Cardiovascular Endocrinology & Metabolism最新文献

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Low sex hormone binding globulin: a potential predictor of future glucose dysregulation in women. 性激素结合球蛋白低:女性未来血糖失调的潜在预测因子。
IF 2.3
Cardiovascular Endocrinology & Metabolism Pub Date : 2021-07-29 eCollection Date: 2021-09-01 DOI: 10.1097/XCE.0000000000000252
Adrian H Heald, Ian Laing, Simon Anderson, Mark Livingston
{"title":"Low sex hormone binding globulin: a potential predictor of future glucose dysregulation in women.","authors":"Adrian H Heald, Ian Laing, Simon Anderson, Mark Livingston","doi":"10.1097/XCE.0000000000000252","DOIUrl":"https://doi.org/10.1097/XCE.0000000000000252","url":null,"abstract":"Adrian H. Heald, Ian Laing, Simon Anderson and Mark Livingston, The Faculty of Biology, Medicine and Health and Manchester Academic Health Sciences Centre, University of Manchester, Department of Diabetes and Endocrinology, Salford Royal Hospital, Salford, UK, Department of Clinical Biochemistry, Royal Preston Hospital, University of the West Indies, Cavehill Campus, Barbados, Department of Clinical Biochemistry, Black Country Pathology Services, Walsall Manor Hospital, Walsall and School of Medicine and Clinical Practice, University of Wolverhampton, Wolverhampton, UK","PeriodicalId":43231,"journal":{"name":"Cardiovascular Endocrinology & Metabolism","volume":"10 3","pages":"191-192"},"PeriodicalIF":2.3,"publicationDate":"2021-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8352627/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39307017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Correlation between the ankle-brachial index and microalbuminuria with certain risk factors in type 2 diabetes patients. 2型糖尿病患者踝肱指数和微量白蛋白尿与某些危险因素的相关性
IF 2.3
Cardiovascular Endocrinology & Metabolism Pub Date : 2021-06-09 eCollection Date: 2021-12-01 DOI: 10.1097/XCE.0000000000000251
Van Tuan Nguyen, Ha Linh Phan, Thi Minh Hoang, Thi Phuong Lan Dam, Thi Hang Ho, Quang Thuan Huynh
{"title":"Correlation between the ankle-brachial index and microalbuminuria with certain risk factors in type 2 diabetes patients.","authors":"Van Tuan Nguyen,&nbsp;Ha Linh Phan,&nbsp;Thi Minh Hoang,&nbsp;Thi Phuong Lan Dam,&nbsp;Thi Hang Ho,&nbsp;Quang Thuan Huynh","doi":"10.1097/XCE.0000000000000251","DOIUrl":"https://doi.org/10.1097/XCE.0000000000000251","url":null,"abstract":"<p><p>The ankle-brachial index (ABI) is a fast, simple, noninvasive method that provides accurate results in the early diagnosis of peripheral artery disease. Microalbuminuria is considered a predictor of renal and cardiovascular complications in patients with diabetes. This study was conducted to determine the correlation between ABI and microalbuminuria with certain risk factors in patients with type 2 diabetes.</p><p><strong>Subjects and research methods: </strong>A cross-sectional descriptive study was performed on 62 inpatients with type 2 diabetes. All patients were measured for ABI as well as microalbuminuria, HbA1c, glucose and lipidemia in the blood.</p><p><strong>Results: </strong>The study results showed that in patients with dyslipidemia, the risk of having microalbuminuria (+) increased 5.7 times and ABI ≤0.90 increased 8.6 times (<i>P</i> = 0.004 and 0.021, respectively). Fasting blood glucose >7.2 mmol/L had 5.7 times higher microalbuminuria (+) risk and 8.6 times higher ABI ≤0.90 (<i>P</i> = 0.004 and 0.021, respectively). Patients with HbA1c ≥7% were 2.9 times more likely to have microalbuminuria (+) and ABI ≤0.90 (<i>P</i> = 0.043 and 0.048, respectively).</p><p><strong>Conclusions: </strong>Peripheral vascular disease risk factors such as hypertension, dyslipidemia and waist circumference and the effectiveness of fasting blood glucose and HbA1c control increased the risk of high microalbuminuria and ABI in patients with type 2 diabetes.</p>","PeriodicalId":43231,"journal":{"name":"Cardiovascular Endocrinology & Metabolism","volume":"10 4","pages":"210-214"},"PeriodicalIF":2.3,"publicationDate":"2021-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/2f/6d/xce-10-210.PMC8575440.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39614096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Recalibration of thinking about adrenocortical function assessment: how the 'random' cortisol relates to the short synacthen test results. 关于肾上腺皮质功能评估的思考的重新校准:“随机”皮质醇如何与短突触测试结果相关。
