexpectedly, the glycemic and lipid profiles were consistently comparable between the two groups in the three sites. Furthermore, vitamin D was strikingly lower in obese patients with diabetes (<i>P</i> = 0.007). Finally, plasma ghrelin (<i>P</i> = 0.163), insulin (<i>P</i> = 0.063), and HOMA-IR (<i>P</i> = 0.166) were comparable between obese and nonobese patients with diabetes.</p><p><strong>Conclusion: </strong>Diabetic obesity was significantly associated with female sex, young age, short disease duration, and noticeably low vitamin D, and a trend of high insulin levels. However, the obese and nonobese patients had comparable metabolic profiles with no differences in insulin resistance and ghrelin levels. Further studies, especially at a molecular level, are needed to explore this topic which is barely investigated.</p>","PeriodicalId":43231,"journal":{"name":"Cardiovascular Endocrinology & Metabolism","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2022-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789207/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39573842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Adrian H Heald, Mark Livingston, Gabriela Moreno, John Martin Gibson
{"title":"The risk factors potentially influencing risk of serious illness/death in people with diabetes, following SARS-CoV-2 infection: What needs to be done from here.","authors":"Adrian H Heald, Mark Livingston, Gabriela Moreno, John Martin Gibson","doi":"10.1097/XCE.0000000000000255","DOIUrl":"https://doi.org/10.1097/XCE.0000000000000255","url":null,"abstract":"Adrian H. Heald, Mark Livingston, Gabriela Moreno and John Martin Gibson, The School of Medicine and Manchester Academic Health Sciences Centre, The University of Manchester, Manchester, Department of Diabetes and Endocrinology, Salford Royal NHS Foundation Trust, Salford, Department of Clinical Biochemistry, Black Country Pathology Services, Walsall Manor Hospital, Walsall, UK and Coordinación Nacional de Investigación, Subdirección de Servicios de Salud, Petróleos Mexicanos, Ciudad de México, México","PeriodicalId":43231,"journal":{"name":"Cardiovascular Endocrinology & Metabolism","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2021-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/58/12/xce-10-231.PMC8575435.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39866823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sara H Malek, Ahmad E Al-Serri, Suzanne A Al-Bustan
{"title":"Genetic association of <i>LPL</i> rs326 with BMI among the Kuwaiti population.","authors":"Sara H Malek, Ahmad E Al-Serri, Suzanne A Al-Bustan","doi":"10.1097/XCE.0000000000000254","DOIUrl":"https://doi.org/10.1097/XCE.0000000000000254","url":null,"abstract":"<p><p>Lipoprotein lipase is a key enzyme in lipid metabolism with reported variants associated with obesity, hypertension, type 2 diabetes, and coronary heart disease. This study was performed to investigate the association between common lipoprotein lipase single nucleotide polymorphisms and metabolic disorders in a sample of Kuwaiti cohort (n = 494). Five lipoprotein lipase variants (rs1801177, rs295, rs326, ss2137497749, and ss2137497750) across the lipoprotein lipase gene were genotyped by real-time PCR employing the TaqMan allele discrimination assay. Genotype, allelic frequencies, and Hardy-Weinberg Equilibrium were determined for each variant in the cohort followed by multivariate and logistic regression analysis. A novel finding was observed for the G allele of single nucleotide polymorphism rs326 which was associated with increased BMI after adjusting for age and sex (β = 1.04; 95% confidence interval = 0.15-1.94; <i>P</i> = 0.02). Moreover, a significant difference in the distribution of the minor C allele of rs295 among coronary heart disease subjects compared with noncoronary heart disease, however, this significance was diminished after controlling for age, sex, and BMI. This study demonstrated that lipoprotein lipase rs326 may be indicative for the increased risk of obesity and possibly rs295 for coronary heart disease. The findings are also in agreement with other reports suggesting that intronic variants are important genetic markers in association studies. The findings warrant further studies in a large cohort to confirm and validate the results presented.</p>","PeriodicalId":43231,"journal":{"name":"Cardiovascular Endocrinology & Metabolism","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2021-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e6/c9/xce-10-215.PMC8575433.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39614097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The microvascular hypothesis underlying neurologic manifestations of long COVID-19 and possible therapeutic strategies.","authors":"","doi":"10.1097/XCE.0000000000000253","DOIUrl":"10.1097/XCE.0000000000000253","url":null,"abstract":"<p><p>With the ongoing distribution of the coronavirus disease (COVID) vaccines, the pandemic of our age is ending, leaving the world to deal with its well-documented aftereffects. Long COVID comprises a variety of symptoms, of which the neurological component prevails. The most permeating theory on the genesis of these symptoms builds upon the development of microvascular dysfunction similar to that seen in numerous vascular diseases such as diabetes. This can occur through the peripheral activation of angiotensin-converting enzyme 2 receptors, or through exacerbations of pro-inflammatory cytokines that can remain in circulation even after the infection diminishes. Several drugs have been identified to act on the neurovascular unit to promote repair, such as gliptins, and others. They also succeeded in improving neurologic outcome in diabetic patients. The repurposing of such drugs for treatment of long COVID-19 can possibly shorten the time to recovery of long COVID-19 syndrome.</p>","PeriodicalId":43231,"journal":{"name":"Cardiovascular Endocrinology & Metabolism","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2021-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/9f/b8/xce-10-193.PMC8575441.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39614094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Adrian H Heald, Ian Laing, Simon Anderson, Mark Livingston
{"title":"Low sex hormone binding globulin: a potential predictor of future glucose dysregulation in women.","authors":"Adrian H Heald, Ian Laing, Simon Anderson, Mark Livingston","doi":"10.1097/XCE.0000000000000252","DOIUrl":"https://doi.org/10.1097/XCE.0000000000000252","url":null,"abstract":"Adrian H. Heald, Ian Laing, Simon Anderson and Mark Livingston, The Faculty of Biology, Medicine and Health and Manchester Academic Health Sciences Centre, University of Manchester, Department of Diabetes and Endocrinology, Salford Royal Hospital, Salford, UK, Department of Clinical Biochemistry, Royal Preston Hospital, University of the West Indies, Cavehill Campus, Barbados, Department of Clinical Biochemistry, Black Country Pathology Services, Walsall Manor Hospital, Walsall and School of Medicine and Clinical Practice, University of Wolverhampton, Wolverhampton, UK","PeriodicalId":43231,"journal":{"name":"Cardiovascular Endocrinology & Metabolism","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2021-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8352627/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39307017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}