Cardiovascular Endocrinology & Metabolism最新文献_第3页

Naltrexone alters cardiovascular function following acute forced swimming in mice 纳曲酮改变小鼠急性强迫游泳后的心血管功能

IF 2.3

Cardiovascular Endocrinology & Metabolism Pub Date : 2022-04-13 DOI: 10.1097/XCE.0000000000000263

C. Longoria, Qudratullah S. Qadiri, E. Matthews, S. Campbell, J. Guers

{"title":"Naltrexone alters cardiovascular function following acute forced swimming in mice","authors":"C. Longoria, Qudratullah S. Qadiri, E. Matthews, S. Campbell, J. Guers","doi":"10.1097/XCE.0000000000000263","DOIUrl":"https://doi.org/10.1097/XCE.0000000000000263","url":null,"abstract":"Purpose Naltrexone (NTX) is an opioid antagonist that can reverse the physiological effects of opioid receptors when bound. Opioid receptors have been found to play a role in cardiovascular (CV) function, and thus, binding of NTX may alter CV activity at rest and in response to acute and chronic exercise (EX). We hypothesized that opioid receptor blockade will alter the typical CV responses following acute EX. Methods We assessed the effects of opioid receptor blockade on CV function via echocardiography in mice following an acute bout of forced swimming (FSw), a model of rodent EX. We administered opioid receptor antagonist, NTX, or saline in mice before FSw and in the absence of an FSw perturbation. Furthermore, we assessed how NTX can influence maximal EX capacity on a rodent treadmill. Results Our data shows that NTX administration does not decrease maximal EX capacity in mice (P > 0.05). However, NTX attenuated cardiac output following FSw (FSw = 52.5 ± 2.5 ml/min vs. FSw + NTX = 32.7 ± 5.2 ml/min; P < 0.05) when compared with saline control (33.5 ± 3.8 ml/min). Further, the administration of NTX in the non-EX condition significantly (P < 0.05) reduced ejection fraction. Conclusion These data suggest that normal opioid receptor activation is necessary for typical CV function following FSw.","PeriodicalId":43231,"journal":{"name":"Cardiovascular Endocrinology & Metabolism","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2022-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48375480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Reducing fatigue-related symptoms in Long COVID-19: a preliminary report of a lymphatic drainage intervention. 减少长期新冠肺炎的疲劳相关症状：淋巴引流干预的初步报告。

IF 2.3

Cardiovascular Endocrinology & Metabolism Pub Date : 2022-04-12 DOI: 10.1097/XCE.0000000000000261

Adrian H Heald, Raymond Perrin, Andreas Walther, Mike Stedman, Mark Hann, Annice Mukherjee, Lisa Riste

{"title":"Reducing fatigue-related symptoms in Long COVID-19: a preliminary report of a lymphatic drainage intervention.","authors":"Adrian H Heald, Raymond Perrin, Andreas Walther, Mike Stedman, Mark Hann, Annice Mukherjee, Lisa Riste","doi":"10.1097/XCE.0000000000000261","DOIUrl":"https://doi.org/10.1097/XCE.0000000000000261","url":null,"abstract":"In the early days of the first global wave of the COVID-19 pandemic, the potential for a postviral syndrome to manifest following COVID-19 infection was first recognized. Here, we present an analysis of a case series of the first 20 patients' data collected in clinical practice to evaluate the potential of a possible alternative treatment for Long COVID.Methods: Face-to-face treatment sessions with Perrin technique practitioners occurred weekly involving effleurage/other manual articulatory techniques. The individuals being treated also undertook daily self-massage along with gentle mobility exercises. Patients recorded symptom severity using the self-report 54-item profile of fatigue-related states (PFRS) before and after treatment.Results: The mean age of male patients was 41.8 years (range, 29-53 years), and for female patients, 39.3 years (range, 28-50 years). None of the participants had a prior diagnosis of chronic fatigue syndrome, and all were new attendees to the clinics at the time of initial assessment. The average number of treatment sessions was 9.7 in men and 9.4 in women. The reduction in PFRS scores was 45% in men and 52% in women. The highest subscale scores on average were for fatigue, with the lowest for somatic symptoms. All subscale scores showed, on average, a similar reduction of approximately 50% postintervention, with the reduction in score relating to a decrease in the severity of symptoms.Conclusion: Our findings suggest that a specific manual lymphatic drainage intervention may help to reduce fatigue symptoms related to Long COVID. Perhaps preventing acute symptoms through early intervention.","PeriodicalId":43231,"journal":{"name":"Cardiovascular Endocrinology & Metabolism","volume":"11 2","pages":"e0261"},"PeriodicalIF":2.3,"publicationDate":"2022-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9010124/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41162575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Living with diabetes and its impact on mental health: results of an online survey 糖尿病患者及其对心理健康的影响:一项在线调查的结果