IF 2.3
Cardiovascular Endocrinology & Metabolism Pub Date : 2021-04-12 eCollection Date: 2021-06-01 DOI: 10.1097/XCE.0000000000000250
Maria Michaelidou, Ghasem Yadegarfar, Lauren Morris, Samantha Dolan, Adam Robinson, Asma Naseem, Mark Livingston, Chris J Duff, Peter Trainer, Anthony A Fryer, Adrian H Heald
{"title":"Recalibration of thinking about adrenocortical function assessment: how the 'random' cortisol relates to the short synacthen test results.","authors":"Maria Michaelidou,&nbsp;Ghasem Yadegarfar,&nbsp;Lauren Morris,&nbsp;Samantha Dolan,&nbsp;Adam Robinson,&nbsp;Asma Naseem,&nbsp;Mark Livingston,&nbsp;Chris J Duff,&nbsp;Peter Trainer,&nbsp;Anthony A Fryer,&nbsp;Adrian H Heald","doi":"10.1097/XCE.0000000000000250","DOIUrl":"https://doi.org/10.1097/XCE.0000000000000250","url":null,"abstract":"<p><strong>Background: </strong>The short synacthen test (SST) is the most commonly performed investigation to assess adrenal function. Appropriate criteria for when an SST is performed are subject to debate. We investigated how random serum cortisol levels relate to SST response.</p><p><strong>Methods: </strong>We examined random cortisol measurements taken between 04.40-23.55 p.m. results of SST baseline and 30-/60-min cortisol performed over 12 months (225 SSTs) at Salford Royal Hospital. Serum cortisol was measured on the Siemens Centaur Analyser.A 30-60-min cortisol concentration of ≥450 nmol/L defined a pass; 350-449 nmol/L defined borderline.</p><p><strong>Results: </strong>Patients only proceeded to SST if random cortisol was <400 nmol/L. For those not on corticosteroids for at least 2 weeks, 42/43 (97.7%) cases with random cortisol concentration of ≥200 nmol/L had an SST 'pass'. The relation was less clear with corticosteroid treatment (19/35 cases; 54%).For those not taking glucocorticoid treatment (including inhaled/topical corticosteroids) in the previous 2 weeks, 91.8% of SSTs were pass/2.7% borderline/5.5% fail. For those on steroids, 51.9% of SSTs were a pass/11.4% were borderline.In relation to the postsynacthen cortisol pass cut-off of ≥450 nmol/L, in 15/207 (7.2%) of cases, the 60-min cortisol was ≥450 nmol/L (adequate adrenocortical function), but 30-min cortisol was below this. In all cases where the 30-min cortisol did indicate a pass (i.e. was ≥450 nmol/L) the 60-min cortisol was also ≥450 nmol/L.</p><p><strong>Conclusion: </strong>Our findings suggest that if the random cortisol level is ≥200 nmol/L, regardless of the time of day and the person was not taking corticosteroid treatment in the previous 2 weeks, SST may not be needed. Our data also suggests that 60-min cortisol retains utility.</p>","PeriodicalId":43231,"journal":{"name":"Cardiovascular Endocrinology & Metabolism","volume":"10 2","pages":"137-145"},"PeriodicalIF":2.3,"publicationDate":"2021-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/79/89/xce-10-137.PMC8186517.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39083654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Dapagliflozin: an effective adjunctive treatment in type 1 diabetes. 达格列净:1型糖尿病的有效辅助治疗。
IF 2.3
Cardiovascular Endocrinology & Metabolism Pub Date : 2021-03-25 eCollection Date: 2021-06-01 DOI: 10.1097/XCE.0000000000000248
Ghasem Yadegarfar, Mark Livingston, Gabriela Cortes, Ramadan Alshames, Kate Leivesley, Ann Metters, Linda Horne, Tom Steele, Adrian H Heald
