Hormonal and metabolic profiles of obese and nonobese type 2 diabetes patients: implications of plasma insulin, ghrelin, and vitamin D levels.

IF 1.3 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS
Cardiovascular Endocrinology & Metabolism Pub Date : 2022-01-21 eCollection Date: 2022-03-01 DOI:10.1097/XCE.0000000000000256
Hayder A Giha, Dhuha M B AlDehaini, Faris E Joatar, Muhalab E Ali, Einas M Al-Harbi, Ali A Al Qarni
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引用次数: 2

Abstract

Type 2 diabetes (T2D) is associated with obesity whereas loss of weight is a feature of the disease; however, the two states are not mutually exclusive. Obesity is linked with changes in hormonal activity and overall body metabolism.

Materials and methods: In this study, 408 T2D patients were recruited in three distinct studies conducted in Bahrain, Saudi Arabia, and Kuwait in three different intervals between 2001 and 2019. In addition to demographics, glycemic and lipid profiles were obtained in all studies, whereas plasma insulin and HOMA-IR, vitamin D, and ghrelin were analyzed in Saudi Arabia. Different techniques such as chemical auto-analyzer, ELISA, chemiluminescent immunoassay, radioimmunoassay were used.

Results: The obese (BMI ≥ 30 kg/m2) compared with nonobese (BMI 18.5 to <30) patients with diabetes were more likely to be women (P < 0.001), smaller in age (P = 0.028), and with shorter disease duration (P = 0.018). Unexpectedly, the glycemic and lipid profiles were consistently comparable between the two groups in the three sites. Furthermore, vitamin D was strikingly lower in obese patients with diabetes (P = 0.007). Finally, plasma ghrelin (P = 0.163), insulin (P = 0.063), and HOMA-IR (P = 0.166) were comparable between obese and nonobese patients with diabetes.

Conclusion: Diabetic obesity was significantly associated with female sex, young age, short disease duration, and noticeably low vitamin D, and a trend of high insulin levels. However, the obese and nonobese patients had comparable metabolic profiles with no differences in insulin resistance and ghrelin levels. Further studies, especially at a molecular level, are needed to explore this topic which is barely investigated.

Abstract Image

Abstract Image

肥胖和非肥胖2型糖尿病患者的激素和代谢特征:血浆胰岛素、胃饥饿素和维生素D水平的影响
2型糖尿病(T2D)与肥胖有关,而体重减轻是该疾病的一个特征;然而,这两个国家并不相互排斥。肥胖与荷尔蒙活动和全身新陈代谢的变化有关。材料和方法:在这项研究中,在2001年至2019年的三个不同时间间隔内,在巴林、沙特阿拉伯和科威特进行了三项不同的研究,招募了408名T2D患者。除人口统计学外,所有研究均获得血糖和脂质谱,而在沙特阿拉伯分析血浆胰岛素和HOMA-IR、维生素D和胃饥饿素。采用了化学自动分析仪、ELISA、化学发光免疫分析法、放射免疫分析法等技术。结果:肥胖者(BMI≥30 kg/m2)与非肥胖者(BMI 18.5至P < 0.001)相比,年龄较小(P = 0.028),病程较短(P = 0.018)。出乎意料的是,两组在三个部位的血糖和脂质谱一致相当。此外,肥胖糖尿病患者的维生素D含量明显较低(P = 0.007)。最后,血浆胃饥饿素(P = 0.163)、胰岛素(P = 0.063)和HOMA-IR (P = 0.166)在肥胖和非肥胖糖尿病患者之间具有可比性。结论:糖尿病性肥胖与女性、年龄小、病程短、维生素D明显偏低、胰岛素水平有升高趋势相关。然而,肥胖和非肥胖患者的代谢谱相似,胰岛素抵抗和胃饥饿素水平没有差异。需要进一步的研究,特别是在分子水平上,探索这个几乎没有研究过的话题。
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来源期刊
Cardiovascular Endocrinology & Metabolism
Cardiovascular Endocrinology & Metabolism CARDIAC & CARDIOVASCULAR SYSTEMS-
CiteScore
5.60
自引率
0.00%
发文量
24
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