IF 2.3

Cardiovascular Endocrinology & Metabolism Pub Date : 2022-03-29 DOI: 10.1097/XCE.0000000000000262

M. Stedman, Saydah Eltom, E. Solomon, R. Rea, K. Grady, Nadia Chaudhury, S. Brown, A. Paisley, R. Gadsby, A. Heald

引用次数: 0

Actiste diabetes management as a service innovation – impact on everyday life – Swedish patients experience assessed by validated MedTech20 questionnaire 将糖尿病管理作为一项服务创新——对日常生活的影响——通过验证的MedTech20问卷评估瑞典患者的体验

IF 2.3

Cardiovascular Endocrinology & Metabolism Pub Date : 2022-02-08 DOI: 10.1097/xce.0000000000000259

A. Heald, Elisabeth Malm, Ghassan Darwiche, Adintya Putri, D. Zdravković

引用次数: 0

SARS-CoV-2, diabetes and mortality: month by month variation in mortality rate from June 2020 to June 2021. SARS-CoV-2、糖尿病和死亡率:2020年6月至2021年6月死亡率逐月变化

IF 2.3

Cardiovascular Endocrinology & Metabolism Pub Date : 2022-01-28 eCollection Date: 2022-03-01 DOI: 10.1097/XCE.0000000000000258

Adrian H Heald, David A Jenkins, Nadia Chaudhury, Richard Williams, Matthew Sperrin, Niels Peek, William Ollier, Kelly Bowden-Davies, Gayathri Delanerolle, Simon G Anderson, John Martin Gibson

{"title":"SARS-CoV-2, diabetes and mortality: month by month variation in mortality rate from June 2020 to June 2021.","authors":"Adrian H Heald, David A Jenkins, Nadia Chaudhury, Richard Williams, Matthew Sperrin, Niels Peek, William Ollier, Kelly Bowden-Davies, Gayathri Delanerolle, Simon G Anderson, John Martin Gibson","doi":"10.1097/XCE.0000000000000258","DOIUrl":"https://doi.org/10.1097/XCE.0000000000000258","url":null,"abstract":"Adrian H. Heald, David A. Jenkins, Nadia Chaudhury, Richard Williams, Matthew Sperrin, Niels Peek, William Ollier, Kelly Bowden-Davies, Gayathri Delanerolle, Simon G. Anderson and John Martin Gibson, The School of Medicine and Manchester Academic Health Sciences Centre, The University of Manchester, Manchester, Department of Diabetes and Endocrinology, Salford Royal NHS Foundation Trust, Salford, Division of Informatics, Imaging and Data Science, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, NIHR Greater Manchester Patient Safety Translational Research Centre, The University of Manchester, Manchester, University Hospitals Coventry and Warwickshire, Coventry, Faculty of Science and Engineering, Manchester Metropolitan University, Manchester, Department of Sport and Exercise Sciences, Musculoskeletal Science and Sports Medicine Research Centre, Manchester Metropolitan University, Manchester, Nuffield Department of Primary Health Care Science, University of Oxford (Substantive), Oxford, Clinical Research Facility, Southern Health NHS Foundation Trust (Honorary), Southampton, UK, The George Alleyne Chronic Disease Research Centre, University of the West Indies, Cave Hill Campus, Bridgetown, Barbados and Division of Cardiovascular Sciences, Faculty of Biology Medicine and Health, University of Manchester, Manchester, UK","PeriodicalId":43231,"journal":{"name":"Cardiovascular Endocrinology & Metabolism","volume":"11 1","pages":"e0258"},"PeriodicalIF":2.3,"publicationDate":"2022-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8805796/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39895413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application of a city wide digital population database for outcome analysis in diabetes: SARS-CoV-2, diabetes and hospital admission rate month by month in Greater Manchester, UK. 应用全市数字人口数据库进行糖尿病结局分析:英国大曼彻斯特逐月的SARS-CoV-2、糖尿病和住院率