{"title":"Dapagliflozin: an effective adjunctive treatment in type 1 diabetes.","authors":"Ghasem Yadegarfar,&nbsp;Mark Livingston,&nbsp;Gabriela Cortes,&nbsp;Ramadan Alshames,&nbsp;Kate Leivesley,&nbsp;Ann Metters,&nbsp;Linda Horne,&nbsp;Tom Steele,&nbsp;Adrian H Heald","doi":"10.1097/XCE.0000000000000248","DOIUrl":"https://doi.org/10.1097/XCE.0000000000000248","url":null,"abstract":"<p><strong>Introduction: </strong>Many people with type 1 diabetes (T1DM) continue to run high HbA1c levels with an associated elevated risk of cardiovascular events and increased mortality. We describe here how adjunctive prescription of an SGLT2 inhibitor has improved the glycaemic control of several people with T1DM, where the new technology has been intensively deployed.</p><p><strong>Methods: </strong>We report outcomes of six adults with T1DM who have been given dapagliflozin in East Cheshire, UK. Initiation was with education/support from the diabetes specialist nurses. All had an HbA1c of 70 mmol/mol (8.6%) or more before this was initiated. All had been monitoring glycemia with a FreeStyle Libre monitor for at least 6 months prior to this.</p><p><strong>Results: </strong>The age range was 30-68 years. The mean duration of T1DM was 23.3 ± 5.5 years. All were on a basal-bolus regime. Over a 6 month period, HbA1c fell from 78.5 mmol/mol (9.3%) to 55 mmol/mol (7.2%). The greatest reduction in HbA1c was 57 mmol/mol (7.4%). Analysis of the FreeStyle Libre blood glucose records showed that the proportion of blood glucose readings on target (4-10 mmol/L) increased from 33.1 to 65.2% with the addition of dapagliflozin(P = 0.007). The proportion of blood glucose readings above target (>10 mmol/L) decreased from 68.0 to 26.4%, 6 months after initiation of dapagliflozin (P = 0.005). There was no increase in symptomatic hypoglycemia.</p><p><strong>Conclusion: </strong>Dapagliflozin as adjunctive therapy to basal-bolus regime insulin in individuals with T1DM was well tolerated and improved glycemic control with no increase in hypoglycemia. We provide further evidence of the value of this intervention.</p>","PeriodicalId":43231,"journal":{"name":"Cardiovascular Endocrinology & Metabolism","volume":"10 2","pages":"132-136"},"PeriodicalIF":2.3,"publicationDate":"2021-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f0/cf/xce-10-132.PMC8189611.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39091866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Successful use of the sodium-glucose co-transporter-2 inhibitor dapagliflozin in patients with renal transplant and diabetes: a case series and literature review. 肾移植合并糖尿病患者成功使用钠-葡萄糖协同转运体-2抑制剂达帕格列净:系列病例和文献综述。
IF 2.3
Cardiovascular Endocrinology & Metabolism Pub Date : 2021-03-17 eCollection Date: 2021-12-01 DOI: 10.1097/XCE.0000000000000246
Wajiha Gul, Emad Naem, Safa Elawad, Tarik Elhadd
{"title":"Successful use of the sodium-glucose co-transporter-2 inhibitor dapagliflozin in patients with renal transplant and diabetes: a case series and literature review.","authors":"Wajiha Gul, Emad Naem, Safa Elawad, Tarik Elhadd","doi":"10.1097/XCE.0000000000000246","DOIUrl":"10.1097/XCE.0000000000000246","url":null,"abstract":"<p><p>Management of patients with diabetes and renal transplant could be challenging. Transplant patients use multiple immune suppressants that can worsen or even trigger hyperglycemia. There are no data about the use of the new class of sodium-glucose co-transporter-2 (SGLT-2) inhibitor dapagliflozin in patients with renal transplant and diabetes.</p><p><strong>Case series: </strong>Four patients, with diabetes, who are attending the diabetes clinic at our institution, are presented here. They were all counseled to be started on dapagliflozin 10 mg to improve diabetes control as they were on multiple agents and not achieving targets. All four patients showed significant improvement in hemoglobin A1c, with no adverse effects on renal parameters and had favorable effect on weight and blood pressure (BP).</p><p><strong>Conclusion: </strong>Use of the SGLT-2 inhibitor dapagliflozin in the standard dose of 10 mg helped to achieve satisfactory control with favorable effects on BP and weight with no adverse effects on renal function.</p>","PeriodicalId":43231,"journal":{"name":"Cardiovascular Endocrinology & Metabolism","volume":"10 4","pages":"222-224"},"PeriodicalIF":2.3,"publicationDate":"2021-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8575439/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39614098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Atypical hemolytic uremic syndrome: when pregnancy leads to lifelong dialysis: a case report and literature review. 非典型溶血性尿毒症综合征:当怀孕导致终身透析:1例报告和文献复习。
IF 2.3
Cardiovascular Endocrinology & Metabolism Pub Date : 2021-03-17 eCollection Date: 2021-12-01 DOI: 10.1097/XCE.0000000000000247
Bair Cadet, Daniel Meshoyrer, Zae Kim
{"title":"Atypical hemolytic uremic syndrome: when pregnancy leads to lifelong dialysis: a case report and literature review.","authors":"Bair Cadet,&nbsp;Daniel Meshoyrer,&nbsp;Zae Kim","doi":"10.1097/XCE.0000000000000247","DOIUrl":"https://doi.org/10.1097/XCE.0000000000000247","url":null,"abstract":"<p><p>Atypical hemolytic uremic syndrome (aHUS), a challenging disorder, commonly caused by inherited defects or regulatory processes of the complement alternative pathway. There are multiple causes, including pregnancy. Pregnancy provokes life-threatening episodes, preeclampsia, hemolysis elevated liver enzymes low platelets, microangiopathic hemolytic anemia (MAHA) and end-stage renal disease. Additionally, complement dysregulation and, with aHUS, affects fetal and maternal outcomes. Pregnancy-associated aHUS results in a poor prognosis with irreversible renal damage. Likewise, it is imperative to know that MAHA can provoke endothelial disruption, destruction of red cells and thrombocytopenia. We present a case of a young 18-year-old woman with MAHA and aHUS, requiring emergent cesarean section at 34 weeks of gestation and hemodialysis, secondary to complications from a recent pregnancy. Elevated blood pressure readings, rising creatinine levels, as well as her mother being on dialysis after pregnancy raised suspicion for thrombotic microangiopathy and aHUS. She was subsequently managed with plasma exchange, steroids, eculizumab and hemodialysis. Thus, plasma exchange should be initiated, with pending additional workup. Upon a definitive diagnosis of aHUS, eculizumab would be warranted to mitigate immune dysregulation. Understanding thrombotic microangiopathies diagnosis, and recognizing concomitant consequences, is vital. Having better insights into endothelial injuries can prevent unfortunate outcomes.</p>","PeriodicalId":43231,"journal":{"name":"Cardiovascular Endocrinology & Metabolism","volume":"10 4","pages":"225-230"},"PeriodicalIF":2.3,"publicationDate":"2021-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ec/86/xce-10-225.PMC8575437.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39614099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Sodium-glucose co-transporter 2 inhibitors and diabetic retinopathy: insights into preservation of sight and looking beyond. 钠-葡萄糖共转运蛋白2抑制剂和糖尿病视网膜病变:对视力保护的见解和展望。
IF 2.3
Cardiovascular Endocrinology & Metabolism Pub Date : 2021-03-01 DOI: 10.1097/XCE.0000000000000209
Sejal Lahoti, Mouhamed Nashawi, Omar Sheikh, David Massop, Mahnoor Mir, Robert Chilton