IF 2.3

Cardiovascular Endocrinology & Metabolism Pub Date : 2022-01-28 eCollection Date: 2022-03-01 DOI: 10.1097/XCE.0000000000000257

Adrian H Heald, David A Jenkins, Nadia Chaudhury, Richard Williams, Matthew Sperrin, Niels Peek, William Ollier, Kelly Bowden-Davies, Gayathri Delanerolle, Simon G Anderson, John Martin Gibson

{"title":"Application of a city wide digital population database for outcome analysis in diabetes: SARS-CoV-2, diabetes and hospital admission rate month by month in Greater Manchester, UK.","authors":"Adrian H Heald, David A Jenkins, Nadia Chaudhury, Richard Williams, Matthew Sperrin, Niels Peek, William Ollier, Kelly Bowden-Davies, Gayathri Delanerolle, Simon G Anderson, John Martin Gibson","doi":"10.1097/XCE.0000000000000257","DOIUrl":"https://doi.org/10.1097/XCE.0000000000000257","url":null,"abstract":"Adrian H. Heald, David A. Jenkins, Nadia Chaudhury, Richard Williams, Matthew Sperrin, Niels Peek, William Ollier, Kelly Bowden-Davies, Gayathri Delanerolle, Simon G. Anderson and John Martin Gibson, The School of Medicine and Manchester Academic Health Sciences Centre, The University of Manchester, Manchester, Department of Diabetes and Endocrinology, Salford Royal NHS Foundation Trust, Salford, Division of Informatics, Imaging and Data Science, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, NIHR Greater Manchester Patient Safety Translational Research Centre, The University of Manchester, Manchester, University Hospitals Coventry and Warwickshire, Coventry, Faculty of Science and Engineering, Manchester Metropolitan University, Manchester, Department of Sport and Exercise Sciences, Musculoskeletal Science and Sports Medicine Research Centre, Manchester Metropolitan University, Manchester, Nuffield Department of Primary Health Care Science, University of Oxford (Substantive), Oxford, Clinical Research Facility, Southern Health NHS Foundation Trust (Honorary), Southampton, UK, The George Alleyne Chronic Disease Research Centre, University of the West Indies, Cave Hill Campus, Bridgetown, Barbados and Division of Cardiovascular Sciences, Faculty of Biology Medicine and Health, University of Manchester, Manchester, UK","PeriodicalId":43231,"journal":{"name":"Cardiovascular Endocrinology & Metabolism","volume":"11 1","pages":"e0257"},"PeriodicalIF":2.3,"publicationDate":"2022-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8805797/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39895412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hormonal and metabolic profiles of obese and nonobese type 2 diabetes patients: implications of plasma insulin, ghrelin, and vitamin D levels. 肥胖和非肥胖2型糖尿病患者的激素和代谢特征:血浆胰岛素、胃饥饿素和维生素D水平的影响

IF 2.3

Cardiovascular Endocrinology & Metabolism Pub Date : 2022-01-21 eCollection Date: 2022-03-01 DOI: 10.1097/XCE.0000000000000256

Hayder A Giha, Dhuha M B AlDehaini, Faris E Joatar, Muhalab E Ali, Einas M Al-Harbi, Ali A Al Qarni

{"title":"Hormonal and metabolic profiles of obese and nonobese type 2 diabetes patients: implications of plasma insulin, ghrelin, and vitamin D levels.","authors":"Hayder A Giha, Dhuha M B AlDehaini, Faris E Joatar, Muhalab E Ali, Einas M Al-Harbi, Ali A Al Qarni","doi":"10.1097/XCE.0000000000000256","DOIUrl":"https://doi.org/10.1097/XCE.0000000000000256","url":null,"abstract":"Type 2 diabetes (T2D) is associated with obesity whereas loss of weight is a feature of the disease; however, the two states are not mutually exclusive. Obesity is linked with changes in hormonal activity and overall body metabolism.Materials and methods: In this study, 408 T2D patients were recruited in three distinct studies conducted in Bahrain, Saudi Arabia, and Kuwait in three different intervals between 2001 and 2019. In addition to demographics, glycemic and lipid profiles were obtained in all studies, whereas plasma insulin and HOMA-IR, vitamin D, and ghrelin were analyzed in Saudi Arabia. Different techniques such as chemical auto-analyzer, ELISA, chemiluminescent immunoassay, radioimmunoassay were used.Results: The obese (BMI ≥ 30 kg/m2) compared with nonobese (BMI 18.5 to <30) patients with diabetes were more likely to be women (P < 0.001), smaller in age (P = 0.028), and with shorter disease duration (P = 0.018). Unexpectedly, the glycemic and lipid profiles were consistently comparable between the two groups in the three sites. Furthermore, vitamin D was strikingly lower in obese patients with diabetes (P = 0.007). Finally, plasma ghrelin (P = 0.163), insulin (P = 0.063), and HOMA-IR (P = 0.166) were comparable between obese and nonobese patients with diabetes.Conclusion: Diabetic obesity was significantly associated with female sex, young age, short disease duration, and noticeably low vitamin D, and a trend of high insulin levels. However, the obese and nonobese patients had comparable metabolic profiles with no differences in insulin resistance and ghrelin levels. Further studies, especially at a molecular level, are needed to explore this topic which is barely investigated.","PeriodicalId":43231,"journal":{"name":"Cardiovascular Endocrinology & Metabolism","volume":"11 1","pages":"e0256"},"PeriodicalIF":2.3,"publicationDate":"2022-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789207/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39573842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