{"title":"Sodium-glucose co-transporter 2 inhibitors and diabetic retinopathy: insights into preservation of sight and looking beyond.","authors":"Sejal Lahoti,&nbsp;Mouhamed Nashawi,&nbsp;Omar Sheikh,&nbsp;David Massop,&nbsp;Mahnoor Mir,&nbsp;Robert Chilton","doi":"10.1097/XCE.0000000000000209","DOIUrl":"https://doi.org/10.1097/XCE.0000000000000209","url":null,"abstract":"<p><p>Sodium-glucose co-transporter 2 Inhibitors (SGLT2i) were initially developed as therapeutic options for patients with type 2 diabetes mellitus (T2DM). Recently, randomized clinical trials have investigated their effects in cardiorenal protection through major adverse cardiovascular event reduction and reductions in diabetic nephropathy. While multiple mechanisms are proposed for this protection, microvascular protection is the primary component of their efficacy. While not primarily emphasized in clinical trials, evidence in other studies suggests that SGLT2i may confer retinoprotective effects via some of the same mechanisms in the aforementioned cardiorenal trials. Diabetic patients are susceptible to vision loss with chronic hyperglycemia promoting inflammation, edema, and retinal pathological changes. Targeting these pathways via SGLT2i may represent opportunities for providers to decrease retinopathy in high-risk T2DM patients, reduce disease progression, and lower drug burden in diabetic retinopathy patients. Further comprehensive clinical trials investigating these associations are needed to establish the potential retinoprotective effects of SGLT2i.</p>","PeriodicalId":43231,"journal":{"name":"Cardiovascular Endocrinology & Metabolism","volume":"10 1","pages":"3-13"},"PeriodicalIF":2.3,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7901818/pdf/xce-10-03.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10291795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Investigation of polycystic ovarian syndrome: variation in practice and impact on the speed of diagnosis. 多囊卵巢综合征的调查:实践差异及其对诊断速度的影响。
IF 2.3
Cardiovascular Endocrinology & Metabolism Pub Date : 2021-02-23 eCollection Date: 2021-06-01 DOI: 10.1097/XCE.0000000000000245
Amar M Karia, Christopher J Duff, Adrian H Heald, Ingrid Britton, Anthony A Fryer, Pensée Wu
{"title":"Investigation of polycystic ovarian syndrome: variation in practice and impact on the speed of diagnosis.","authors":"Amar M Karia,&nbsp;Christopher J Duff,&nbsp;Adrian H Heald,&nbsp;Ingrid Britton,&nbsp;Anthony A Fryer,&nbsp;Pensée Wu","doi":"10.1097/XCE.0000000000000245","DOIUrl":"https://doi.org/10.1097/XCE.0000000000000245","url":null,"abstract":"<p><strong>Objective: </strong>Accurate diagnosis of polycystic ovarian syndrome (PCOS) enables clinical interventions/cardiometabolic risk factor management. Diagnosis can take over 2 years and multiple clinician contacts. We examined patterns of PCOS-associated biochemical investigations following initial consultation prior to pelvic ultrasound scan (USS).</p><p><strong>Methods: </strong>We determined in 206 women (i) the range of different biochemical test panels used in the diagnosis of PCOS in primary/secondary care prior to USS relative to national guidance in the UK and (ii) the relation between testing patterns and time to USS to highlight potential delays introduced by inappropriate testing.</p><p><strong>Results: </strong>In these 206 women, 47 different test combinations were requested at initial venepuncture; only 7 (3%) had the test panel suggested in UK guidance (follicle-stimulating hormone/luteinizing hormone/testosterone/sex hormone-binding globulin/prolactin). The number of tests performed prior to USS varied from one test to all seven tests. There was an inverse relation between the number of biochemistry tests requested at initial venepuncture episode and 'time to scan'. Those who had <3 tests had a significantly longer time from first request to USS (median 70 days) than those with 3-7 tests (median 40 days; <i>P</i> = 0.002). One venepuncture episode prior to USS was associated with shorter 'time to scan' (median 29 days) than those with 2-4 episodes (median 255 days; <i>P</i> < 0.001).</p><p><strong>Conclusion: </strong>There was no identifiable pattern to biochemical investigations requested as part of the initial diagnostic evaluation in women with suspected PCOS. We recommend standardization of the initial biochemical panel of analytes for PCOS workup, with incorporation into hospital/general practice ordering software systems.</p>","PeriodicalId":43231,"journal":{"name":"Cardiovascular Endocrinology & Metabolism","volume":"10 2","pages":"120-124"},"PeriodicalIF":2.3,"publicationDate":"2021-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/36/d9/xce-10-120.PMC8186510.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39100979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