The risk factors potentially influencing risk of serious illness/death in people with diabetes, following SARS-CoV-2 infection: What needs to be done from here. 在SARS-CoV-2感染后，可能影响糖尿病患者严重疾病/死亡风险的危险因素:从这里需要做些什么?

IF 2.3

Cardiovascular Endocrinology & Metabolism Pub Date : 2021-10-28 eCollection Date: 2021-12-01 DOI: 10.1097/XCE.0000000000000255

Adrian H Heald, Mark Livingston, Gabriela Moreno, John Martin Gibson

引用次数: 1

Genetic association of LPL rs326 with BMI among the Kuwaiti population. 科威特人群中LPL rs326与BMI的遗传关联

IF 2.3

Cardiovascular Endocrinology & Metabolism Pub Date : 2021-09-27 eCollection Date: 2021-12-01 DOI: 10.1097/XCE.0000000000000254

Sara H Malek, Ahmad E Al-Serri, Suzanne A Al-Bustan

{"title":"Genetic association of LPL rs326 with BMI among the Kuwaiti population.","authors":"Sara H Malek, Ahmad E Al-Serri, Suzanne A Al-Bustan","doi":"10.1097/XCE.0000000000000254","DOIUrl":"https://doi.org/10.1097/XCE.0000000000000254","url":null,"abstract":"Lipoprotein lipase is a key enzyme in lipid metabolism with reported variants associated with obesity, hypertension, type 2 diabetes, and coronary heart disease. This study was performed to investigate the association between common lipoprotein lipase single nucleotide polymorphisms and metabolic disorders in a sample of Kuwaiti cohort (n = 494). Five lipoprotein lipase variants (rs1801177, rs295, rs326, ss2137497749, and ss2137497750) across the lipoprotein lipase gene were genotyped by real-time PCR employing the TaqMan allele discrimination assay. Genotype, allelic frequencies, and Hardy-Weinberg Equilibrium were determined for each variant in the cohort followed by multivariate and logistic regression analysis. A novel finding was observed for the G allele of single nucleotide polymorphism rs326 which was associated with increased BMI after adjusting for age and sex (β = 1.04; 95% confidence interval = 0.15-1.94; P = 0.02). Moreover, a significant difference in the distribution of the minor C allele of rs295 among coronary heart disease subjects compared with noncoronary heart disease, however, this significance was diminished after controlling for age, sex, and BMI. This study demonstrated that lipoprotein lipase rs326 may be indicative for the increased risk of obesity and possibly rs295 for coronary heart disease. The findings are also in agreement with other reports suggesting that intronic variants are important genetic markers in association studies. The findings warrant further studies in a large cohort to confirm and validate the results presented.","PeriodicalId":43231,"journal":{"name":"Cardiovascular Endocrinology & Metabolism","volume":"10 4","pages":"215-221"},"PeriodicalIF":2.3,"publicationDate":"2021-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e6/c9/xce-10-215.PMC8575433.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39614097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

The microvascular hypothesis underlying neurologic manifestations of long COVID-19 and possible therapeutic strategies. 长期COVID-19神经系统表现的微血管假说及可能的治疗策略

IF 2.3

Cardiovascular Endocrinology & Metabolism Pub Date : 2021-08-19 eCollection Date: 2021-12-01 DOI: 10.1097/XCE.0000000000000253

引用次数: 8