The relationship between rheumatoid arthritis and diabetes mellitus: a systematic review and meta-analysis. 类风湿关节炎与糖尿病的关系:系统回顾和荟萃分析。
IF 2.3
Cardiovascular Endocrinology & Metabolism Pub Date : 2021-02-19 eCollection Date: 2021-06-01 DOI: 10.1097/XCE.0000000000000244
Zixing Tian, John Mclaughlin, Arpana Verma, Hector Chinoy, Adrian H Heald
{"title":"The relationship between rheumatoid arthritis and diabetes mellitus: a systematic review and meta-analysis.","authors":"Zixing Tian,&nbsp;John Mclaughlin,&nbsp;Arpana Verma,&nbsp;Hector Chinoy,&nbsp;Adrian H Heald","doi":"10.1097/XCE.0000000000000244","DOIUrl":"https://doi.org/10.1097/XCE.0000000000000244","url":null,"abstract":"<p><strong>Objective: </strong>This systematic review/meta-analysis was conducted to investigate the relationship between rheumatoid arthritis and the incidence of diabetes mellitus.</p><p><strong>Methods: </strong>A comprehensive search was conducted up to 10 March 2020 in Medline (via Ovid), Embase (via Ovid) and Web of Science core collection to identify cohort studies comparing the risk of diabetes mellitus incidence in people with rheumatoid arthritis with the general population. The I2 statistic was used to test heterogeneity. Pooled relative risks were calculated using random-effects models. Publication bias was assessed using Egger's test and Begg's test.</p><p><strong>Results: </strong>The initial search provided 3669 articles. Of those, five journal articles/two conference abstracts comprising 1 629 854 participants were included in this study. The funnel plot showed potential publication bias, proven by Egger's test (-3.15, P < 0.01), but not Begg's test (-0.05, P = 1.00). Heterogeneity was observed in I2 test (I2 = 96%, P < 0.01). We found that rheumatoid arthritis was associated with a higher risk of diabetes mellitus incidence (pooled relative risk, 1.23; 95% confidence interval, 1.07-1.40). Exploration of potential sources of heterogeneity found significant heterogeneity in different countries/regions (P = 0.002), but heterogeneity was NS in different study designs (P = 0.30). Sensitivity analyses confirmed that the association between rheumatoid arthritis and diabetes mellitus incidence was robust.</p><p><strong>Conclusion: </strong>Rheumatoid arthritis is associated with an increased risk of diabetes mellitus incidence. This finding supports the notion that inflammatory pathways are involved in the pathogenesis of diabetes. More intensive interventions targeting diabetes risk factors should be considered in people with rheumatoid arthritis.</p>","PeriodicalId":43231,"journal":{"name":"Cardiovascular Endocrinology & Metabolism","volume":"10 2","pages":"125-131"},"PeriodicalIF":2.3,"publicationDate":"2021-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b2/f8/xce-10-125.PMC8189616.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39092932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 19
Acute cardiac overload does not induce cardiac or skeletal expression of fibroblast growth factor 23 in rats. 急性心脏负荷不能诱导成纤维细胞生长因子23在大鼠心脏或骨骼中的表达。
IF 2.3
Cardiovascular Endocrinology & Metabolism Pub Date : 2021-02-14 eCollection Date: 2021-12-01 DOI: 10.1097/XCE.0000000000000249
Abul Fajol, Hirotaka Komaba, Chigusa Ishioka, Takehiko Wada, Masafumi Fukagawa
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